HRP20070327T3 - Derivati n-[heteroaril(piperidin-2-il)metil]benzamida, njihovo dobivanje i terapijska primjena - Google Patents

Derivati n-[heteroaril(piperidin-2-il)metil]benzamida, njihovo dobivanje i terapijska primjena

Info

Publication number
HRP20070327T3
HRP20070327T3 HR20070327T HRP20070327T HRP20070327T3 HR P20070327 T3 HRP20070327 T3 HR P20070327T3 HR 20070327 T HR20070327 T HR 20070327T HR P20070327 T HRP20070327 T HR P20070327T HR P20070327 T3 HRP20070327 T3 HR P20070327T3
Authority
HR
Croatia
Prior art keywords
group
alkyl
branched
cycloalkyl
optionally substituted
Prior art date
Application number
HR20070327T
Other languages
English (en)
Inventor
Dargazanli Gihad
Estenne-Bouhtou Geneviève
Medaisko Florence
Renones Maria-Carmen
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of HRP20070327T3 publication Critical patent/HRP20070327T3/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Spoj opće formule (I) naznačen time štoR1 predstavlja bilo atom vodika, ili nerazgranatu ili razgranatu (C1-C7)alkilnu skupinu, izborno supstituiranus jednim ili više atoma fluora, ili (C3-C7)cikloalkilnu skupinu, ili (C3-C7)cikloalkil(C1-C3)alkilnu skupinu, ili fenil(C1-C3)alkilnu skupinu, izborno supstituiranu s jednom ili dvije metoksi skupine, ili (C2-C4)alkenilnu skupinu, ili (C2-C4)alkinilnu skupinu; R2 predstavlja piridinilnu, furanilnu,tienilnu, tiazolilnu ili oksazolilnu skupinu, gdje je navedena skupina izborno supstituirana s jednim ili više supstituenata, koje se bira između atoma halogena i trifluormetilne skupine, te nerazgranatih ili razgranatih (C1-C6)alkilnih i (C1-C6)alkoksi skupina; R3 predstavlja bilo atom vodika, ilijedan ili više supstituenata, koje se bira izmeđuatoma halogena i trifluormetilne, nerazgranate ili razgranate (C1-C6)alkilne, (C3-C7)cikloalkilne, (C1-C6)alkoksi, fenilne, cijano, acetilne, benzoilne, (C1-C6)tioalkilne, (C1-C6)alkilsulfonilne, karboksi ili (C1-C6)alkoksikarbonilne skupine, ili skupinu opće formule NR4R5 ili SO2NR4R5 ili CONR4R5,gdjesvaki od R4 i R5 predstavlja, međusobno neovisno, atom vodika ili nerazgranatu ili razgranatu (C1-C6)alkilnu ili
HR20070327T 2003-10-17 2007-07-17 Derivati n-[heteroaril(piperidin-2-il)metil]benzamida, njihovo dobivanje i terapijska primjena HRP20070327T3 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0312142A FR2861073B1 (fr) 2003-10-17 2003-10-17 Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
PCT/FR2004/002641 WO2005037781A2 (fr) 2003-10-17 2004-10-15 Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
HRP20070327T3 true HRP20070327T3 (hr) 2007-09-30

Family

ID=34385235

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20070327T HRP20070327T3 (hr) 2003-10-17 2007-07-17 Derivati n-[heteroaril(piperidin-2-il)metil]benzamida, njihovo dobivanje i terapijska primjena

Country Status (27)

