EA201501000A1 - Спироиндолиновые производные для применения в качестве антагонистов рецептора гонадотропин-рилизинг-гормона - Google Patents
Спироиндолиновые производные для применения в качестве антагонистов рецептора гонадотропин-рилизинг-гормонаInfo
- Publication number
- EA201501000A1 EA201501000A1 EA201501000A EA201501000A EA201501000A1 EA 201501000 A1 EA201501000 A1 EA 201501000A1 EA 201501000 A EA201501000 A EA 201501000A EA 201501000 A EA201501000 A EA 201501000A EA 201501000 A1 EA201501000 A1 EA 201501000A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- gonadotropin
- derivatives
- receptor antagonists
- antagonists
- diseases
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Спироиндолиновые производные, способы их получения и их фармацевтические композиции, их применение для лечения заболеваний и их применение для изготовления лекарственных средств для лечения заболеваний, особенно заболеваний, обусловленных дисфункцией половых гормонов, как у мужчин, так и у женщин, в частности, выбранных из группы, которая включает эндометриоз, лейомиому матки (фиброиды), поликистоз яичников, меноррагию, дисменорею, гирсутизм, преждевременное половое созревание, гонадную стероид-зависимую неоплазию, такую как рак предстательной железы, молочной железы и яичников, гонадотропные аденомы гипофиза, апноэ во сне, синдром раздражённой толстой кишки, предменструальный синдром, доброкачественную гипертрофию предстательной железы, бесплодие, для контрацепции и для вспомогательной репродуктивной терапии, такой как оплодотворение in vitro. Данная заявка касается, в частности, спироиндолиновых производных в качестве антагонистов рецептора гонадотропин-рилизинг-гормона (ГнРГ) антагонистов рецептора гонадотропин-рилизинг-гормона (ГнРГ).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13162986 | 2013-04-09 | ||
| PCT/EP2014/057079 WO2014166958A1 (en) | 2013-04-09 | 2014-04-08 | Spiroindoline derivatives for use as gonadotropin-releasing hormone receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201501000A1 true EA201501000A1 (ru) | 2016-04-29 |
Family
ID=48047908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201501000A EA201501000A1 (ru) | 2013-04-09 | 2014-04-08 | Спироиндолиновые производные для применения в качестве антагонистов рецептора гонадотропин-рилизинг-гормона |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20160052936A1 (ru) |
| EP (1) | EP2984092A1 (ru) |
| JP (1) | JP2016519104A (ru) |
| KR (1) | KR20150139917A (ru) |
| CN (1) | CN105308053A (ru) |
| AP (1) | AP2015008822A0 (ru) |
| AR (1) | AR095785A1 (ru) |
| AU (1) | AU2014253232A1 (ru) |
| BR (1) | BR112015025700A2 (ru) |
| CA (1) | CA2908869A1 (ru) |
| CL (1) | CL2015003013A1 (ru) |
| CR (1) | CR20150530A (ru) |
| CU (1) | CU20150141A7 (ru) |
| DO (1) | DOP2015000259A (ru) |
| EA (1) | EA201501000A1 (ru) |
| HK (1) | HK1216101A1 (ru) |
| IL (1) | IL241067A0 (ru) |
| MA (1) | MA38463B1 (ru) |
| MX (1) | MX2015014267A (ru) |
| NI (1) | NI201500149A (ru) |
| PE (1) | PE20160007A1 (ru) |
| PH (1) | PH12015502318A1 (ru) |
| SG (1) | SG11201506962TA (ru) |
| TN (1) | TN2015000453A1 (ru) |
| TW (1) | TW201518304A (ru) |
| UY (1) | UY35526A (ru) |
| WO (1) | WO2014166958A1 (ru) |
