HRP20110113T1 - Kapecitabin tablete za djecu - Google Patents
Kapecitabin tablete za djecu Download PDFInfo
- Publication number
- HRP20110113T1 HRP20110113T1 HR20110113T HRP20110113T HRP20110113T1 HR P20110113 T1 HRP20110113 T1 HR P20110113T1 HR 20110113 T HR20110113 T HR 20110113T HR P20110113 T HRP20110113 T HR P20110113T HR P20110113 T1 HRP20110113 T1 HR P20110113T1
- Authority
- HR
- Croatia
- Prior art keywords
- composition according
- capecitabine
- pharmaceutical composition
- mannitol
- microcrystalline cellulose
- Prior art date
Links
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 title claims abstract 29
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 title claims abstract 29
- 229960004117 capecitabine Drugs 0.000 title claims abstract 29
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 27
- 239000000203 mixture Substances 0.000 claims abstract 20
- 239000007884 disintegrant Substances 0.000 claims abstract 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 3
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 36
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 21
- 229930195725 Mannitol Natural products 0.000 claims 21
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 21
- 239000000594 mannitol Substances 0.000 claims 21
- 235000010355 mannitol Nutrition 0.000 claims 21
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 21
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 21
- 239000008108 microcrystalline cellulose Substances 0.000 claims 21
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 20
- 229960000913 crospovidone Drugs 0.000 claims 19
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 19
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 19
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 19
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 19
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 19
- 108010011485 Aspartame Proteins 0.000 claims 18
- 241000220223 Fragaria Species 0.000 claims 18
- 235000016623 Fragaria vesca Nutrition 0.000 claims 18
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims 18
- 244000290333 Vanilla fragrans Species 0.000 claims 18
- 235000009499 Vanilla fragrans Nutrition 0.000 claims 18
- 235000012036 Vanilla tahitensis Nutrition 0.000 claims 18
- 239000000605 aspartame Substances 0.000 claims 18
- 235000010357 aspartame Nutrition 0.000 claims 18
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims 18
- 229960003438 aspartame Drugs 0.000 claims 18
- 230000000595 bitter masking effect Effects 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 18
- 239000000796 flavoring agent Substances 0.000 claims 18
- 235000019634 flavors Nutrition 0.000 claims 18
- 229960003943 hypromellose Drugs 0.000 claims 18
- 235000019359 magnesium stearate Nutrition 0.000 claims 18
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims 17
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 7
- 229960004977 anhydrous lactose Drugs 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims 1
- 229920002261 Corn starch Polymers 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 239000008120 corn starch Substances 0.000 claims 1
- 229960001681 croscarmellose sodium Drugs 0.000 claims 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 235000019264 food flavour enhancer Nutrition 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 229960001375 lactose Drugs 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229940069328 povidone Drugs 0.000 claims 1
- 229940085605 saccharin sodium Drugs 0.000 claims 1
