HRP20110851T1 - Derivati metastina i njihova uporaba - Google Patents
Derivati metastina i njihova uporaba Download PDFInfo
- Publication number
- HRP20110851T1 HRP20110851T1 HR20110851T HRP20110851T HRP20110851T1 HR P20110851 T1 HRP20110851 T1 HR P20110851T1 HR 20110851 T HR20110851 T HR 20110851T HR P20110851 T HRP20110851 T HR P20110851T HR P20110851 T1 HRP20110851 T1 HR P20110851T1
- Authority
- HR
- Croatia
- Prior art keywords
- trp
- azagly
- asn
- tyr
- arg
- Prior art date
Links
- KAHDONZOCXSKII-NJVVDGNHSA-N kisspeptin Chemical class C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)O)C1=CN=CN1 KAHDONZOCXSKII-NJVVDGNHSA-N 0.000 title claims abstract 29
- 150000001875 compounds Chemical class 0.000 claims abstract 83
- 150000003839 salts Chemical class 0.000 claims abstract 28
- 229910018828 PO3H2 Inorganic materials 0.000 claims abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 13
- 230000002265 prevention Effects 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 8
- 239000005556 hormone Substances 0.000 claims 8
- 229940088597 hormone Drugs 0.000 claims 8
- 230000002159 abnormal effect Effects 0.000 claims 4
- 230000001419 dependent effect Effects 0.000 claims 4
- 239000003163 gonadal steroid hormone Substances 0.000 claims 4
- 230000001456 gonadotroph Effects 0.000 claims 4
- 230000001939 inductive effect Effects 0.000 claims 3
- 206010000234 Abortion spontaneous Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 206010003805 Autism Diseases 0.000 claims 2
- 208000020706 Autistic disease Diseases 0.000 claims 2
- 208000006332 Choriocarcinoma Diseases 0.000 claims 2
- 208000028698 Cognitive impairment Diseases 0.000 claims 2
- 201000009273 Endometriosis Diseases 0.000 claims 2
- 208000006937 Hydatidiform mole Diseases 0.000 claims 2
- 208000005125 Invasive Hydatidiform Mole Diseases 0.000 claims 2
- 102100034845 KiSS-1 receptor Human genes 0.000 claims 2
- 101710104293 KiSS-1 receptor Proteins 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 206010046798 Uterine leiomyoma Diseases 0.000 claims 2
- 150000001413 amino acids Chemical group 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 230000002222 downregulating effect Effects 0.000 claims 2
- 230000003828 downregulation Effects 0.000 claims 2
- 230000001605 fetal effect Effects 0.000 claims 2
- 230000004153 glucose metabolism Effects 0.000 claims 2
- 230000002710 gonadal effect Effects 0.000 claims 2
- 208000000509 infertility Diseases 0.000 claims 2
- 230000036512 infertility Effects 0.000 claims 2
- 231100000535 infertility Toxicity 0.000 claims 2
- 201000010260 leiomyoma Diseases 0.000 claims 2
- 230000037356 lipid metabolism Effects 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 208000015994 miscarriage Diseases 0.000 claims 2
- 230000016087 ovulation Effects 0.000 claims 2
- 210000002826 placenta Anatomy 0.000 claims 2
- 230000002028 premature Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000000452 restraining effect Effects 0.000 claims 2
- 230000000580 secretagogue effect Effects 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 208000000995 spontaneous abortion Diseases 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 230000004614 tumor growth Effects 0.000 claims 2
- 230000035606 childbirth Effects 0.000 claims 1
