AR057350A1 - Derivados de ciclohexanosulfonilo como inhibidores de glyt1 para tratar esquizofrenia. composiciones farmaceuticas - Google Patents
Derivados de ciclohexanosulfonilo como inhibidores de glyt1 para tratar esquizofrenia. composiciones farmaceuticasInfo
- Publication number
- AR057350A1 AR057350A1 ARP060102342A ARP060102342A AR057350A1 AR 057350 A1 AR057350 A1 AR 057350A1 AR P060102342 A ARP060102342 A AR P060102342A AR P060102342 A ARP060102342 A AR P060102342A AR 057350 A1 AR057350 A1 AR 057350A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- nr10r11
- halogen
- alkyl
- unsubstituted
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/70—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a saturated carbon skeleton containing rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/76—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/30—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
Composiciones farmacéuticas que los contienen. Reivindicacion 1: Un compuesto de la formula (1), en el que: R1 es -(CH2)n-R1a, en el que n es independientemente 0-6, y R1a se selecciona del grupo que consiste en: i) alquilo C1-6, que no está sustituido o está sustituido con 1-6 halogeno, hidroxi, ii) fenilo sustituido con R2a, R2b y R2c, iii) heterociclo sustituido con R2a, R2b y R2c, iv) cicloalquilo C3-6, que no está sustituido o está sustituido con alquilo C1-6, 1-6 halogeno, hidroxi o -NR10R11, v) -O-alquiloC1-6, que no está sustituido o está sustituido con 1-6 halogeno, hidroxi o -NR10R11, vi) -CO2R9, en el que R9 se selecciona independientemente de: a) hidrogeno, b) -alquiloC1-6, que no está sustituido o está sustituido con 1- 6 fluoro, c) bencilo, y d) fenilo, vii) -NR10R11, en el que R10 y R11 se seleccionan independientemente de: a) hidrogeno, b) -alquiloC1-6, que no está sustituido o está sustituido con hidroxi, 1-6 fluoro o -NR12R13, donde R12 y R13 se seleccionan independientemente de hidrogeno y -alquiloC1-6, c) -cicloalquiloC3-6, que no está sustituido o está sustituido con hidroxi, 1-6 fluoro o -NR12R13, d) bencilo, e) fenilo, y viii) -CONR10R11; R2 se selecciona del grupo consiste en: i) fenilo, que está sustituido con R2a, R2b y R2c, ii) heterociclo, que está sustituido con R2a, R2b y R2c, iii) alquilo C1-8, que no está sustituido o está sustituido con 1-6 halogeno, hidroxi, -NR10R11, fenilo o heterociclo, donde el fenilo o heterociclo está sustituido con R2a, R2b y R2c, iv) cicloalquilo C3-6, que no está sustituido o está sustituido con 1-6 halogeno, hidroxi o -NR10R11, y v) -alquilC1-6-cicloalquiloC3-6, que no está sustituido o está sustituido con 1-6 halogeno, hidroxi o -NR10R11; R2a, R2b y R2c se selecciona independientemente del grupo que consiste de: i) hidrogeno, ii) halogeno, iii) -alquiloC1-6, que no está sustituido o está sustituido con: a) 1-6 halogeno, b) fenilo, c) cicloalquiloC3-6, o d) -NR10R11, iv) -O-alquiloC1- 6, que no está sustituido o está sustituido con 1-6 halogeno, v) hidroxi, vi) -SCF3, vii) -SCHF2, viii) -SCH3, ix) -CO2R9 , x) -CN, xi) -SO2R9 , xii) -SO2-NR10R11, xiii) -NR10R11, xiv) -CONR10R11, y xv) -NO2, o dos de R2a, R2b y R2c están enlazados formando un grupo de formula (2), en el que r es 1 a 3; R3 se selecciona del grupo que consiste de: i) alquilo C1-6, que no está sustituido o está sustituido con 1-6 halogeno, hidroxilo, -NR10R11, o heterociclo, que está sustituido con R2a, R2b y R2c, ii) cicloalquilo C3-6, que no está sustituido o está sustituido con 1-6 halogeno, hidroxilo o -NR10R11, iii) -alquilC1-6-cicloalquiloC3-6, que no está sustituido o está sustituido con 1-6 halogeno, hidroxi o -NR10R11, y iv) -NR10R11, y v) heterociclo, que está sustituido con R2a, R2b y R2c; R4 y R5 se seleccionan independientemente del grupo que consiste de: i) hidrogeno, y ii) alquilo C1-6, que no está sustituido o está sustituido con halogeno o hidroxilo, o R4 y R5 tomados conjuntamente forman un anillo cicloalquilo C3-6; A se selecciona del grupo que consiste en: i) -O-, y ii) -NR10-; m es cero o uno, por lo que cuando m es cero R2 está unido directamente al carbonilo; y sus sales farmacéuticamente aceptables y sus enantiomeros y diastereoisomeros individuales.