| ZA (1) | ZA201508209B (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018224498A1 (en) | 2017-06-05 | 2018-12-13 | ObsEva S.A. | Gonadotropin-releasing hormone antagonist dosing regimens for the treatment of endometriosis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0213715D0 (en) * | 2002-06-14 | 2002-07-24 | Syngenta Ltd | Chemical compounds |
| PE20141699A1 (es) * | 2012-01-16 | 2014-11-29 | Bayer Ip Gmbh | Derivados de espiroindolina como antagonistas del receptor de la hormona liberadora de gonadotropina |
-
2014
- 2014-04-07 AR ARP140101498A patent/AR095785A1/es unknown
- 2014-04-08 MX MX2015014267A patent/MX2015014267A/es unknown
- 2014-04-08 SG SG11201506962TA patent/SG11201506962TA/en unknown
- 2014-04-08 AU AU2014253232A patent/AU2014253232A1/en not_active Abandoned
- 2014-04-08 KR KR1020157031635A patent/KR20150139917A/ko not_active Application Discontinuation
- 2014-04-08 JP JP2016506935A patent/JP2016519104A/ja active Pending
- 2014-04-08 AP AP2015008822A patent/AP2015008822A0/xx unknown
- 2014-04-08 WO PCT/EP2014/057079 patent/WO2014166958A1/en active Application Filing
- 2014-04-08 US US14/783,458 patent/US20160052936A1/en not_active Abandoned
- 2014-04-08 CN CN201480032796.7A patent/CN105308053A/zh active Pending
- 2014-04-08 MA MA38463A patent/MA38463B1/fr unknown
- 2014-04-08 TN TN2015000453A patent/TN2015000453A1/en unknown
- 2014-04-08 BR BR112015025700A patent/BR112015025700A2/pt not_active IP Right Cessation
- 2014-04-08 CA CA2908869A patent/CA2908869A1/en not_active Abandoned
- 2014-04-08 EP EP14715930.5A patent/EP2984092A1/en not_active Withdrawn
- 2014-04-08 EA EA201501000A patent/EA201501000A1/ru unknown
- 2014-04-08 PE PE2015002137A patent/PE20160007A1/es not_active Application Discontinuation
- 2014-04-09 TW TW103113078A patent/TW201518304A/zh unknown
- 2014-04-09 UY UY0001035526A patent/UY35526A/es not_active Application Discontinuation
-
2015
- 2015-09-02 IL IL241067A patent/IL241067A0/en unknown
- 2015-10-06 PH PH12015502318A patent/PH12015502318A1/en unknown
- 2015-10-08 CU CUP2015000141A patent/CU20150141A7/es unknown
- 2015-10-09 CR CR20150530A patent/CR20150530A/es unknown
- 2015-10-09 CL CL2015003013A patent/CL2015003013A1/es unknown
- 2015-10-09 NI NI201500149A patent/NI201500149A/es unknown
- 2015-10-09 DO DO2015000259A patent/DOP2015000259A/es unknown
- 2015-11-06 ZA ZA2015/08209A patent/ZA201508209B/en unknown
-
2016
- 2016-04-11 HK HK16104067.2A patent/HK1216101A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN105308053A (zh) | 2016-02-03 |
| EP2984092A1 (en) | 2016-02-17 |
| MA38463A1 (fr) | 2018-05-31 |
| NI201500149A (es) | 2015-11-30 |
| MX2015014267A (es) | 2016-03-01 |
| TN2015000453A1 (en) | 2017-04-06 |
| IL241067A0 (en) | 2015-11-30 |
| PH12015502318A1 (en) | 2016-02-15 |
| TW201518304A (zh) | 2015-05-16 |
| SG11201506962TA (en) | 2015-10-29 |
| AR095785A1 (es) | 2015-11-11 |
| US20160052936A1 (en) | 2016-02-25 |
| JP2016519104A (ja) | 2016-06-30 |
| PE20160007A1 (es) | 2016-02-14 |
| BR112015025700A2 (pt) | 2017-07-18 |
| AP2015008822A0 (en) | 2015-10-31 |
| HK1216101A1 (zh) | 2016-10-14 |
| WO2014166958A1 (en) | 2014-10-16 |
| CA2908869A1 (en) | 2014-10-16 |
| UY35526A (es) | 2014-11-28 |
| DOP2015000259A (es) | 2015-11-15 |
| KR20150139917A (ko) | 2015-12-14 |
| CL2015003013A1 (es) | 2016-04-08 |
| ZA201508209B (en) | 2018-05-30 |
| MA38463B1 (fr) | 2018-11-30 |
| CU20150141A7 (es) | 2016-03-31 |
| CR20150530A (es) | 2016-01-29 |
| AU2014253232A1 (en) | 2015-11-05 |
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