CY1106393T1 - Μεθοδος παρασκευης υποκατεστημενων 5-αμινο-πυραζολο [4,3-ε]-1,2,4-τριαζολο [1,5-c]πυριμιδινων - Google Patents

Μεθοδος παρασκευης υποκατεστημενων 5-αμινο-πυραζολο [4,3-ε]-1,2,4-τριαζολο [1,5-c]πυριμιδινων

Info

Publication number
CY1106393T1
CY1106393T1 CY20071100375T CY071100375T CY1106393T1 CY 1106393 T1 CY1106393 T1 CY 1106393T1 CY 20071100375 T CY20071100375 T CY 20071100375T CY 071100375 T CY071100375 T CY 071100375T CY 1106393 T1 CY1106393 T1 CY 1106393T1
Authority
CY
Cyprus
Prior art keywords
pyrimidines
amino
substituted
pyrazole
triazole
Prior art date
Application number
CY20071100375T
Other languages
English (en)
Inventor
Shen-Chun Kuo
David Jieh-Shyh Tsai
Loc Thanh Tran
Pengyi Zhang
Andrew D. Jones
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of CY1106393T1 publication Critical patent/CY1106393T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Αποκαλύπτεται μια μέθοδος για την παρασκευή ενώσεων υποκατεστημένων 5-αμινο-πυραζολο [4,3-e]-1,2,4-τριαζολο- [1,5-c] πυριμιδινών που έχουν ένα υποκαταστάτη αμινοαλκυλίου στην 7-θέση, όπου ο δακτύλιος πυριμιδίνης κυκλοποιείται με χρήση ενός μέσου κυάνωσης.
CY20071100375T 2003-10-28 2007-03-16 Μεθοδος παρασκευης υποκατεστημενων 5-αμινο-πυραζολο [4,3-ε]-1,2,4-τριαζολο [1,5-c]πυριμιδινων CY1106393T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51505103P 2003-10-28 2003-10-28
PCT/US2004/035472 WO2005044819A1 (en) 2003-10-28 2004-10-26 Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines

Publications (1)

Publication Number Publication Date
CY1106393T1 true CY1106393T1 (el) 2011-10-12

Family

ID=34572798

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100375T CY1106393T1 (el) 2003-10-28 2007-03-16 Μεθοδος παρασκευης υποκατεστημενων 5-αμινο-πυραζολο [4,3-ε]-1,2,4-τριαζολο [1,5-c]πυριμιδινων

Country Status (19)

Country Link
US (4) US7223861B2 (el)
EP (1) EP1678182B1 (el)
JP (2) JP4782693B2 (el)
CN (2) CN1898246B (el)
AR (1) AR046560A1 (el)
AT (1) ATE353331T1 (el)
CA (1) CA2543431A1 (el)
CY (1) CY1106393T1 (el)
DE (1) DE602004004677T2 (el)
DK (1) DK1678182T3 (el)
ES (1) ES2278353T3 (el)
HK (1) HK1086008A1 (el)
HR (1) HRP20070063T3 (el)
MX (1) MXPA06004722A (el)
PL (1) PL1678182T3 (el)
PT (1) PT1678182E (el)
SI (1) SI1678182T1 (el)
WO (1) WO2005044819A1 (el)
ZA (1) ZA200603307B (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY132006A (en) * 2000-05-26 2007-09-28 Schering Corp ADENOSINE A2a RECEPTOR ANTAGONISTS
PT1678182E (pt) * 2003-10-28 2007-04-30 Schering Corp Processo para preparar 5-amino-pirazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pirimidinas
EP1902716A4 (en) * 2005-06-07 2009-05-13 Kyowa Hakko Kirin Co Ltd PROPHYLACTIC AND / OR THERAPEUTIC AGENT FOR MOTOR TROUBLESHOOTING
US8598343B2 (en) * 2009-08-07 2013-12-03 Merck Sharp & Dohme Corp. Process for preparing a 2-alkynyl substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
US20110144049A1 (en) * 2009-10-21 2011-06-16 Serebruany Victor L Treating Cardiac Arrhythmias, Heart Failure, Peripheral Artery Disease and Stroke with Cyclopentyl-Triazolo-Pyrimidine or Derivative Thereof
WO2013024474A1 (en) * 2011-08-18 2013-02-21 Mapi Phrarma Ltd. Polymorphs of preladenant
WO2013168196A1 (ja) 2012-05-10 2013-11-14 ユニテクノ株式会社 半導体搬送テスト治具
BR112017005931B1 (pt) * 2014-09-26 2024-04-30 F. Hoffmann-La Roche Ag Processos para preparar um composto de ciclopentil[d]pirimidin-4-il) piperazina e composto de ciclopentil[d]pirimidin-4-il)piperazina
EA202191498A1 (ru) 2018-11-30 2021-08-20 Мерк Шарп энд Доум Корп. 9-замещенные производные аминотриазолохиназолина в качестве антагонистов аденозиновых рецепторов, фармацевтические композиции и их применение

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4039733A1 (de) * 1990-12-13 1992-06-17 Basf Ag Substituierte 5-aminopyrazole
IT1264901B1 (it) 1993-06-29 1996-10-17 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
US6448253B1 (en) * 1998-09-16 2002-09-10 King Pharmaceuticals Research And Development, Inc. Adenosine A3 receptor modulators
MY132006A (en) * 2000-05-26 2007-09-28 Schering Corp ADENOSINE A2a RECEPTOR ANTAGONISTS
WO2002062801A1 (fr) * 2001-02-05 2002-08-15 Otsuka Pharmaceutical Factory, Inc. Derives de triazoloquinazoline et de pyrazolotriazolopyrimidine, compositions pharmaceutiques, agents presentant une affinite pour le recepteur de l'adenosine a3, agents de reduction de la tension oculaire, preparations pour prevenir et traiter un glaucome et methode pour reduire la tension oculaire
KR20030090794A (ko) * 2001-05-01 2003-11-28 후지사와 야꾸힝 고교 가부시키가이샤 세펨 화합물
EP1448565B1 (en) * 2001-11-30 2009-12-30 Schering Corporation ADENOSINE A2a RECEPTOR ANTAGONISTS
PT1678182E (pt) * 2003-10-28 2007-04-30 Schering Corp Processo para preparar 5-amino-pirazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pirimidinas
EP1689749B1 (en) * 2003-12-01 2007-11-07 Schering Corporation Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines

Also Published As

Publication number Publication date
US7601833B2 (en) 2009-10-13
US20090326241A1 (en) 2009-12-31
US7223861B2 (en) 2007-05-29
SI1678182T1 (sl) 2007-06-30
WO2005044819A1 (en) 2005-05-19
JP4782693B2 (ja) 2011-09-28
DK1678182T3 (da) 2007-06-04
PT1678182E (pt) 2007-04-30
ZA200603307B (en) 2008-07-30
DE602004004677T2 (de) 2007-11-15
US20050090492A1 (en) 2005-04-28
JP2007509948A (ja) 2007-04-19
CN101899050A (zh) 2010-12-01
US20090005559A1 (en) 2009-01-01
CN1898246B (zh) 2010-10-27
MXPA06004722A (es) 2006-07-05
CA2543431A1 (en) 2005-05-19
ES2278353T3 (es) 2007-08-01
HK1086008A1 (en) 2006-09-08
JP2011116795A (ja) 2011-06-16
US20070203340A1 (en) 2007-08-30
HRP20070063T3 (en) 2007-04-30
ATE353331T1 (de) 2007-02-15
US7439361B2 (en) 2008-10-21
CN1898246A (zh) 2007-01-17
PL1678182T3 (pl) 2007-05-31
EP1678182A1 (en) 2006-07-12
DE602004004677D1 (de) 2007-03-22
AR046560A1 (es) 2005-12-14
EP1678182B1 (en) 2007-02-07

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