HRP20110554T1 - "klik" kemija za proizvodnju reporter molekula - Google Patents
"klik" kemija za proizvodnju reporter molekula Download PDFInfo
- Publication number
- HRP20110554T1 HRP20110554T1 HR20110554T HRP20110554T HRP20110554T1 HR P20110554 T1 HRP20110554 T1 HR P20110554T1 HR 20110554 T HR20110554 T HR 20110554T HR P20110554 T HRP20110554 T HR P20110554T HR P20110554 T1 HRP20110554 T1 HR P20110554T1
- Authority
- HR
- Croatia
- Prior art keywords
- group
- handle
- groups
- reporter molecule
- reaction partner
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 238000000034 method Methods 0.000 claims abstract 9
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 3
- 102000039446 nucleic acids Human genes 0.000 claims abstract 3
- 108020004707 nucleic acids Proteins 0.000 claims abstract 3
- 125000002355 alkine group Chemical group 0.000 claims 10
- 238000006243 chemical reaction Methods 0.000 claims 8
- 125000000524 functional group Chemical group 0.000 claims 8
- 238000002372 labelling Methods 0.000 claims 4
- 238000003786 synthesis reaction Methods 0.000 claims 3
- 239000007983 Tris buffer Substances 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 2
- 238000010791 quenching Methods 0.000 claims 2
- 230000000171 quenching effect Effects 0.000 claims 2
- 239000007790 solid phase Substances 0.000 claims 2
- 150000001345 alkine derivatives Chemical class 0.000 claims 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 238000001514 detection method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85557406P | 2006-10-31 | 2006-10-31 | |
| PCT/EP2007/009474 WO2008052775A2 (en) | 2006-10-31 | 2007-10-31 | Click chemistry for the production of reporter molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110554T1 true HRP20110554T1 (hr) | 2011-09-30 |
Family
ID=39344631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110554T HRP20110554T1 (hr) | 2006-10-31 | 2011-07-25 | "klik" kemija za proizvodnju reporter molekula |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8193335B2 (pl) |
| EP (1) | EP2089343B1 (pl) |
| JP (1) | JP5646172B2 (pl) |
| CN (1) | CN101605743A (pl) |
| AT (1) | ATE515488T1 (pl) |
| AU (1) | AU2007315190B2 (pl) |
| CA (1) | CA2667136A1 (pl) |
| DK (1) | DK2089343T3 (pl) |
| ES (1) | ES2369299T3 (pl) |
| HR (1) | HRP20110554T1 (pl) |
| PL (1) | PL2089343T3 (pl) |
| PT (1) | PT2089343E (pl) |
| SI (1) | SI2089343T1 (pl) |
| WO (1) | WO2008052775A2 (pl) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI406952B (zh) * | 2005-05-02 | 2013-09-01 | Basf Ag | 分析物之敏感偵測的新標記策略 |
| KR101335218B1 (ko) | 2005-05-02 | 2013-12-12 | 바스프 에스이 | 분석물의 감응성 검출을 위한 신규한 표지화 전략 |
| JP5646172B2 (ja) | 2006-10-31 | 2014-12-24 | ベースクリック ゲーエムベーハー | リポーター分子の製造のためのクリックケミストリー |
| JP2010522583A (ja) | 2007-02-27 | 2010-07-08 | トラスティーズ オブ タフツ カレッジ | 組織工学的に作製された絹製臓器 |
| CN104013598A (zh) | 2007-05-29 | 2014-09-03 | 塔夫茨大学信托人 | 利用超声处理使丝纤蛋白凝胶化的方法 |
| US8618297B2 (en) | 2008-07-25 | 2013-12-31 | Basf Se | Azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions |
| WO2010039548A2 (en) * | 2008-09-23 | 2010-04-08 | Alnylam Pharmaceuticals, Inc. | Chemical modifications of monomers and oligonucleotides with cycloaddition |
| US9150910B2 (en) | 2008-11-17 | 2015-10-06 | Headway Technologies, Inc. | Methods and compositions in particle-based detection of target molecules using linking molecules |