- SENJXOPIZNYLHU-UHFFFAOYSA-N L-leucyl-L-arginine Natural products CC(C)CC(N)C(=O)NC(C(O)=O)CCCN=C(N)N SENJXOPIZNYLHU-UHFFFAOYSA-N 0.000 abstract 1
- 108010000761 leucylarginine Proteins 0.000 abstract 1
- -1 p-hydroxyphenyl Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005370388 | 2005-12-22 | ||
JP2006275843 | 2006-10-06 | ||
PCT/JP2006/326176 WO2007072997A1 (fr) | 2005-12-22 | 2006-12-21 | Derives de metastine et leur utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20110851T1 true HRP20110851T1 (hr) | 2011-12-31 |
Family
ID=37846230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20110851T HRP20110851T1 (hr) | 2005-12-22 | 2011-11-15 | Derivati metastina i njihova uporaba |
Country Status (30)
Country | Link |
---|---|
US (1) | US7960348B2 (fr) |
EP (1) | EP1963362B1 (fr) |
JP (2) | JP4653840B2 (fr) |
KR (1) | KR101368607B1 (fr) |
AR (1) | AR058584A1 (fr) |
AU (1) | AU2006328333B2 (fr) |
BR (1) | BRPI0619399B8 (fr) |
CA (1) | CA2634647C (fr) |
CR (1) | CR10019A (fr) |
CY (1) | CY1112353T1 (fr) |
DK (1) | DK1963362T3 (fr) |
ES (1) | ES2375038T3 (fr) |
GE (1) | GEP20115356B (fr) |
HK (1) | HK1120809A1 (fr) |
HR (1) | HRP20110851T1 (fr) |
IL (1) | IL190888A (fr) |
JO (1) | JO2799B1 (fr) |
MA (1) | MA30060B1 (fr) |
ME (1) | ME01015B (fr) |
MY (1) | MY151967A (fr) |
NO (1) | NO341879B1 (fr) |
NZ (1) | NZ568322A (fr) |
PE (1) | PE20071141A1 (fr) |
PL (1) | PL1963362T3 (fr) |
PT (1) | PT1963362E (fr) |
RS (1) | RS52007B (fr) |
RU (1) | RU2430107C2 (fr) |
SI (1) | SI1963362T1 (fr) |
TW (1) | TWI386417B (fr) |
WO (1) | WO2007072997A1 (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1761680A (zh) | 2002-12-26 | 2006-04-19 | 武田药品工业株式会社 | 肿瘤迁移抑制素衍生物及其用途 |
EP1604682A4 (fr) | 2003-03-12 | 2009-06-24 | Takeda Chemical Industries Ltd | Agents ameliorant la fonction gonadique |
CN101863971A (zh) | 2004-06-25 | 2010-10-20 | 武田药品工业株式会社 | 转移素衍生物及其用途 |
TWI386417B (zh) | 2005-12-22 | 2013-02-21 | Takeda Pharmaceutical | 轉移抑素衍生物及其用途 |
US8404643B2 (en) * | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
US20090093615A1 (en) * | 2005-12-22 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
TWI404726B (zh) | 2006-10-25 | 2013-08-11 | Takeda Pharmaceutical | 腫瘤轉移抑制素衍生物及其用途 |
JPWO2009131191A1 (ja) * | 2008-04-24 | 2011-08-25 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
JP5698977B2 (ja) | 2008-07-30 | 2015-04-08 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
MA32935B1 (fr) * | 2008-12-29 | 2012-01-02 | Takeda Pharmaceutical | Agent prophylactique/therapeutique pour le cancer |
MX2012006441A (es) * | 2009-12-22 | 2012-06-28 | Takeda Pharmaceutical | Formulacion de liberacion sostenida. |
MA34321B1 (fr) * | 2010-06-25 | 2013-06-01 | Takeda Pharmaceutical | Formulation à libération prolongée |
US9127038B2 (en) | 2011-08-04 | 2015-09-08 | Merck Sharp & Dohme Corp. | Kisspeptide-pentasaccharide conjugates |
EP2873455B1 (fr) | 2012-07-12 | 2021-07-07 | Takeda Pharmaceutical Company Limited | Procédé de fabrication de poudre de microcapsule |
WO2015112703A1 (fr) * | 2014-01-22 | 2015-07-30 | The Johns Hopkins University | Compositions et méthodes de traitement du diabète |
JP6253146B2 (ja) * | 2014-02-04 | 2017-12-27 | 国立大学法人山口大学 | 新規なペプチド誘導体及びこれを含有する医薬 |
EP4094766A1 (fr) | 2016-09-30 | 2022-11-30 | Myovant Sciences GmbH | Méthodes de traitement des fibromes utérins et de l'endométriose |