- 229920003109 sodium starch glycolate Polymers 0.000 claims 1
- 229940079832 sodium starch glycolate Drugs 0.000 claims 1
- 239000008109 sodium starch glycolate Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85017406P | 2006-10-06 | 2006-10-06 | |
| US95155707P | 2007-07-24 | 2007-07-24 | |
| PCT/EP2007/060186 WO2008040665A2 (en) | 2006-10-06 | 2007-09-26 | Capecitabine pediatric tablets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110113T1 true HRP20110113T1 (hr) | 2011-03-31 |
Family
ID=39186803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110113T HRP20110113T1 (hr) | 2006-10-06 | 2011-02-16 | Kapecitabin tablete za djecu |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US20080085310A1 (es) |
| EP (1) | EP2073791B1 (es) |
| JP (1) | JP5330248B2 (es) |
| KR (1) | KR101177730B1 (es) |
| CN (1) | CN101522168B (es) |
| AR (1) | AR063138A1 (es) |
| AT (1) | ATE492267T1 (es) |
| AU (1) | AU2007304293A1 (es) |
| BR (1) | BRPI0719241A2 (es) |
| CA (1) | CA2664922C (es) |
| CL (1) | CL2007002875A1 (es) |
| CO (1) | CO6150122A2 (es) |
| CR (1) | CR10668A (es) |
| CY (1) | CY1111223T1 (es) |
| DE (1) | DE602007011475D1 (es) |
| DK (1) | DK2073791T3 (es) |
| HK (1) | HK1135905A1 (es) |
| HR (1) | HRP20110113T1 (es) |
| IL (1) | IL197767A0 (es) |
| MA (1) | MA30779B1 (es) |
| MX (1) | MX2009003317A (es) |
| MY (1) | MY145637A (es) |
| NO (1) | NO20090980L (es) |
| NZ (1) | NZ575280A (es) |
| PE (1) | PE20081106A1 (es) |
| PL (1) | PL2073791T3 (es) |
| PT (1) | PT2073791E (es) |
| RU (1) | RU2455979C2 (es) |
| SI (1) | SI2073791T1 (es) |
| TW (1) | TW200825096A (es) |
| WO (1) | WO2008040665A2 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110027374A1 (en) * | 2008-12-16 | 2011-02-03 | Maria Oksana Bachynsky | Capecitabine rapidly disintegrating tablets |
| TWI455733B (zh) * | 2009-03-30 | 2014-10-11 | Toray Industries | 口腔內崩壞性被覆錠劑 |
| CN102266303A (zh) * | 2011-07-07 | 2011-12-07 | 程雪翔 | 一种卡培他滨药用组合物及其制备方法 |
| CN102516338B (zh) * | 2011-12-09 | 2014-04-02 | 海南锦瑞制药股份有限公司 | 一种卡培他滨化合物、其药物组合物及其制备方法 |
| CN103156877B (zh) * | 2011-12-13 | 2015-11-25 | 深圳海王药业有限公司 | 一种卡培他滨速释微丸及其制备方法 |
| CN102988320B (zh) * | 2012-12-13 | 2014-04-16 | 哈药集团技术中心 | 一种卡培他滨分散片及其制备方法 |
| CN104739800A (zh) * | 2015-02-03 | 2015-07-01 | 吉林修正药业新药开发有限公司 | 一种卡培他滨片组合物及其制备方法 |
| JP6673798B2 (ja) * | 2016-10-12 | 2020-03-25 | 日本化薬株式会社 | カペシタビンを有効成分とするフィルムコート医薬製剤 |
| JP6866113B2 (ja) * | 2016-11-01 | 2021-04-28 | 日本化薬株式会社 | カペシタビンを有効成分とする医薬製剤 |
| JP6792418B2 (ja) * | 2016-11-08 | 2020-11-25 | 日本化薬株式会社 | カペシタビンを有効成分とする医薬製剤の製造方法 |
| JP7170554B2 (ja) | 2019-02-06 | 2022-11-14 | ゼネラル株式会社 | 感熱転写媒体 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8628359D0 (en) * | 1986-11-27 | 1986-12-31 | Zyma Sa | Galenical formulation |
| CA1327358C (en) * | 1987-11-17 | 1994-03-01 | Morio Fujiu | Fluoro cytidine derivatives |
| TW254946B (es) * | 1992-12-18 | 1995-08-21 | Hoffmann La Roche | |
| AU671491B2 (en) * | 1992-12-18 | 1996-08-29 | F. Hoffmann-La Roche Ag | N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines |
| US5476932A (en) * | 1994-08-26 | 1995-12-19 | Hoffmann-La Roche Inc. | Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives |
| JPH0971523A (ja) * | 1995-09-07 | 1997-03-18 | Riyuukakusan:Kk | 口腔内で崩壊性の速い錠剤 |
| CA2322315C (en) * | 1998-03-06 | 2008-09-16 | Eurand International S.P.A. | Fast disintegrating tablets |
| RU2135169C1 (ru) * | 1998-12-02 | 1999-08-27 | Государственное предприятие Казанское производственное химико-фармацевтическое объединение "Татхимфармпрепараты" | Противовоспалительное, болеутоляющее, жаропонижающее лекарственное средство и способ его получения |
