ECSP10010465A - Derivados de amida como moduladores alostéricos positivos y métodos para usarlos - Google Patents
Derivados de amida como moduladores alostéricos positivos y métodos para usarlosInfo
- Publication number
- ECSP10010465A ECSP10010465A EC2010010465A ECSP10010465A ECSP10010465A EC SP10010465 A ECSP10010465 A EC SP10010465A EC 2010010465 A EC2010010465 A EC 2010010465A EC SP10010465 A ECSP10010465 A EC SP10010465A EC SP10010465 A ECSP10010465 A EC SP10010465A
- Authority
- EC
- Ecuador
- Prior art keywords
- methods
- positive
- modulators
- derivatives
- amida
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Nuevos derivados de amida que son PAM de receptores nicotínicos neuronales, composiciones que los comprenden, procesos para preparar dichos compuestos y métodos para usar dichos compuestos y dichas composiciones.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2688608P | 2008-02-07 | 2008-02-07 | |
US14362809P | 2009-01-09 | 2009-01-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP10010465A true ECSP10010465A (es) | 2010-10-30 |
Family
ID=40952708
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2010010465A ECSP10010465A (es) | 2008-02-07 | 2010-09-06 | Derivados de amida como moduladores alostéricos positivos y métodos para usarlos |
Country Status (17)
Country | Link |
---|---|
US (1) | US8536221B2 (es) |
EP (1) | EP2250162B1 (es) |
JP (1) | JP2011511800A (es) |
KR (1) | KR20100124272A (es) |
CN (1) | CN101990537A (es) |
AU (1) | AU2009212259A1 (es) |
BR (1) | BRPI0907492A2 (es) |
CA (1) | CA2713519A1 (es) |
CO (1) | CO6290763A2 (es) |
CR (1) | CR11664A (es) |
DO (1) | DOP2010000241A (es) |
EC (1) | ECSP10010465A (es) |
IL (1) | IL207332A0 (es) |
MX (1) | MX2010008714A (es) |
RU (1) | RU2010137114A (es) |
WO (1) | WO2009100294A2 (es) |
ZA (1) | ZA201005514B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2007260836B2 (en) | 2006-06-23 | 2012-11-15 | Abbvie Bahamas Ltd. | Cyclopropyl amine derivatives as histamin H3 receptor modulators |
US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
US8377941B2 (en) * | 2008-04-17 | 2013-02-19 | Proximagen Limited | Indoles as modulators of nicotinic acetylcholine receptor subtype alpha-7 |
BRPI1014471A2 (pt) * | 2009-04-16 | 2016-04-05 | Proximagen Ltd | moduladores derivados de indol do receptor nicotínico alfa 7 de acetilcolina |
US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
TW201245185A (en) | 2011-04-01 | 2012-11-16 | Lundbeck & Co As H | New positive allosteric modulators of nicotinic acetylcholine receptor |
AR086791A1 (es) | 2011-07-01 | 2014-01-22 | Lundbeck & Co As H | Moduladores alostericos positivos del receptor de acetilcolina nicotinico |
WO2014049133A1 (en) * | 2012-09-28 | 2014-04-03 | H. Lundbeck A/S | New positive allosteric modulators of nicotinic acetylcholine receptor |
EP3071205B1 (en) | 2013-11-18 | 2020-02-05 | Forma Therapeutics, Inc. | Benzopiperazine compositions as bet bromodomain inhibitors |
WO2015074064A2 (en) | 2013-11-18 | 2015-05-21 | Bair Kenneth W | Tetrahydroquinoline compositions as bet bromodomain inhibitors |
ES2764660T3 (es) | 2014-12-16 | 2020-06-04 | Axovant Sciences Gmbh | Compuestos de amida de quinuclidina sustituida geminal como agonistas de receptores alfa-7 nicotínicos de acetilcolina |
AU2016274694A1 (en) | 2015-06-10 | 2018-01-18 | Axovant Sciences Gmbh | Aminobenzisoxazole compounds as agonists of A7-nicotinic acetylcholine receptors |
WO2017027600A1 (en) | 2015-08-12 | 2017-02-16 | Forum Pharmaceuticals, Inc. | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS |
US11274092B2 (en) * | 2016-02-24 | 2022-03-15 | Acesion Pharma Aps | Potassium channel inhibitors |
AR108586A1 (es) * | 2016-06-10 | 2018-09-05 | Lilly Co Eli | Compuestos de 2,3-dihidro-1h-indol |
CN109803956B (zh) * | 2016-07-18 | 2023-08-29 | 日本欧爱特农业科技株式会社 | 新颖的苯甲酰胺化合物、其制备方法及杀螨剂 |
WO2018051252A2 (en) * | 2016-09-15 | 2018-03-22 | Insecticides (India) Limited | Novel amide compound, method for producing the same, and miticide |
