HRP20100207T1 - Novi kristalni oblici {2-[1-(3,5-bistrifluormetilbenzil)-5-piridin-4-il-1h-[1,2,3]triazol-4-il]piridin-3-il}(2-klorfenil)metanona - Google Patents
Novi kristalni oblici {2-[1-(3,5-bistrifluormetilbenzil)-5-piridin-4-il-1h-[1,2,3]triazol-4-il]piridin-3-il}(2-klorfenil)metanona Download PDFInfo
- Publication number
- HRP20100207T1 HRP20100207T1 HR20100207T HRP20100207T HRP20100207T1 HR P20100207 T1 HRP20100207 T1 HR P20100207T1 HR 20100207 T HR20100207 T HR 20100207T HR P20100207 T HRP20100207 T HR P20100207T HR P20100207 T1 HRP20100207 T1 HR P20100207T1
- Authority
- HR
- Croatia
- Prior art keywords
- pyridin
- chlorophenyl
- methanone
- triazol
- bistrifluoromethylbenzyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51430003P | 2003-10-24 | 2003-10-24 | |
| PCT/US2004/030914 WO2005042515A1 (en) | 2003-10-24 | 2004-10-12 | Novel crystalline forms of {2-[1-(3,5-bis-trifluoromethylbenzyl)-5-pyridin-4-yl-1h-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100207T1 true HRP20100207T1 (hr) | 2010-05-31 |
Family
ID=34549327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100207T HRP20100207T1 (hr) | 2003-10-24 | 2004-10-12 | Novi kristalni oblici {2-[1-(3,5-bistrifluormetilbenzil)-5-piridin-4-il-1h-[1,2,3]triazol-4-il]piridin-3-il}(2-klorfenil)metanona |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7381826B2 (https=) |
| JP (1) | JP4959336B2 (https=) |
| KR (1) | KR100848407B1 (https=) |
| CN (1) | CN1863791B (https=) |
| AR (1) | AR046131A1 (https=) |
| AT (1) | ATE462700T1 (https=) |
| AU (1) | AU2004285855B8 (https=) |
| BR (1) | BRPI0415010B8 (https=) |
| CA (1) | CA2542140C (https=) |
| CL (2) | CL2009001311A1 (https=) |
| CR (1) | CR8353A (https=) |
| DE (1) | DE602004026333D1 (https=) |
| DK (1) | DK1675846T3 (https=) |
| EA (1) | EA008881B1 (https=) |
| EC (1) | ECSP066517A (https=) |
| ES (1) | ES2340772T3 (https=) |
| HR (1) | HRP20100207T1 (https=) |
| IL (1) | IL174926A0 (https=) |
| MA (1) | MA28329A1 (https=) |
| MY (1) | MY157375A (https=) |
| NO (1) | NO335090B1 (https=) |
| NZ (2) | NZ545917A (https=) |
| PE (1) | PE20050481A1 (https=) |
| PT (1) | PT1675846E (https=) |
| TW (1) | TW200524906A (https=) |
| UA (1) | UA82901C2 (https=) |
| WO (1) | WO2005042515A1 (https=) |
| ZA (1) | ZA200603234B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0721069A2 (pt) | 2006-12-20 | 2014-02-04 | Lilly Co Eli | Intermediários e processo útil na preparação de {2-[1-(3,5-bis-trifluorometil-benzil)-5-piridin-4-il-1h[1,2, 3]triazol-4-il]-piridin-3-il}-2-clorofenil)-metanona |
| WO2009075778A2 (en) * | 2007-12-06 | 2009-06-18 | The Regents Of The University Of California | Nonpeptidic inhibitors of cruzain |
| US8080568B1 (en) * | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
| ES2824552T3 (es) | 2015-03-04 | 2021-05-12 | Vanda Pharmaceuticals Inc | Método de tratamiento con tradipitant |
| WO2017031215A1 (en) * | 2015-08-17 | 2017-02-23 | Eli Lilly And Company | Process development of a pyridine-containing nk-1 receptor antagonist |
| AU2018331267B2 (en) | 2017-09-13 | 2024-03-07 | Vanda Pharmaceuticals Inc. | Improved treatment of atopic dermatitis with tradipitant |
| CN119074729A (zh) * | 2017-11-17 | 2024-12-06 | 万达制药公司 | 使用川地匹坦治疗胃肠疾病的方法 |
| CA3101210A1 (en) * | 2018-06-08 | 2019-12-12 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
| US10821099B2 (en) | 2018-09-28 | 2020-11-03 | Vanda Pharmaceuticals Inc. | Use of tradipitant in motion sickness |
| HUE070000T2 (hu) | 2018-09-28 | 2025-04-28 | Vanda Pharmaceuticals Inc | Tradipitant alkalmazása utazási betegségben |
| WO2020117811A1 (en) * | 2018-12-03 | 2020-06-11 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
| KR20220145844A (ko) | 2020-02-25 | 2022-10-31 | 반다 파마슈티칼즈, 인코퍼레이티드. | 트라디피탄트를 이용한 아토피 피부염의 개선된 치료 |
| JP7791832B2 (ja) | 2020-03-26 | 2025-12-24 | バンダ・ファーマシューティカルズ・インコーポレイテッド | トラジピタントによる下気道感染症の治療 |
| WO2023019084A1 (en) | 2021-08-12 | 2023-02-16 | Vanda Pharmaceuticals Inc. | Treatment of gastric accommodation with tradipitant |
| US20240350469A1 (en) | 2021-08-31 | 2024-10-24 | Vanda Pharmaceuticals Inc. | Treatment of lower respiratory tract infection with tradipitant |
| AU2023413130A1 (en) | 2022-12-21 | 2025-06-05 | Vanda Pharmaceuticals Inc. | Methods of treatment with tradipitant |
| EP4599831A1 (en) | 2024-02-09 | 2025-08-13 | Vanda Pharmaceuticals Inc. | Treatment of gastroparesis with tradipitant |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020099067A1 (en) * | 1993-07-08 | 2002-07-25 | Ulrich Posanski | Pharmaceutical compositions for sparingly soluble therapeutic agents |
| GB9505492D0 (en) * | 1995-03-18 | 1995-05-03 | Merck Sharp & Dohme | Therapeutic agents |
| GB9525296D0 (en) * | 1995-12-11 | 1996-02-07 | Merck Sharp & Dohme | Therapeutic agents |
| DE69736390T2 (de) * | 1996-10-07 | 2007-07-26 | Merck Sharp & Dohme Ltd., Hoddesdon | Zns-penetrierende nk-1 rezeptorantagonisten als antidepressivum und / oder anxiolytikum |
| BR0013551A (pt) * | 1999-08-13 | 2003-06-17 | Vertex Pharma | Inibidores de cinases n-terminal cjun (jnk) e outras cinases de proteìnas |
| AU1343901A (en) * | 1999-10-29 | 2001-05-14 | Merck & Co., Inc. | Polymorphic form of a tachykinin receptor antagonist |
| US20020044971A1 (en) * | 2000-07-07 | 2002-04-18 | Amidon Gordon L. | Dissolution rate of poorly soluble drugs |
| AU2003230829B8 (en) | 2002-04-26 | 2008-12-11 | Eli Lilly And Company | Triazole derivatives as tachykinin receptor antagonists |
-
2004
- 2004-10-12 BR BRPI0415010A patent/BRPI0415010B8/pt not_active IP Right Cessation
- 2004-10-12 CN CN2004800291393A patent/CN1863791B/zh not_active Expired - Lifetime
- 2004-10-12 PT PT04793893T patent/PT1675846E/pt unknown
- 2004-10-12 AU AU2004285855A patent/AU2004285855B8/en not_active Expired
- 2004-10-12 DE DE602004026333T patent/DE602004026333D1/de not_active Expired - Lifetime
- 2004-10-12 ES ES04793893T patent/ES2340772T3/es not_active Expired - Lifetime
- 2004-10-12 WO PCT/US2004/030914 patent/WO2005042515A1/en not_active Ceased
- 2004-10-12 KR KR1020067007751A patent/KR100848407B1/ko not_active Expired - Lifetime
- 2004-10-12 NZ NZ545917A patent/NZ545917A/en unknown
- 2004-10-12 US US10/574,712 patent/US7381826B2/en not_active Expired - Lifetime
- 2004-10-12 CA CA2542140A patent/CA2542140C/en not_active Expired - Lifetime
- 2004-10-12 NZ NZ580480A patent/NZ580480A/en unknown
- 2004-10-12 EA EA200600829A patent/EA008881B1/ru not_active IP Right Cessation
- 2004-10-12 DK DK04793893.1T patent/DK1675846T3/da active
- 2004-10-12 AT AT04793893T patent/ATE462700T1/de active
- 2004-10-12 HR HR20100207T patent/HRP20100207T1/hr unknown
- 2004-10-12 JP JP2006536635A patent/JP4959336B2/ja not_active Expired - Lifetime
