EA200801734A1 - Производные n-тиазол-2-илбензамида - Google Patents

Производные n-тиазол-2-илбензамида

Info

Publication number
EA200801734A1
EA200801734A1 EA200801734A EA200801734A EA200801734A1 EA 200801734 A1 EA200801734 A1 EA 200801734A1 EA 200801734 A EA200801734 A EA 200801734A EA 200801734 A EA200801734 A EA 200801734A EA 200801734 A1 EA200801734 A1 EA 200801734A1
Authority
EA
Eurasian Patent Office
Prior art keywords
thiazol
ilbenzamide
derivatives
agonists
receptor
Prior art date
Application number
EA200801734A
Other languages
English (en)
Inventor
Аннете Гравен Самс
Могенс Ларсен
Гитте Миккельсен
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA200801734A1 publication Critical patent/EA200801734A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к производным N-тиазол-2-илбензамида формулы I, переменные в которой определены в формуле изобретения. Соединения являются лигандами рецептора A, такими как антагонисты, агонисты, обратные агонисты или частичные агонисты, и полезны при лечении неврологических и психиатрических расстройств, в которые вовлечен рецептор A.
EA200801734A 2003-10-27 2004-10-25 Производные n-тиазол-2-илбензамида EA200801734A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200301579 2003-10-27
DKPA200400229 2004-02-13

Publications (1)

Publication Number Publication Date
EA200801734A1 true EA200801734A1 (ru) 2008-12-30

Family

ID=34524309

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200600860A EA010790B1 (ru) 2003-10-27 2004-10-25 Производные n-тиазол-2-илбензамида
EA200801734A EA200801734A1 (ru) 2003-10-27 2004-10-25 Производные n-тиазол-2-илбензамида

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200600860A EA010790B1 (ru) 2003-10-27 2004-10-25 Производные n-тиазол-2-илбензамида

Country Status (28)

Country Link
US (2) US20060154974A1 (ru)
EP (2) EP1803455A1 (ru)
JP (1) JP2007509083A (ru)
KR (1) KR20060093726A (ru)
AR (1) AR047621A1 (ru)
AT (1) ATE354365T1 (ru)
AU (1) AU2004283019A1 (ru)
BR (1) BRPI0415661A (ru)
CA (1) CA2542816A1 (ru)
CO (1) CO5690582A2 (ru)
CY (1) CY1106526T1 (ru)
DE (1) DE602004004925T2 (ru)
DK (1) DK1682129T3 (ru)
EA (2) EA010790B1 (ru)
ES (1) ES2279414T3 (ru)
HR (1) HRP20070194T3 (ru)
IL (1) IL175189A0 (ru)
IS (1) IS8364A (ru)
ME (1) MEP6708A (ru)
MX (1) MXPA06004436A (ru)
NO (1) NO20062417L (ru)
PL (1) PL1682129T3 (ru)
PT (1) PT1682129E (ru)
RS (1) RS20060289A (ru)
SG (1) SG147472A1 (ru)
SI (1) SI1682129T1 (ru)
TW (1) TW200524887A (ru)
WO (1) WO2005039572A1 (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060106040A1 (en) 2002-12-19 2006-05-18 Michael Grzelak Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
TW200524887A (en) * 2003-10-27 2005-08-01 Lundbeck & Co As H N-thiazol-2-yl-benzamide derivatives
WO2006032273A1 (en) 2004-09-22 2006-03-30 H. Lundbeck A/S 2-acylaminothiazole derivatives
TW200720264A (en) * 2005-04-25 2007-06-01 Lundbeck & Co As H Pro-drugs of n-thiazol-2-yl-benzamide derivatives
US7674912B2 (en) 2005-04-25 2010-03-09 H. Lundbeck A/S Pro-drugs of N-thiazol-2-yl-benzamide derivatives
EP1894930A4 (en) * 2005-06-23 2010-06-23 Kyowa Hakko Kirin Co Ltd THIAZOLE DERIVATIVE
PL1921077T3 (pl) * 2005-08-02 2018-01-31 Kyowa Hakko Kirin Co Ltd Środek do zapobiegania i/lub leczenia zaburzenia snu
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
EP2210891A1 (en) * 2009-01-26 2010-07-28 Domain Therapeutics New adenosine receptor ligands and uses thereof
GB201106817D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compound
RU2483722C1 (ru) * 2012-05-22 2013-06-10 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Аминотиазольные производные усниновой кислоты как новые противотуберкулезные агенты
GB201218850D0 (en) 2012-10-19 2012-12-05 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
GB201218862D0 (en) 2012-10-19 2012-12-05 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
GB201218864D0 (en) 2012-10-19 2012-12-05 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
US9980973B2 (en) 2012-10-19 2018-05-29 Astex Therapeutics Limited Bicyclic heterocycle compounds and their uses in therapy
AU2014369446C1 (en) 2013-12-20 2020-03-12 Astex Therapeutics Limited Bicyclic heterocycle compounds and their uses in therapy

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE855120C (de) * 1950-10-08 1953-01-05 Schering Ag Verfahren zur Herstellung von Aminosalicylsaeureamiden
JP2903339B2 (ja) * 1990-10-12 1999-06-07 大日精化工業株式会社 電子写真感光体
CA2269531C (en) * 1996-10-24 2006-03-14 Zeria Pharmaceutical Co., Ltd. Substituted benzoylaminothiazole derivatives and drugs containing the same
GB9823871D0 (en) * 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
GB0028383D0 (en) * 2000-11-21 2001-01-03 Novartis Ag Organic compounds
US20040063764A1 (en) * 2001-01-26 2004-04-01 Hiroshi Takemoto Halogen compounds having thrombopoietin receptor agonism
US7429593B2 (en) * 2001-09-14 2008-09-30 Shionogi & Co., Ltd. Utilities of amide compounds
US6624163B2 (en) * 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
US6713499B2 (en) * 2001-12-12 2004-03-30 Hoffman-La Roche Inc. 7-Amino-benzothiazole derivatives
TW200524887A (en) * 2003-10-27 2005-08-01 Lundbeck & Co As H N-thiazol-2-yl-benzamide derivatives
CN1902196B (zh) * 2003-12-26 2010-12-29 协和发酵麒麟株式会社 噻唑衍生物
US7674912B2 (en) * 2005-04-25 2010-03-09 H. Lundbeck A/S Pro-drugs of N-thiazol-2-yl-benzamide derivatives

Also Published As

Publication number Publication date
US20090247593A1 (en) 2009-10-01
ES2279414T3 (es) 2007-08-16
PT1682129E (pt) 2007-04-30
JP2007509083A (ja) 2007-04-12
MXPA06004436A (es) 2006-06-20
SI1682129T1 (sl) 2007-06-30
KR20060093726A (ko) 2006-08-25
MEP6708A (xx) 2010-02-10
NO20062417L (no) 2006-05-26
EP1803455A1 (en) 2007-07-04
EA010790B1 (ru) 2008-10-30
PL1682129T3 (pl) 2007-07-31
WO2005039572A1 (en) 2005-05-06
EP1682129A1 (en) 2006-07-26
EP1682129B1 (en) 2007-02-21
CY1106526T1 (el) 2012-01-25
US20060154974A1 (en) 2006-07-13
RS20060289A (en) 2008-06-05
AR047621A1 (es) 2006-02-01
DE602004004925D1 (de) 2007-04-05
SG147472A1 (en) 2008-11-28
DK1682129T3 (da) 2007-06-11
TW200524887A (en) 2005-08-01
IS8364A (is) 2006-03-20
HRP20070194T3 (en) 2007-06-30
EA200600860A1 (ru) 2006-08-25
ATE354365T1 (de) 2007-03-15
CA2542816A1 (en) 2005-05-06
CO5690582A2 (es) 2006-10-31
IL175189A0 (en) 2006-09-05
DE602004004925T2 (de) 2007-10-31
BRPI0415661A (pt) 2006-12-19
AU2004283019A1 (en) 2005-05-06

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