HRP20100056T1 - Endoparaziticidna sredstva za lokalnu primjenu - Google Patents
Endoparaziticidna sredstva za lokalnu primjenu Download PDFInfo
- Publication number
- HRP20100056T1 HRP20100056T1 HR20100056T HRP20100056T HRP20100056T1 HR P20100056 T1 HRP20100056 T1 HR P20100056T1 HR 20100056 T HR20100056 T HR 20100056T HR P20100056 T HRP20100056 T HR P20100056T HR P20100056 T1 HRP20100056 T1 HR P20100056T1
- Authority
- HR
- Croatia
- Prior art keywords
- preparation according
- terpene
- penetration enhancer
- preparation
- praziquantel
- Prior art date
Links
- 230000000699 topical effect Effects 0.000 title 1
- 235000007586 terpenes Nutrition 0.000 claims abstract 8
- -1 terpene hydrocarbon Chemical class 0.000 claims abstract 7
- 239000003961 penetration enhancing agent Substances 0.000 claims abstract 6
- FSVJFNAIGNNGKK-UHFFFAOYSA-N 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one Chemical compound C1C(C2=CC=CC=C2CC2)N2C(=O)CN1C(=O)C1CCCCC1 FSVJFNAIGNNGKK-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000004215 Carbon black (E152) Substances 0.000 claims abstract 4
- 229930195733 hydrocarbon Natural products 0.000 claims abstract 4
- 229960002957 praziquantel Drugs 0.000 claims abstract 4
- 150000003505 terpenes Chemical class 0.000 claims abstract 4
- 239000002904 solvent Substances 0.000 claims abstract 3
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000002360 preparation method Methods 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 3
- 229930195729 fatty acid Natural products 0.000 claims 3
- 239000000194 fatty acid Substances 0.000 claims 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- 108010002156 Depsipeptides Proteins 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- 108010056417 emodepside Proteins 0.000 claims 2
- ZMQMTKVVAMWKNY-YSXLEBCMSA-N emodepside Chemical compound C([C@@H]1C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N(C)[C@H](C(O[C@H](CC=2C=CC(=CC=2)N2CCOCC2)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O1)=O)CC(C)C)C(C=C1)=CC=C1N1CCOCC1 ZMQMTKVVAMWKNY-YSXLEBCMSA-N 0.000 claims 2
- 229960001575 emodepside Drugs 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 244000079386 endoparasite Species 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 235000001510 limonene Nutrition 0.000 claims 1
- 229940087305 limonene Drugs 0.000 claims 1
- 229960004488 linolenic acid Drugs 0.000 claims 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims 1
- 125000005481 linolenic acid group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10358525A DE10358525A1 (de) | 2003-12-13 | 2003-12-13 | Endoparasitizide Mittel zur topischen Applikation |
| PCT/EP2004/013552 WO2005055973A2 (fr) | 2003-12-13 | 2004-11-30 | Agents endoparasiticides a application topique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100056T1 true HRP20100056T1 (hr) | 2010-03-31 |
Family
ID=34638681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100056T HRP20100056T1 (hr) | 2003-12-13 | 2010-01-29 | Endoparaziticidna sredstva za lokalnu primjenu |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US7763583B2 (fr) |
| EP (1) | EP1694291B1 (fr) |
| JP (1) | JP4842141B2 (fr) |
| KR (1) | KR101272139B1 (fr) |
| CN (1) | CN1893919B (fr) |
| AR (1) | AR046878A1 (fr) |
| AT (1) | ATE447940T1 (fr) |
| AU (1) | AU2004296537B2 (fr) |
| BR (1) | BRPI0417578B1 (fr) |
| CA (1) | CA2548897C (fr) |
| CR (1) | CR8428A (fr) |
| DE (2) | DE10358525A1 (fr) |
| DK (1) | DK1694291T3 (fr) |
| ES (1) | ES2334920T3 (fr) |
| GT (1) | GT200400264A (fr) |
| HK (1) | HK1102915A1 (fr) |
| HR (1) | HRP20100056T1 (fr) |
| IL (1) | IL176151A (fr) |
| MX (1) | MXPA06006594A (fr) |
| MY (1) | MY142044A (fr) |
| NO (1) | NO20063171L (fr) |
| NZ (1) | NZ547837A (fr) |
| PE (1) | PE20050919A1 (fr) |
| PL (1) | PL1694291T3 (fr) |
| PT (1) | PT1694291E (fr) |
| RU (1) | RU2401108C2 (fr) |
| SI (1) | SI1694291T1 (fr) |
| TW (1) | TWI341202B (fr) |
| UA (1) | UA85574C2 (fr) |
| UY (1) | UY28662A1 (fr) |
| WO (1) | WO2005055973A2 (fr) |
| ZA (1) | ZA200604744B (fr) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070148228A1 (en) * | 1999-02-22 | 2007-06-28 | Merrion Research I Limited | Solid oral dosage form containing an enhancer |
| US8119159B2 (en) | 1999-02-22 | 2012-02-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| DE102004055316A1 (de) * | 2004-11-16 | 2006-05-18 | Bayer Healthcare Ag | Verhinderung vertikaler Endoparasiten-Infektionen |
| DE102005011779A1 (de) * | 2005-03-11 | 2006-09-14 | Bayer Healthcare Ag | Endoparasitizide Mittel |
| WO2007117706A2 (fr) | 2006-04-07 | 2007-10-18 | Merrion Research Iii Limited | Forme pharmaceutique solide par voie orale contenant un activateur |
| CA2654566A1 (fr) * | 2006-06-09 | 2007-12-21 | Merrion Research Iii Limited | Forme posologique solide a administrer par voie orale contenant un activateur |
| PE20081406A1 (es) * | 2006-12-20 | 2008-10-17 | Schering Plough Ltd | Composiciones farmaceuticas de flunixina |
| US20090280169A1 (en) | 2008-05-07 | 2009-11-12 | Merrion Research Iii Limited | Compositions of peptides and processes of preparation thereof |
| DE102008022520A1 (de) * | 2008-05-07 | 2009-11-12 | Bayer Animal Health Gmbh | Feste Arzneimittelformulierung mit verzögerter Freisetzung |
| NZ591741A (en) * | 2008-10-08 | 2013-01-25 | Zoetis W Llc | Benzimidazole anthelmintic compositions |
| AR075613A1 (es) * | 2009-02-25 | 2011-04-20 | Merrion Res Iii Ltd | Composicion y suministro de drogas de bifosfonato. metodo de tratamiento |
| DE102009012423A1 (de) | 2009-03-10 | 2010-09-16 | Bayer Animal Health Gmbh | Zubereitung auf Ölbasis |
| EP2408771B1 (fr) | 2009-03-17 | 2016-11-16 | Concert Pharmaceuticals, Inc. | Composés de pyrazinoisoquinoline |
| WO2011013003A2 (fr) | 2009-07-31 | 2011-02-03 | Shin Nippon Biomedical Laboratories, Ltd. | Granisétron pour administration intranasale et applicateur nasal |
| US20110182985A1 (en) * | 2010-01-28 | 2011-07-28 | Coughlan David C | Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof |
| WO2011120033A1 (fr) | 2010-03-26 | 2011-09-29 | Merrion Research Iii Limited | Compositions pharmaceutiques d'inhibiteurs de facteur xa sélectifs destinées à une administration orale |
| BR112013017169A2 (pt) | 2011-01-07 | 2016-10-04 | Merrion Res Iii Ltd | composições farmacêuticas de ferro para administração oral |
| US8680054B2 (en) * | 2011-04-20 | 2014-03-25 | Novartis Ag | Suspension type topical formulations comprising cyclic depsipeptide |
