MX2009013581A - Derivados de 4-(n-azacicloalquil)anilidas como moduladores del canal de potasio. - Google Patents

Derivados de 4-(n-azacicloalquil)anilidas como moduladores del canal de potasio.

Info

Publication number
MX2009013581A
MX2009013581A MX2009013581A MX2009013581A MX2009013581A MX 2009013581 A MX2009013581 A MX 2009013581A MX 2009013581 A MX2009013581 A MX 2009013581A MX 2009013581 A MX2009013581 A MX 2009013581A MX 2009013581 A MX2009013581 A MX 2009013581A
Authority
MX
Mexico
Prior art keywords
formula
provides
potassium channel
channel modulators
azacycloalkyl
Prior art date
Application number
MX2009013581A
Other languages
English (en)
Inventor
La Rosa Martha Alicia De
Jean-Michel Vernier
Samedy Ouk
Original Assignee
Valeant Pharmaceuticals Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valeant Pharmaceuticals Int filed Critical Valeant Pharmaceuticals Int
Publication of MX2009013581A publication Critical patent/MX2009013581A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Esta invención proporciona moduladores del canal de potasio que son compuestos de fórmula I (ver fórmula (I)) en donde al menos uno de W y Z es N; en donde la porción (ver fórmula (II)) es uno de los Grupos A o B siguientes (ver fórmula (A)) en donde Ar es un grupo anular aromático fusionado en las posiciones 1,2, de seis miembros, que porta los sustituyentes R1 y R2 como se define a continuación, y que contiene cero o un átomo de nitrógeno en el anillo; y en donde los otros sustituyentes son como se define en la presente; la invención también proporciona una composición que comprende un portador farmacéuticamente aceptable y al menos uno de lo siguiente: i) una cantidad farmacéuticamente efectiva de un compuesto de fórmula I y ii) una sal, éster o profármaco farmacéuticamente aceptable del mismo; la invención también proporciona un método para prevenir o tratar una enfermedad o trastorno, que es afectado por las actividades de los canales de potasio, que comprende administrar a un paciente en necesidad del mismo, una cantidad terapéuticamente efectiva de un compuesto de fórmula I o una sal, éster o profármaco del mismo.
MX2009013581A 2007-06-13 2008-06-13 Derivados de 4-(n-azacicloalquil)anilidas como moduladores del canal de potasio. MX2009013581A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93439607P 2007-06-13 2007-06-13
US12/138,251 US8367684B2 (en) 2007-06-13 2008-06-12 Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
PCT/US2008/066984 WO2008157404A2 (en) 2007-06-13 2008-06-13 Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators

Publications (1)

Publication Number Publication Date
MX2009013581A true MX2009013581A (es) 2010-01-26

Family

ID=40137141

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013581A MX2009013581A (es) 2007-06-13 2008-06-13 Derivados de 4-(n-azacicloalquil)anilidas como moduladores del canal de potasio.

Country Status (18)

Country Link
US (1) US8367684B2 (es)
EP (1) EP2170861B1 (es)
JP (1) JP2010530002A (es)
KR (1) KR20100018618A (es)
CN (1) CN101868451A (es)
AU (1) AU2008266009B2 (es)
BR (1) BRPI0812564A2 (es)
CA (1) CA2689208A1 (es)
DK (1) DK2170861T3 (es)
ES (1) ES2392774T3 (es)
HR (1) HRP20120857T1 (es)
MX (1) MX2009013581A (es)
PL (1) PL2170861T3 (es)
PT (1) PT2170861E (es)
RU (1) RU2010100893A (es)
SI (1) SI2170861T1 (es)
TW (1) TW200914452A (es)
WO (1) WO2008157404A2 (es)

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CN108250128A (zh) * 2012-09-27 2018-07-06 江苏先声药业有限公司 作为钾通道调节剂的化合物
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WO2023125935A1 (zh) * 2021-12-31 2023-07-06 上海翰森生物医药科技有限公司 苯并哌啶衍生物调节剂、其制备方法和应用
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Also Published As

Publication number Publication date
HRP20120857T1 (hr) 2012-11-30
CN101868451A (zh) 2010-10-20
US8367684B2 (en) 2013-02-05
WO2008157404A2 (en) 2008-12-24
TW200914452A (en) 2009-04-01
ES2392774T3 (es) 2012-12-13
PL2170861T3 (pl) 2013-01-31
RU2010100893A (ru) 2011-07-20
AU2008266009B2 (en) 2013-06-06
JP2010530002A (ja) 2010-09-02
BRPI0812564A2 (pt) 2015-02-10
US20080318979A1 (en) 2008-12-25
CA2689208A1 (en) 2008-12-24
EP2170861A2 (en) 2010-04-07
DK2170861T3 (da) 2012-11-26
EP2170861B1 (en) 2012-08-29
PT2170861E (pt) 2012-09-06
WO2008157404A3 (en) 2009-02-19
AU2008266009A1 (en) 2008-12-24
SI2170861T1 (sl) 2012-12-31
KR20100018618A (ko) 2010-02-17

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