CO6290763A2 - Derivados de benzamidas, carboxamidas y nicotinamidas como moduladores alostericos positivos y sus composiciones - Google Patents
Derivados de benzamidas, carboxamidas y nicotinamidas como moduladores alostericos positivos y sus composicionesInfo
- Publication number
- CO6290763A2 CO6290763A2 CO10101155A CO10101155A CO6290763A2 CO 6290763 A2 CO6290763 A2 CO 6290763A2 CO 10101155 A CO10101155 A CO 10101155A CO 10101155 A CO10101155 A CO 10101155A CO 6290763 A2 CO6290763 A2 CO 6290763A2
- Authority
- CO
- Colombia
- Prior art keywords
- methyl
- benzamide
- indol
- compositions
- indole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Nuevos derivados de amida que son PAM de receptores nicotínicos neuronales, composiciones que los comprenden, procesos para preparar dichos compuestos y métodos para usar dichos compuestos y dichas composiciones.1.- Un compuesto de fórmula (II), o una sal aceptacie farmacéuticamente, éster, amida o prodroga del mismo:donde R1 y R2 son en forma independiente hidrógeno o metilo, siempre que no sean ambos metilo;a es una unión simple o doble;X1 es N o CH;X2 es CH cuando a es una unión doble, y X2 es CH2 o-CH2CH2- cuenda a es una unión simple;X3 y X4 son en forma independiente N o CH;T1 y T2 son en forma independiente hidrógeno, arilo, cicloalquilo, halo, haloalquilo, o R3-L2-, donde al menos uno de T1 y T2 no es hidrógeno;L2 es O o S; yR3 es alquilo, arilo, cicloalquilo, o haloalquilo;donde el compuesto de fórmula (II) no es:3,4-difluoro-N-[(2-metil-1H-indol-5-iI)metil]benzamida;4-bromo-N-[(2-metil-1H-indol-5-il)metil]benzamida;4-cloro-N-[(2-metil-1H-indol-5-il)metil)benzamida;3,4-dietoxi-N-[(2-metil-1H-indol-5-il)metil]benzamida;3,4-dimetoxi-N-[(2-metil-1H-indol-5-il)metil]benzamida;4-butoxi-N-[(2metil-1H-indol-5-il)metil]benzamida;4-isopropoxi-N-[(2-metil-1H-indol-5-il)metil]benzamida;4-etoxi-N-[(2-metil-1H-indol-5-il)metil]benzamida;4-fluoro-N-[(2-metil-1H-indoI-5-il)metil]benzanida; o4-metoxi-N-[(2-metil-1H-indol-5-il)metil]benzamida.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2688608P | 2008-02-07 | 2008-02-07 | |
| US14362809P | 2009-01-09 | 2009-01-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6290763A2 true CO6290763A2 (es) | 2011-06-20 |
Family
ID=40952708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10101155A CO6290763A2 (es) | 2008-02-07 | 2010-08-18 | Derivados de benzamidas, carboxamidas y nicotinamidas como moduladores alostericos positivos y sus composiciones |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8536221B2 (es) |
| EP (1) | EP2250162B1 (es) |
| JP (1) | JP2011511800A (es) |
| KR (1) | KR20100124272A (es) |
| CN (1) | CN101990537A (es) |
| AU (1) | AU2009212259A1 (es) |
| BR (1) | BRPI0907492A2 (es) |
| CA (1) | CA2713519A1 (es) |
| CO (1) | CO6290763A2 (es) |
| CR (1) | CR11664A (es) |
| DO (1) | DOP2010000241A (es) |
| EC (1) | ECSP10010465A (es) |
| IL (1) | IL207332A0 (es) |
| MX (1) | MX2010008714A (es) |
| RU (1) | RU2010137114A (es) |
| WO (1) | WO2009100294A2 (es) |
