HRP20120643T1 - Liječenje poremećaja hrskavice sa fgf-18 - Google Patents
Liječenje poremećaja hrskavice sa fgf-18 Download PDFInfo
- Publication number
- HRP20120643T1 HRP20120643T1 HRP20120643TT HRP20120643T HRP20120643T1 HR P20120643 T1 HRP20120643 T1 HR P20120643T1 HR P20120643T T HRP20120643T T HR P20120643TT HR P20120643 T HRP20120643 T HR P20120643T HR P20120643 T1 HRP20120643 T1 HR P20120643T1
- Authority
- HR
- Croatia
- Prior art keywords
- fgf
- compound
- use according
- osteoarthritis
- mcg
- Prior art date
Links
- 102000003977 fibroblast growth factor 18 Human genes 0.000 title claims abstract 29
- 108090000370 fibroblast growth factor 18 Proteins 0.000 title claims abstract 29
- 208000015100 cartilage disease Diseases 0.000 title claims abstract 5
- 150000001875 compounds Chemical class 0.000 claims abstract 27
- 206010061762 Chondropathy Diseases 0.000 claims abstract 4
- 201000008482 osteoarthritis Diseases 0.000 claims 5
- 238000002560 therapeutic procedure Methods 0.000 claims 4
- 208000007353 Hip Osteoarthritis Diseases 0.000 claims 2
- 206010007710 Cartilage injury Diseases 0.000 claims 1
- 208000003947 Knee Osteoarthritis Diseases 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06119557 | 2006-08-25 | ||
| US84060006P | 2006-08-28 | 2006-08-28 | |
| PCT/EP2007/058830 WO2008023063A2 (en) | 2006-08-25 | 2007-08-24 | Treatment of cartilage disorders with fgf-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120643T1 true HRP20120643T1 (hr) | 2012-08-31 |
Family
ID=38984134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20120643TT HRP20120643T1 (hr) | 2006-08-25 | 2012-08-08 | Liječenje poremećaja hrskavice sa fgf-18 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8207115B2 (de) |
| EP (1) | EP2054050B1 (de) |
| JP (2) | JP5815206B2 (de) |
| KR (1) | KR101419961B1 (de) |
| AR (1) | AR062522A1 (de) |
| AU (1) | AU2007287510B2 (de) |
| CA (1) | CA2658511C (de) |
| CY (1) | CY1113136T1 (de) |
| EA (1) | EA015644B1 (de) |
| HR (1) | HRP20120643T1 (de) |
| IL (1) | IL197169A (de) |
| MX (1) | MX2009002063A (de) |
| PL (1) | PL2054050T3 (de) |
| WO (1) | WO2008023063A2 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012038953A2 (en) | 2010-09-21 | 2012-03-29 | Hepacore Ltd. | Fgf-18 truncated variants having increased receptor specificity and uses thereof |
| WO2012140650A2 (en) | 2011-04-12 | 2012-10-18 | Hepacore Ltd. | Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof |
| TWI527590B (zh) | 2011-06-17 | 2016-04-01 | 艾瑞斯貿易公司 | Ｆｇｆ－１８之凍乾調配物 |
| US9790264B2 (en) | 2012-06-25 | 2017-10-17 | The Brigham And Women's Hospital, Inc. | Compounds and methods for modulating pharmacokinetics |
| PT2864360T (pt) | 2012-06-25 | 2018-01-05 | The Brigham And Women`S Hospital Inc | Terapêuticas dirigidas ao alvo |
| CA2881027C (en) * | 2012-08-06 | 2022-06-28 | Merck Patent Gmbh | Prognosis biomarkers in cartilage disorders |
| CN104736723B (zh) * | 2012-08-06 | 2017-10-31 | 默克专利有限公司 | 用于预测对fgf‑18化合物的响应性的遗传标记 |
| JP6791754B2 (ja) | 2013-12-24 | 2020-11-25 | アレス トレーディング ソシエテ アノニム | キシログルカンゲル中のｆｇｆ−１８製剤 |
| AR099557A1 (es) * | 2014-02-20 | 2016-08-03 | Merck Patent Gmbh | Fgf-18 en trasplantes de injertos y procedimientos de ingeniería de tejido |
| SG11201606505UA (en) * | 2014-02-20 | 2016-09-29 | Merck Patent Gmbh | Fgf-18 compound dosing regimen |
| US20180024142A1 (en) | 2015-01-29 | 2018-01-25 | Ares Trading S.A. | Immunoassays for high positively charged proteins |
| DK3265115T3 (da) * | 2015-03-03 | 2022-09-05 | Radius Health Inc | Abaloparatid kombineret med alendronat til reduktion af ikke-vertebrale knoglebrud |
| MX2017013802A (es) | 2015-04-29 | 2018-08-15 | Radius Pharmaceuticals Inc | Métodos para tratar el cáncer. |
| JP6951318B2 (ja) * | 2015-07-15 | 2021-10-20 | プロージット ソウル バイオテクノロジー （ベイジン） カンパニー リミテッド | 融合ポリペプチドおよび使用方法 |
| KR20180035911A (ko) * | 2015-08-13 | 2018-04-06 | 메르크 파텐트 게엠베하 | Fgf-18 화합물을 포함하는 조합 조성물 |
| EP3318563A1 (de) | 2016-11-07 | 2018-05-09 | Sanofi | Substituierte pyrido[3,4-b]indole zur behandlung von knorpelerkrankungen |
| MX2019007748A (es) | 2017-01-05 | 2019-09-09 | Radius Pharmaceuticals Inc | Formas polimorficas de rad1901-2hcl. |
| CN107338218B (zh) * | 2017-07-28 | 2020-11-24 | 中国人民解放军总医院第一附属医院 | 一种诱导脂肪干细胞向软骨细胞分化的诱导分化培养基和方法 |
| SG11202001772SA (en) * | 2017-09-21 | 2020-04-29 | Merck Patent Gmbh | Fusion protein comprising an fgf-18 moiety |
| SI3688468T1 (sl) * | 2017-09-29 | 2022-08-31 | Merck Patent Gmbh | Vnetni biomarkerji za predvidevanje odzivov na spojino FGF-18 |
| RS63293B1 (sr) * | 2017-09-29 | 2022-06-30 | Merck Patent Gmbh | Metabolički biomarkeri za predviđanje reakcije na jedinjenje fgf-18 |
| SG11202013177WA (en) | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals Inc | Polymorphic forms of rad 1901-2hcl |
| MX2021002803A (es) | 2018-09-10 | 2021-07-16 | Merck Patent Gmbh | Marcadores utiles en estrategias de enriquecimiento para el tratamiento de osteoartritis. |
| WO2020104833A1 (en) * | 2018-11-19 | 2020-05-28 | 4P-Pharma | Composition and methods for regulating chondrocyte proliferation and increasing of cartilage matrix production |
| CA3127729A1 (en) | 2019-02-08 | 2020-08-13 | Merck Patent Gmbh | Treatment of patients at risk of rapid progression of osteoarthritis |
| CN109836487B (zh) * | 2019-03-01 | 2022-06-17 | 重庆派金生物科技有限公司 | 一种人成纤维细胞生长因子18及其可溶性重组表达方法、制备方法、制剂和应用 |
| CN117721115A (zh) * | 2022-09-06 | 2024-03-19 | 深圳瑞吉生物科技有限公司 | 用于治疗骨关节炎的mRNA及其制备方法与应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2225840T3 (es) * | 1994-03-08 | 2005-03-16 | Osteosa Liquidation Trust | Utilizacion de factores de crecimiento de fibroblasto para estimular el crecimiento oseo. |
