HRP20070063T3 - PROCESS FOR PREPARING SUBSTITUTED 5-AMINO-PYRAZOLO- [4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINES - Google Patents
PROCESS FOR PREPARING SUBSTITUTED 5-AMINO-PYRAZOLO- [4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINESInfo
- Publication number
- HRP20070063T3 HRP20070063T3 HR20070063T HRP20070063T HRP20070063T3 HR P20070063 T3 HRP20070063 T3 HR P20070063T3 HR 20070063 T HR20070063 T HR 20070063T HR P20070063 T HRP20070063 T HR P20070063T HR P20070063 T3 HRP20070063 T3 HR P20070063T3
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- alkoxy
- formula
- compound
- group
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 12
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 6
- -1 -CF 3 Chemical class 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005085 alkoxycarbonylalkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000005111 carboxyalkoxy group Chemical group 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 150000001913 cyanates Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 abstract 1
- 125000004984 dialkylaminoalkoxy group Chemical group 0.000 abstract 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- JMANVNJQNLATNU-UHFFFAOYSA-N glycolonitrile Natural products N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51505103P | 2003-10-28 | 2003-10-28 | |
| PCT/US2004/035472 WO2005044819A1 (en) | 2003-10-28 | 2004-10-26 | Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20070063T3 true HRP20070063T3 (en) | 2007-04-30 |
Family
ID=34572798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20070063T HRP20070063T3 (en) | 2003-10-28 | 2007-02-19 | PROCESS FOR PREPARING SUBSTITUTED 5-AMINO-PYRAZOLO- [4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINES |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US7223861B2 (xx) |
| EP (1) | EP1678182B1 (xx) |
| JP (2) | JP4782693B2 (xx) |
| CN (2) | CN1898246B (xx) |
| AR (1) | AR046560A1 (xx) |
| AT (1) | ATE353331T1 (xx) |
| CA (1) | CA2543431A1 (xx) |
| CY (1) | CY1106393T1 (xx) |
| DE (1) | DE602004004677T2 (xx) |
| DK (1) | DK1678182T3 (xx) |
| ES (1) | ES2278353T3 (xx) |
| HK (1) | HK1086008A1 (xx) |
| HR (1) | HRP20070063T3 (xx) |
| MX (1) | MXPA06004722A (xx) |
| PL (1) | PL1678182T3 (xx) |
| PT (1) | PT1678182E (xx) |
| SI (1) | SI1678182T1 (xx) |
| WO (1) | WO2005044819A1 (xx) |
| ZA (1) | ZA200603307B (xx) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2237576T3 (es) * | 2000-05-26 | 2005-08-01 | Schering Corporation | Antagonistas del receptor a2a de adenosina. |
| PL1678182T3 (pl) * | 2003-10-28 | 2007-05-31 | Schering Corp | Sposób wytwarzania podstawionych 5-aminopirazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pirymidyn |
| US7851478B2 (en) * | 2005-06-07 | 2010-12-14 | Kyowa Hakko Kirin Co., Ltd. | Agent for preventing and/or treating movement disorder |
| WO2011017299A2 (en) | 2009-08-07 | 2011-02-10 | Schering Corporation | PROCESS FOR PREPARING A 2-ALKYNYL SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE |
| US20110144049A1 (en) * | 2009-10-21 | 2011-06-16 | Serebruany Victor L | Treating Cardiac Arrhythmias, Heart Failure, Peripheral Artery Disease and Stroke with Cyclopentyl-Triazolo-Pyrimidine or Derivative Thereof |
| WO2013024474A1 (en) * | 2011-08-18 | 2013-02-21 | Mapi Phrarma Ltd. | Polymorphs of preladenant |
| WO2013168196A1 (ja) | 2012-05-10 | 2013-11-14 | ユニテクノ株式会社 | 半導体搬送テスト治具 |
| EP3197875B1 (en) * | 2014-09-26 | 2019-08-14 | F.Hoffmann-La Roche Ag | Processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds |
| EA202191498A1 (ru) | 2018-11-30 | 2021-08-20 | Мерк Шарп энд Доум Корп. | 9-замещенные производные аминотриазолохиназолина в качестве антагонистов аденозиновых рецепторов, фармацевтические композиции и их применение |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4039733A1 (de) * | 1990-12-13 | 1992-06-17 | Basf Ag | Substituierte 5-aminopyrazole |
| IT1264901B1 (it) | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
| US6448253B1 (en) * | 1998-09-16 | 2002-09-10 | King Pharmaceuticals Research And Development, Inc. | Adenosine A3 receptor modulators |
| ES2237576T3 (es) * | 2000-05-26 | 2005-08-01 | Schering Corporation | Antagonistas del receptor a2a de adenosina. |
| CA2437437A1 (en) * | 2001-02-05 | 2002-08-15 | Yasuhisa Kurogi | Triazoloquinazoline and pyrazolotriazolopyrimidine derivatives, pharmaceutical, composition adenosine a3 receptor affinitive agent, intraocular-pressure reducing agent, pharmaceutical preparation for prevention and treatment of glaucoma, and intraocular-pressure reducing method |
| US7179801B2 (en) * | 2001-05-01 | 2007-02-20 | Astellas Pharma Inc. | Cephem compounds |
| JP4284182B2 (ja) * | 2001-11-30 | 2009-06-24 | シェーリング コーポレイション | アデノシンＡ２ａレセプターアンタゴニスト |
| PL1678182T3 (pl) * | 2003-10-28 | 2007-05-31 | Schering Corp | Sposób wytwarzania podstawionych 5-aminopirazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pirymidyn |
| DE602004009962T2 (de) * | 2003-12-01 | 2008-08-28 | Schering Corp. | Verfahren zur herstellung von substituierten 5-aminopyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidinen |
-
2004
- 2004-10-26 PL PL04796445T patent/PL1678182T3/pl unknown
- 2004-10-26 PT PT04796445T patent/PT1678182E/pt unknown
- 2004-10-26 ES ES04796445T patent/ES2278353T3/es not_active Expired - Lifetime
- 2004-10-26 WO PCT/US2004/035472 patent/WO2005044819A1/en active IP Right Grant
- 2004-10-26 US US10/973,631 patent/US7223861B2/en active Active
- 2004-10-26 EP EP04796445A patent/EP1678182B1/en not_active Expired - Lifetime
- 2004-10-26 MX MXPA06004722A patent/MXPA06004722A/es active IP Right Grant
- 2004-10-26 JP JP2006538174A patent/JP4782693B2/ja not_active Expired - Fee Related
- 2004-10-26 DE DE602004004677T patent/DE602004004677T2/de not_active Expired - Lifetime
- 2004-10-26 DK DK04796445T patent/DK1678182T3/da active
- 2004-10-26 CN CN200480039044XA patent/CN1898246B/zh not_active Expired - Fee Related
- 2004-10-26 SI SI200430198T patent/SI1678182T1/sl unknown
- 2004-10-26 AT AT04796445T patent/ATE353331T1/de active
- 2004-10-26 CA CA002543431A patent/CA2543431A1/en not_active Abandoned
- 2004-10-26 CN CN2010101611983A patent/CN101899050A/zh active Pending
- 2004-10-27 AR ARP040103912A patent/AR046560A1/es not_active Application Discontinuation
-
2006
- 2006-04-25 ZA ZA200603307A patent/ZA200603307B/en unknown
- 2006-07-20 HK HK06108129A patent/HK1086008A1/xx not_active IP Right Cessation
-
2007
- 2007-02-19 HR HR20070063T patent/HRP20070063T3/xx unknown
- 2007-03-16 CY CY20071100375T patent/CY1106393T1/el unknown
- 2007-04-20 US US11/788,682 patent/US7439361B2/en not_active Expired - Lifetime
-
2008
- 2008-09-11 US US12/208,717 patent/US7601833B2/en not_active Expired - Lifetime
-
2009
- 2009-09-02 US US12/552,765 patent/US20090326241A1/en not_active Abandoned
-
2011
- 2011-03-22 JP JP2011063381A patent/JP2011116795A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06004722A (es) | 2006-07-05 |
| JP4782693B2 (ja) | 2011-09-28 |
| EP1678182B1 (en) | 2007-02-07 |
| WO2005044819A1 (en) | 2005-05-19 |
| CA2543431A1 (en) | 2005-05-19 |
| US7601833B2 (en) | 2009-10-13 |
| US20070203340A1 (en) | 2007-08-30 |
| US20050090492A1 (en) | 2005-04-28 |
| AR046560A1 (es) | 2005-12-14 |
| US20090005559A1 (en) | 2009-01-01 |
| SI1678182T1 (sl) | 2007-06-30 |
| DE602004004677T2 (de) | 2007-11-15 |
| EP1678182A1 (en) | 2006-07-12 |
| CN101899050A (zh) | 2010-12-01 |
| PL1678182T3 (pl) | 2007-05-31 |
| CN1898246B (zh) | 2010-10-27 |
| JP2011116795A (ja) | 2011-06-16 |
| ZA200603307B (en) | 2008-07-30 |
| DK1678182T3 (da) | 2007-06-04 |
| CY1106393T1 (el) | 2011-10-12 |
| US7439361B2 (en) | 2008-10-21 |
| CN1898246A (zh) | 2007-01-17 |
| JP2007509948A (ja) | 2007-04-19 |
| ATE353331T1 (de) | 2007-02-15 |
| DE602004004677D1 (de) | 2007-03-22 |
| ES2278353T3 (es) | 2007-08-01 |
| PT1678182E (pt) | 2007-04-30 |
| US20090326241A1 (en) | 2009-12-31 |
| HK1086008A1 (en) | 2006-09-08 |
| US7223861B2 (en) | 2007-05-29 |
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