PE20141699A1 - Derivados de espiroindolina como antagonistas del receptor de la hormona liberadora de gonadotropina - Google Patents

Derivados de espiroindolina como antagonistas del receptor de la hormona liberadora de gonadotropina

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Publication number
PE20141699A1
PE20141699A1 PE2014001114A PE2014001114A PE20141699A1 PE 20141699 A1 PE20141699 A1 PE 20141699A1 PE 2014001114 A PE2014001114 A PE 2014001114A PE 2014001114 A PE2014001114 A PE 2014001114A PE 20141699 A1 PE20141699 A1 PE 20141699A1
Authority
PE
Peru
Prior art keywords
methyl
antagonists
hormone receptor
releasing hormone
sulfonil
Prior art date
Application number
PE2014001114A
Other languages
English (en)
Inventor
Olaf Panknin
Stefan Baurle
Sven Ring
Wolfgang Schwede
Wilhelm Bone
Katrin Nowak-Reppel
Eckhard Bender
Reinhard Nubbemeyer
Mark Jean Gnoth
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47559493&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20141699(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of PE20141699A1 publication Critical patent/PE20141699A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE ESPIROINDOLINA DE FORMULA (I) DONDE W ES O U S(O)x, DONDE x ES DE 0 A 2; R1 ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C10), ARILO, ENTRE OTROS; R2 ES ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDO CON R4, EN DONDE R4 ES HALOGENO, HIDROXI, C(O)NH2, ENTRE OTROS; R3 ES C(O)N(R5a)(R5b), N(H)C(O)R6, ENTRE OTROS, EN DONDE R5a, R5b Y R6 SON CADA UNO H, ALQUILO(C1-C6), ALQUENILO(C2-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[(3-CLOROPIRIDIN-2-IL)METIL]-1-[(4-FLUOROFENIL)SULFONIL]-2-METIL-1,2,2',3',5',6'-HEXAHIDROESPIRO[INDOL-3,4'-PIRAN]-5-CARBOXAMIDA; N-(2-CLOROBENCIL)-1-[(4-FLUOROFENIL)SULFONIL]-2-METIL-1,2,2',3',5',6'-HEXAHIDROESPIRO[INDOL-3,4'-PIRAN]-5-CARBOXAMIDA; 1-[(4-FLUOROFENIL)SULFONIL]-2-METIL-N-{[3-(TRIFLUOROMETIL)PIRIDIN-2-IL]METIL}-1,2,2',3',5',6'-HEXAHIDROESPIRO[INDOL-3,4'-PIRAN]-5-CARBOXAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE LA HORMONA LIBERADORA DE GONADOTROPINA (GnRH) SIENDO UTILES EN EL TRATAMIENTO DE ENDOMETRIOSIS, FIBROIDES EN EL UTERO, OVARIO POLIQUISTICO
PE2014001114A 2012-01-16 2013-01-15 Derivados de espiroindolina como antagonistas del receptor de la hormona liberadora de gonadotropina PE20141699A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12151291 2012-01-16

Publications (1)

Publication Number Publication Date
PE20141699A1 true PE20141699A1 (es) 2014-11-29

Family

ID=47559493

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014001114A PE20141699A1 (es) 2012-01-16 2013-01-15 Derivados de espiroindolina como antagonistas del receptor de la hormona liberadora de gonadotropina

Country Status (25)

Country Link
US (1) US20140357655A1 (es)
EP (1) EP2804867A1 (es)
JP (1) JP2015503607A (es)
KR (1) KR20140112075A (es)
CN (1) CN104169287A (es)
AP (1) AP2014007738A0 (es)
AU (1) AU2013211091A1 (es)
BR (1) BR112014017483A8 (es)
CA (1) CA2860986A1 (es)
CL (1) CL2014001871A1 (es)
CO (1) CO7010832A2 (es)
CR (1) CR20140343A (es)
CU (1) CU20140088A7 (es)
DO (1) DOP2014000167A (es)
EA (1) EA201491344A1 (es)
GT (1) GT201400153A (es)
HK (1) HK1199878A1 (es)
IL (1) IL233485A0 (es)
MA (1) MA35867B1 (es)
MX (1) MX2014008630A (es)
PE (1) PE20141699A1 (es)
PH (1) PH12014501616A1 (es)
SG (1) SG11201403749VA (es)
TN (1) TN2014000306A1 (es)
WO (1) WO2013107743A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR095785A1 (es) * 2013-04-09 2015-11-11 Bayer Pharma AG Derivados de espiroindolina y composiciones farmacéutica de los mismos
WO2015007606A1 (en) * 2013-07-15 2015-01-22 Bayer Pharma Aktiengesellschaft Spiroindoline derivatives and pharmaceutical compositions thereof
WO2015082374A1 (en) * 2013-12-05 2015-06-11 Bayer Pharma Aktiengesellschaft Spiroindoline-thiopyran-imine-oxide derivatives as gonadotropin-releasing hormone receptor antagonists and pharmaceutical compositions thereof
EP2881391A1 (en) 2013-12-05 2015-06-10 Bayer Pharma Aktiengesellschaft Spiroindoline carbocycle derivatives and pharmaceutical compositions thereof
WO2015091315A1 (en) * 2013-12-19 2015-06-25 Bayer Pharma Aktiengesellschaft Spiro[indolin-3,4'-piperidine] derivatives as gnrh receptor antagonists
EP3339846B1 (en) * 2016-12-22 2020-12-09 Malvern Panalytical B.V. Method of measuring properties of a thin film stack
CN110996956A (zh) 2017-06-05 2020-04-10 奥布赛瓦股份公司 用于治疗子宫内膜异位症的促性腺激素释放激素拮抗剂给药方案
CN107840851A (zh) * 2017-12-21 2018-03-27 扬州大学 吲哚螺吡咯嗪化合物及其合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849780A (en) * 1992-01-30 1998-12-15 Sanofi 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
TW200522944A (en) * 2003-12-23 2005-07-16 Lilly Co Eli CB1 modulator compounds

Also Published As

Publication number Publication date
IL233485A0 (en) 2014-08-31
CN104169287A (zh) 2014-11-26
TN2014000306A1 (en) 2015-12-21
AU2013211091A1 (en) 2014-08-07
SG11201403749VA (en) 2014-07-30
BR112014017483A2 (pt) 2017-06-13
CR20140343A (es) 2014-09-08
EA201491344A1 (ru) 2015-04-30
JP2015503607A (ja) 2015-02-02
US20140357655A1 (en) 2014-12-04
KR20140112075A (ko) 2014-09-22
AP2014007738A0 (en) 2014-07-31
PH12014501616A1 (en) 2014-10-13
BR112014017483A8 (pt) 2017-07-04
EP2804867A1 (en) 2014-11-26
WO2013107743A1 (en) 2013-07-25
HK1199878A1 (en) 2015-07-24
CO7010832A2 (es) 2014-07-31
CL2014001871A1 (es) 2014-11-03
CA2860986A1 (en) 2013-07-25
DOP2014000167A (es) 2014-08-31
MX2014008630A (es) 2014-08-29
CU20140088A7 (es) 2014-12-26
MA35867B1 (fr) 2014-12-01
GT201400153A (es) 2015-05-22

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