HRP20090411T1 - Suspenzijska formulacija feksofenadina - Google Patents
Suspenzijska formulacija feksofenadina Download PDFInfo
- Publication number
- HRP20090411T1 HRP20090411T1 HR20090411T HRP20090411T HRP20090411T1 HR P20090411 T1 HRP20090411 T1 HR P20090411T1 HR 20090411 T HR20090411 T HR 20090411T HR P20090411 T HRP20090411 T HR P20090411T HR P20090411 T1 HRP20090411 T1 HR P20090411T1
- Authority
- HR
- Croatia
- Prior art keywords
- approximately
- aqueous pharmaceutical
- suspension according
- pharmaceutical suspension
- volume
- Prior art date
Links
- 229960003592 fexofenadine Drugs 0.000 title claims abstract 15
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 title claims abstract 14
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000000725 suspension Substances 0.000 title 1
- 239000007971 pharmaceutical suspension Substances 0.000 claims abstract 94
- 229930006000 Sucrose Natural products 0.000 claims abstract 31
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract 31
- 239000005720 sucrose Substances 0.000 claims abstract 31
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract 21
- 239000000600 sorbitol Substances 0.000 claims abstract 21
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 claims abstract 20
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims abstract 20
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract 20
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract 20
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims abstract 20
- 239000000811 xylitol Substances 0.000 claims abstract 20
- 235000010447 xylitol Nutrition 0.000 claims abstract 20
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract 20
- 229960002675 xylitol Drugs 0.000 claims abstract 20
- 150000004683 dihydrates Chemical group 0.000 claims abstract 13
- 239000007853 buffer solution Substances 0.000 claims abstract 11
- 239000000243 solution Substances 0.000 claims abstract 11
- 229940067596 butylparaben Drugs 0.000 claims abstract 10
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims abstract 10
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims abstract 10
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims abstract 10
- 229960003415 propylparaben Drugs 0.000 claims abstract 10
- 235000003599 food sweetener Nutrition 0.000 claims abstract 7
- 239000003765 sweetening agent Substances 0.000 claims abstract 7
- 239000000080 wetting agent Substances 0.000 claims abstract 7
- 239000000416 hydrocolloid Substances 0.000 claims abstract 5
- 239000002245 particle Substances 0.000 claims abstract 5
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims abstract 4
- TUMYXYVXTFDMTJ-UHFFFAOYSA-M potassium;4-propoxycarbonylphenolate Chemical compound [K+].CCCOC(=O)C1=CC=C([O-])C=C1 TUMYXYVXTFDMTJ-UHFFFAOYSA-M 0.000 claims abstract 4
- 239000003755 preservative agent Substances 0.000 claims abstract 4
- 230000002335 preservative effect Effects 0.000 claims abstract 4
- OGBHACNFHJJTQT-UHFFFAOYSA-M sodium;4-butoxycarbonylphenolate Chemical compound [Na+].CCCCOC(=O)C1=CC=C([O-])C=C1 OGBHACNFHJJTQT-UHFFFAOYSA-M 0.000 claims abstract 4
- IXMINYBUNCWGER-UHFFFAOYSA-M sodium;4-propoxycarbonylphenolate Chemical compound [Na+].CCCOC(=O)C1=CC=C([O-])C=C1 IXMINYBUNCWGER-UHFFFAOYSA-M 0.000 claims abstract 4
- 239000000375 suspending agent Substances 0.000 claims abstract 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 24
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical group O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 12
- 239000000796 flavoring agent Substances 0.000 claims 12
- 229940045641 monobasic sodium phosphate Drugs 0.000 claims 12
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims 12
- 235000019799 monosodium phosphate Nutrition 0.000 claims 12
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 12
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 9
- 230000003139 buffering effect Effects 0.000 claims 9
- 239000006071 cream Substances 0.000 claims 9
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical group C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 8
- PYLIXCKOHOHGKQ-UHFFFAOYSA-L disodium;hydrogen phosphate;heptahydrate Chemical compound O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O PYLIXCKOHOHGKQ-UHFFFAOYSA-L 0.000 claims 8
- BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 claims 8
- OVBJJZOQPCKUOR-UHFFFAOYSA-L EDTA disodium salt dihydrate Chemical compound O.O.[Na+].[Na+].[O-]C(=O)C[NH+](CC([O-])=O)CC[NH+](CC([O-])=O)CC([O-])=O OVBJJZOQPCKUOR-UHFFFAOYSA-L 0.000 claims 7
- 229940052354 dibasic sodium phosphate heptahydrate Drugs 0.000 claims 7
- 229920001992 poloxamer 407 Polymers 0.000 claims 7
- 229940044476 poloxamer 407 Drugs 0.000 claims 7
- 240000007651 Rubus glaucus Species 0.000 claims 6
- 235000011034 Rubus glaucus Nutrition 0.000 claims 6
- 235000009122 Rubus idaeus Nutrition 0.000 claims 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 229940111685 dibasic potassium phosphate Drugs 0.000 claims 6
- 229940061607 dibasic sodium phosphate Drugs 0.000 claims 6
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims 6
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 6
- DGLRDKLJZLEJCY-UHFFFAOYSA-L disodium hydrogenphosphate dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O DGLRDKLJZLEJCY-UHFFFAOYSA-L 0.000 claims 6
- 235000019634 flavors Nutrition 0.000 claims 6
- 235000013355 food flavoring agent Nutrition 0.000 claims 6
- 239000004408 titanium dioxide Substances 0.000 claims 6
- 239000000230 xanthan gum Substances 0.000 claims 6
- 229920001285 xanthan gum Polymers 0.000 claims 6
- 235000010493 xanthan gum Nutrition 0.000 claims 6
- 229940082509 xanthan gum Drugs 0.000 claims 6
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims 3
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims 3
- 239000005711 Benzoic acid Substances 0.000 claims 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 3
- 239000004376 Sucralose Substances 0.000 claims 3
- 235000010358 acesulfame potassium Nutrition 0.000 claims 3
- 229960004998 acesulfame potassium Drugs 0.000 claims 3
- 239000000619 acesulfame-K Substances 0.000 claims 3
- 235000010233 benzoic acid Nutrition 0.000 claims 3
- 235000019445 benzyl alcohol Nutrition 0.000 claims 3
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims 3
- 229940111688 monobasic potassium phosphate Drugs 0.000 claims 3
- 235000019796 monopotassium phosphate Nutrition 0.000 claims 3
- 229940113115 polyethylene glycol 200 Drugs 0.000 claims 3
- 229940068886 polyethylene glycol 300 Drugs 0.000 claims 3
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims 3
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 claims 3
- 235000010241 potassium sorbate Nutrition 0.000 claims 3
- 239000004302 potassium sorbate Substances 0.000 claims 3
- 229940069338 potassium sorbate Drugs 0.000 claims 3
- 235000019204 saccharin Nutrition 0.000 claims 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims 3