EP3518952A1 (fr) | 2016-09-30 | 2019-08-07 | Myovant Sciences GmbH | Méthodes de traitement de l'infertilité féminine |
TW202334178A (zh) * | 2017-07-05 | 2023-09-01 | 大陸商尚華醫藥科技(江西)有限公司 | 一種Kiss1肽類化合物、其應用及含其的組合物 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL74827A (en) | 1984-05-21 | 1989-06-30 | Salk Inst For Biological Studi | Peptides active as gnrh antagonists and pharmaceutical compositions containing them |
MX9100717A (es) | 1990-08-24 | 1992-04-01 | Syntex Inc | Antagonistas de la bradiquinina |
JPH09169735A (ja) | 1995-10-19 | 1997-06-30 | Takeda Chem Ind Ltd | キノリン誘導体、その製造法および用途 |
AU7333496A (en) | 1995-10-19 | 1997-05-07 | Takeda Chemical Industries Ltd. | Quinoline derivatives as gnrh antagonists |
JP2000510453A (ja) | 1996-04-19 | 2000-08-15 | ノボ ノルディスク アクティーゼルスカブ | 成長ホルモン遊離特性を有する化合物 |
WO1998039448A2 (fr) | 1997-03-07 | 1998-09-11 | Human Genome Sciences, Inc. | 186 nouvelles proteines secretees |
JP4486187B2 (ja) | 1998-10-27 | 2010-06-23 | 武田薬品工業株式会社 | 新規g蛋白質共役型レセプター蛋白質、そのdnaおよびそのリガンド |
US6528054B1 (en) | 1998-12-28 | 2003-03-04 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of breast cancer |
TR200103841T2 (tr) | 1999-06-28 | 2002-06-21 | Basf Aktiengesellschaft | Tümör büyümesini önlemek için yöntem. |
KR100815041B1 (ko) | 1999-08-02 | 2008-03-18 | 아처 다니엘 미드랜드 캄파니 | 아미노산 생산의 대사 공학 |
EP1239037A4 (fr) | 1999-12-17 | 2004-03-31 | Takeda Chemical Industries Ltd | PROCEDE DE PRODUCTION DE PEPTIDE KiSS-1 |
PL366626A1 (en) | 2000-03-29 | 2005-02-07 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
AU2001244609A1 (en) * | 2000-03-30 | 2001-10-15 | Takeda Chemical Industries Ltd. | Novel protein, dna thereof and process for producing the same |
US7834141B1 (en) | 2000-03-31 | 2010-11-16 | Theresa Siler-Khodr | Non-mammalian GnRH analogs and uses thereof in tumor cell growth regulation and cancer therapy |
RU2311920C2 (ru) | 2000-09-20 | 2007-12-10 | Корикса Корпорейшн | Композиции и способы для лечения и диагностики рака легких |
JP2003026601A (ja) | 2000-11-29 | 2003-01-29 | Takeda Chem Ind Ltd | 医薬組成物およびその製造法 |
JP2002320496A (ja) | 2001-02-26 | 2002-11-05 | Takeda Chem Ind Ltd | 新規マウス型KiSS−1レセプタータンパク質およびそのDNA |
WO2002085399A1 (fr) | 2001-04-20 | 2002-10-31 | Takeda Chemical Industries, Ltd. | Preparations contenant un peptide |
CN1509336A (zh) * | 2001-05-17 | 2004-06-30 | 株式会社岛津制作所 | 肽的制备方法 |
CA2460803A1 (fr) | 2001-09-19 | 2003-04-03 | Takeda Chemical Industries, Ltd. | Anticorps et utilisation de ce dernier |
CA2472423A1 (fr) | 2002-01-11 | 2003-07-24 | Takeda Chemical Industries, Ltd. | Procede de production du peptide kiss-1 |
JP2003300906A (ja) | 2002-04-12 | 2003-10-21 | Daiichi Fine Chemical Co Ltd | がん転移抑制因子の安定化 |
BR0314912A (pt) | 2002-10-25 | 2005-08-02 | Paradigm Therapeutics Ltd | Método para produzir uma célula compreendendo em gene gpr54 funcionalmente inativo, constructo de ácido nucléico, composição, método para prover uma indicação de utilidade no diagnóstico de uma doença ou de uma condição, uso de um polipeptìdio gpr54, de um agonista, de um antanogista ou de um modulador da atividade do polipeptìdio gpr54 |
JP4804714B2 (ja) | 2002-12-26 | 2011-11-02 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
CN1761680A (zh) | 2002-12-26 | 2006-04-19 | 武田药品工业株式会社 | 肿瘤迁移抑制素衍生物及其用途 |
US6800611B2 (en) * | 2003-01-06 | 2004-10-05 | Takeda Chemical Industries, Ltd. | Metastin derivatives and their use |
