MA38463A1 - Dérivés de spiroindoline pour une utilisation en tant qu'antagonistes du récepteur de l'hormone de libération des gonadotrophines - Google Patents
Dérivés de spiroindoline pour une utilisation en tant qu'antagonistes du récepteur de l'hormone de libération des gonadotrophinesInfo
- Publication number
- MA38463A1 MA38463A1 MA38463A MA38463A MA38463A1 MA 38463 A1 MA38463 A1 MA 38463A1 MA 38463 A MA38463 A MA 38463A MA 38463 A MA38463 A MA 38463A MA 38463 A1 MA38463 A1 MA 38463A1
- Authority
- MA
- Morocco
- Prior art keywords
- diseases
- receptor antagonists
- releasing hormone
- gonadotropin releasing
- spiroindoline derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
L'invention concerne des dérivés de la spiroindoline, des procédés pour leur préparation et des compositions pharmaceutiques de ceux-ci, leur utilisation dans le traitement de maladies, et leur utilisation pour la fabrication de médicaments pour le traitement de maladies, notamment des maladies liées aux hormones sexuelles à la fois chez l'homme et la femme, en particulier celles choisies dans le groupe constitué par: l'endométriose, le fibromyome (léiomyomes), le syndrome des ovaires polykystiques, la ménorragie, la dysménorrhée, l'hirsutisme, la puberté précoce, les néoplasies gonadiques dues aux stéroïdes telles que les cancers de la prostate, du sein et des ovaires, les adénomes hypophysaires gonadotropes, l'apnée du sommeil, le syndrome du côlon irritable, le syndrome prémenstruel, l'hypertrophie prostatique bénigne, la contraception, l'infertilité et la thérapie reproductive assistée telle que la fécondation in vitro. La présente invention concerne en particulier des dérivés de la spiroindoline comme antagonistes du récepteur de l'hormone de libération des gonadotrophines (gnrh).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13162986 | 2013-04-09 | ||
PCT/EP2014/057079 WO2014166958A1 (fr) | 2013-04-09 | 2014-04-08 | Dérivés de spiroindoline pour une utilisation en tant qu'antagonistes du récepteur de l'hormone de libération des gonadotrophines |
Publications (2)
Publication Number | Publication Date |
---|---|
MA38463A1 true MA38463A1 (fr) | 2018-05-31 |
MA38463B1 MA38463B1 (fr) | 2018-11-30 |
Family
ID=48047908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA38463A MA38463B1 (fr) | 2013-04-09 | 2014-04-08 | Dérivés de spiroindoline pour une utilisation en tant qu'antagonistes du récepteur de l'hormone de libération des gonadotrophines |
Country Status (28)
Country | Link |
---|---|
US (1) | US20160052936A1 (fr) |
EP (1) | EP2984092A1 (fr) |
JP (1) | JP2016519104A (fr) |
KR (1) | KR20150139917A (fr) |
CN (1) | CN105308053A (fr) |
AP (1) | AP2015008822A0 (fr) |
AR (1) | AR095785A1 (fr) |
AU (1) | AU2014253232A1 (fr) |
BR (1) | BR112015025700A2 (fr) |
CA (1) | CA2908869A1 (fr) |
CL (1) | CL2015003013A1 (fr) |
CR (1) | CR20150530A (fr) |
CU (1) | CU20150141A7 (fr) |
DO (1) | DOP2015000259A (fr) |
EA (1) | EA201501000A1 (fr) |
HK (1) | HK1216101A1 (fr) |
IL (1) | IL241067A0 (fr) |
MA (1) | MA38463B1 (fr) |
MX (1) | MX2015014267A (fr) |
NI (1) | NI201500149A (fr) |
PE (1) | PE20160007A1 (fr) |
PH (1) | PH12015502318A1 (fr) |
SG (1) | SG11201506962TA (fr) |
TN (1) | TN2015000453A1 (fr) |
TW (1) | TW201518304A (fr) |
UY (1) | UY35526A (fr) |
WO (1) | WO2014166958A1 (fr) |