| JP2000273039A (ja) * | 1999-01-20 | 2000-10-03 | Taisho Pharmaceut Co Ltd | 口腔内崩壊性組成物 |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| FR2790387B1 (fr) * | 1999-03-01 | 2001-05-18 | Prographarm Laboratoires | Comprime orodispersible presentant une faible friabilite et son procede de preparation |
| CA2403594A1 (en) * | 2000-03-27 | 2002-09-18 | Kyowa Hakko Kogyo Co., Ltd. | Granules having good taking property |
| WO2002069934A1 (fr) * | 2001-03-06 | 2002-09-12 | Kyowa Hakko Kogyo Co., Ltd. | Préparations se délitant rapidement dans la bouche |
| US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| US8545881B2 (en) * | 2004-04-19 | 2013-10-01 | Eurand Pharmaceuticals, Ltd. | Orally disintegrating tablets and methods of manufacture |
| DE102004028940A1 (de) * | 2004-06-15 | 2006-01-12 | Krka Tovarna Zdravil, D.D. | Oral zerfallende pharmazeutische Zusammensetzung, die Risperidon enthält |
| DE112006000873T5 (de) * | 2005-04-12 | 2008-03-06 | Elan Pharma International Ltd. | Zusammensetzungen mit modifizierter Freisetzung, umfassend ein Fluorcytidin-Derivate zur Behandlung von Krebs |
-
2007
- 2007-09-25 US US11/860,708 patent/US20080085310A1/en not_active Abandoned
- 2007-09-26 WO PCT/EP2007/060186 patent/WO2008040665A2/en active Application Filing
- 2007-09-26 EP EP07820581A patent/EP2073791B1/en active Active
- 2007-09-26 AT AT07820581T patent/ATE492267T1/de active
- 2007-09-26 JP JP2009530851A patent/JP5330248B2/ja active Active
- 2007-09-26 MX MX2009003317A patent/MX2009003317A/es active IP Right Grant
- 2007-09-26 SI SI200730529T patent/SI2073791T1/sl unknown
- 2007-09-26 RU RU2009116816/15A patent/RU2455979C2/ru not_active IP Right Cessation
- 2007-09-26 DE DE602007011475T patent/DE602007011475D1/de active Active
- 2007-09-26 PL PL07820581T patent/PL2073791T3/pl unknown
- 2007-09-26 KR KR1020097006166A patent/KR101177730B1/ko active IP Right Grant
- 2007-09-26 CA CA2664922A patent/CA2664922C/en not_active Expired - Fee Related
- 2007-09-26 AU AU2007304293A patent/AU2007304293A1/en not_active Abandoned
- 2007-09-26 CN CN2007800362049A patent/CN101522168B/zh active Active
- 2007-09-26 MY MYPI20091372A patent/MY145637A/en unknown
- 2007-09-26 PT PT07820581T patent/PT2073791E/pt unknown
- 2007-09-26 NZ NZ575280A patent/NZ575280A/en not_active IP Right Cessation
- 2007-09-26 DK DK07820581.2T patent/DK2073791T3/da active
- 2007-09-26 BR BRPI0719241-0A patent/BRPI0719241A2/pt not_active Application Discontinuation
- 2007-10-03 TW TW096137096A patent/TW200825096A/zh unknown
- 2007-10-04 CL CL2007002875A patent/CL2007002875A1/es unknown
- 2007-10-04 AR ARP070104409A patent/AR063138A1/es not_active Application Discontinuation
- 2007-10-04 PE PE2007001349A patent/PE20081106A1/es not_active Application Discontinuation
-
2009
- 2009-03-04 NO NO20090980A patent/NO20090980L/no not_active Application Discontinuation
- 2009-03-11 CO CO09025204A patent/CO6150122A2/es unknown
- 2009-03-18 CR CR10668A patent/CR10668A/es not_active Application Discontinuation
- 2009-03-23 IL IL197767A patent/IL197767A0/en unknown
- 2009-04-06 MA MA31762A patent/MA30779B1/fr unknown
-
2010
- 2010-02-22 HK HK10101826.6A patent/HK1135905A1/xx not_active IP Right Cessation
-
2011
- 2011-02-10 CY CY20111100161T patent/CY1111223T1/el unknown
- 2011-02-16 HR HR20110113T patent/HRP20110113T1/hr unknown
-
2014
- 2014-10-22 US US14/521,357 patent/US20150044287A1/en not_active Abandoned
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