HRP20090578T1 - Postupak za pripravu dorzolamida - Google Patents
Postupak za pripravu dorzolamida Download PDFInfo
- Publication number
- HRP20090578T1 HRP20090578T1 HR20090578T HRP20090578T HRP20090578T1 HR P20090578 T1 HRP20090578 T1 HR P20090578T1 HR 20090578 T HR20090578 T HR 20090578T HR P20090578 T HRP20090578 T HR P20090578T HR P20090578 T1 HRP20090578 T1 HR P20090578T1
- Authority
- HR
- Croatia
- Prior art keywords
- dorzolamide
- formula
- racemate
- image
- camphorsulfonic acid
- Prior art date
Links
- IAVUPMFITXYVAF-XPUUQOCRSA-N dorzolamide Chemical compound CCN[C@H]1C[C@H](C)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 IAVUPMFITXYVAF-XPUUQOCRSA-N 0.000 title claims abstract 16
- 229960003933 dorzolamide Drugs 0.000 title claims abstract 16
- 238000004519 manufacturing process Methods 0.000 title claims 2
- MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 claims abstract 7
- MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 claims abstract 6
- 238000000034 method Methods 0.000 claims abstract 6
- 230000003472 neutralizing effect Effects 0.000 claims abstract 3
- 230000001376 precipitating effect Effects 0.000 claims abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 150000002688 maleic acid derivatives Chemical class 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 238000001953 recrystallisation Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Catalysts (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06112883 | 2006-04-21 | ||
| PCT/EP2007/053691 WO2007122130A1 (en) | 2006-04-21 | 2007-04-16 | Process for preparing dorzolamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090578T1 true HRP20090578T1 (hr) | 2009-11-30 |
Family
ID=38137401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20090578T HRP20090578T1 (hr) | 2006-04-21 | 2009-10-30 | Postupak za pripravu dorzolamida |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8183391B2 (ja) |
| EP (1) | EP2010544B1 (ja) |
| JP (1) | JP5097770B2 (ja) |
| CN (1) | CN101426795B (ja) |
| AT (1) | ATE438649T1 (ja) |
| CA (1) | CA2646133A1 (ja) |
| CY (1) | CY1110510T1 (ja) |
| DE (1) | DE602007001885D1 (ja) |
| DK (1) | DK2010544T3 (ja) |
| ES (1) | ES2331162T3 (ja) |
| HR (1) | HRP20090578T1 (ja) |
| PT (1) | PT2010544E (ja) |
| SI (1) | SI2010544T1 (ja) |
| WO (1) | WO2007122130A1 (ja) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20121165A1 (it) * | 2012-07-03 | 2014-01-04 | Zach System Spa | Processo di riduzione asimmetrica |
| CN103497202B (zh) * | 2013-10-23 | 2015-12-02 | 武汉武药科技有限公司 | 盐酸多佐胺中间体的合成方法 |
| US20160332962A1 (en) * | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
| CN108586485B (zh) * | 2018-05-30 | 2020-05-15 | 沈阳药科大学 | 1-(4-羟亚胺基噻吩并[2,3-b]噻喃甲酰基)哌嗪类化合物及其应用 |
| CN108822126B (zh) * | 2018-05-30 | 2020-05-15 | 沈阳药科大学 | 噻吩并噻喃甲酰基哌嗪类化合物及其医药用途 |
| CN108822127B (zh) * | 2018-05-30 | 2020-05-15 | 沈阳药科大学 | 4-羟亚胺基噻吩并[2,3-b]噻喃-2-甲酰胺类化合物及其用途 |