ZA (1) | ZA201508209B (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA201992612A1 (ru) | 2017-06-05 | 2020-05-20 | Обсева С.А. | Схемы применения антагониста гонадотропин-высвобождающего гормона для лечения эндометриоза |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0213715D0 (en) * | 2002-06-14 | 2002-07-24 | Syngenta Ltd | Chemical compounds |
WO2013107743A1 (fr) * | 2012-01-16 | 2013-07-25 | Bayer Intellectual Property Gmbh | Dérivés de la spiroindoline comme antagonistes du récepteur de l'hormone libérant la gonatrophine (gnrh) |
-
2014
- 2014-04-07 AR ARP140101498A patent/AR095785A1/es unknown
- 2014-04-08 MA MA38463A patent/MA38463B1/fr unknown
- 2014-04-08 JP JP2016506935A patent/JP2016519104A/ja active Pending
- 2014-04-08 MX MX2015014267A patent/MX2015014267A/es unknown
- 2014-04-08 SG SG11201506962TA patent/SG11201506962TA/en unknown
- 2014-04-08 KR KR1020157031635A patent/KR20150139917A/ko not_active Application Discontinuation
- 2014-04-08 AU AU2014253232A patent/AU2014253232A1/en not_active Abandoned
- 2014-04-08 CN CN201480032796.7A patent/CN105308053A/zh active Pending
- 2014-04-08 PE PE2015002137A patent/PE20160007A1/es not_active Application Discontinuation
- 2014-04-08 US US14/783,458 patent/US20160052936A1/en not_active Abandoned
- 2014-04-08 AP AP2015008822A patent/AP2015008822A0/xx unknown
- 2014-04-08 BR BR112015025700A patent/BR112015025700A2/pt not_active IP Right Cessation
- 2014-04-08 WO PCT/EP2014/057079 patent/WO2014166958A1/fr active Application Filing
- 2014-04-08 TN TN2015000453A patent/TN2015000453A1/en unknown
- 2014-04-08 EA EA201501000A patent/EA201501000A1/ru unknown
- 2014-04-08 EP EP14715930.5A patent/EP2984092A1/fr not_active Withdrawn
- 2014-04-08 CA CA2908869A patent/CA2908869A1/fr not_active Abandoned
- 2014-04-09 UY UY0001035526A patent/UY35526A/es not_active Application Discontinuation
- 2014-04-09 TW TW103113078A patent/TW201518304A/zh unknown
-
2015
- 2015-09-02 IL IL241067A patent/IL241067A0/en unknown
- 2015-10-06 PH PH12015502318A patent/PH12015502318A1/en unknown
- 2015-10-08 CU CUP2015000141A patent/CU20150141A7/es unknown
- 2015-10-09 CL CL2015003013A patent/CL2015003013A1/es unknown
- 2015-10-09 DO DO2015000259A patent/DOP2015000259A/es unknown
- 2015-10-09 CR CR20150530A patent/CR20150530A/es unknown
- 2015-10-09 NI NI201500149A patent/NI201500149A/es unknown
- 2015-11-06 ZA ZA2015/08209A patent/ZA201508209B/en unknown
-
2016
- 2016-04-11 HK HK16104067.2A patent/HK1216101A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CR20150530A (es) | 2016-01-29 |
WO2014166958A1 (fr) | 2014-10-16 |
MX2015014267A (es) | 2016-03-01 |
TN2015000453A1 (en) | 2017-04-06 |
AU2014253232A1 (en) | 2015-11-05 |
UY35526A (es) | 2014-11-28 |
DOP2015000259A (es) | 2015-11-15 |
CL2015003013A1 (es) | 2016-04-08 |
IL241067A0 (en) | 2015-11-30 |
HK1216101A1 (zh) | 2016-10-14 |
NI201500149A (es) | 2015-11-30 |
EA201501000A1 (ru) | 2016-04-29 |
ZA201508209B (en) | 2018-05-30 |
CU20150141A7 (es) | 2016-03-31 |
CA2908869A1 (fr) | 2014-10-16 |
MA38463B1 (fr) | 2018-11-30 |
KR20150139917A (ko) | 2015-12-14 |
EP2984092A1 (fr) | 2016-02-17 |
PE20160007A1 (es) | 2016-02-14 |
AR095785A1 (es) | 2015-11-11 |
AP2015008822A0 (en) | 2015-10-31 |
BR112015025700A2 (pt) | 2017-07-18 |
CN105308053A (zh) | 2016-02-03 |
PH12015502318A1 (en) | 2016-02-15 |
TW201518304A (zh) | 2015-05-16 |
SG11201506962TA (en) | 2015-10-29 |
US20160052936A1 (en) | 2016-02-25 |
JP2016519104A (ja) | 2016-06-30 |
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