DK1675846T3 - Nye krystallinske former af {2-[1-(3,5-bis-trifluormethylbenzyl)-5-pyridin-4-YL-1H-[1,2,3]triazol-4-YL]-pyridin-3-YL}-(2-chlorphenyl)-methanon - Google Patents
Nye krystallinske former af {2-[1-(3,5-bis-trifluormethylbenzyl)-5-pyridin-4-YL-1H-[1,2,3]triazol-4-YL]-pyridin-3-YL}-(2-chlorphenyl)-methanonInfo
- Publication number
- DK1675846T3 DK1675846T3 DK04793893.1T DK04793893T DK1675846T3 DK 1675846 T3 DK1675846 T3 DK 1675846T3 DK 04793893 T DK04793893 T DK 04793893T DK 1675846 T3 DK1675846 T3 DK 1675846T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyridin
- trifluoromethylbenzyl
- methanone
- triazol
- chlorophenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51430003P | 2003-10-24 | 2003-10-24 | |
| PCT/US2004/030914 WO2005042515A1 (en) | 2003-10-24 | 2004-10-12 | Novel crystalline forms of {2-[1-(3,5-bis-trifluoromethylbenzyl)-5-pyridin-4-yl-1h-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1675846T3 true DK1675846T3 (da) | 2010-05-31 |
Family
ID=34549327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04793893.1T DK1675846T3 (da) | 2003-10-24 | 2004-10-12 | Nye krystallinske former af {2-[1-(3,5-bis-trifluormethylbenzyl)-5-pyridin-4-YL-1H-[1,2,3]triazol-4-YL]-pyridin-3-YL}-(2-chlorphenyl)-methanon |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7381826B2 (da) |
| JP (1) | JP4959336B2 (da) |
| KR (1) | KR100848407B1 (da) |
| CN (1) | CN1863791B (da) |
| AR (1) | AR046131A1 (da) |
| AT (1) | ATE462700T1 (da) |
| AU (1) | AU2004285855B8 (da) |
| BR (1) | BRPI0415010B8 (da) |
| CA (1) | CA2542140C (da) |
| CL (2) | CL2009001311A1 (da) |
| CR (1) | CR8353A (da) |
| DE (1) | DE602004026333D1 (da) |
| DK (1) | DK1675846T3 (da) |
| EA (1) | EA008881B1 (da) |
| EC (1) | ECSP066517A (da) |
| ES (1) | ES2340772T3 (da) |
| HR (1) | HRP20100207T1 (da) |
| IL (1) | IL174926A0 (da) |
| MA (1) | MA28329A1 (da) |
| MY (1) | MY157375A (da) |
| NO (1) | NO335090B1 (da) |
| NZ (2) | NZ545917A (da) |
| PE (1) | PE20050481A1 (da) |
| PT (1) | PT1675846E (da) |
| TW (1) | TW200524906A (da) |
| UA (1) | UA82901C2 (da) |
| WO (1) | WO2005042515A1 (da) |
| ZA (1) | ZA200603234B (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA200970604A1 (ru) * | 2006-12-20 | 2009-10-30 | Эли Лилли Энд Компани | Новое промежуточное соединение и способ, используемый для получения {2-[1-(3,5-бис-трифторметилбензил)-5-пиридин-4-ил-1н-[1,2,3]триазол-4-ил]пиридин-3-ил}-(2-хлорфенил)метанона |
| WO2009075778A2 (en) * | 2007-12-06 | 2009-06-18 | The Regents Of The University Of California | Nonpeptidic inhibitors of cruzain |
| US8080568B1 (en) * | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
| DK3265087T3 (da) | 2015-03-04 | 2020-10-19 | Vanda Pharmaceuticals Inc | Fremgangsmåde til behandling med tradipitant |
| WO2017031215A1 (en) * | 2015-08-17 | 2017-02-23 | Eli Lilly And Company | Process development of a pyridine-containing nk-1 receptor antagonist |
| US11549147B2 (en) | 2017-09-13 | 2023-01-10 | Vanda Pharmaceuticals Inc. | Treatment of atopic dermatitis with tradipitant |
| AU2018367623B2 (en) | 2017-11-17 | 2024-03-28 | Vanda Pharmaceuticals Inc. | Method of treatment of gastrointestinal diseases with tradipitant |
| CN112218636A (zh) | 2018-06-08 | 2021-01-12 | 万达制药公司 | 使用川地匹坦进行治疗的方法 |
| US10821099B2 (en) | 2018-09-28 | 2020-11-03 | Vanda Pharmaceuticals Inc. | Use of tradipitant in motion sickness |
| MX2020008456A (es) * | 2018-09-28 | 2020-09-25 | Vanda Pharmaceuticals Inc | Uso de tradipitant para tratar la cinetosis. |
| WO2020117811A1 (en) | 2018-12-03 | 2020-06-11 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