| CN102283843A (zh) * | 2011-06-29 | 2011-12-21 | 梁晓天 | 一种吡喹酮外用制剂及其制备方法和应用 |
| BR112014014973A2 (pt) * | 2011-12-21 | 2017-06-13 | Bayer Ip Gmbh | preparações contendo emodepside amorfo |
| CN104994852A (zh) * | 2012-12-18 | 2015-10-21 | 唐纳吉有限公司 | 透皮的杀寄生虫制剂 |
| EP3104940B1 (fr) * | 2014-02-14 | 2021-10-06 | DSM IP Assets B.V. | Acide arachidonique et praziquantel pour prévenir et/ou traiter une schistosomiase |
| EP3250191B1 (fr) | 2015-01-29 | 2024-01-17 | Novo Nordisk A/S | Comprimés contenant un agoniste de glp-1 et revêtement gastro-résistant |
| RS62130B1 (sr) | 2015-05-20 | 2021-08-31 | Boehringer Ingelheim Animal Health Usa Inc | Antihelmintička depsipeptidna jedinjenja |
| RU2020107484A (ru) | 2015-12-28 | 2020-03-19 | Мериал, Инк. | Противогельминтные депсипептидные соединения |
| US11382949B2 (en) | 2016-11-16 | 2022-07-12 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| CA3081673A1 (fr) | 2017-11-07 | 2019-05-16 | Bayer Animal Health Gmbh | Procede de synthese de depsipeptides cycliques |
| EP3480195A1 (fr) | 2017-11-07 | 2019-05-08 | Bayer Animal Health GmbH | Procédé de synthèse de depsipeptides cycliques |
| CN111346046B (zh) * | 2020-03-06 | 2021-07-09 | 安徽农业大学 | 一种含莫西菌素注射用缓释凝胶制剂及制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US281292A (en) * | 1883-07-17 | onslow | ||
| DE2362539C2 (de) | 1973-12-17 | 1986-05-07 | Merck Patent Gmbh, 6100 Darmstadt | 2-Acyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isochinoline, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE3619030A1 (de) * | 1986-06-06 | 1987-12-10 | Bayer Ag | Topisch anwendbare zubereitungen |
| DE3634755A1 (de) | 1986-10-11 | 1988-04-14 | Bayer Ag | Dermale behandlung von wurmerkrankungen der katze mit praziquantel |
| NO176766C (no) | 1989-02-07 | 1995-05-24 | Meiji Seika Kaisha | Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet |
| US5874479A (en) * | 1991-03-01 | 1999-02-23 | Warner-Lambert Company | Therapeutic permeation enhanced-wound healing compositions and methods for preparing and using same |
| DE4317458A1 (de) | 1992-06-11 | 1993-12-16 | Bayer Ag | Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 18 Ringatomen und Verfahren zu ihrer Herstellung |
| DE4317432A1 (de) | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
| DE4317457A1 (de) | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
| DE4400464A1 (de) * | 1994-01-11 | 1995-07-13 | Bayer Ag | Endoparasitizide Mittel |
| NZ260018A (en) | 1994-03-03 | 1995-10-26 | Bomac Lab Ltd | Benzimidazole compositions and anthelmintic compositions |
| DE19520275A1 (de) * | 1995-06-02 | 1996-12-05 | Bayer Ag | Endoparasitizide Mittel |
| US5780487A (en) | 1995-08-07 | 1998-07-14 | Amer Moh Samir | S-2'- 2-(1-methyl-2-piperidyl) ethyl! cinnamanilide |
| DE19601263A1 (de) | 1996-01-16 | 1997-07-17 | Bayer Ag | Anthelmintische Paste |
| DE19628776A1 (de) | 1996-07-17 | 1998-01-22 | Bayer Ag | Oral applizierbare Granulate von Hexahydropyrazinderivaten |
| US5837289A (en) * | 1996-07-23 | 1998-11-17 | Grasela; John C. | Transdermal delivery of medications using a combination of penetration enhancers |
| DE19921887A1 (de) | 1999-05-12 | 2000-11-16 | Bayer Ag | Endoparasitizide Mittel |
