HRP20110959T1 - Pirfenidonska terapija kojom se izbjegava upotreba fluvoksamina - Google Patents
Pirfenidonska terapija kojom se izbjegava upotreba fluvoksamina Download PDFInfo
- Publication number
- HRP20110959T1 HRP20110959T1 HR20110959T HRP20110959T HRP20110959T1 HR P20110959 T1 HRP20110959 T1 HR P20110959T1 HR 20110959 T HR20110959 T HR 20110959T HR P20110959 T HRP20110959 T HR P20110959T HR P20110959 T1 HRP20110959 T1 HR P20110959T1
- Authority
- HR
- Croatia
- Prior art keywords
- pirfenidone
- disease
- patient
- use according
- fluvoxamine
- Prior art date
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- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 title claims abstract 28
- 229960003073 pirfenidone Drugs 0.000 title claims abstract 28
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 title claims abstract 10
- 229960004038 fluvoxamine Drugs 0.000 title claims abstract 10
- 238000002560 therapeutic procedure Methods 0.000 title claims abstract 7
- 208000002193 Pain Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 4
- 230000036407 pain Effects 0.000 claims 4
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 206010040070 Septic Shock Diseases 0.000 claims 3
- 230000003176 fibrotic effect Effects 0.000 claims 3
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
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- 208000026310 Breast neoplasm Diseases 0.000 claims 2
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- 230000001154 acute effect Effects 0.000 claims 2
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- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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Abstract
Pirfenidon za upotrebu u liječenju pacijenta kojem je potrebna terapija pirfenidona, naznačen time, što liječenje obuhvaća izbjegavanje, sprječavanje primjene ili prekidanje istovremene upotrebe fluvoksamina. Patent sadrži još 12 patentnih zahtjeva.
Claims (13)
1. Pirfenidon za upotrebu u liječenju pacijenta kojem je potrebna terapija pirfenidona, naznačen time, što liječenje obuhvaća izbjegavanje, sprječavanje primjene ili prekidanje istovremene upotrebe fluvoksamina.
2. Upotreba pirfenidona u proizvodnji lijeka za liječenje pacijenta kojem je potrebna pirfenidonska terapija, naznačen time, što liječenje obuhvaća izbjegavanje, sprječavanje primjene ili prekidanje zajedničke upotrebe fluvoksamina.
3. Pirfenidon za upotrebu prema zahtjevu 1 ili upotrebu prema zahtjevu 2, naznačen time što je pacijent, pacijent koji izbjegava istovremenu upotrebu fluvoksamina zato što je istovremena upotreba pirfenidona sa fluvoksaminom kontraindikativna.
4. Pirfenidon za upotrebu prema zahtjevu 1 ili upotrebu prema zahtjevu 2, naznačen time što je pacijent, pacijent koji je prekinuo upotrebu fluvoksamina prije početka pirfenidonske terapije u cilju izbjegavanja smanjenog klirensa ili povećanog izlaganja pirfenidonu.
5. Pirfenidon za upotrebu ili upotreba prema bilo kojem od zahtjeva 1 do 3, naznačen time što je davanje fluvoksamina pacijentima kontraindikativno ili izbjegavano u cilju izbjegavanja smanjenog klirensa ili povećanog izlaganja pirfenidonu.
6. Pirfenidon za upotrebu ili upotreba prema zahtjevu 4, naznačen time što je pacijent prekinuo uzimanje fluvoksamina u toku 1 mjeseca prije početka pirfenidonske terapije.
7. Pirfenidon za upotrebu ili upotreba prema zahtjevu 4, naznačen time što je pacijent prekinuo uzimanje fluvoksamina u toku 2 tjedna prije početka pirfenidonske terapije.