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0511452A GB0511452D0 (en) | 2005-06-06 | 2005-06-06 | Therapeutic agents |
GB0516787A GB0516787D0 (en) | 2005-08-17 | 2005-08-17 | Therapeutic agents |
GB0524968A GB0524968D0 (en) | 2005-12-08 | 2005-12-08 | Therapeutic agents |
Publications (1)
Publication Number | Publication Date |
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AR057350A1 true AR057350A1 (es) | 2007-11-28 |
Family
ID=36636407
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP060102342A AR057350A1 (es) | 2005-06-06 | 2006-06-05 | Derivados de ciclohexanosulfonilo como inhibidores de glyt1 para tratar esquizofrenia. composiciones farmaceuticas |
Country Status (10)
Country | Link |
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US (2) | US7626056B2 (es) |
EP (2) | EP1891002B1 (es) |
JP (1) | JP5281395B2 (es) |
AR (1) | AR057350A1 (es) |
AU (1) | AU2006256583B2 (es) |
CA (1) | CA2609969C (es) |
DO (1) | DOP2006000125A (es) |
PE (1) | PE20061490A1 (es) |
TW (1) | TW200716531A (es) |
WO (2) | WO2006131713A1 (es) |
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JP2007512251A (ja) * | 2003-11-12 | 2007-05-17 | メルク エンド カムパニー インコーポレーテッド | 4−フェニルピペリジンスルホニルグリシン輸送体インヒビター |
EP1729772B8 (en) * | 2004-03-24 | 2017-04-19 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine glycine transporter inhibitors |
EP1745018A1 (en) * | 2004-04-29 | 2007-01-24 | Merck & Co., Inc. | Azetidine glycine transporter inhibitors |
WO2005107469A2 (en) * | 2004-05-05 | 2005-11-17 | Merck & Co., Inc. | Morpholinyl piperidine glycine transporter inhibitors |
JP4646984B2 (ja) * | 2004-09-30 | 2011-03-09 | メルク・シャープ・エンド・ドーム・コーポレイション | シクロプロピルピペリジングリシン輸送体阻害剤 |
WO2006067529A1 (en) * | 2004-12-21 | 2006-06-29 | Merck Sharp & Dohme Limited | Piperidine and azetidine derivatives as glyt1 inhibitors |
PE20061490A1 (es) | 2005-06-06 | 2007-02-09 | Merck Sharp & Dohme | Derivados de ciclohexanosulfonilo como inhibidores del transportador de glicina glyt1 |
EP1899294B1 (en) * | 2005-06-13 | 2015-03-18 | Merck Sharp & Dohme Limited | Therapeutic agents |
GB0523998D0 (en) * | 2005-11-25 | 2006-01-04 | Merck Sharp & Dohme | Therapeutic agents |
AU2008341953B2 (en) * | 2007-12-26 | 2013-05-02 | Msd K.K. | Sulfonyl substituted 6-membered ring derivative |
AU2010295481A1 (en) * | 2009-09-18 | 2012-03-08 | Zalicus Pharmaceuticals Ltd. | Aryl sulphone derivatives as calcium channel blockers |
US8937900B2 (en) | 2010-07-20 | 2015-01-20 | Qualcomm Incorporated | Enhancing pilot channel transmission in TD-SCDMA multicarrier systems using secondary carrier frequencies |
EP2595484B1 (en) * | 2010-07-20 | 2017-10-18 | Minerva Neurosciences, Inc. | Use of cyclic amide derivatives to treat sleep disorders |
EP3009421A1 (en) * | 2013-06-10 | 2016-04-20 | Taisho Pharmaceutical Co., Ltd. | Glycine transporter inhibitor |
US9708334B2 (en) | 2014-04-24 | 2017-07-18 | Dart Neuroscience (Cayman) Ltd. | Substituted 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole and 4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine compounds as GlyT1 inhibitors |
TWI601712B (zh) | 2014-11-05 | 2017-10-11 | 達特神經科學(開曼)有限責任公司 | 作為glyt1抑制劑之經取代之氮雜環丁基化合物 |
ES2910528T3 (es) | 2014-12-02 | 2022-05-12 | Minerva Neurosciences Inc | Composiciones que comprenden 2-((1-(2(4-fluorofenil)-2-oxoetil)piperidin-4-il)metil)isoindolin-1-ona para tratar la esquizofrenia |
CN106467477A (zh) * | 2016-08-26 | 2017-03-01 | 天津雅奥科技发展有限公司 | 一种合成化合物(1‑环丙基‑1‑氰基‑4‑环己酮)的新方法 |
CN106916089B (zh) * | 2017-03-14 | 2018-10-19 | 大连九信精细化工有限公司 | 一种选择性合成顺式4-正戊基环己硫醇的制备方法 |
CN111511353A (zh) | 2017-06-21 | 2020-08-07 | 田边三菱制药株式会社 | 耐胃液的控释口服剂型 |
CA3108882A1 (en) | 2018-08-21 | 2020-02-27 | Minerva Neurosciences, Inc. | Use of roluperidone to treat negative symptoms and disorders, increase neuroplasticity, and promote neuroprotection |
CN115038690A (zh) | 2020-01-31 | 2022-09-09 | 索尔维公司 | 用于制造卤代烷基取代的吡啶化合物的方法 |
CN114426494B (zh) * | 2022-01-13 | 2023-09-15 | 江苏海洋大学 | 一种具有作用于taar激动剂的取代甲胺类衍生物 |
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US6127191A (en) * | 1996-12-03 | 2000-10-03 | 3-Dimensional Pharmaceuticals, Inc. | Aminobenzenedicarboxylic acid-based combinatorial libraries |
SE9704544D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
KR20040066896A (ko) * | 2001-12-12 | 2004-07-27 | 에프. 호프만-라 로슈 아게 | 치환된 사이클로헥산 유도체 |
GB0223039D0 (en) * | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
FR2861073B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
JP2007512251A (ja) * | 2003-11-12 | 2007-05-17 | メルク エンド カムパニー インコーポレーテッド | 4−フェニルピペリジンスルホニルグリシン輸送体インヒビター |
EP1729772B8 (en) * | 2004-03-24 | 2017-04-19 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine glycine transporter inhibitors |
EP1745018A1 (en) * | 2004-04-29 | 2007-01-24 | Merck & Co., Inc. | Azetidine glycine transporter inhibitors |
WO2005107469A2 (en) * | 2004-05-05 | 2005-11-17 | Merck & Co., Inc. | Morpholinyl piperidine glycine transporter inhibitors |
JP4646984B2 (ja) * | 2004-09-30 | 2011-03-09 | メルク・シャープ・エンド・ドーム・コーポレイション | シクロプロピルピペリジングリシン輸送体阻害剤 |
WO2006067529A1 (en) * | 2004-12-21 | 2006-06-29 | Merck Sharp & Dohme Limited | Piperidine and azetidine derivatives as glyt1 inhibitors |
PE20061490A1 (es) | 2005-06-06 | 2007-02-09 | Merck Sharp & Dohme | Derivados de ciclohexanosulfonilo como inhibidores del transportador de glicina glyt1 |
-
2006
- 2006-06-05 PE PE2006000608A patent/PE20061490A1/es not_active Application Discontinuation
- 2006-06-05 AR ARP060102342A patent/AR057350A1/es unknown
- 2006-06-05 WO PCT/GB2006/002052 patent/WO2006131713A1/en not_active Application Discontinuation
- 2006-06-05 DO DO2006000125A patent/DOP2006000125A/es unknown
- 2006-06-05 JP JP2008514201A patent/JP5281395B2/ja not_active Expired - Fee Related
- 2006-06-05 US US11/446,735 patent/US7626056B2/en active Active
- 2006-06-05 EP EP06744106A patent/EP1891002B1/en active Active
- 2006-06-05 EP EP06744089A patent/EP1893566B1/en active Active
- 2006-06-05 CA CA2609969A patent/CA2609969C/en not_active Expired - Fee Related
- 2006-06-05 WO PCT/GB2006/002035 patent/WO2006131711A1/en active Application Filing
- 2006-06-05 TW TW095119888A patent/TW200716531A/zh unknown
- 2006-06-05 AU AU2006256583A patent/AU2006256583B2/en not_active Ceased
-
2009
- 2009-10-01 US US12/571,904 patent/US7851638B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US7851638B2 (en) | 2010-12-14 |
JP2008542348A (ja) | 2008-11-27 |
EP1891002A1 (en) | 2008-02-27 |
AU2006256583A1 (en) | 2006-12-14 |
EP1893566B1 (en) | 2013-02-13 |
US20060276655A1 (en) | 2006-12-07 |
US20100029726A1 (en) | 2010-02-04 |
US7626056B2 (en) | 2009-12-01 |
TW200716531A (en) | 2007-05-01 |
EP1891002B1 (en) | 2012-05-30 |
WO2006131711A1 (en) | 2006-12-14 |
CA2609969C (en) | 2015-10-27 |
EP1893566A1 (en) | 2008-03-05 |
WO2006131713A1 (en) | 2006-12-14 |
CA2609969A1 (en) | 2006-12-14 |
AU2006256583B2 (en) | 2012-01-12 |
PE20061490A1 (es) | 2007-02-09 |
DOP2006000125A (es) | 2006-12-31 |
JP5281395B2 (ja) | 2013-09-04 |
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