KR100595364B1 (ko) | 2003-02-20 | 2006-07-03 | 재단법인 목암생명공학연구소 | Lk8 단백질을 유효성분으로 포함하는 항암제 |
EP1604682A4 (fr) * | 2003-03-12 | 2009-06-24 | Takeda Chemical Industries Ltd | Agents ameliorant la fonction gonadique |
EP1464652A1 (fr) | 2003-04-02 | 2004-10-06 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Agoniste et antagoniste du récepteur GPR54 utiles pour le traitement des maladies associées à la gonadotrophine |
US20050002935A1 (en) | 2003-04-17 | 2005-01-06 | Vincent Ling | Use of B7-H3 as an immunoregulatory agent |
AU2004234399A1 (en) | 2003-04-28 | 2004-11-11 | Wyeth | Methods utilising G-protein coupled receptor 54 |
WO2004101747A2 (fr) | 2003-05-07 | 2004-11-25 | The General Hospital Corporation | Identification et utilisation de gpr54 et de ses ligands pour les troubles de la reproduction et la contraception |
EP1975153A3 (fr) * | 2003-05-30 | 2010-03-31 | Prozymex A/S | Inhibiteurs de protéase |
RU2333221C2 (ru) | 2003-11-03 | 2008-09-10 | Бейцзин Санбио Байотек Ко., Лтд. | Рекомбинантный белок, обладающий противораковым действием, кодирующий его ген и его применение |
US7666989B2 (en) | 2003-11-03 | 2010-02-23 | Beijing Sunbio Biotech Co., Ltd. | Recombinant protein having an anti-cancer effect, its encoding gene and uses thereof |
WO2005095973A2 (fr) | 2004-03-25 | 2005-10-13 | Bayer Healthcare Ag | Methodes diagnostiques et therapeutiques pour des maladies associees au recepteur 54 couple a la proteine g (gpr54) |
CN101863971A (zh) * | 2004-06-25 | 2010-10-20 | 武田药品工业株式会社 | 转移素衍生物及其用途 |
US7725869B1 (en) * | 2005-04-07 | 2010-05-25 | Xilinx, Inc. | Method and apparatus for modeling multiple instances of an electronic circuit using an imperative programming language description |
WO2007084211A2 (fr) | 2005-11-11 | 2007-07-26 | The General Hospital Corporation | Utilisation de ligands du gpr54 pour le traitement de troubles de la reproduction, de troubles proliferatifs et pour la contraception |
TWI386417B (zh) | 2005-12-22 | 2013-02-21 | Takeda Pharmaceutical | 轉移抑素衍生物及其用途 |
US8404643B2 (en) * | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
US20090099334A1 (en) * | 2005-12-22 | 2009-04-16 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
US20090093615A1 (en) * | 2005-12-22 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
TWI404726B (zh) | 2006-10-25 | 2013-08-11 | Takeda Pharmaceutical | 腫瘤轉移抑制素衍生物及其用途 |
-
2006
- 2006-12-20 TW TW095147852A patent/TWI386417B/zh active
- 2006-12-20 AR ARP060105651A patent/AR058584A1/es active IP Right Grant
- 2006-12-21 PL PL06843555T patent/PL1963362T3/pl unknown
- 2006-12-21 AU AU2006328333A patent/AU2006328333B2/en active Active
- 2006-12-21 EP EP06843555A patent/EP1963362B1/fr active Active
- 2006-12-21 NZ NZ568322A patent/NZ568322A/en unknown
- 2006-12-21 WO PCT/JP2006/326176 patent/WO2007072997A1/fr active Application Filing
- 2006-12-21 PE PE2006001686A patent/PE20071141A1/es active IP Right Grant
- 2006-12-21 ME MEP-2009-175A patent/ME01015B/fr unknown
- 2006-12-21 KR KR1020087012506A patent/KR101368607B1/ko active IP Right Grant
- 2006-12-21 JP JP2008529406A patent/JP4653840B2/ja active Active
- 2006-12-21 JO JO2006486A patent/JO2799B1/en active
- 2006-12-21 RU RU2008125063/04A patent/RU2430107C2/ru active
- 2006-12-21 MY MYPI20082169 patent/MY151967A/en unknown
- 2006-12-21 US US12/158,251 patent/US7960348B2/en active Active