| CN110903299A (zh) * | 2018-09-17 | 2020-03-24 | 武汉武药科技有限公司 | 一种盐酸多佐胺的精制方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3810899A (en) * | 1972-03-10 | 1974-05-14 | Hoffmann La Roche | 2-hydroxy-n-substituted-morphinan derivatives |
| DD150456A5 (de) * | 1979-03-01 | 1981-09-02 | Ciba Geigy Ag | Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols |
| US4863922A (en) | 1984-12-12 | 1989-09-05 | Merck & Co., Inc. | Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use |
| JP4218310B2 (ja) * | 2002-11-06 | 2009-02-04 | 住友化学株式会社 | 光学活性２−アミノ−２−フェニルエタノール類の製造方法およびその中間体 |
| US20050059696A1 (en) * | 2003-05-08 | 2005-03-17 | Dr. Reddy's Laboratories Limited | Process for the recovery of S -(+)-methyl- (2-chlorophenyl)- (6,7-dihydro- 4H-thieno [3,2-c] pyrid-5-yl) acetate hydrogen sulfate (clopidogrel bisulfate) from its (R) and mixture of (R) and (S)- isomers |
| CN1293041C (zh) * | 2003-05-30 | 2007-01-03 | 上海实业化工有限公司 | D－(－)－1－苯甘氨酸的制备方法 |
| DE10336185A1 (de) * | 2003-08-07 | 2005-02-24 | Bayer Chemicals Ag | Enantiomerenangereicherte 1-Phenylethylamine |
| WO2006038222A1 (en) * | 2004-07-09 | 2006-04-13 | Fdc Ltd | AN IMPROVED PROCESS FOR THE PREPARATION OF 5,6 -DIHYDRO -4H-4(S)-ETHYLAMINO-6(S)-METHYLTHIENO[2,3-b] THIOPYRAN-2-SULFONAMIDE- 7,7 -DIOXIDE AND ITS SALT |
-
2007
- 2007-04-16 CA CA002646133A patent/CA2646133A1/en not_active Abandoned
- 2007-04-16 DE DE602007001885T patent/DE602007001885D1/de active Active
- 2007-04-16 EP EP07728156A patent/EP2010544B1/en active Active
- 2007-04-16 SI SI200730081T patent/SI2010544T1/sl unknown
- 2007-04-16 DK DK07728156T patent/DK2010544T3/da active
- 2007-04-16 WO PCT/EP2007/053691 patent/WO2007122130A1/en active Application Filing
- 2007-04-16 CN CN2007800143959A patent/CN101426795B/zh not_active Expired - Fee Related
- 2007-04-16 JP JP2009505862A patent/JP5097770B2/ja not_active Expired - Fee Related
- 2007-04-16 AT AT07728156T patent/ATE438649T1/de active
- 2007-04-16 ES ES07728156T patent/ES2331162T3/es active Active
- 2007-04-16 US US12/296,834 patent/US8183391B2/en not_active Expired - Fee Related
- 2007-04-16 PT PT07728156T patent/PT2010544E/pt unknown
-
2009
- 2009-10-20 CY CY20091101089T patent/CY1110510T1/el unknown
- 2009-10-30 HR HR20090578T patent/HRP20090578T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1110510T1 (el) | 2015-04-29 |
| PT2010544E (pt) | 2009-11-03 |
| ES2331162T3 (es) | 2009-12-22 |
| JP5097770B2 (ja) | 2012-12-12 |
| DE602007001885D1 (de) | 2009-09-17 |
| EP2010544B1 (en) | 2009-08-05 |
| US8183391B2 (en) | 2012-05-22 |
| SI2010544T1 (sl) | 2009-12-31 |
| ATE438649T1 (de) | 2009-08-15 |
| CN101426795B (zh) | 2011-01-12 |
| US20090275759A1 (en) | 2009-11-05 |
| CA2646133A1 (en) | 2007-11-01 |
| DK2010544T3 (da) | 2009-11-30 |
| WO2007122130A1 (en) | 2007-11-01 |
| EP2010544A1 (en) | 2009-01-07 |
| JP2009534349A (ja) | 2009-09-24 |
| CN101426795A (zh) | 2009-05-06 |
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