CL2009001310A1 - Compuesto intermediario (2-clorofenil)-[2-(2-hidroxi-2-piridin-4-ilvinil)piridin-3-il]metanona o una sal del mismo en lapreparacion del compuesto {2-[1-(3,5-bistrifluorometilbencil)-5-piridin-4-il-1h-[1,2,3]triazol-4-il]piridin-3-il}-(2-cloofenil)metanona (div. sol. 2680-04). - Google Patents
Compuesto intermediario (2-clorofenil)-[2-(2-hidroxi-2-piridin-4-ilvinil)piridin-3-il]metanona o una sal del mismo en lapreparacion del compuesto {2-[1-(3,5-bistrifluorometilbencil)-5-piridin-4-il-1h-[1,2,3]triazol-4-il]piridin-3-il}-(2-cloofenil)metanona (div. sol. 2680-04).Info
- Publication number
- CL2009001310A1 CL2009001310A1 CL2009001310A CL2009001310A CL2009001310A1 CL 2009001310 A1 CL2009001310 A1 CL 2009001310A1 CL 2009001310 A CL2009001310 A CL 2009001310A CL 2009001310 A CL2009001310 A CL 2009001310A CL 2009001310 A1 CL2009001310 A1 CL 2009001310A1
- Authority
- CL
- Chile
- Prior art keywords
- pyridin
- methanone
- compound
- cloophenyl
- bistrifluoromethylbenzyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Compuesto intermediario (2-clorofenil)-[2-(2-hidroxi-2-piridin-4-ilvinil)piridin-3-il]metanona o una sal del mismo en la preparación del compuesto {2-[1-(3,5-bistrifluorometilbencil)-5-piridin-4-il-1h-[1,2,3]triazol-4-il]piridin-3-il}-(2-cloofenil)metanona (Div. Sol. 2680-04).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51430003P | 2003-10-24 | 2003-10-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2009001310A1 true CL2009001310A1 (es) | 2009-12-04 |
Family
ID=34549327
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2009001310A CL2009001310A1 (es) | 2003-10-24 | 2009-05-29 | Compuesto intermediario (2-clorofenil)-[2-(2-hidroxi-2-piridin-4-ilvinil)piridin-3-il]metanona o una sal del mismo en lapreparacion del compuesto {2-[1-(3,5-bistrifluorometilbencil)-5-piridin-4-il-1h-[1,2,3]triazol-4-il]piridin-3-il}-(2-cloofenil)metanona (div. sol. 2680-04). |
CL2009001311A CL2009001311A1 (es) | 2003-10-24 | 2009-05-29 | Procedimiento para preparar {2-[1-(3,5-bistrifluorometilbencil)-5-piridin-4-il-1h-[1,2,3]triazol-4-il]-piridin-3-il}-(2-clorofenil)metanona a partir de (2-clorofenil)-[2-(2-hidroxi-2-piridin-4-ilvinil)piridin-3-il]metanona y 1-azidometil-3,5-bistrifluorometilbenceno en presencia de una base y un disolvente (div.sol.2680-04). |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2009001311A CL2009001311A1 (es) | 2003-10-24 | 2009-05-29 | Procedimiento para preparar {2-[1-(3,5-bistrifluorometilbencil)-5-piridin-4-il-1h-[1,2,3]triazol-4-il]-piridin-3-il}-(2-clorofenil)metanona a partir de (2-clorofenil)-[2-(2-hidroxi-2-piridin-4-ilvinil)piridin-3-il]metanona y 1-azidometil-3,5-bistrifluorometilbenceno en presencia de una base y un disolvente (div.sol.2680-04). |
Country Status (28)
Country | Link |
---|---|
US (1) | US7381826B2 (es) |
JP (1) | JP4959336B2 (es) |
KR (1) | KR100848407B1 (es) |
CN (1) | CN1863791B (es) |
AR (1) | AR046131A1 (es) |
AT (1) | ATE462700T1 (es) |
AU (1) | AU2004285855B8 (es) |
BR (1) | BRPI0415010B8 (es) |
CA (1) | CA2542140C (es) |
CL (2) | CL2009001310A1 (es) |
CR (1) | CR8353A (es) |
DE (1) | DE602004026333D1 (es) |
DK (1) | DK1675846T3 (es) |
EA (1) | EA008881B1 (es) |
EC (1) | ECSP066517A (es) |
ES (1) | ES2340772T3 (es) |
HR (1) | HRP20100207T1 (es) |
IL (1) | IL174926A0 (es) |
MA (1) | MA28329A1 (es) |
MY (1) | MY157375A (es) |
NO (1) | NO335090B1 (es) |
NZ (2) | NZ580480A (es) |
PE (1) | PE20050481A1 (es) |
PT (1) | PT1675846E (es) |
TW (1) | TW200524906A (es) |
UA (1) | UA82901C2 (es) |
WO (1) | WO2005042515A1 (es) |
ZA (1) | ZA200603234B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0721069A2 (pt) * | 2006-12-20 | 2014-02-04 | Lilly Co Eli | Intermediários e processo útil na preparação de {2-[1-(3,5-bis-trifluorometil-benzil)-5-piridin-4-il-1h[1,2, 3]triazol-4-il]-piridin-3-il}-2-clorofenil)-metanona |
WO2009075778A2 (en) * | 2007-12-06 | 2009-06-18 | The Regents Of The University Of California | Nonpeptidic inhibitors of cruzain |
US8080568B1 (en) * | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
MX2017011279A (es) | 2015-03-04 | 2018-01-25 | Vanda Pharmaceuticals Inc | Metodo de tratamiento con tradipitant. |
US10287287B2 (en) | 2015-08-17 | 2019-05-14 | Eli Lilly And Company | Process development of a pyridine-containing NK-1 receptor antagonist |