- 2006-12-21 GE GEAP200610770A patent/GEP20115356B/en unknown
- 2006-12-21 CA CA2634647A patent/CA2634647C/fr active Active
- 2006-12-21 DK DK06843555.1T patent/DK1963362T3/da active
- 2006-12-21 ES ES06843555T patent/ES2375038T3/es active Active
- 2006-12-21 PT PT06843555T patent/PT1963362E/pt unknown
- 2006-12-21 BR BRPI0619399A patent/BRPI0619399B8/pt active IP Right Grant
- 2006-12-21 RS RS20110437A patent/RS52007B/en unknown
- 2006-12-21 SI SI200631152T patent/SI1963362T1/sl unknown
-
2008
- 2008-04-15 IL IL190888A patent/IL190888A/en active IP Right Grant
- 2008-05-26 CR CR10019A patent/CR10019A/es unknown
- 2008-06-10 NO NO20082595A patent/NO341879B1/no unknown
- 2008-06-18 MA MA31044A patent/MA30060B1/fr unknown
- 2008-11-12 HK HK08112400.1A patent/HK1120809A1/xx unknown
-
2010
- 2010-08-17 JP JP2010182482A patent/JP5298087B2/ja active Active
-
2011
- 2011-11-15 HR HR20110851T patent/HRP20110851T1/hr unknown
- 2011-11-18 CY CY20111101116T patent/CY1112353T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20110851T1 (hr) | Derivati metastina i njihova uporaba | |
TN2012000294A1 (en) | Neutralizing prolactin receptor antibodies and their therapeutic use | |
ES2545817T3 (es) | Vacunas de péptidos para cánceres que expresan los polipéptidos MPHOSPH1 | |
JP2018052951A (ja) | 薬物複合体、複合体形成方法、およびその使用 | |
EA201491344A1 (ru) | Производные спироиндолина в качестве антагонистов рецептора гонадотропин-рилизинг гормона | |
TWI325003B (en) | Ghrelin analogs | |
MX339684B (es) | Metodos, compuestos, composiciones y vehiculos para suministrar el acido 3-amino-1-propanosulfonico. | |
EA200600055A1 (ru) | Агонисты рецептора меланокортина 4 (мк4 ) и их применение | |
UA106502C2 (uk) | Похідні 17-гідрокси-17-пентафторетил-естра-4,9(10)-дієн-11-арилу, спосіб їх одержання та їх застосування для лікування захворювань | |
AR056328A1 (es) | TANAPROGET MICRONIZADO, COMPOSICIONES Y MÉTODOS PARA SU PREPARACIoN | |
ATE486890T1 (de) | Ephb-rezeptorbindende peptide | |
JP2014506568A5 (fr) | ||
JP2002505318A (ja) | 非ペプチドGnRH因子 | |
MX2012002481A (es) | Compuestos terapeuticos de aril-amido-arilo y su uso. | |
Ramzan et al. | Insight into the serum kisspeptin levels in infertile males | |
HRP20170306T1 (hr) | Identifikacija izvanstaničnog oblika pten-a koj se može primjenjivati u liječenju tumora | |
CN101861160B (zh) | 亲吻肽拮抗剂及其用途 | |
AU2003255820A8 (en) | Derivatives of 3-hydroxy-4-(cyclyl-alkylaminoalkyl)-5-phenyl-1h-pyrazole as antagonists of the gonadotropin releasing hormone (gnrh) for use in the treatment of sex hormone related conditions, such as prostatic of uterine cancer | |
ATE433331T1 (de) | Kontrastmittel für die magnetresonanztomographie und entsprechende verfahren | |
HRP20170319T1 (hr) | Derivat metastina i njegova uporaba | |
Vickram et al. | Semenogelin, a coagulum macromolecule monitoring factor involved in the first step of fertilization: A prospective review | |
EP4114430A2 (fr) | Traitement de maladies inflammatoires avec des peptides et compositions pharmaceutiques | |
MA32477B1 (fr) | Derives estratrienes comprenant des bioisosteres heterocycliques pour le cycle a phenolique | |
Rodríguez Sarmiento et al. | Structural analysis and cytotoxic evaluation of kisspeptin10 and analogs in types of cancer. Revis Bionatura 2023; 8 (3) 61 | |
Hutson | Testis embryology, anatomy and physiology |