HRP20070194T3 - N-thiazol-2-yl-benzamide derivatives - Google Patents
N-thiazol-2-yl-benzamide derivativesInfo
- Publication number
- HRP20070194T3 HRP20070194T3 HR20070194T HRP20070194T HRP20070194T3 HR P20070194 T3 HRP20070194 T3 HR P20070194T3 HR 20070194 T HR20070194 T HR 20070194T HR P20070194 T HRP20070194 T HR P20070194T HR P20070194 T3 HRP20070194 T3 HR P20070194T3
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- alkoxy
- aryl
- alkylamino
- heteroaryl
- Prior art date
Links
- SCQBDADQAVXTMZ-UHFFFAOYSA-N n-(1,3-thiazol-2-yl)benzamide Chemical class C=1C=CC=CC=1C(=O)NC1=NC=CS1 SCQBDADQAVXTMZ-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 6
- -1 aryl-C1-6-alkoxy Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 125000006621 (C3-C8) cycloalkyl-(C1-C6) alkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 101150051188 Adora2a gene Proteins 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200301579 | 2003-10-27 | ||
| DKPA200400229 | 2004-02-13 | ||
| PCT/DK2004/000733 WO2005039572A1 (en) | 2003-10-27 | 2004-10-25 | N-thiazol-2-yl-benzamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20070194T3 true HRP20070194T3 (en) | 2007-06-30 |
Family
ID=34524309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20070194T HRP20070194T3 (en) | 2003-10-27 | 2007-05-07 | N-thiazol-2-yl-benzamide derivatives |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US20060154974A1 (xx) |
| EP (2) | EP1803455A1 (xx) |
| JP (1) | JP2007509083A (xx) |
| KR (1) | KR20060093726A (xx) |
| AR (1) | AR047621A1 (xx) |
| AT (1) | ATE354365T1 (xx) |
| AU (1) | AU2004283019A1 (xx) |
| BR (1) | BRPI0415661A (xx) |
| CA (1) | CA2542816A1 (xx) |
| CO (1) | CO5690582A2 (xx) |
| CY (1) | CY1106526T1 (xx) |
| DE (1) | DE602004004925T2 (xx) |
| DK (1) | DK1682129T3 (xx) |
| EA (2) | EA010790B1 (xx) |
| ES (1) | ES2279414T3 (xx) |
| HR (1) | HRP20070194T3 (xx) |
| IL (1) | IL175189A0 (xx) |
| IS (1) | IS8364A (xx) |
| ME (1) | MEP6708A (xx) |
| MX (1) | MXPA06004436A (xx) |
| NO (1) | NO20062417L (xx) |
| PL (1) | PL1682129T3 (xx) |
| PT (1) | PT1682129E (xx) |
| RS (1) | RS20060289A (xx) |
| SG (1) | SG147472A1 (xx) |
| SI (1) | SI1682129T1 (xx) |
| TW (1) | TW200524887A (xx) |
| WO (1) | WO2005039572A1 (xx) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060106040A1 (en) | 2002-12-19 | 2006-05-18 | Michael Grzelak | Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders |
| TW200524887A (en) * | 2003-10-27 | 2005-08-01 | Lundbeck & Co As H | N-thiazol-2-yl-benzamide derivatives |
| CA2581105A1 (en) | 2004-09-22 | 2006-03-30 | H. Lundbeck A/S | 2-acylaminothiazole derivatives |
| US7674912B2 (en) | 2005-04-25 | 2010-03-09 | H. Lundbeck A/S | Pro-drugs of N-thiazol-2-yl-benzamide derivatives |
| TW200720264A (en) * | 2005-04-25 | 2007-06-01 | Lundbeck & Co As H | Pro-drugs of n-thiazol-2-yl-benzamide derivatives |
| WO2006137527A1 (ja) | 2005-06-23 | 2006-12-28 | Kyowa Hakko Kogyo Co., Ltd. | チアゾール誘導体 |
| LT1921077T (lt) * | 2005-08-02 | 2017-09-25 | Kyowa Hakko Kirin Co., Ltd. | Agentas, skirtas miego sutrikimo gydymui ir (arba) prevencijai |
| ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
| EP2210891A1 (en) * | 2009-01-26 | 2010-07-28 | Domain Therapeutics | New adenosine receptor ligands and uses thereof |
| GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| RU2483722C1 (ru) * | 2012-05-22 | 2013-06-10 | Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" | Аминотиазольные производные усниновой кислоты как новые противотуберкулезные агенты |
| US9980973B2 (en) | 2012-10-19 | 2018-05-29 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| MY186311A (en) | 2013-12-20 | 2021-07-08 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE855120C (de) * | 1950-10-08 | 1953-01-05 | Schering Ag | Verfahren zur Herstellung von Aminosalicylsaeureamiden |
| JP2903339B2 (ja) * | 1990-10-12 | 1999-06-07 | 大日精化工業株式会社 | 電子写真感光体 |
| US6121301A (en) * | 1996-10-24 | 2000-09-19 | Zeria Pharmaceutical Co., Ltd. | Substituted benzoylaminothiazole derivatives and drugs containing the same |
| GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| GB0028383D0 (en) * | 2000-11-21 | 2001-01-03 | Novartis Ag | Organic compounds |
