ATE460412T1 - Trisubstituierte thiophene als progesteronreceptor-modulatoren - Google Patents
Trisubstituierte thiophene als progesteronreceptor-modulatorenInfo
- Publication number
- ATE460412T1 ATE460412T1 AT05816130T AT05816130T ATE460412T1 AT E460412 T1 ATE460412 T1 AT E460412T1 AT 05816130 T AT05816130 T AT 05816130T AT 05816130 T AT05816130 T AT 05816130T AT E460412 T1 ATE460412 T1 AT E460412T1
- Authority
- AT
- Austria
- Prior art keywords
- progesterone receptor
- tris
- receptor modulators
- prevention
- treatment
- Prior art date
Links
- 150000003577 thiophenes Chemical class 0.000 title abstract 2
- 239000002379 progesterone receptor modulator Substances 0.000 title 1
- 229940095745 sex hormone and modulator of the genital system progesterone receptor modulator Drugs 0.000 title 1
- 229930192474 thiophene Natural products 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 201000000736 Amenorrhea Diseases 0.000 abstract 1
- 206010001928 Amenorrhoea Diseases 0.000 abstract 1
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 206010013908 Dysfunctional uterine bleeding Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 206010027514 Metrorrhagia Diseases 0.000 abstract 1
- 208000009956 adenocarcinoma Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 231100000540 amenorrhea Toxicity 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 210000001072 colon Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 210000004696 endometrium Anatomy 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- 235000012631 food intake Nutrition 0.000 abstract 1
- 230000003054 hormonal effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 210000001672 ovary Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 abstract 1
- 102000003998 progesterone receptors Human genes 0.000 abstract 1
- 108090000468 progesterone receptors Proteins 0.000 abstract 1
- 210000002307 prostate Anatomy 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Optical Communication System (AREA)
- Amplifiers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62258104P | 2004-10-27 | 2004-10-27 | |
| PCT/US2005/037827 WO2006049891A1 (en) | 2004-10-27 | 2005-10-21 | Trisubstituted thiophenes as progesterone receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE460412T1 true ATE460412T1 (de) | 2010-03-15 |
Family
ID=35840022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05816130T ATE460412T1 (de) | 2004-10-27 | 2005-10-21 | Trisubstituierte thiophene als progesteronreceptor-modulatoren |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7638525B2 (de) |
| EP (1) | EP1807420B1 (de) |
| JP (1) | JP5137578B2 (de) |
| CN (1) | CN101087783B (de) |
| AT (1) | ATE460412T1 (de) |
| AU (1) | AU2005302708A1 (de) |
| CA (1) | CA2585337C (de) |
| DE (1) | DE602005019905D1 (de) |
| ES (1) | ES2341268T3 (de) |
| WO (1) | WO2006049891A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20081803A1 (es) * | 2007-03-09 | 2008-12-11 | Wyeth Corp | Sintesis y caracterizacion de la forma ii polimorfica de 4-(2-(4,4-dimetil-2-oxooxazolidin-3-il)tiazol-4-il)benzonitrilo |
| EP4464384A3 (de) | 2007-08-17 | 2025-01-08 | Purdue Research Foundation | Psma-bindungsliganden-linker-konjugate und anwendungsverfahren |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| EP2664325A1 (de) * | 2012-05-16 | 2013-11-20 | PregLem S.A. | Verfahren zur Prävention oder Behandlung von androgenvermittelten Erkrankungen |
| BR112015011118B1 (pt) | 2012-11-15 | 2022-12-13 | Endocyte, Inc | Conjugado; composição farmacêutica; e uso de um conjugado |
| LT4095130T (lt) | 2013-10-18 | 2024-04-25 | Novartis Ag | Žymėti prostatos specifinio membranos antigeno (psma) inhibitoriai, jų naudojimas kaip vizualizavimo medžiagų ir farmacinių medžiagų prostatos vėžiui gydyti |
| BR112016010927A2 (pt) | 2013-11-14 | 2017-08-08 | Endocyte Inc | Conjugado de fórmula |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| US12208102B2 (en) | 2018-04-17 | 2025-01-28 | Endocyte, Inc. | Methods of treating cancer |
| CN114096264B (zh) | 2019-05-20 | 2025-03-14 | 因多塞特股份有限公司 | 制备psma缀合物的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD201306A1 (de) * | 1981-12-10 | 1983-07-13 | Juergen Liebscher | Verfahren zur herstellung von 5-acyl-3-aryl-2-dialkylaminothiophenen |