| EP2358898B1 (en) | 2008-11-17 | 2016-08-31 | Headway Technologies, Inc. | Methods and compositions in particle-based detection of target molecules using covalent bond forming reactive pairs |
| JP5569768B2 (ja) * | 2008-12-02 | 2014-08-13 | 国立大学法人九州大学 | ヌクレオシド三リン酸誘導体、核酸プローブ、マルチラベル化核酸プローブおよび標的核酸の検出方法 |
| EP2239053A1 (en) | 2009-04-09 | 2010-10-13 | baseclick GmbH | Click chemistry on heterogeneous catalysts |
| CA2775706A1 (en) | 2009-09-28 | 2011-03-31 | Trustees Of Tufts College | Drawn silk egel fibers and methods of making same |
| EP4218891A1 (en) | 2010-10-19 | 2023-08-02 | Trustees Of Tufts College | Silk fibroin-based microneedles and methods of making the same |
| CN102010508B (zh) * | 2010-10-19 | 2012-10-03 | 北京大学 | 一种阳离子聚合物及其制备方法和应用 |
| US9447455B2 (en) | 2011-02-16 | 2016-09-20 | Headway Technologies, Inc. | Methods and compositions for the target-localized anchoring of detectable label |
| WO2012145652A1 (en) | 2011-04-20 | 2012-10-26 | Trustees Of Tufts College | Dynamic silk coatings for implantable devices |
| EP2825546B1 (en) * | 2011-09-01 | 2017-07-12 | Case Western Reserve University | Non-natural nucleosides as theranostic agents |
| WO2013152619A1 (en) * | 2012-04-12 | 2013-10-17 | The Hong Kong University Of Science And Technology | Thermosetting poly(siloxane-diphenylbutadiyne) with readily tunable glass transition temperature and high thermal stability |
| AU2013288738A1 (en) | 2012-07-10 | 2015-01-29 | Baseclick Gmbh | Anandamide-modified nucleic acid molecules |
| AU2013361605A1 (en) | 2012-12-20 | 2015-06-04 | Sirna Therapeutics, Inc. | Post-synthetic orthogonal amidation plus metal catalyzed azide-alkyne cycloaddition click chemistry on siRNA |
| US20160159834A1 (en) * | 2013-04-22 | 2016-06-09 | Northwestern University | Alkyne phosphoramidites and preparation of spherical nucleic acid constructs |
| ES2791279T3 (es) * | 2013-08-19 | 2020-11-03 | Univ Houston | Indicadores fosforescentes |
| JP6564369B2 (ja) | 2013-12-09 | 2019-08-21 | デュレクト コーポレイション | 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法 |
| US10301345B2 (en) | 2014-11-20 | 2019-05-28 | Stratos Genomics, Inc. | Phosphoroamidate esters, and use and synthesis thereof |
| WO2016152980A1 (ja) * | 2015-03-24 | 2016-09-29 | 国立大学法人岐阜大学 | オリゴヌクレオチド誘導体及びそれを用いたオリゴヌクレオチド構築物並びにそれらの製造方法 |
| JP7283727B2 (ja) | 2016-06-16 | 2023-05-30 | ヘイスタック サイエンシィズ コーポレーション | コードプローブ分子のコンビナトリアル合成が指令されかつ記録されたオリゴヌクレオチド |
| EP3619340A4 (en) | 2017-05-02 | 2021-01-20 | Haystack Sciences Corporation | MOLECULES FOR THE VERIFICATION OF OLIGONUCLEOTIDE DIRECTED COMBINATIONAL SYNTHESIS AND METHOD OF MANUFACTURING AND USING THEREOF |
| CN109490523A (zh) * | 2018-10-22 | 2019-03-19 | 北京纳晶生物科技有限公司 | 用于标记的纳米材料、核酸探针及核酸与纳米材料偶联的方法 |
| CN112305227A (zh) * | 2019-07-31 | 2021-02-02 | 深圳市帝迈生物技术有限公司 | 自交联蛋白、配体组合物、制备方法、试剂盒及系统 |
| CN111018930A (zh) * | 2019-12-06 | 2020-04-17 | 深圳大学 | Tpe-2’-脱氧核苷、荧光凝胶及其制备方法与应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2209754A (en) | 1987-09-17 | 1989-05-24 | Thomas Lee Mattson | Polyaldehydic polynucleotides in use as probes,their preparation and use |
| AU636110B2 (en) | 1988-06-08 | 1993-04-22 | Nichols Institute Diagnostics | Assays utilizing sensitizer-induced production of detectable signal |
| US5723289A (en) | 1990-06-11 | 1998-03-03 | Nexstar Pharmaceuticals, Inc. | Parallel selex |
| US5843650A (en) | 1995-05-01 | 1998-12-01 | Segev; David | Nucleic acid detection and amplification by chemical linkage of oligonucleotides |