| US20050043234A1 (en) * | 1996-10-16 | 2005-02-24 | Deisher Theresa A. | Novel FGF homologs |
| JPH11332570A (ja) * | 1998-05-27 | 1999-12-07 | Shionogi & Co Ltd | 新規な線維芽細胞成長因子及びそれをコードする遺伝子 |
| CA2393200C (en) * | 1999-12-02 | 2011-07-12 | Zymogenetics, Inc. | Methods for targeting cells that express fibroblast growth receptor-3 or-2 |
| KR20040055733A (ko) * | 2001-02-28 | 2004-06-26 | 콘드로진 인코포레이티드 | 골관절염에 관련된 조성물 및 방법 |
| CA2500742C (en) * | 2002-10-07 | 2014-02-18 | Zymogenetics, Inc. | Compositions of fgf-18 and hyaluronic acid for stimulating cartilage production and treating osteoarthritis |
| AU2005269995C1 (en) * | 2004-07-06 | 2011-12-01 | Zymogenetics, Inc. | Pharmaceutical composition comprising FGF18 and IL-1 antagonist and method of use |
| AU2005314438B2 (en) * | 2004-12-10 | 2012-03-29 | Zymogenetics, Inc. | FGF18 production in prokaryotic hosts |
-
2007
- 2007-08-24 US US12/374,488 patent/US8207115B2/en active Active
- 2007-08-24 AU AU2007287510A patent/AU2007287510B2/en active Active
- 2007-08-24 JP JP2009525079A patent/JP5815206B2/ja active Active
- 2007-08-24 EP EP07802876A patent/EP2054050B1/de active Active
- 2007-08-24 EA EA200970224A patent/EA015644B1/ru unknown
- 2007-08-24 KR KR1020097006119A patent/KR101419961B1/ko active IP Right Grant
- 2007-08-24 AR ARP070103770A patent/AR062522A1/es not_active Application Discontinuation
- 2007-08-24 MX MX2009002063A patent/MX2009002063A/es active IP Right Grant
- 2007-08-24 CA CA2658511A patent/CA2658511C/en active Active
- 2007-08-24 WO PCT/EP2007/058830 patent/WO2008023063A2/en active Application Filing
- 2007-08-24 PL PL07802876T patent/PL2054050T3/pl unknown
-
2009
- 2009-02-22 IL IL197169A patent/IL197169A/en active IP Right Grant
-
2012
- 2012-08-08 HR HRP20120643TT patent/HRP20120643T1/hr unknown
- 2012-09-13 CY CY20121100837T patent/CY1113136T1/el unknown
-
2014
- 2014-01-14 JP JP2014004339A patent/JP2014088429A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007287510A1 (en) | 2008-02-28 |
| IL197169A (en) | 2013-08-29 |
| PL2054050T3 (pl) | 2013-01-31 |
| AR062522A1 (es) | 2008-11-12 |
| EA200970224A1 (ru) | 2009-08-28 |
| US8207115B2 (en) | 2012-06-26 |
| CY1113136T1 (el) | 2016-04-13 |
| JP5815206B2 (ja) | 2015-11-17 |
| KR101419961B1 (ko) | 2014-07-30 |
| WO2008023063A2 (en) | 2008-02-28 |
| WO2008023063A3 (en) | 2008-05-02 |
| CA2658511A1 (en) | 2008-02-28 |
| JP2010501531A (ja) | 2010-01-21 |
| AU2007287510B2 (en) | 2012-08-30 |
| JP2014088429A (ja) | 2014-05-15 |
| CA2658511C (en) | 2019-02-19 |
| EA015644B1 (ru) | 2011-10-31 |
| MX2009002063A (es) | 2009-03-06 |
| IL197169A0 (en) | 2009-12-24 |
| EP2054050A2 (de) | 2009-05-06 |
| EP2054050B1 (de) | 2012-08-08 |
| US20100016223A1 (en) | 2010-01-21 |
| KR20090051100A (ko) | 2009-05-20 |
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