| WO2021173641A1 (en) | 2020-02-25 | 2021-09-02 | Vanda Pharmaceuticals Inc. | Improved treatment of atopic dermatitis with tradipitant |
| WO2021195205A1 (en) | 2020-03-26 | 2021-09-30 | Vanda Pharmaceuticals Inc. | Treatment of lower respiratory tract infection with tradipitant |
| WO2023019084A1 (en) | 2021-08-12 | 2023-02-16 | Vanda Pharmaceuticals Inc. | Treatment of gastric accommodation with tradipitant |
| WO2023034718A1 (en) | 2021-08-31 | 2023-03-09 | Vanda Pharmaceuticals Inc. | Treatment of lower respiratory tract infection with tradipitant |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020099067A1 (en) * | 1993-07-08 | 2002-07-25 | Ulrich Posanski | Pharmaceutical compositions for sparingly soluble therapeutic agents |
| GB9505492D0 (en) * | 1995-03-18 | 1995-05-03 | Merck Sharp & Dohme | Therapeutic agents |
| GB9525296D0 (en) * | 1995-12-11 | 1996-02-07 | Merck Sharp & Dohme | Therapeutic agents |
| JP2001502311A (ja) * | 1996-10-07 | 2001-02-20 | メルク シヤープ エンド ドーム リミテツド | 抗鬱及び／又は抗不安薬としてのｃｎｓ浸透性ｎｋ―１受容体拮抗薬 |
| JP2003531103A (ja) * | 1999-08-12 | 2003-10-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | ｃ−ＪＵＮＮ−末端キナーゼ（ＪＮＫ）および他のタンパク質キナーゼの阻害剤 |
| JP2003513095A (ja) * | 1999-10-29 | 2003-04-08 | メルク エンド カムパニー インコーポレーテッド | タキキニン受容体アンタゴニストの多形 |
| US20020044971A1 (en) * | 2000-07-07 | 2002-04-18 | Amidon Gordon L. | Dissolution rate of poorly soluble drugs |
| ATE384053T1 (de) * | 2002-04-26 | 2008-02-15 | Lilly Co Eli | Triazolderivate als tachykininrezeptor- antagonisten |
-
2004
- 2004-10-12 US US10/574,712 patent/US7381826B2/en active Active
- 2004-10-12 CN CN2004800291393A patent/CN1863791B/zh active Active
- 2004-10-12 WO PCT/US2004/030914 patent/WO2005042515A1/en active Application Filing
- 2004-10-12 AT AT04793893T patent/ATE462700T1/de active
- 2004-10-12 EA EA200600829A patent/EA008881B1/ru not_active IP Right Cessation
- 2004-10-12 NZ NZ545917A patent/NZ545917A/en unknown
- 2004-10-12 NZ NZ580480A patent/NZ580480A/en unknown
- 2004-10-12 PT PT04793893T patent/PT1675846E/pt unknown
- 2004-10-12 KR KR1020067007751A patent/KR100848407B1/ko active IP Right Grant
- 2004-10-12 JP JP2006536635A patent/JP4959336B2/ja active Active
- 2004-10-12 ES ES04793893T patent/ES2340772T3/es active Active
- 2004-10-12 DE DE602004026333T patent/DE602004026333D1/de active Active
- 2004-10-12 DK DK04793893.1T patent/DK1675846T3/da active
- 2004-10-12 CA CA2542140A patent/CA2542140C/en active Active
- 2004-10-12 AU AU2004285855A patent/AU2004285855B8/en active Active
- 2004-10-12 BR BRPI0415010A patent/BRPI0415010B8/pt active IP Right Grant
- 2004-10-20 AR ARP040103801A patent/AR046131A1/es not_active Application Discontinuation
- 2004-10-20 PE PE2004001008A patent/PE20050481A1/es not_active Application Discontinuation
- 2004-10-21 MY MYPI20044338A patent/MY157375A/en unknown
- 2004-10-22 TW TW093132097A patent/TW200524906A/zh unknown
- 2004-12-10 UA UAA200604473A patent/UA82901C2/uk unknown
-
2006
- 2006-04-11 IL IL174926A patent/IL174926A0/en unknown
- 2006-04-21 EC EC2006006517A patent/ECSP066517A/es unknown
- 2006-04-21 ZA ZA200603234A patent/ZA200603234B/en unknown
- 2006-04-21 CR CR8353A patent/CR8353A/es not_active Application Discontinuation
- 2006-05-22 MA MA29043A patent/MA28329A1/fr unknown
- 2006-05-24 NO NO20062371A patent/NO335090B1/no unknown
-
2009
- 2009-05-29 CL CL2009001311A patent/CL2009001311A1/es unknown
- 2009-05-29 CL CL2009001310A patent/CL2009001310A1/es unknown
-
2010
- 2010-04-13 HR HR20100207T patent/HRP20100207T1/hr unknown
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