- 2004-10-20 AR ARP040103801A patent/AR046131A1/es not_active Application Discontinuation
- 2004-10-20 PE PE2004001008A patent/PE20050481A1/es not_active Application Discontinuation
- 2004-10-21 MY MYPI20044338A patent/MY157375A/en unknown
- 2004-10-22 TW TW093132097A patent/TW200524906A/zh unknown
- 2004-12-10 UA UAA200604473A patent/UA82901C2/uk unknown
-
2006
- 2006-04-11 IL IL174926A patent/IL174926A0/en unknown
- 2006-04-21 CR CR8353A patent/CR8353A/es not_active Application Discontinuation
- 2006-04-21 ZA ZA200603234A patent/ZA200603234B/en unknown
- 2006-04-21 EC EC2006006517A patent/ECSP066517A/es unknown
- 2006-05-22 MA MA29043A patent/MA28329A1/fr unknown
- 2006-05-24 NO NO20062371A patent/NO335090B1/no unknown
-
2009
- 2009-05-29 CL CL2009001311A patent/CL2009001311A1/es unknown
- 2009-05-29 CL CL2009001310A patent/CL2009001310A1/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20100207T1 (hr) | Novi kristalni oblici {2-[1-(3,5-bistrifluormetilbenzil)-5-piridin-4-il-1h-[1,2,3]triazol-4-il]piridin-3-il}(2-klorfenil)metanona | |
| ES2634291T3 (es) | Sales de 4-metil-n-[3-(4-metil-imidazol-1-il)-5-trifluorometil-fenil]-3-(4-piridin-3-il-pirimidin-2-ilamino)-benzamida | |
| ES2325140T3 (es) | Amidas sustituidas con heterociclos como inhibidores de la calpaina. | |
| AU727820B2 (en) | 1,3-diheterocyclic metalloprotease inhibitors | |
| AU732653B2 (en) | Phosphinic acid amides as matrix metalloprotease inhibitors | |
| CA2160444C (en) | Aroyl-piperdine derivatives | |
| US20040006062A1 (en) | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors | |
| SK25199A3 (en) | Heterocyclic metalloprotease inhibitors | |
| WO2005058884A3 (en) | Cyclopropane compounds and pharmaceutical use thereof | |
| ES2269474T3 (es) | Fenilaretamidas sustituidas con aminopiridinilo, aminoguanidinilo y alcoxiguanidinilo utilizados como inhibidores de proteasas. | |
| KR950032120A (ko) | 인간 nk₃수용기의 선택적 길항제인 화합물, 및 의약품 및 진단기구로서의 그의 용도 | |
| CA2661166A1 (en) | Compounds and methods for inhibiting the interaction of bcl proteins with binding partners | |
| JP2012530703A (ja) | 置換ヒドロキサム酸およびその使用 | |
| NO341019B1 (no) | Propan-1,3-dion-derivat og salt derav, farmasøytisk preparat, anvendelse til fremstilling av et medikament, samt anvendelse i en fremgangsmåte for behandling | |
| US20040077635A1 (en) | Lactam-containing diaminoalkyl, beta-aminoacids, alpha-aminoacids and derivatives thereof as factor Xa inhibitors | |
| US20070004761A1 (en) | Pyrazolo [3,4-d] pyrimidine derivatives and their use in the treatment of h.pylori infection | |
| NO20016389L (no) | Fremgangsmåte for fremstilling av substituerte cyklopentanderivater og nye krystallinske strukturer derav | |
| OA12602A (en) | Aromatic sulfone hydroxamates and their use as protease inhibitors. | |
| JP2007509143A5 (https=) | ||
| GB2095252A (en) | N-(substituted aminoalkanoyl)heterocyclic compounds | |
| WO2000058304A1 (en) | Heterocyclic sulfonamide derivatives | |
| CA2406829A1 (en) | Protease inhibitors | |
| RU2335494C2 (ru) | Производные бициклических иминокислот в качестве ингибиторов матриксных металлопротеиназ | |
| ES2367920T3 (es) | Beta-lactamas sustituidas y su uso en medicina. | |
| BRPI0619848A2 (pt) | (2,5-dioxoimidazolidin-1-ila)-n-hidróxi-acetamidas como inibidores de metaloproteinase |