- 229940081974 saccharin Drugs 0.000 claims 3
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims 3
- 235000010234 sodium benzoate Nutrition 0.000 claims 3
- 239000004299 sodium benzoate Substances 0.000 claims 3
- 235000010199 sorbic acid Nutrition 0.000 claims 3
- 239000004334 sorbic acid Substances 0.000 claims 3
- 229940075582 sorbic acid Drugs 0.000 claims 3
- 235000019408 sucralose Nutrition 0.000 claims 3
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims 3
- 229920001993 poloxamer 188 Polymers 0.000 claims 1
- 229940044519 poloxamer 188 Drugs 0.000 claims 1
- -1 fexofenadine dihydrate Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75030305P | 2005-12-14 | 2005-12-14 | |
| PCT/US2006/047393 WO2007070517A2 (en) | 2005-12-14 | 2006-12-12 | Fexofenadine suspension formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090411T1 true HRP20090411T1 (hr) | 2010-01-31 |
Family
ID=38120312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20090411T HRP20090411T1 (hr) | 2005-12-14 | 2009-07-23 | Suspenzijska formulacija feksofenadina |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US8933097B2 (ko) |
| EP (1) | EP1965768B1 (ko) |
| JP (1) | JP5308824B2 (ko) |
| KR (1) | KR101452792B1 (ko) |
| CN (1) | CN101316580B (ko) |
| AR (1) | AR058323A1 (ko) |
| AT (1) | ATE431137T1 (ko) |
| AU (1) | AU2006326551B2 (ko) |
| BR (1) | BRPI0619895B1 (ko) |
| CA (1) | CA2633086C (ko) |
| CR (1) | CR9993A (ko) |
| CY (1) | CY1109320T1 (ko) |
| DE (1) | DE602006006870D1 (ko) |
| DK (1) | DK1965768T3 (ko) |
| DO (1) | DOP2006000274A (ko) |
| EC (1) | ECSP088532A (ko) |
| EG (1) | EG25866A (ko) |
| ES (1) | ES2327168T3 (ko) |
| HK (1) | HK1123197A1 (ko) |
| HN (1) | HN2008000875A (ko) |
| HR (1) | HRP20090411T1 (ko) |
| IL (1) | IL192067A (ko) |
| JO (1) | JO2549B1 (ko) |
| MA (1) | MA30152B1 (ko) |
| MY (1) | MY146988A (ko) |
| NO (1) | NO339877B1 (ko) |
| NZ (1) | NZ568943A (ko) |
| PE (1) | PE20071003A1 (ko) |
| PL (1) | PL1965768T3 (ko) |
| PT (1) | PT1965768E (ko) |
| RS (1) | RS51135B (ko) |
| RU (1) | RU2405538C2 (ko) |
| SI (1) | SI1965768T1 (ko) |
| TN (1) | TNSN08186A1 (ko) |
| TW (1) | TWI377061B (ko) |
| UA (1) | UA89584C2 (ko) |
| UY (1) | UY30021A1 (ko) |
| WO (1) | WO2007070517A2 (ko) |
| ZA (1) | ZA200803985B (ko) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101546774B1 (ko) | 2008-07-29 | 2015-08-24 | 엘지전자 주식회사 | 휴대 단말기 및 그 동작제어 방법 |
| CA2852447A1 (en) | 2011-10-19 | 2013-04-25 | R.P. Scherer Technologies, Llc | Two phase pharmaceutical delivery system |
| US10130620B2 (en) | 2013-07-01 | 2018-11-20 | Aventisub Llc | Liquid pharmaceutical composition for oral administration comprising fexofenadine |
| JP2016523928A (ja) * | 2013-07-03 | 2016-08-12 | アール．ピー．シェーラー テクノロジーズ、エルエルシー | フェキソフェナジンを有するカプセル製剤 |
| CN103610645B (zh) * | 2013-11-25 | 2016-05-11 | 浙江万晟药业有限公司 | 一种非索非那定盐酸盐的药物组合物及制备方法 |
| CN106806346B (zh) * | 2015-12-01 | 2020-09-11 | 国药集团广东环球制药有限公司 | 一种非索非那定盐酸盐干混悬剂制剂及其制备方法 |
| WO2017218894A1 (en) | 2016-06-16 | 2017-12-21 | Cutispharma, Inc. | Composition and method for proton pump inhibitor suspension |
| US11318095B2 (en) | 2017-06-02 | 2022-05-03 | Teika Pharmaceutical Co., Ltd. | Micelle for solubilizing a sparingly water-soluble ingredient and solution comprising the same |
| US11633478B2 (en) | 2019-07-16 | 2023-04-25 | Azurity Pharmaceuticals, Inc. | Compositions and kits for Omeprazole suspension |
