CY1110510T1 - Διαδικασια για την παρασκευη δορζολαμιδης - Google Patents

Διαδικασια για την παρασκευη δορζολαμιδης

Info

Publication number
CY1110510T1
CY1110510T1 CY20091101089T CY091101089T CY1110510T1 CY 1110510 T1 CY1110510 T1 CY 1110510T1 CY 20091101089 T CY20091101089 T CY 20091101089T CY 091101089 T CY091101089 T CY 091101089T CY 1110510 T1 CY1110510 T1 CY 1110510T1
Authority
CY
Cyprus
Prior art keywords
dorzolamide
dorzolamid
preparation procedure
camphorsulfonic acid
camphorsulfonate
Prior art date
Application number
CY20091101089T
Other languages
English (en)
Inventor
Paolo Maragni
Ivan Michieletto
Livius Cotarca
Original Assignee
Zach System S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zach System S.P.A. filed Critical Zach System S.P.A.
Publication of CY1110510T1 publication Critical patent/CY1110510T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Catalysts (AREA)
  • Dental Preparations (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

Μια διαδικασία για διάλυση trans ρακεμικής ένωσης δορζολαμίδης, που περιλαμβάνει αντίδραση της αναφερθείσας ρακεμικής ένωσης με (1S)-(+)-10-καμφοροσουλφονικό οξύ λαμβάνοντας κατ’ αυτόν τον τρόπο το (4S, 6S) εναντιομερές με επιλεκτική κατακρήμνιση και ανάκτηση του άλατος καμφοροσουλφονικού οξέος αυτού (καμφοροσουλφονική δορζολαμίδη), και ουδετεροποίηση της καμφοροσουλφονικής δορζολαμίδης για να ληφθεί δορζολαμίδη.
CY20091101089T 2006-04-21 2009-10-20 Διαδικασια για την παρασκευη δορζολαμιδης CY1110510T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06112883 2006-04-21
EP07728156A EP2010544B1 (en) 2006-04-21 2007-04-16 Process for preparing dorzolamide

Publications (1)

Publication Number Publication Date
CY1110510T1 true CY1110510T1 (el) 2015-04-29

Family

ID=38137401

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091101089T CY1110510T1 (el) 2006-04-21 2009-10-20 Διαδικασια για την παρασκευη δορζολαμιδης

Country Status (14)

Country Link
US (1) US8183391B2 (el)
EP (1) EP2010544B1 (el)
JP (1) JP5097770B2 (el)
CN (1) CN101426795B (el)
AT (1) ATE438649T1 (el)
CA (1) CA2646133A1 (el)
CY (1) CY1110510T1 (el)
DE (1) DE602007001885D1 (el)
DK (1) DK2010544T3 (el)
ES (1) ES2331162T3 (el)
HR (1) HRP20090578T1 (el)
PT (1) PT2010544E (el)
SI (1) SI2010544T1 (el)
WO (1) WO2007122130A1 (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20121165A1 (it) 2012-07-03 2014-01-04 Zach System Spa Processo di riduzione asimmetrica
CN103497202B (zh) * 2013-10-23 2015-12-02 武汉武药科技有限公司 盐酸多佐胺中间体的合成方法
US20160332962A1 (en) * 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
CN108822127B (zh) * 2018-05-30 2020-05-15 沈阳药科大学 4-羟亚胺基噻吩并[2,3-b]噻喃-2-甲酰胺类化合物及其用途
CN108822126B (zh) * 2018-05-30 2020-05-15 沈阳药科大学 噻吩并噻喃甲酰基哌嗪类化合物及其医药用途
CN108586485B (zh) * 2018-05-30 2020-05-15 沈阳药科大学 1-(4-羟亚胺基噻吩并[2,3-b]噻喃甲酰基)哌嗪类化合物及其应用
CN110903299A (zh) * 2018-09-17 2020-03-24 武汉武药科技有限公司 一种盐酸多佐胺的精制方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3810899A (en) * 1972-03-10 1974-05-14 Hoffmann La Roche 2-hydroxy-n-substituted-morphinan derivatives
DD150456A5 (de) * 1979-03-01 1981-09-02 Ciba Geigy Ag Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
JP4218310B2 (ja) * 2002-11-06 2009-02-04 住友化学株式会社 光学活性２−アミノ−２−フェニルエタノール類の製造方法およびその中間体
US20050059696A1 (en) * 2003-05-08 2005-03-17 Dr. Reddy's Laboratories Limited Process for the recovery of S -(+)-methyl- (2-chlorophenyl)- (6,7-dihydro- 4H-thieno [3,2-c] pyrid-5-yl) acetate hydrogen sulfate (clopidogrel bisulfate) from its (R) and mixture of (R) and (S)- isomers
CN1293041C (zh) * 2003-05-30 2007-01-03 上海实业化工有限公司 D－(－)－1－苯甘氨酸的制备方法
DE10336185A1 (de) * 2003-08-07 2005-02-24 Bayer Chemicals Ag Enantiomerenangereicherte 1-Phenylethylamine
EP1765828B1 (en) * 2004-07-09 2007-12-05 FDC Limited AN IMPROVED PROCESS FOR THE PREPARATION OF 5,6 -DIHYDRO -4H-4(S)-ETHYLAMINO-6(S)-METHYLTHIENO[2,3-b] THIOPYRAN-2-SULFONAMIDE- 7,7 -DIOXIDE AND ITS SALT

Also Published As

Publication number Publication date
CN101426795B (zh) 2011-01-12
HRP20090578T1 (hr) 2009-11-30
ES2331162T3 (es) 2009-12-22
PT2010544E (pt) 2009-11-03
CA2646133A1 (en) 2007-11-01
WO2007122130A1 (en) 2007-11-01
JP2009534349A (ja) 2009-09-24
DK2010544T3 (da) 2009-11-30
SI2010544T1 (sl) 2009-12-31
US20090275759A1 (en) 2009-11-05
EP2010544B1 (en) 2009-08-05
EP2010544A1 (en) 2009-01-07
US8183391B2 (en) 2012-05-22
JP5097770B2 (ja) 2012-12-12
DE602007001885D1 (de) 2009-09-17
ATE438649T1 (de) 2009-08-15
CN101426795A (zh) 2009-05-06

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