US11549147B2 (en) | 2017-09-13 | 2023-01-10 | Vanda Pharmaceuticals Inc. | Treatment of atopic dermatitis with tradipitant |
EP3710000A1 (en) | 2017-11-17 | 2020-09-23 | Vanda Pharmaceuticals Inc. | Method of treatment of gastrointestinal diseases with tradipitant |
EP3801514A1 (en) | 2018-06-08 | 2021-04-14 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
CN111918701A (zh) | 2018-09-28 | 2020-11-10 | 万达制药公司 | 曲地匹坦在晕动病中的用途 |
US10821099B2 (en) | 2018-09-28 | 2020-11-03 | Vanda Pharmaceuticals Inc. | Use of tradipitant in motion sickness |
US20220096449A1 (en) | 2018-12-03 | 2022-03-31 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
EP4110335A1 (en) | 2020-02-25 | 2023-01-04 | Vanda Pharmaceuticals Inc. | Improved treatment of atopic dermatitis with tradipitant |
WO2021195205A1 (en) | 2020-03-26 | 2021-09-30 | Vanda Pharmaceuticals Inc. | Treatment of lower respiratory tract infection with tradipitant |
WO2023019084A1 (en) | 2021-08-12 | 2023-02-16 | Vanda Pharmaceuticals Inc. | Treatment of gastric accommodation with tradipitant |
WO2023034718A1 (en) | 2021-08-31 | 2023-03-09 | Vanda Pharmaceuticals Inc. | Treatment of lower respiratory tract infection with tradipitant |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020099067A1 (en) | 1993-07-08 | 2002-07-25 | Ulrich Posanski | Pharmaceutical compositions for sparingly soluble therapeutic agents |
GB9505492D0 (en) * | 1995-03-18 | 1995-05-03 | Merck Sharp & Dohme | Therapeutic agents |
GB9525296D0 (en) * | 1995-12-11 | 1996-02-07 | Merck Sharp & Dohme | Therapeutic agents |
ES2267153T3 (es) * | 1996-10-07 | 2007-03-01 | MERCK SHARP & DOHME LTD. | Antagonistas del receptor nk-1 penetrantes del snc como agentes antidepresivos y/o antiansiedad. |
AU6909600A (en) * | 1999-08-13 | 2001-03-13 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
JP2003513095A (ja) * | 1999-10-29 | 2003-04-08 | メルク エンド カムパニー インコーポレーテッド | タキキニン受容体アンタゴニストの多形 |
US20020044971A1 (en) | 2000-07-07 | 2002-04-18 | Amidon Gordon L. | Dissolution rate of poorly soluble drugs |
NZ535886A (en) * | 2002-04-26 | 2007-07-27 | Lilly Co Eli | Triazole derivatives as tachykinin receptor antagonists |
-
2004
- 2004-10-12 NZ NZ580480A patent/NZ580480A/en unknown
- 2004-10-12 DE DE602004026333T patent/DE602004026333D1/de active Active
- 2004-10-12 AT AT04793893T patent/ATE462700T1/de active
- 2004-10-12 KR KR1020067007751A patent/KR100848407B1/ko active IP Right Grant
- 2004-10-12 ES ES04793893T patent/ES2340772T3/es active Active
- 2004-10-12 CA CA2542140A patent/CA2542140C/en active Active
- 2004-10-12 EA EA200600829A patent/EA008881B1/ru not_active IP Right Cessation
- 2004-10-12 WO PCT/US2004/030914 patent/WO2005042515A1/en active Application Filing
- 2004-10-12 PT PT04793893T patent/PT1675846E/pt unknown
- 2004-10-12 BR BRPI0415010A patent/BRPI0415010B8/pt active IP Right Grant
- 2004-10-12 NZ NZ545917A patent/NZ545917A/en unknown
- 2004-10-12 JP JP2006536635A patent/JP4959336B2/ja active Active
- 2004-10-12 US US10/574,712 patent/US7381826B2/en active Active
- 2004-10-12 AU AU2004285855A patent/AU2004285855B8/en active Active
- 2004-10-12 CN CN2004800291393A patent/CN1863791B/zh active Active
- 2004-10-12 DK DK04793893.1T patent/DK1675846T3/da active
- 2004-10-20 AR ARP040103801A patent/AR046131A1/es not_active Application Discontinuation
- 2004-10-20 PE PE2004001008A patent/PE20050481A1/es not_active Application Discontinuation
- 2004-10-21 MY MYPI20044338A patent/MY157375A/en unknown
- 2004-10-22 TW TW093132097A patent/TW200524906A/zh unknown
- 2004-12-10 UA UAA200604473A patent/UA82901C2/uk unknown
-
2006
- 2006-04-11 IL IL174926A patent/IL174926A0/en unknown
- 2006-04-21 CR CR8353A patent/CR8353A/es not_active Application Discontinuation
- 2006-04-21 ZA ZA200603234A patent/ZA200603234B/en unknown
- 2006-04-21 EC EC2006006517A patent/ECSP066517A/es unknown
- 2006-05-22 MA MA29043A patent/MA28329A1/fr unknown
- 2006-05-24 NO NO20062371A patent/NO335090B1/no unknown
-
2009
- 2009-05-29 CL CL2009001310A patent/CL2009001310A1/es unknown
- 2009-05-29 CL CL2009001311A patent/CL2009001311A1/es unknown
-
2010
- 2010-04-13 HR HR20100207T patent/HRP20100207T1/hr unknown
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