| US10751333B1 (en) | 2019-07-16 | 2020-08-25 | Cutispharma, Inc. | Compositions and kits for omeprazole suspension |
| WO2022175829A1 (en) | 2021-02-17 | 2022-08-25 | Cellix Bio Private Limited | Topical formulations and compositions |
| CN115715759B (zh) * | 2022-11-03 | 2024-01-12 | 京海盛达(北京)科技有限公司 | 一种抗组胺混悬剂及其制备方法 |
| CN118714999A (zh) | 2023-01-20 | 2024-09-27 | 欧彼乐医疗集团公司 | 不含对羟基苯甲酸酯的非索非那定制剂 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4254129A (en) | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
| US4829064A (en) | 1987-06-08 | 1989-05-09 | Analgesic Associates | Cough/cold mixtures comprising non-sedating antihistamine drugs |
| CA2449419C (en) | 1994-05-18 | 2011-09-06 | Aventis Pharmaceuticals Inc. | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof |
| US6132758A (en) | 1998-06-01 | 2000-10-17 | Schering Corporation | Stabilized antihistamine syrup |
| US6319513B1 (en) * | 1998-08-24 | 2001-11-20 | The Procter & Gamble Company | Oral liquid mucoadhesive compounds |
| GB9822170D0 (en) | 1998-10-13 | 1998-12-02 | Danbioyst Uk Ltd | Novel formulations of fexofenadine |
| US20060083691A1 (en) * | 2000-05-10 | 2006-04-20 | Wermeling Daniel P | Intranasal opioid compositions, delivery devices and methods of using same |
| WO2003011295A1 (en) | 2001-07-31 | 2003-02-13 | Texcontor Etablissement | Fexofenadine polymorph |
| US6723348B2 (en) * | 2001-11-16 | 2004-04-20 | Ethypharm | Orodispersible tablets containing fexofenadine |
| DE602004023478D1 (de) | 2003-01-30 | 2009-11-19 | Ethypharm Sa | Geschmacksmaskierte beschichtete teilchen, verfahren zur herstellung und in der mundhöhle dispergierbare tabletten enthaltend die beschichteten teilchen |
| US20050250737A1 (en) * | 2003-11-12 | 2005-11-10 | Allergan, Inc. | Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods |
| US20050266031A1 (en) | 2004-05-25 | 2005-12-01 | Jay Dickerson | Pharmaceutical suspension composition |
| WO2006058022A1 (en) * | 2004-11-24 | 2006-06-01 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
| US20090149508A1 (en) | 2005-07-27 | 2009-06-11 | Sandoz Ag | Process for the preparation of substituted phenyl ether compounds |
| JP5133244B2 (ja) * | 2005-08-05 | 2013-01-30 | ルピン・リミテッド | フェキソフェナジンの経口用医薬懸濁組成物 |
-
2006
- 2006-12-06 DO DO2006000274A patent/DOP2006000274A/es unknown
- 2006-12-12 AU AU2006326551A patent/AU2006326551B2/en active Active
- 2006-12-12 PE PE2006001593A patent/PE20071003A1/es not_active Application Discontinuation
- 2006-12-12 AR ARP060105470A patent/AR058323A1/es not_active Application Discontinuation
- 2006-12-12 WO PCT/US2006/047393 patent/WO2007070517A2/en active Application Filing
- 2006-12-12 CN CN200680044516XA patent/CN101316580B/zh active Active
- 2006-12-12 KR KR1020087014471A patent/KR101452792B1/ko active IP Right Grant
- 2006-12-12 MY MYPI20081743A patent/MY146988A/en unknown
- 2006-12-12 RS RSP-2009/0360A patent/RS51135B/sr unknown
- 2006-12-12 RU RU2008128418/15A patent/RU2405538C2/ru not_active IP Right Cessation
- 2006-12-12 PT PT06839331T patent/PT1965768E/pt unknown
- 2006-12-12 PL PL06839331T patent/PL1965768T3/pl unknown
- 2006-12-12 BR BRPI0619895-3A patent/BRPI0619895B1/pt active IP Right Grant
- 2006-12-12 CA CA2633086A patent/CA2633086C/en active Active
- 2006-12-12 UA UAA200809121A patent/UA89584C2/uk unknown
- 2006-12-12 JP JP2008545740A patent/JP5308824B2/ja not_active Expired - Fee Related
- 2006-12-12 DE DE602006006870T patent/DE602006006870D1/de active Active
- 2006-12-12 EP EP06839331A patent/EP1965768B1/en active Active
- 2006-12-12 AT AT06839331T patent/ATE431137T1/de active
- 2006-12-12 ES ES06839331T patent/ES2327168T3/es active Active
- 2006-12-12 SI SI200630374T patent/SI1965768T1/sl unknown
- 2006-12-12 NZ NZ568943A patent/NZ568943A/en not_active IP Right Cessation
- 2006-12-12 DK DK06839331T patent/DK1965768T3/da active
- 2006-12-14 JO JO2006458A patent/JO2549B1/en active
- 2006-12-14 TW TW095146788A patent/TWI377061B/zh not_active IP Right Cessation
- 2006-12-15 UY UY30021A patent/UY30021A1/es not_active Application Discontinuation
-
2008
- 2008-04-24 TN TNP2008000186A patent/TNSN08186A1/en unknown
- 2008-05-06 ZA ZA200803985A patent/ZA200803985B/xx unknown
- 2008-05-20 CR CR9993A patent/CR9993A/es not_active Application Discontinuation
- 2008-06-11 IL IL192067A patent/IL192067A/en not_active IP Right Cessation
- 2008-06-12 EC EC2008008532A patent/ECSP088532A/es unknown
- 2008-06-13 US US12/138,468 patent/US8933097B2/en active Active
- 2008-06-13 HN HN2008000875A patent/HN2008000875A/es unknown
- 2008-06-15 EG EG2008060996A patent/EG25866A/xx active
- 2008-06-26 NO NO20082904A patent/NO339877B1/no not_active IP Right Cessation
- 2008-07-11 MA MA31103A patent/MA30152B1/fr unknown
-
2009
- 2009-01-23 HK HK09100732.4A patent/HK1123197A1/xx not_active IP Right Cessation
- 2009-07-23 HR HR20090411T patent/HRP20090411T1/hr unknown
- 2009-08-12 CY CY20091100862T patent/CY1109320T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20090411T1 (hr) | Suspenzijska formulacija feksofenadina | |
| JP2009519935A5 (ko) | ||
| ES2262122T3 (es) | Formulacion intranasal de rotigotina. | |
| CA2668733C (en) | Liquid preparation comprising a complex of pimobendan and cyclodextrin | |
| CN101500539A (zh) | 增强稳定性的脱羟肾上腺素液体组合物 | |
| ES2277635T3 (es) | Formulacion de disolucion solida oral de una sustancia activa escasamente soluble en agua. | |
| WO2016159897A1 (en) | Potassium citrate suspension | |
| JP2590156B2 (ja) | 経口投与用医薬組成物 | |
| MXPA97002456A (en) | Liquid antiacidal compositions containing calcium carbonate and possibly simeticone as active compounds and monobasic potassium phosphate and potassium bicarbonate as regula | |
| ES2781755T3 (es) | Composición farmacéutica en forma de suspensión oral que comprende una fracción flavonoica y goma de xantano | |
| ES2223595T3 (es) | Composicion farmaceutica acuosa de contiene ciclesonida. | |
| HUE026162T2 (en) | Olopatadine preparation for topical nasal administration | |
| DK175752B1 (da) | Flydende oralt farmaceutisk diclofenacpræparat og fremgangsmåde til fremstilling deraf | |
| TWI327913B (en) | Pharmaceutical composition comprising 5-methyl-2-(2'-chloro-6'-fluoroanilino)phenylacetic acid | |
| US20150140111A1 (en) | Preparations of effervescent formulations comprising second and third generation cephalosporin and uses thereof | |
| CN102078612A (zh) | 含有糠酸莫米松和h1受体拮抗剂的鼻用原位凝胶 | |
| EP2515862A1 (en) | Rapidly dispersing pharmaceutical formulation with cefdinir | |
| ES2705238T3 (es) | Composición de compuestos de tiacumicina | |
| EP2515858A1 (en) | Pharmaceutical composition with high purity | |
| WO2008015695A2 (en) | Inclusion complex of olopatadine and cyclodextrin | |
| US5698562A (en) | Palatable trimethoprim oral solution | |
| JP3364453B2 (ja) | センノシド含有水性液剤 | |
| KR100718211B1 (ko) | 틱소코르톨 피발레이트 현탁액, 그를 기재로 한 함수제 및그를 함유하는 패키징 | |
| WO2014191414A1 (en) | Syrup formulation of salbutamol | |
| KR20150127483A (ko) | 몬테루카스트 또는 이의 약제학적으로 허용가능한 염을 포함하는 안정성이 개선된 액상 제제 및 이의 제조방법 |