| WO2002059100A1 (fr) * | 2001-01-26 | 2002-08-01 | Shionogi & Co., Ltd. | Composes halogene ayant un agonisme envers le recepteur de thrombopoietine |
| US7429593B2 (en) * | 2001-09-14 | 2008-09-30 | Shionogi & Co., Ltd. | Utilities of amide compounds |
| US6624163B2 (en) * | 2001-11-29 | 2003-09-23 | Hoffman-La Roche Inc. | Benzothiazole derivatives |
| US6713499B2 (en) * | 2001-12-12 | 2004-03-30 | Hoffman-La Roche Inc. | 7-Amino-benzothiazole derivatives |
| TW200524887A (en) * | 2003-10-27 | 2005-08-01 | Lundbeck & Co As H | N-thiazol-2-yl-benzamide derivatives |
| SI3002283T1 (en) * | 2003-12-26 | 2018-06-29 | Kyowa Hakko Kirin Co., Ltd. | Thiazole derivatives |
| US7674912B2 (en) * | 2005-04-25 | 2010-03-09 | H. Lundbeck A/S | Pro-drugs of N-thiazol-2-yl-benzamide derivatives |
-
2004
- 2004-10-08 TW TW093130498A patent/TW200524887A/zh unknown
- 2004-10-21 AR ARP040103822A patent/AR047621A1/es not_active Application Discontinuation
- 2004-10-25 SI SI200430225T patent/SI1682129T1/sl unknown
- 2004-10-25 CA CA002542816A patent/CA2542816A1/en not_active Abandoned
- 2004-10-25 EA EA200600860A patent/EA010790B1/ru not_active IP Right Cessation
- 2004-10-25 PL PL04762951T patent/PL1682129T3/pl unknown
- 2004-10-25 MX MXPA06004436A patent/MXPA06004436A/es active IP Right Grant
- 2004-10-25 AU AU2004283019A patent/AU2004283019A1/en not_active Abandoned
- 2004-10-25 WO PCT/DK2004/000733 patent/WO2005039572A1/en active IP Right Grant
- 2004-10-25 EP EP07102639A patent/EP1803455A1/en not_active Withdrawn
- 2004-10-25 BR BRPI0415661-7A patent/BRPI0415661A/pt not_active IP Right Cessation
- 2004-10-25 JP JP2006535952A patent/JP2007509083A/ja not_active Withdrawn
- 2004-10-25 ES ES04762951T patent/ES2279414T3/es active Active
- 2004-10-25 PT PT04762951T patent/PT1682129E/pt unknown
- 2004-10-25 RS YUP-2006/0289A patent/RS20060289A/sr unknown
- 2004-10-25 SG SG200807988-1A patent/SG147472A1/en unknown
- 2004-10-25 KR KR1020067008181A patent/KR20060093726A/ko not_active Application Discontinuation
- 2004-10-25 EP EP04762951A patent/EP1682129B1/en active Active
- 2004-10-25 EA EA200801734A patent/EA200801734A1/ru unknown
- 2004-10-25 ME MEP-67/08A patent/MEP6708A/xx unknown
- 2004-10-25 AT AT04762951T patent/ATE354365T1/de not_active IP Right Cessation
- 2004-10-25 DE DE602004004925T patent/DE602004004925T2/de not_active Expired - Fee Related
- 2004-10-25 DK DK04762951T patent/DK1682129T3/da active
-
2005
- 2005-12-20 US US11/312,661 patent/US20060154974A1/en not_active Abandoned
-
2006
- 2006-03-20 IS IS8364A patent/IS8364A/is unknown
- 2006-04-25 CO CO06039105A patent/CO5690582A2/es not_active Application Discontinuation
- 2006-04-25 IL IL175189A patent/IL175189A0/en unknown
- 2006-05-26 NO NO20062417A patent/NO20062417L/no not_active Application Discontinuation
-
2007
- 2007-04-19 CY CY20071100529T patent/CY1106526T1/el unknown
- 2007-05-07 HR HR20070194T patent/HRP20070194T3/xx unknown
-
2008
- 2008-12-19 US US12/339,438 patent/US20090247593A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2279414T3 (es) | 2007-08-16 |
| BRPI0415661A (pt) | 2006-12-19 |
| AR047621A1 (es) | 2006-02-01 |
| SI1682129T1 (sl) | 2007-06-30 |
| EP1682129B1 (en) | 2007-02-21 |
| PL1682129T3 (pl) | 2007-07-31 |
| KR20060093726A (ko) | 2006-08-25 |
| MEP6708A (xx) | 2010-02-10 |
| TW200524887A (en) | 2005-08-01 |
| EA200801734A1 (ru) | 2008-12-30 |
| US20090247593A1 (en) | 2009-10-01 |
| DK1682129T3 (da) | 2007-06-11 |
| WO2005039572A1 (en) | 2005-05-06 |
| ATE354365T1 (de) | 2007-03-15 |
| MXPA06004436A (es) | 2006-06-20 |
| IS8364A (is) | 2006-03-20 |
| AU2004283019A1 (en) | 2005-05-06 |
| DE602004004925T2 (de) | 2007-10-31 |
| IL175189A0 (en) | 2006-09-05 |
| RS20060289A (xx) | 2008-06-05 |
| EP1803455A1 (en) | 2007-07-04 |
| US20060154974A1 (en) | 2006-07-13 |
| CA2542816A1 (en) | 2005-05-06 |
| SG147472A1 (en) | 2008-11-28 |
| EA010790B1 (ru) | 2008-10-30 |
| DE602004004925D1 (de) | 2007-04-05 |
| CY1106526T1 (el) | 2012-01-25 |
| EP1682129A1 (en) | 2006-07-26 |
| EA200600860A1 (ru) | 2006-08-25 |
| PT1682129E (pt) | 2007-04-30 |
| JP2007509083A (ja) | 2007-04-12 |
| CO5690582A2 (es) | 2006-10-31 |
| NO20062417L (no) | 2006-05-26 |
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