Country Link
US (1) US7335670B2 (hr)
EP (1) EP1680418B1 (hr)
JP (1) JP4696069B2 (hr)
KR (1) KR20060087598A (hr)
CN (1) CN100430394C (hr)
AT (1) ATE361923T1 (hr)
AU (1) AU2004281215B2 (hr)
BR (1) BRPI0415452A (hr)
CA (1) CA2542370A1 (hr)
CY (1) CY1106786T1 (hr)
DE (1) DE602004006431T2 (hr)
DK (1) DK1680418T3 (hr)
ES (1) ES2287782T3 (hr)
FR (1) FR2861073B1 (hr)
HK (1) HK1098456A1 (hr)
HR (1) HRP20070327T3 (hr)
IL (1) IL174941A (hr)
MA (1) MA28097A1 (hr)
ME (1) MEP22008A (hr)
NO (1) NO20062151L (hr)
NZ (1) NZ547165A (hr)
PL (1) PL1680418T3 (hr)
PT (1) PT1680418E (hr)
RS (1) RS20060316A (hr)
RU (1) RU2351596C2 (hr)
WO (1) WO2005037781A2 (hr)
ZA (1) ZA200603941B (hr)

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FR2842804B1 (fr) 2002-07-29 2004-09-03 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861074B1 (fr) * 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861071B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
PT1828154E (pt) * 2004-12-09 2009-06-08 Hoffmann La Roche Derivados de fenil-piperazina-metanona
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EP1874721A2 (en) * 2004-12-23 2008-01-09 Glaxo Group Limited Glycine transport inhibitors
PE20061156A1 (es) 2004-12-23 2006-12-16 Glaxo Group Ltd Derivados de benzamida como agentes inhibidores del transportador de glicina
AR057350A1 (es) 2005-06-06 2007-11-28 Merck Sharp & Dohme Derivados de ciclohexanosulfonilo como inhibidores de glyt1 para tratar esquizofrenia. composiciones farmaceuticas
FR2906251B1 (fr) 2006-09-22 2008-11-07 Sanofi Aventis Sa Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique
SI1961735T1 (sl) * 2007-02-22 2010-01-29 Indena Spa Postopek za pripravo acetatne soli (2r,3s)-3-fenilizoserin-metilestra
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MX2014006004A (es) 2011-11-18 2015-04-16 Abbvie Deutschland Derivados de aminobenzociclohepteno, aminotetralina, aminoindano y fenalcilamina n-sustituidas, composiciones farmaceuticas que los contienen, y su uso en terapia.
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KR101542939B1 (ko) 2011-11-29 2015-08-10 주식회사 비보존 신규한 벤즈아마이드 유도체 및 그 용도
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Also Published As

Publication number Publication date
CN1882581A (zh) 2006-12-20
RU2006116887A (ru) 2007-11-27
PT1680418E (pt) 2007-08-10
CY1106786T1 (el) 2012-05-23
PL1680418T3 (pl) 2008-01-31
DE602004006431T2 (de) 2008-01-10
ZA200603941B (en) 2007-11-28
CN100430394C (zh) 2008-11-05
DE602004006431D1 (de) 2007-06-21
JP2007508359A (ja) 2007-04-05
RU2351596C2 (ru) 2009-04-10
US20060223886A1 (en) 2006-10-05
KR20060087598A (ko) 2006-08-02
NO20062151L (no) 2006-05-12
WO2005037781A2 (fr) 2005-04-28
BRPI0415452A (pt) 2006-12-19
AU2004281215B2 (en) 2010-09-30
MA28097A1 (fr) 2006-08-01
EP1680418A2 (fr) 2006-07-19
MEP22008A (en) 2010-06-10
IL174941A0 (en) 2006-08-20
CA2542370A1 (fr) 2005-04-28
DK1680418T3 (da) 2007-09-10
HK1098456A1 (en) 2007-07-20
US7335670B2 (en) 2008-02-26
FR2861073A1 (fr) 2005-04-22
ES2287782T3 (es) 2007-12-16
NZ547165A (en) 2010-01-29
FR2861073B1 (fr) 2006-01-06
RS20060316A (en) 2008-11-28
IL174941A (en) 2011-12-29
ATE361923T1 (de) 2007-06-15
WO2005037781A3 (fr) 2005-07-14
AU2004281215A1 (en) 2005-04-28
JP4696069B2 (ja) 2011-06-08
EP1680418B1 (fr) 2007-05-09

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