| DE19941024A1 (de) | 1999-08-28 | 2001-03-01 | Hartmut Klocke | Wirkstoffpräparat für tierärztliche Applikation und Verfahren zu seiner Herstellung |
| US6340672B1 (en) | 2000-02-16 | 2002-01-22 | Phoenix Scientific, Inc. | Parasiticidal formulation and a method of making this formulation |
| DE10008128A1 (de) * | 2000-02-22 | 2001-08-23 | Bayer Ag | Endoparasitizide Mittel |
| DE60118132T2 (de) | 2000-10-10 | 2006-10-19 | Wyeth | Anthelmintika |
| GB0108485D0 (en) | 2001-04-04 | 2001-05-23 | Pfizer Ltd | Combination therapy |
| US6893652B2 (en) | 2001-08-27 | 2005-05-17 | Wyeth | Endoparasiticidal gel composition |
| AU2004228041B2 (en) * | 2003-04-04 | 2009-06-04 | Boehringer Ingelheim Animal Health USA Inc. | Topical anthelmintic veterinary formulations |
-
2003
- 2003-12-13 DE DE10358525A patent/DE10358525A1/de not_active Withdrawn
-
2004
- 2004-11-30 MX MXPA06006594A patent/MXPA06006594A/es active IP Right Grant
- 2004-11-30 PT PT04798121T patent/PT1694291E/pt unknown
- 2004-11-30 ES ES04798121T patent/ES2334920T3/es active Active
- 2004-11-30 WO PCT/EP2004/013552 patent/WO2005055973A2/fr active Application Filing
- 2004-11-30 PL PL04798121T patent/PL1694291T3/pl unknown
- 2004-11-30 NZ NZ547837A patent/NZ547837A/en not_active IP Right Cessation
- 2004-11-30 UA UAA200607858A patent/UA85574C2/uk unknown
- 2004-11-30 EP EP04798121A patent/EP1694291B1/fr active Active
- 2004-11-30 AU AU2004296537A patent/AU2004296537B2/en not_active Ceased
- 2004-11-30 DE DE502004010367T patent/DE502004010367D1/de active Active
- 2004-11-30 SI SI200431331T patent/SI1694291T1/sl unknown
- 2004-11-30 RU RU2006124964/15A patent/RU2401108C2/ru not_active IP Right Cessation
- 2004-11-30 KR KR1020067014014A patent/KR101272139B1/ko not_active IP Right Cessation
- 2004-11-30 JP JP2006543431A patent/JP4842141B2/ja not_active Expired - Fee Related
- 2004-11-30 CA CA2548897A patent/CA2548897C/fr not_active Expired - Fee Related
- 2004-11-30 AT AT04798121T patent/ATE447940T1/de active
- 2004-11-30 BR BRPI0417578A patent/BRPI0417578B1/pt not_active IP Right Cessation
- 2004-11-30 CN CN2004800371839A patent/CN1893919B/zh not_active Expired - Fee Related
- 2004-11-30 DK DK04798121.2T patent/DK1694291T3/da active
- 2004-12-09 UY UY28662A patent/UY28662A1/es not_active Application Discontinuation
- 2004-12-09 AR ARP040104591A patent/AR046878A1/es unknown
- 2004-12-10 TW TW093138222A patent/TWI341202B/zh not_active IP Right Cessation
- 2004-12-10 MY MYPI20045106A patent/MY142044A/en unknown
- 2004-12-10 GT GT200400264A patent/GT200400264A/es unknown
- 2004-12-10 PE PE2004001220A patent/PE20050919A1/es not_active Application Discontinuation
-
2006
- 2006-06-01 CR CR8428A patent/CR8428A/es unknown
- 2006-06-06 IL IL176151A patent/IL176151A/en not_active IP Right Cessation
- 2006-06-09 ZA ZA200604744A patent/ZA200604744B/en unknown
- 2006-06-13 US US11/451,676 patent/US7763583B2/en active Active
- 2006-07-07 NO NO20063171A patent/NO20063171L/no not_active Application Discontinuation
-
2007
- 2007-07-10 HK HK07107397.7A patent/HK1102915A1/xx not_active IP Right Cessation
-
2010
- 2010-01-29 HR HR20100056T patent/HRP20100056T1/hr unknown
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