HU231333B1 (hu) | 2018-07-13 | 2023-01-28 | Richter Gedeon Nyrt | Spirokromán származékok |
HU231478B1 (hu) | 2018-07-13 | 2024-02-28 | Richter Gedeon Nyrt. | Szubsztituált (aza)indol származékok |
HU231414B1 (hu) | 2018-07-13 | 2023-08-28 | Richter Gedeon Nyrt. | Tiadiazin származékok |
WO2020096871A1 (en) * | 2018-11-06 | 2020-05-14 | Merck Sharp & Dohme Corp. | Novel substituted tricyclic compounds as indoleamine 2,3-dioxygenase inhibitors |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997021707A1 (en) | 1995-12-14 | 1997-06-19 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
GB9919411D0 (en) * | 1999-08-18 | 1999-10-20 | Zeneca Ltd | Chemical compounds |
US6306890B1 (en) | 1999-08-30 | 2001-10-23 | Vanderbilt University | Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors |
SE9903997D0 (sv) * | 1999-11-03 | 1999-11-03 | Astra Ab | New compounds |
DE10217006A1 (de) | 2002-04-16 | 2003-11-06 | Merck Patent Gmbh | Substituierte Indole |
ES2280836T3 (es) | 2002-09-30 | 2007-09-16 | Neurosearch A/S | Nuevos derivados de 1,4-diazabicicloalcano, su preparacion y uso. |
JP2006522794A (ja) | 2003-04-10 | 2006-10-05 | ファイザー株式会社 | Nr2b受容体拮抗物質としての二環系化合物 |
US20050065178A1 (en) | 2003-09-19 | 2005-03-24 | Anwer Basha | Substituted diazabicycloakane derivatives |
US20050137204A1 (en) | 2003-12-22 | 2005-06-23 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
US20050245531A1 (en) | 2003-12-22 | 2005-11-03 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
US20060106011A1 (en) | 2004-11-12 | 2006-05-18 | Bock Mark G | 2-(Bicyclo)alkylamino-derivatives as mediators of chronic pain and inflammation |
US20100093767A1 (en) | 2004-12-03 | 2010-04-15 | Takeda San Diego, Inc. | Mitotic Kinase Inhibitors |
EA018724B1 (ru) | 2006-08-07 | 2013-10-30 | Айронвуд Фармасьютикалз, Инк. | Соединения индола |
-
2009
- 2009-02-06 US US12/367,096 patent/US8536221B2/en active Active
- 2009-02-06 CA CA2713519A patent/CA2713519A1/en not_active Abandoned
- 2009-02-06 JP JP2010546032A patent/JP2011511800A/ja not_active Withdrawn
- 2009-02-06 AU AU2009212259A patent/AU2009212259A1/en not_active Abandoned
- 2009-02-06 KR KR1020107019897A patent/KR20100124272A/ko not_active Application Discontinuation
- 2009-02-06 WO PCT/US2009/033329 patent/WO2009100294A2/en active Application Filing
- 2009-02-06 CN CN2009801122272A patent/CN101990537A/zh active Pending
- 2009-02-06 EP EP09707625.1A patent/EP2250162B1/en active Active
- 2009-02-06 RU RU2010137114/04A patent/RU2010137114A/ru not_active Application Discontinuation
- 2009-02-06 MX MX2010008714A patent/MX2010008714A/es not_active Application Discontinuation
- 2009-02-06 BR BRPI0907492A patent/BRPI0907492A2/pt not_active IP Right Cessation
-
2010
- 2010-08-01 IL IL207332A patent/IL207332A0/en unknown
- 2010-08-02 ZA ZA2010/05514A patent/ZA201005514B/en unknown
- 2010-08-04 DO DO2010000241A patent/DOP2010000241A/es unknown
- 2010-08-18 CO CO10101155A patent/CO6290763A2/es not_active Application Discontinuation
- 2010-09-01 CR CR11664A patent/CR11664A/es not_active Application Discontinuation
- 2010-09-06 EC EC2010010465A patent/ECSP10010465A/es unknown
Also Published As
Publication number | Publication date |
---|---|
ZA201005514B (en) | 2012-01-25 |
CN101990537A (zh) | 2011-03-23 |
CO6290763A2 (es) | 2011-06-20 |
BRPI0907492A2 (pt) | 2017-06-13 |
EP2250162B1 (en) | 2014-03-19 |
EP2250162A2 (en) | 2010-11-17 |
CA2713519A1 (en) | 2009-08-13 |
KR20100124272A (ko) | 2010-11-26 |
IL207332A0 (en) | 2010-12-30 |
CR11664A (es) | 2011-01-06 |
RU2010137114A (ru) | 2012-03-20 |
JP2011511800A (ja) | 2011-04-14 |
WO2009100294A2 (en) | 2009-08-13 |
US20090270408A1 (en) | 2009-10-29 |
WO2009100294A3 (en) | 2009-11-12 |
EP2250162A4 (en) | 2012-10-31 |
DOP2010000241A (es) | 2010-08-31 |
US8536221B2 (en) | 2013-09-17 |
MX2010008714A (es) | 2010-09-24 |
AU2009212259A1 (en) | 2009-08-13 |
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