8. Pirfenidon za upotrebu ili upotreba prema bilo kojem od zahtjeva 1 do 7, naznačen time što pacijent pati od bolesti izabrane od plućne fibroze, idiopatske pulmonarne fibroze, idiopatske interstinalne pneumonije, autoimune bolesti pluća, benigne hipertrofije prostate, koronarnog ili miokardialnog infarkta, atrijalne fibrilacije, cerebralnog infarkta, miokardijalne fibroze, muskuloskeletalne fibroze, post-kirurške adhezije, ciroze jetre, renalne fibrozne bolesti, fibrozne vaskularne bolesti, skleroderme, Hermansky-Pudlakovog sindroma, neurofibromatoze, Alzheimerove bolesti, dijabetičarske retinopatije i /ili lezije na koži, fibrozih limfoidnih čvorova u vezi sa HIV-om, kronične opstruktivne bolesti pluća (COPD), inflamatorne plućne fibroze, reumatoidnog artritisa, reumatoidnog spondilitisa; osteoartritisa; gihta, drugih artritičnih stanja; sepse; septičkog šoka; endotoksičnog šoka; gram negativne sepse; sindroma toksičnog šoka; sindroma miofacijalnog bola (MPS); šigeloze; astme; respiratornog distres sindroma odraslih; inflamatorne bolesti crijeva; Crohnove bolest; psorijaze; ekcema; ulceroznog kolitisa; glomerularnog nefritisa; skleroderme; kroničnog tiroiditisa; Gravesove bolesti; Ormondove bolesti; autoimunog gastritisa; mijastenije gravis; autoimune kemolitičke anemije; autoimune neutropenije; trombocitopenije; fibroze pankreasa; kroničnog aktivnog hepatitisa koji uključuje fibrozu jetre; akutnu i kroničnu bolest bubrega; fibrozu bubrega; dijabetičarsku nefropatiju; sindrom iritiranih crijeva; gorušicu; restenoze; cerebralnu malariju; moždani udar i ishemične povrede; neuralnu traumu; Alzheimerove bolesti; Huntingtonove bolesti; Parkinsonove bolesti; akutne i kronične boli; alergije; uključujući alergijski rinitis i alergijski konjuktivitis; srčanu hipertrofiju; kronični zastoj srca; akutni koronarni sindrom; kaheksiju; malariju; leprozu; lajšmanijazu; Lajmsku bolest; Reiterov sindrom; akutni sinovitis; mišićnu degeneraciju, burzitis; tendonitis; tenosinovitis; sindrom hernije, rupture ili prolapsa intervertebralnog diska; osteoporozu; trombozu; silikozu; plućnu sarkozu; bolest resorpcije kostiju, kao što je osteoporoza ili poremećaj kostiju u vezi sa multiplim mijelomom; rak, uključujući ali bez ograničenja na metastaze karcinoma grudi, kolorektalnog karcinoma, malignog melanoma, raka želuca, raka ne-malih stanica pluća; reakciju neprihvaćanja grafta; ili autoimune bolesti kao što su multipla skleroza, lupus i fibromijalgija; AIDS ili druge virusne bolesti kao što je Herpes Zoster, Herpes Simplex I ili II, virus gripa, ozbiljni aktutni respiratorni sindrom (SARS) ili citomegalovirus; ili dijabetes melitus, proliferativne poremećaje (uključujući i benigne ili maligne hiperplazije), uključujući akutnu mijelogenoznu leukemiju, kroničnu mijelogenoznu leukemiju, Kapošijev sarkom, metastatički melanom, višestruki mijelom, rak grudi, uključujući metastatički karcinom grudi; kolorektalni karcionom; maligni melanom; rak želuca ; rak ne-malih stanica pluća (NSCLC); metastaze kostiju i slično; poremećaji bola uključujući neuromuskularnu bol; glavobolju, bol uslijed raka; bol zuba, ili bol uslijed artritisa; poremećaje angiogeneze uključujući angiogenezu čvrstog tumora, okularnu neovaskularizaciju i hemangiom kod djece; stanja u vezi sa signalizacijom puteva ciklooksigeneze ili lipoksigeneze, uključujući stanja u vezi sa prostaglandin endoperoksid sintetazom-2 (uključujući edem, groznicu, analgeziju ili bol); hipoksiju organa; agregacija pločica izazvana trombinom; ili protozoalne bolesti.
9. Pirfenidon za upotrebu ili upotreba prema bilo kojem od zahtjeva 1 do 7, naznačen time što pacijent ima idiopatsku pulmonarnu fibrozu (IPF).
10. Pirfenidon za upotrebu ili upotreba prema bilo kojem od zahtjeva 1 do 9, naznačen time što je pirfenidon davan u ukupnoj dnevnoj dozi od 1800 mg po danu.
11. Pirfenidon za upotrebu ili upotreba prema bilo kojem od zahtjeva 1 do 9, naznačen time što je pirfenidon davan u ukupnoj dnevnoj dozi od 2400 mg ili 2403 mg po danu.
12. Pirfenidon za upotrebu ili upotreba prema bilo kojem od zahtjeva 1 do 9 ili 11, naznačen time što je svaka davana doza pirfenidona 801 mg.
13. Pirfenidon za upotrebu ili upotreba prema zahtjevima 10 do 12, naznačen time što se pirfenidon daje pacijentu tri puta dnevno.
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