MX2009003317A - Tabletas pediatricas de capecitabina. - Google Patents

Tabletas pediatricas de capecitabina.

Info

Publication number
MX2009003317A
MX2009003317A MX2009003317A MX2009003317A MX2009003317A MX 2009003317 A MX2009003317 A MX 2009003317A MX 2009003317 A MX2009003317 A MX 2009003317A MX 2009003317 A MX2009003317 A MX 2009003317A MX 2009003317 A MX2009003317 A MX 2009003317A
Authority
MX
Mexico
Prior art keywords
capecitabine
tablet
pediatric tablets
pharmaburst
crospovidone
Prior art date
Application number
MX2009003317A
Other languages
English (en)
Inventor
Martin Howard Infeld
Navnit Hargovindas Shah
Maria Oksana Bachynsky
Mohammad Rashed
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39186803&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009003317(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009003317A publication Critical patent/MX2009003317A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención se relaciona con una composición farmacéutica recubierta por una película que comprende 5´-desoxi-5-fluoro-N-[(pentiloxi)-carbonil]-citidina (capecitabina) y por lo menos un desintegrante seleccionado del grupo que comprende crospovidona (tamaño de partícula <15-400 µ), croscarmelosa sódica, glicolato de almidón sódico, hidroxipropilcelulosa poco sustituida, Pharmaburst C o cualquier combinación de éstos, junto con otros excipientes farmacéuticamente aceptables para formar una tableta que se desintegra rápidamente. Esta tableta se desintegra en agua a 37ºC en un aparato de desintegración USP en menos de 2 minutos, de preferencia 1 minuto y posee una dureza de 8-13 unidades de fuerza Cobb.
MX2009003317A 2006-10-06 2007-09-26 Tabletas pediatricas de capecitabina. MX2009003317A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85017406P 2006-10-06 2006-10-06
US95155707P 2007-07-24 2007-07-24
PCT/EP2007/060186 WO2008040665A2 (en) 2006-10-06 2007-09-26 Capecitabine pediatric tablets

Publications (1)

Publication Number Publication Date
MX2009003317A true MX2009003317A (es) 2009-04-09

Family

ID=39186803

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009003317A MX2009003317A (es) 2006-10-06 2007-09-26 Tabletas pediatricas de capecitabina.

Country Status (31)

Country Link
US (2) US20080085310A1 (es)
EP (1) EP2073791B1 (es)
JP (1) JP5330248B2 (es)
KR (1) KR101177730B1 (es)
CN (1) CN101522168B (es)
AR (1) AR063138A1 (es)
AT (1) ATE492267T1 (es)
AU (1) AU2007304293A1 (es)
BR (1) BRPI0719241A2 (es)
CA (1) CA2664922C (es)
CL (1) CL2007002875A1 (es)
CO (1) CO6150122A2 (es)
CR (1) CR10668A (es)
CY (1) CY1111223T1 (es)
DE (1) DE602007011475D1 (es)
DK (1) DK2073791T3 (es)
HK (1) HK1135905A1 (es)
HR (1) HRP20110113T1 (es)
IL (1) IL197767A0 (es)
MA (1) MA30779B1 (es)
MX (1) MX2009003317A (es)
MY (1) MY145637A (es)
NO (1) NO20090980L (es)
NZ (1) NZ575280A (es)
PE (1) PE20081106A1 (es)
PL (1) PL2073791T3 (es)
PT (1) PT2073791E (es)
RU (1) RU2455979C2 (es)
SI (1) SI2073791T1 (es)
TW (1) TW200825096A (es)
WO (1) WO2008040665A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110027374A1 (en) * 2008-12-16 2011-02-03 Maria Oksana Bachynsky Capecitabine rapidly disintegrating tablets
TWI455733B (zh) * 2009-03-30 2014-10-11 Toray Industries 口腔內崩壞性被覆錠劑
CN102266303A (zh) * 2011-07-07 2011-12-07 程雪翔 一种卡培他滨药用组合物及其制备方法
CN102516338B (zh) * 2011-12-09 2014-04-02 海南锦瑞制药股份有限公司 一种卡培他滨化合物、其药物组合物及其制备方法
CN103156877B (zh) * 2011-12-13 2015-11-25 深圳海王药业有限公司 一种卡培他滨速释微丸及其制备方法
CN102988320B (zh) * 2012-12-13 2014-04-16 哈药集团技术中心 一种卡培他滨分散片及其制备方法
CN104739800A (zh) * 2015-02-03 2015-07-01 吉林修正药业新药开发有限公司 一种卡培他滨片组合物及其制备方法
JP6673798B2 (ja) * 2016-10-12 2020-03-25 日本化薬株式会社 カペシタビンを有効成分とするフィルムコート医薬製剤
JP6866113B2 (ja) * 2016-11-01 2021-04-28 日本化薬株式会社 カペシタビンを有効成分とする医薬製剤
JP6792418B2 (ja) * 2016-11-08 2020-11-25 日本化薬株式会社 カペシタビンを有効成分とする医薬製剤の製造方法
JP7170554B2 (ja) 2019-02-06 2022-11-14 ゼネラル株式会社 感熱転写媒体

