EA201491344A1 - Производные спироиндолина в качестве антагонистов рецептора гонадотропин-рилизинг гормона - Google Patents

Производные спироиндолина в качестве антагонистов рецептора гонадотропин-рилизинг гормона

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Publication number
EA201491344A1
EA201491344A1 EA201491344A EA201491344A EA201491344A1 EA 201491344 A1 EA201491344 A1 EA 201491344A1 EA 201491344 A EA201491344 A EA 201491344A EA 201491344 A EA201491344 A EA 201491344A EA 201491344 A1 EA201491344 A1 EA 201491344A1
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EA
Eurasian Patent Office
Prior art keywords
derivatives
diseases
prevention
treatment
antagonists
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EA201491344A
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English (en)
Inventor
Олаф Панкнин
Штефан Бойрле
Свен Ринг
Вольфганг Шведе
Вильхельм Бонэ
Катрин Новак-Реппель
Экхард Бендер
Райнхард Нуббемайер
Марк Жан Гнот
Original Assignee
Байер Интеллектуэль Проперти Гмбх
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47559493&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201491344(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Байер Интеллектуэль Проперти Гмбх filed Critical Байер Интеллектуэль Проперти Гмбх
Publication of EA201491344A1 publication Critical patent/EA201491344A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Производные спироиндолина, способ их получения и их фармацевтические композиции, их применение для лечения и/или профилактики заболеваний, а также их применение для производства лекарственных средств для лечения и/или профилактики заболеваний, в особенности заболеваний, связанных с половыми гормонами, как у мужчин, так и у женщин, в частности заболеваний, выбранных из группы эндометриоза, фибромы матки, болезни поликистозных яичников, гирсутизма, преждевременного полового созревания, неоплазии, зависимой от половых гормонов, такой как рак предстательной железы, рак молочной железы, рак яичников, гонадотропных гипофизарных аденом, апноэ во время сна, синдрома раздраженной толстой кишки, предменструального синдрома, доброкачественной гиперплазии предстательной железы, для контрацепции и при бесплодии (например, вспомогательная репродуктивная терапия, такая как оплодотворение in vitro (ЭКО)). Настоящая заявка относится, в частности, к производным спироиндолина, применяемым в качестве антагонистов рецепторов гонадотропин-рилизинг гормона (ГнРГ).
EA201491344A 2012-01-16 2013-01-15 Производные спироиндолина в качестве антагонистов рецептора гонадотропин-рилизинг гормона EA201491344A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12151291 2012-01-16
PCT/EP2013/050676 WO2013107743A1 (en) 2012-01-16 2013-01-15 Spiroindoline derivatives as gonadotropin- releasing hormone receptor antagonists

Publications (1)

Publication Number Publication Date
EA201491344A1 true EA201491344A1 (ru) 2015-04-30

Family

ID=47559493

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491344A EA201491344A1 (ru) 2012-01-16 2013-01-15 Производные спироиндолина в качестве антагонистов рецептора гонадотропин-рилизинг гормона

Country Status (25)

Country Link
US (1) US20140357655A1 (ru)
EP (1) EP2804867A1 (ru)
JP (1) JP2015503607A (ru)
KR (1) KR20140112075A (ru)
CN (1) CN104169287A (ru)
AP (1) AP2014007738A0 (ru)
AU (1) AU2013211091A1 (ru)
BR (1) BR112014017483A8 (ru)
CA (1) CA2860986A1 (ru)
CL (1) CL2014001871A1 (ru)
CO (1) CO7010832A2 (ru)
CR (1) CR20140343A (ru)
CU (1) CU20140088A7 (ru)
DO (1) DOP2014000167A (ru)
EA (1) EA201491344A1 (ru)
GT (1) GT201400153A (ru)
HK (1) HK1199878A1 (ru)
IL (1) IL233485A0 (ru)
MA (1) MA35867B1 (ru)
MX (1) MX2014008630A (ru)
PE (1) PE20141699A1 (ru)
PH (1) PH12014501616A1 (ru)
SG (1) SG11201403749VA (ru)
TN (1) TN2014000306A1 (ru)
WO (1) WO2013107743A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR095785A1 (es) * 2013-04-09 2015-11-11 Bayer Pharma AG Derivados de espiroindolina y composiciones farmacéutica de los mismos
WO2015007606A1 (en) * 2013-07-15 2015-01-22 Bayer Pharma Aktiengesellschaft Spiroindoline derivatives and pharmaceutical compositions thereof
EP2881391A1 (en) 2013-12-05 2015-06-10 Bayer Pharma Aktiengesellschaft Spiroindoline carbocycle derivatives and pharmaceutical compositions thereof
WO2015082374A1 (en) * 2013-12-05 2015-06-11 Bayer Pharma Aktiengesellschaft Spiroindoline-thiopyran-imine-oxide derivatives as gonadotropin-releasing hormone receptor antagonists and pharmaceutical compositions thereof
WO2015091315A1 (en) * 2013-12-19 2015-06-25 Bayer Pharma Aktiengesellschaft Spiro[indolin-3,4'-piperidine] derivatives as gnrh receptor antagonists
EP3339846B1 (en) * 2016-12-22 2020-12-09 Malvern Panalytical B.V. Method of measuring properties of a thin film stack
US11980621B2 (en) 2017-06-05 2024-05-14 Kissei Pharmaceutical Co., Ltd. Gonadotropin-releasing hormone antagonist dosing regimens for the treatment of endometriosis
CN107840851A (zh) * 2017-12-21 2018-03-27 扬州大学 吲哚螺吡咯嗪化合物及其合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849780A (en) * 1992-01-30 1998-12-15 Sanofi 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
TW200522944A (en) * 2003-12-23 2005-07-16 Lilly Co Eli CB1 modulator compounds

Also Published As

Publication number Publication date
SG11201403749VA (en) 2014-07-30
AP2014007738A0 (en) 2014-07-31
TN2014000306A1 (en) 2015-12-21
CU20140088A7 (es) 2014-12-26
WO2013107743A1 (en) 2013-07-25
US20140357655A1 (en) 2014-12-04
PH12014501616A1 (en) 2014-10-13
EP2804867A1 (en) 2014-11-26
HK1199878A1 (en) 2015-07-24
MX2014008630A (es) 2014-08-29
BR112014017483A8 (pt) 2017-07-04
CN104169287A (zh) 2014-11-26
IL233485A0 (en) 2014-08-31
GT201400153A (es) 2015-05-22
CR20140343A (es) 2014-09-08
CL2014001871A1 (es) 2014-11-03
CA2860986A1 (en) 2013-07-25
DOP2014000167A (es) 2014-08-31
CO7010832A2 (es) 2014-07-31
KR20140112075A (ko) 2014-09-22
AU2013211091A1 (en) 2014-08-07
JP2015503607A (ja) 2015-02-02
PE20141699A1 (es) 2014-11-29
MA35867B1 (fr) 2014-12-01
BR112014017483A2 (pt) 2017-06-13

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