| ZA (1) | ZA201005514B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007150010A2 (en) | 2006-06-23 | 2007-12-27 | Abbott Laboratories | Cyclopropyl amine derivatives as histamin h3 receptor modulators |
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| ES2392795T3 (es) * | 2008-04-17 | 2012-12-13 | Proximagen Limited | Indoles como moduladores del receptor nicotínico de acetilcolina de subtipo alfa-7 |
| KR20120089190A (ko) * | 2009-04-16 | 2012-08-09 | 프록시머겐 리미티드 | 알파 7 니코틴 아세틸콜린 수용체(ｎＡＣｈＲ)의 인돌 유도체 조절체 |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| TW201245185A (en) | 2011-04-01 | 2012-11-16 | Lundbeck & Co As H | New positive allosteric modulators of nicotinic acetylcholine receptor |
| AR086791A1 (es) | 2011-07-01 | 2014-01-22 | Lundbeck & Co As H | Moduladores alostericos positivos del receptor de acetilcolina nicotinico |
| WO2014049133A1 (en) * | 2012-09-28 | 2014-04-03 | H. Lundbeck A/S | New positive allosteric modulators of nicotinic acetylcholine receptor |
| US9422281B2 (en) | 2013-11-18 | 2016-08-23 | Forma Therapeutics, Inc. | Benzopiperazine compositions as BET bromodomain inhibitors |
| HUE053645T2 (hu) | 2013-11-18 | 2021-07-28 | Forma Therapeutics Inc | Tetrahidrokinolin kompozíciók mint BET bromodomén inhibitorok |
| JP6612874B2 (ja) | 2014-12-16 | 2019-11-27 | アクソファント サイエンシーズ ゲーエムベーハー | α７−ニコチン性アセチルコリン受容体のアゴニストとしてのジェミナル置換キヌクリジンアミド化合物 |
| RU2017145964A (ru) | 2015-06-10 | 2019-07-10 | Аксовант Сайенсиз Гмбх | Аминобензизоксазольные соединения в качестве агонистов α7-никотиновых ацетилхолиновых рецепторов |
| US10428062B2 (en) | 2015-08-12 | 2019-10-01 | Axovant Sciences Gmbh | Geminal substituted aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors |
| CN109153667B (zh) * | 2016-02-24 | 2021-04-02 | 阿塞西翁制药公司 | 新型钾通道抑制剂 |
| AR108586A1 (es) | 2016-06-10 | 2018-09-05 | Lilly Co Eli | Compuestos de 2,3-dihidro-1h-indol |
| CA3031173A1 (en) * | 2016-07-18 | 2018-01-25 | Insecticides (India) Limited | Novel benzylamide compound, method for producing the same, and miticide |
| WO2018051252A2 (en) * | 2016-09-15 | 2018-03-22 | Insecticides (India) Limited | Novel amide compound, method for producing the same, and miticide |
| HU231478B1 (hu) | 2018-07-13 | 2024-02-28 | Richter Gedeon Nyrt. | Szubsztituált (aza)indol származékok |
| HU231414B1 (hu) | 2018-07-13 | 2023-08-28 | Richter Gedeon Nyrt. | Tiadiazin származékok |
| HU231333B1 (hu) | 2018-07-13 | 2023-01-28 | Richter Gedeon Nyrt | Spirokromán származékok |
| US20210403469A1 (en) * | 2018-11-06 | 2021-12-30 | Merck Sharp & Dohme Corp. | Novel substituted tricyclic compounds as indoleamine 2,3-dioxygenase inhibitors |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3092946B2 (ja) | 1995-12-14 | 2000-09-25 | メルク エンド カンパニー インコーポレーテッド | ゴナドトロピン放出ホルモン拮抗剤 |
| GB9919411D0 (en) | 1999-08-18 | 1999-10-20 | Zeneca Ltd | Chemical compounds |
| US6306890B1 (en) | 1999-08-30 | 2001-10-23 | Vanderbilt University | Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors |
| SE9903997D0 (sv) * | 1999-11-03 | 1999-11-03 | Astra Ab | New compounds |
| DE10217006A1 (de) | 2002-04-16 | 2003-11-06 | Merck Patent Gmbh | Substituierte Indole |
| US7220741B2 (en) | 2002-09-30 | 2007-05-22 | Neurosearch A/S | 1,4-diazabicycloalkane derivatives, their preparation and use |
| BRPI0409241A (pt) * | 2003-04-10 | 2006-03-28 | Pfizer | compostos bicìclicos como antagonistas do receptor de nr2b, composições farmacêuticas compreendendo os mesmos e seu uso |
| US20050065178A1 (en) | 2003-09-19 | 2005-03-24 | Anwer Basha | Substituted diazabicycloakane derivatives |
| US20050245531A1 (en) | 2003-12-22 | 2005-11-03 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
| US20050137204A1 (en) | 2003-12-22 | 2005-06-23 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
| US20060106011A1 (en) | 2004-11-12 | 2006-05-18 | Bock Mark G | 2-(Bicyclo)alkylamino-derivatives as mediators of chronic pain and inflammation |
| WO2006060737A2 (en) | 2004-12-03 | 2006-06-08 | Takeda San Diego, Inc. | Mitotic kinesin inhibitors |
| NZ596024A (en) * | 2006-08-07 | 2013-07-26 | Ironwood Pharmaceuticals Inc | Indole compounds |
-
2009
- 2009-02-06 US US12/367,096 patent/US8536221B2/en active Active
- 2009-02-06 EP EP09707625.1A patent/EP2250162B1/en active Active
- 2009-02-06 JP JP2010546032A patent/JP2011511800A/ja not_active Withdrawn
- 2009-02-06 WO PCT/US2009/033329 patent/WO2009100294A2/en active Application Filing
- 2009-02-06 KR KR1020107019897A patent/KR20100124272A/ko not_active Application Discontinuation
- 2009-02-06 MX MX2010008714A patent/MX2010008714A/es not_active Application Discontinuation
- 2009-02-06 BR BRPI0907492A patent/BRPI0907492A2/pt not_active IP Right Cessation
- 2009-02-06 AU AU2009212259A patent/AU2009212259A1/en not_active Abandoned
- 2009-02-06 RU RU2010137114/04A patent/RU2010137114A/ru not_active Application Discontinuation
- 2009-02-06 CN CN2009801122272A patent/CN101990537A/zh active Pending
- 2009-02-06 CA CA2713519A patent/CA2713519A1/en not_active Abandoned
-
2010
- 2010-08-01 IL IL207332A patent/IL207332A0/en unknown
- 2010-08-02 ZA ZA2010/05514A patent/ZA201005514B/en unknown
- 2010-08-04 DO DO2010000241A patent/DOP2010000241A/es unknown
- 2010-08-18 CO CO10101155A patent/CO6290763A2/es not_active Application Discontinuation
- 2010-09-01 CR CR11664A patent/CR11664A/es not_active Application Discontinuation
- 2010-09-06 EC EC2010010465A patent/ECSP10010465A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP10010465A (es) | 2010-10-30 |
| WO2009100294A2 (en) | 2009-08-13 |
| BRPI0907492A2 (pt) | 2017-06-13 |
| WO2009100294A3 (en) | 2009-11-12 |
| JP2011511800A (ja) | 2011-04-14 |
| CA2713519A1 (en) | 2009-08-13 |
| CN101990537A (zh) | 2011-03-23 |
| DOP2010000241A (es) | 2010-08-31 |
| EP2250162A2 (en) | 2010-11-17 |
| KR20100124272A (ko) | 2010-11-26 |
| CR11664A (es) | 2011-01-06 |
| EP2250162B1 (en) | 2014-03-19 |
| RU2010137114A (ru) | 2012-03-20 |
| US8536221B2 (en) | 2013-09-17 |
| ZA201005514B (en) | 2012-01-25 |
| EP2250162A4 (en) | 2012-10-31 |
| IL207332A0 (en) | 2010-12-30 |
| MX2010008714A (es) | 2010-09-24 |
| US20090270408A1 (en) | 2009-10-29 |
| AU2009212259A1 (en) | 2009-08-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |