ATE515488T1 - Click-chemie zur herstellung von reportermolekülen - Google Patents

Click-chemie zur herstellung von reportermolekülen

Info

Publication number
ATE515488T1
ATE515488T1 AT07819506T AT07819506T ATE515488T1 AT E515488 T1 ATE515488 T1 AT E515488T1 AT 07819506 T AT07819506 T AT 07819506T AT 07819506 T AT07819506 T AT 07819506T AT E515488 T1 ATE515488 T1 AT E515488T1
Authority
AT
Austria
Prior art keywords
reporter molecules
click chemistry
producing reporter
producing
methods
Prior art date
Application number
AT07819506T
Other languages
German (de)
English (en)
Inventor
Thomas Carell
Anja Schwoegler
Original Assignee
Baseclick Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baseclick Gmbh filed Critical Baseclick Gmbh
Application granted granted Critical
Publication of ATE515488T1 publication Critical patent/ATE515488T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
AT07819506T 2006-10-31 2007-10-31 Click-chemie zur herstellung von reportermolekülen ATE515488T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85557406P 2006-10-31 2006-10-31
PCT/EP2007/009474 WO2008052775A2 (en) 2006-10-31 2007-10-31 Click chemistry for the production of reporter molecules

Publications (1)

Publication Number Publication Date
ATE515488T1 true ATE515488T1 (de) 2011-07-15

Family

ID=39344631

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07819506T ATE515488T1 (de) 2006-10-31 2007-10-31 Click-chemie zur herstellung von reportermolekülen

Country Status (14)

Country Link
US (1) US8193335B2 (pl)
EP (1) EP2089343B1 (pl)
JP (1) JP5646172B2 (pl)
CN (1) CN101605743A (pl)
AT (1) ATE515488T1 (pl)
AU (1) AU2007315190B2 (pl)
CA (1) CA2667136A1 (pl)
DK (1) DK2089343T3 (pl)
ES (1) ES2369299T3 (pl)
HR (1) HRP20110554T1 (pl)
PL (1) PL2089343T3 (pl)
PT (1) PT2089343E (pl)
SI (1) SI2089343T1 (pl)
WO (1) WO2008052775A2 (pl)

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TWI406952B (zh) * 2005-05-02 2013-09-01 Basf Ag 分析物之敏感偵測的新標記策略
KR101335218B1 (ko) 2005-05-02 2013-12-12 바스프 에스이 분석물의 감응성 검출을 위한 신규한 표지화 전략
JP5646172B2 (ja) 2006-10-31 2014-12-24 ベースクリック ゲーエムベーハー リポーター分子の製造のためのクリックケミストリー
JP2010522583A (ja) 2007-02-27 2010-07-08 トラスティーズ オブ タフツ カレッジ 組織工学的に作製された絹製臓器
CN104013598A (zh) 2007-05-29 2014-09-03 塔夫茨大学信托人 利用超声处理使丝纤蛋白凝胶化的方法
US8618297B2 (en) 2008-07-25 2013-12-31 Basf Se Azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions
WO2010039548A2 (en) * 2008-09-23 2010-04-08 Alnylam Pharmaceuticals, Inc. Chemical modifications of monomers and oligonucleotides with cycloaddition
US9150910B2 (en) 2008-11-17 2015-10-06 Headway Technologies, Inc. Methods and compositions in particle-based detection of target molecules using linking molecules
EP2358898B1 (en) 2008-11-17 2016-08-31 Headway Technologies, Inc. Methods and compositions in particle-based detection of target molecules using covalent bond forming reactive pairs
JP5569768B2 (ja) * 2008-12-02 2014-08-13 国立大学法人九州大学 ヌクレオシド三リン酸誘導体、核酸プローブ、マルチラベル化核酸プローブおよび標的核酸の検出方法
EP2239053A1 (en) 2009-04-09 2010-10-13 baseclick GmbH Click chemistry on heterogeneous catalysts
CA2775706A1 (en) 2009-09-28 2011-03-31 Trustees Of Tufts College Drawn silk egel fibers and methods of making same
EP4218891A1 (en) 2010-10-19 2023-08-02 Trustees Of Tufts College Silk fibroin-based microneedles and methods of making the same
CN102010508B (zh) * 2010-10-19 2012-10-03 北京大学 一种阳离子聚合物及其制备方法和应用
US9447455B2 (en) 2011-02-16 2016-09-20 Headway Technologies, Inc. Methods and compositions for the target-localized anchoring of detectable label
WO2012145652A1 (en) 2011-04-20 2012-10-26 Trustees Of Tufts College Dynamic silk coatings for implantable devices
EP2825546B1 (en) * 2011-09-01 2017-07-12 Case Western Reserve University Non-natural nucleosides as theranostic agents
WO2013152619A1 (en) * 2012-04-12 2013-10-17 The Hong Kong University Of Science And Technology Thermosetting poly(siloxane-diphenylbutadiyne) with readily tunable glass transition temperature and high thermal stability
AU2013288738A1 (en) 2012-07-10 2015-01-29 Baseclick Gmbh Anandamide-modified nucleic acid molecules
AU2013361605A1 (en) 2012-12-20 2015-06-04 Sirna Therapeutics, Inc. Post-synthetic orthogonal amidation plus metal catalyzed azide-alkyne cycloaddition click chemistry on siRNA
US20160159834A1 (en) * 2013-04-22 2016-06-09 Northwestern University Alkyne phosphoramidites and preparation of spherical nucleic acid constructs
ES2791279T3 (es) * 2013-08-19 2020-11-03 Univ Houston Indicadores fosforescentes
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
US10301345B2 (en) 2014-11-20 2019-05-28 Stratos Genomics, Inc. Phosphoroamidate esters, and use and synthesis thereof
WO2016152980A1 (ja) * 2015-03-24 2016-09-29 国立大学法人岐阜大学 オリゴヌクレオチド誘導体及びそれを用いたオリゴヌクレオチド構築物並びにそれらの製造方法
JP7283727B2 (ja) 2016-06-16 2023-05-30 ヘイスタック サイエンシィズ コーポレーション コードプローブ分子のコンビナトリアル合成が指令されかつ記録されたオリゴヌクレオチド
EP3619340A4 (en) 2017-05-02 2021-01-20 Haystack Sciences Corporation MOLECULES FOR THE VERIFICATION OF OLIGONUCLEOTIDE DIRECTED COMBINATIONAL SYNTHESIS AND METHOD OF MANUFACTURING AND USING THEREOF
CN109490523A (zh) * 2018-10-22 2019-03-19 北京纳晶生物科技有限公司 用于标记的纳米材料、核酸探针及核酸与纳米材料偶联的方法
CN112305227A (zh) * 2019-07-31 2021-02-02 深圳市帝迈生物技术有限公司 自交联蛋白、配体组合物、制备方法、试剂盒及系统
CN111018930A (zh) * 2019-12-06 2020-04-17 深圳大学 Tpe-2’-脱氧核苷、荧光凝胶及其制备方法与应用