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8628359D0 (en) * 1986-11-27 1986-12-31 Zyma Sa Galenical formulation
CA1327358C (en) * 1987-11-17 1994-03-01 Morio Fujiu Fluoro cytidine derivatives
TW254946B (es) * 1992-12-18 1995-08-21 Hoffmann La Roche
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
US5476932A (en) * 1994-08-26 1995-12-19 Hoffmann-La Roche Inc. Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
JPH0971523A (ja) * 1995-09-07 1997-03-18 Riyuukakusan:Kk 口腔内で崩壊性の速い錠剤
CA2322315C (en) * 1998-03-06 2008-09-16 Eurand International S.P.A. Fast disintegrating tablets
RU2135169C1 (ru) * 1998-12-02 1999-08-27 Государственное предприятие Казанское производственное химико-фармацевтическое объединение "Татхимфармпрепараты" Противовоспалительное, болеутоляющее, жаропонижающее лекарственное средство и способ его получения
JP2000273039A (ja) * 1999-01-20 2000-10-03 Taisho Pharmaceut Co Ltd 口腔内崩壊性組成物
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
FR2790387B1 (fr) * 1999-03-01 2001-05-18 Prographarm Laboratoires Comprime orodispersible presentant une faible friabilite et son procede de preparation
CA2403594A1 (en) * 2000-03-27 2002-09-18 Kyowa Hakko Kogyo Co., Ltd. Granules having good taking property
WO2002069934A1 (fr) * 2001-03-06 2002-09-12 Kyowa Hakko Kogyo Co., Ltd. Préparations se délitant rapidement dans la bouche
US8377952B2 (en) * 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8545881B2 (en) * 2004-04-19 2013-10-01 Eurand Pharmaceuticals, Ltd. Orally disintegrating tablets and methods of manufacture
DE102004028940A1 (de) * 2004-06-15 2006-01-12 Krka Tovarna Zdravil, D.D. Oral zerfallende pharmazeutische Zusammensetzung, die Risperidon enthält
DE112006000873T5 (de) * 2005-04-12 2008-03-06 Elan Pharma International Ltd. Zusammensetzungen mit modifizierter Freisetzung, umfassend ein Fluorcytidin-Derivate zur Behandlung von Krebs

Also Published As

Publication number Publication date
CO6150122A2 (es) 2010-04-20
CY1111223T1 (el) 2015-06-11
HK1135905A1 (en) 2010-06-18
KR20090045948A (ko) 2009-05-08
KR101177730B1 (ko) 2012-09-07
MY145637A (en) 2012-03-15
US20080085310A1 (en) 2008-04-10
EP2073791B1 (en) 2010-12-22
NO20090980L (no) 2009-03-31
PL2073791T3 (pl) 2011-05-31
SI2073791T1 (sl) 2011-04-29
PE20081106A1 (es) 2008-09-17
JP5330248B2 (ja) 2013-10-30
US20150044287A1 (en) 2015-02-12
CN101522168A (zh) 2009-09-02
WO2008040665A3 (en) 2008-06-19
MA30779B1 (fr) 2009-10-01
CA2664922A1 (en) 2008-04-10
IL197767A0 (en) 2009-12-24
ATE492267T1 (de) 2011-01-15
JP2010505791A (ja) 2010-02-25
CL2007002875A1 (es) 2008-01-25
NZ575280A (en) 2012-03-30
AR063138A1 (es) 2008-12-30
EP2073791A2 (en) 2009-07-01
DK2073791T3 (da) 2011-01-31
RU2009116816A (ru) 2010-11-20
BRPI0719241A2 (pt) 2014-07-15
PT2073791E (pt) 2011-01-21
RU2455979C2 (ru) 2012-07-20
CN101522168B (zh) 2011-09-28
CR10668A (es) 2009-04-29
HRP20110113T1 (hr) 2011-03-31
AU2007304293A1 (en) 2008-04-10
TW200825096A (en) 2008-06-16
DE602007011475D1 (de) 2011-02-03
WO2008040665A2 (en) 2008-04-10
CA2664922C (en) 2015-06-30

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