| WO1998030575A1 (en) | 1997-01-08 | 1998-07-16 | Proligo Llc | Bioconjugation of macromolecules |
| US7427678B2 (en) | 1998-01-08 | 2008-09-23 | Sigma-Aldrich Co. | Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method |
| US6727356B1 (en) | 1999-12-08 | 2004-04-27 | Epoch Pharmaceuticals, Inc. | Fluorescent quenching detection reagents and methods |
| US7205105B2 (en) | 1999-12-08 | 2007-04-17 | Epoch Biosciences, Inc. | Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis |
| DE10013600A1 (de) | 2000-03-18 | 2002-01-10 | Aventis Res & Tech Gmbh & Co | Reaktive Monomere für die Oligonucleotid- und Polynucleotidsynthese, modifizierte Oligonucleotide und Polynucleotiden und ein Verfahren zu deren Herstellung |
| WO2003079014A1 (en) * | 2002-03-03 | 2003-09-25 | Activx Biosciences, Inc. | Tethered activity-based probes and uses thereof |
| AU2003240482B2 (en) | 2002-05-30 | 2009-03-12 | The Scripps Research Institute | Copper-catalysed ligation of azides and acetylenes |
| US20050032081A1 (en) | 2002-12-13 | 2005-02-10 | Jingyue Ju | Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry |
| KR100540509B1 (ko) | 2004-01-07 | 2006-01-11 | 학교법인 포항공과대학교 | 수화젤레이터로 사용되는 2'-데옥시우리딘 유도체 |
| CA2562285A1 (en) | 2004-04-08 | 2006-03-16 | Nimblegen Systems, Inc. | Comparative genomic resequencing |
| WO2006116629A2 (en) | 2005-04-27 | 2006-11-02 | Siemens Medical Solutions Usa, Inc. | The preparation of molecular imaging probes using click chemistry |
| TWI406952B (zh) * | 2005-05-02 | 2013-09-01 | Basf Ag | 分析物之敏感偵測的新標記策略 |
| EP3591069A3 (en) | 2005-10-27 | 2020-03-04 | The President and Fellows of Harvard College | Methods and compositions for labeling nucleic acids |
| JP5646172B2 (ja) | 2006-10-31 | 2014-12-24 | ベースクリック ゲーエムベーハー | リポーター分子の製造のためのクリックケミストリー |
-
2007
- 2007-10-31 JP JP2009533756A patent/JP5646172B2/ja active Active
- 2007-10-31 US US12/447,526 patent/US8193335B2/en active Active
- 2007-10-31 PT PT07819506T patent/PT2089343E/pt unknown
- 2007-10-31 AU AU2007315190A patent/AU2007315190B2/en active Active
- 2007-10-31 WO PCT/EP2007/009474 patent/WO2008052775A2/en active Application Filing
- 2007-10-31 SI SI200730721T patent/SI2089343T1/sl unknown
- 2007-10-31 ES ES07819506T patent/ES2369299T3/es active Active
- 2007-10-31 EP EP07819506A patent/EP2089343B1/en active Active
- 2007-10-31 DK DK07819506.2T patent/DK2089343T3/da active
- 2007-10-31 CN CNA2007800405932A patent/CN101605743A/zh active Pending
- 2007-10-31 AT AT07819506T patent/ATE515488T1/de active
- 2007-10-31 PL PL07819506T patent/PL2089343T3/pl unknown
- 2007-10-31 CA CA002667136A patent/CA2667136A1/en not_active Abandoned
-
2011
- 2011-07-25 HR HR20110554T patent/HRP20110554T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK2089343T3 (da) | 2011-10-24 |
| WO2008052775A3 (en) | 2009-01-15 |
| JP2010508015A (ja) | 2010-03-18 |
| CN101605743A (zh) | 2009-12-16 |
| ES2369299T3 (es) | 2011-11-29 |
| AU2007315190B2 (en) | 2012-05-31 |
| EP2089343B1 (en) | 2011-07-06 |
| US8193335B2 (en) | 2012-06-05 |
| SI2089343T1 (sl) | 2011-10-28 |
| JP5646172B2 (ja) | 2014-12-24 |
| PL2089343T3 (pl) | 2011-12-30 |
| AU2007315190A1 (en) | 2008-05-08 |
| WO2008052775A2 (en) | 2008-05-08 |
| CA2667136A1 (en) | 2008-05-08 |
| ATE515488T1 (de) | 2011-07-15 |
| EP2089343A2 (en) | 2009-08-19 |
| US20100081137A1 (en) | 2010-04-01 |
| PT2089343E (pt) | 2011-09-06 |
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