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AU636110B2 (en) 1988-06-08 1993-04-22 Nichols Institute Diagnostics Assays utilizing sensitizer-induced production of detectable signal
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WO2003079014A1 (en) * 2002-03-03 2003-09-25 Activx Biosciences, Inc. Tethered activity-based probes and uses thereof
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US20050032081A1 (en) 2002-12-13 2005-02-10 Jingyue Ju Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
KR100540509B1 (ko) 2004-01-07 2006-01-11 학교법인 포항공과대학교 수화젤레이터로 사용되는 2'-데옥시우리딘 유도체
CA2562285A1 (en) 2004-04-08 2006-03-16 Nimblegen Systems, Inc. Comparative genomic resequencing
WO2006116629A2 (en) 2005-04-27 2006-11-02 Siemens Medical Solutions Usa, Inc. The preparation of molecular imaging probes using click chemistry
TWI406952B (zh) * 2005-05-02 2013-09-01 Basf Ag 分析物之敏感偵測的新標記策略
EP3591069A3 (en) 2005-10-27 2020-03-04 The President and Fellows of Harvard College Methods and compositions for labeling nucleic acids
JP5646172B2 (ja) 2006-10-31 2014-12-24 ベースクリック ゲーエムベーハー リポーター分子の製造のためのクリックケミストリー

Also Published As

Publication number Publication date
DK2089343T3 (da) 2011-10-24
WO2008052775A3 (en) 2009-01-15
JP2010508015A (ja) 2010-03-18
CN101605743A (zh) 2009-12-16
ES2369299T3 (es) 2011-11-29
AU2007315190B2 (en) 2012-05-31
EP2089343B1 (en) 2011-07-06
US8193335B2 (en) 2012-06-05
SI2089343T1 (sl) 2011-10-28
JP5646172B2 (ja) 2014-12-24
PL2089343T3 (pl) 2011-12-30
AU2007315190A1 (en) 2008-05-08
WO2008052775A2 (en) 2008-05-08
CA2667136A1 (en) 2008-05-08
HRP20110554T1 (hr) 2011-09-30
EP2089343A2 (en) 2009-08-19
US20100081137A1 (en) 2010-04-01
PT2089343E (pt) 2011-09-06

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