| US5696127A (en) * | 1994-12-22 | 1997-12-09 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
| US6306851B1 (en) * | 1999-05-04 | 2001-10-23 | American Home Products Corporation | Cyclocarbamate and cyclic amide derivatives |
| AU4688800A (en) * | 1999-05-04 | 2000-11-17 | American Home Products Corporation | Cyclocarbamate and cyclic amide derivatives |
| AUPR738301A0 (en) | 2001-08-30 | 2001-09-20 | Starpharma Limited | Chemotherapeutic agents |
-
2005
- 2005-10-21 WO PCT/US2005/037827 patent/WO2006049891A1/en not_active Ceased
- 2005-10-21 CN CN2005800446628A patent/CN101087783B/zh not_active Expired - Fee Related
- 2005-10-21 US US11/255,445 patent/US7638525B2/en not_active Expired - Fee Related
- 2005-10-21 ES ES05816130T patent/ES2341268T3/es not_active Expired - Lifetime
- 2005-10-21 JP JP2007538998A patent/JP5137578B2/ja not_active Expired - Fee Related
- 2005-10-21 AT AT05816130T patent/ATE460412T1/de not_active IP Right Cessation
- 2005-10-21 DE DE602005019905T patent/DE602005019905D1/de not_active Expired - Lifetime
- 2005-10-21 CA CA2585337A patent/CA2585337C/en not_active Expired - Fee Related
- 2005-10-21 AU AU2005302708A patent/AU2005302708A1/en not_active Abandoned
- 2005-10-21 EP EP05816130A patent/EP1807420B1/de not_active Expired - Lifetime
-
2009
- 2009-08-17 US US12/542,135 patent/US20090306118A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2585337A1 (en) | 2006-05-11 |
| CN101087783A (zh) | 2007-12-12 |
| ES2341268T3 (es) | 2010-06-17 |
| CA2585337C (en) | 2013-12-24 |
| EP1807420B1 (de) | 2010-03-10 |
| JP2008518011A (ja) | 2008-05-29 |
| WO2006049891A1 (en) | 2006-05-11 |
| DE602005019905D1 (de) | 2010-04-22 |
| AU2005302708A1 (en) | 2006-05-11 |
| US20090306118A1 (en) | 2009-12-10 |
| JP5137578B2 (ja) | 2013-02-06 |
| EP1807420A1 (de) | 2007-07-18 |
| US20060106047A1 (en) | 2006-05-18 |
| CN101087783B (zh) | 2010-12-08 |
| US7638525B2 (en) | 2009-12-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201200860A1 (ru) | Нейтрализующие пролактиновый рецептор антитела и их терапевтическое применение | |
| CY1121926T1 (el) | (11.βητα., 17.βητα.)-17-υδροξυ-11-[4(μεθυλοσουλφονυλο)φαινυλο]-17-(πενταφθορομεθυλο)οιστρα-4,9-διεν-3-ονη για την αγωγη παθησεων | |
| ATE514700T1 (de) | Neues tetrazyklisches heteroatom mit als sexualsteroidhormon-rezeptormodulatoren geeigneten derivaten | |
| ATE460412T1 (de) | Trisubstituierte thiophene als progesteronreceptor-modulatoren | |
| CY1110017T1 (el) | Μικρονισμενη ταναπρογετη και συνθεσεις που περιεχουν αυτην | |
| WO2011098437A3 (de) | Progesteronrezeptorantagonisten | |
| NO20070248L (no) | Fremgangsmater for fremstilling av gonadotropinfrigjorende hormon reseptor antagonister | |
| EA201491344A1 (ru) | Производные спироиндолина в качестве антагонистов рецептора гонадотропин-рилизинг гормона | |
| TR200103285T2 (tr) | Projesteron reseptörü modülatörleri olarak siklokarbamat türevleri. | |
| CY1109919T1 (el) | Παραγωγα της ινδολης που ειναι χρησιμα σα ρυθμιστες του υποδοχεα της προγεστερονης | |
| ECSP078043A (es) | Derivados de benzofurarona como moduladores no esteroides de receptores de progesterona | |
| EA201792524A1 (ru) | Режим приема селективного модулятора рецептора прогестерона (sprm) | |
| ATE407120T1 (de) | 3-((hetero)arylsulfonyl)-8- ä(aminoalkyl)oxyüchinoline als antagonisten des 5-ht6-rezeptors zur behandlung von erkrankungen des zns | |
| ATE275973T1 (de) | Empfängnisverhütende zusammensetzungen die progestagen und progesteronantagonisten enthalten | |
| DK1874278T3 (da) | Sammensætninger indeholdende mikroniseret tanaproget | |
| MA32477B1 (fr) | Derives estratrienes comprenant des bioisosteres heterocycliques pour le cycle a phenolique | |
| NO20080440L (no) | Ikke-steroide progesteronreseptormodulatorer | |
| WO2008109055A3 (en) | Cyanopyrrole sulfonamides useful for modulation of the progesterone receptor | |
| UY30805A1 (es) | Moduladores no esteroides de receptores de progesterona | |
| AR023854A1 (es) | Uso de derivados de indolina y equipo farmaceutico para regimenes ciclicos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |