ES8703409A1 - Un metodo para preparar un derivado de urea sustituido con aminoalquilo - Google Patents

Un metodo para preparar un derivado de urea sustituido con aminoalquilo

Info

Publication number
ES8703409A1
ES8703409A1 ES550744A ES550744A ES8703409A1 ES 8703409 A1 ES8703409 A1 ES 8703409A1 ES 550744 A ES550744 A ES 550744A ES 550744 A ES550744 A ES 550744A ES 8703409 A1 ES8703409 A1 ES 8703409A1
Authority
ES
Spain
Prior art keywords
groups
formula
acid addition
addition salts
urea derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES550744A
Other languages
English (en)
Other versions
ES550744A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of ES8703409A1 publication Critical patent/ES8703409A1/es
Publication of ES550744A0 publication Critical patent/ES550744A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN DERIVADO DE UREA. CONSISTENTE EN: HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN CIANATO DE METAL ALCALINO, PREFERENTEMENTE CIANATO POTASICO, EN MEDIO ACUOSO O EN AGUA MEZCLADA CON ALCOHOL INFERIOR, A TEMPERATURA AMBIENTE Y A REACCION NEUTRA, PARA OBTENER LOS COMPUESTOS DE FORMULA (I). SIENDO: X E Y, IGUALES O DIFERENTES, UN GRUPO FENILO, OPCIONALMENTE SUSTITUIDO CON UNO O DOS GRUPOS ELEGIDOS ENTRE HALOGENO, CF3, OH O ALCOXI; RK Y RE, IGUALES O DIFERENTES, SON GRUPOS ALQUILO INFERIOR DE 1 A 4 C, O FORMAN JUNTO CON EL ATOMO DE NITROGENO UN ANILLO HETEROCICLICO SATURADO DE 1 A 4 C; R3 Y R4 SON INDEPENDIENTEMENTE H, GRUPOS ALQUILO O ALQUENILO DE 1 A 6 C, CICLOPENTILO O CICLOHEXILO; Y N ES 0 O 1. UTILIZABLES POR SU ACTIVIDAD ANTINEOPLASTICA.
ES550744A 1985-01-10 1986-01-09 Un metodo para preparar un derivado de urea sustituido con aminoalquilo Expired ES8703409A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858500615A GB8500615D0 (en) 1985-01-10 1985-01-10 Organic compounds

Publications (2)

Publication Number Publication Date
ES8703409A1 true ES8703409A1 (es) 1987-02-16
ES550744A0 ES550744A0 (es) 1987-02-16

Family

ID=10572663

Family Applications (1)

Application Number Title Priority Date Filing Date
ES550744A Expired ES8703409A1 (es) 1985-01-10 1986-01-09 Un metodo para preparar un derivado de urea sustituido con aminoalquilo

Country Status (16)

Country Link
US (1) US4650900A (es)
EP (1) EP0187700B1 (es)
JP (1) JPS62123164A (es)
AT (1) ATE52249T1 (es)
AU (1) AU584157B2 (es)
CA (1) CA1244022A (es)
DE (1) DE3670630D1 (es)
DK (1) DK160486C (es)
ES (1) ES8703409A1 (es)
FI (1) FI84598C (es)
GB (1) GB8500615D0 (es)
GR (1) GR860019B (es)
NO (1) NO162154C (es)
NZ (1) NZ214509A (es)
PT (1) PT81808B (es)
ZA (1) ZA859878B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8914061D0 (en) * 1989-06-19 1989-08-09 Wellcome Found Agents for potentiating the effects of antitumour agents and combating multiple drug resistance
NZ234110A (en) * 1989-06-19 1993-01-27 Wellcome Found Dibenzoazepine, -oxepine and -cycloheptane substituted alkylidene amines; pharmaceutical compositions containing such compounds or various other aryl substituted amines
GB8914062D0 (en) * 1989-06-19 1989-08-09 Wellcome Found Agents for potentiating the effects of antitumour agents and combating multiple drug resistance
GB8914040D0 (en) * 1989-06-19 1989-08-09 Wellcome Found Agents for potentiating the effects of antitumour agents and combating multiple drug resistance
GB8914060D0 (en) * 1989-06-19 1989-08-09 Wellcome Found Agents for potentiating the effects of antitumour agents and combating multiple drug resistance
CA2163325A1 (en) * 1994-11-21 1996-05-22 Kaneyoshi Kato Amine compounds, their production and use
US5981521A (en) * 1998-11-13 1999-11-09 Abbott Laboratories Tetrahydroisoquinoline derivatives as LHRH antagonists
CA2351187A1 (en) * 1998-11-13 2000-05-25 Abbott Laboratories Tetrahydroisoquinoline derivatives as lhrh antagonists
CN101663262B (zh) * 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3388158A (en) * 1965-08-09 1968-06-11 Sterling Drug Inc 1-(dichlorobenzyl)-3-methyl (or 3, 3-dimethyl) ureas
DE2131034A1 (de) * 1971-06-23 1973-01-11 Hoechst Ag Acylharnstoffe und verfahren zu ihrer herstellung
JPS5419943A (en) * 1977-07-12 1979-02-15 Nippon Tokushu Noyaku Seizo Kk Urea or thiourea compounds, their preparation, and agricultural and horticultural fungicides comprising them as active constituents
FR2421891A1 (fr) * 1977-10-17 1979-11-02 Fabre Sa Pierre Obtention industrielle d'amides de la pyrrolidine ethyl amine
IE50228B1 (en) * 1979-10-03 1986-03-05 Kefalas As Nitrosourea derivatives,process for preparing them,and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
GR860019B (en) 1986-04-29
CA1244022A (en) 1988-11-01
FI854945A (fi) 1986-07-11
EP0187700A1 (en) 1986-07-16
DE3670630D1 (de) 1990-05-31
NO855375L (no) 1986-07-11
ZA859878B (en) 1986-11-26
PT81808A (en) 1986-02-01
FI84598B (fi) 1991-09-13
NO162154C (no) 1989-11-15
NZ214509A (en) 1988-08-30
AU584157B2 (en) 1989-05-18
DK5086D0 (da) 1986-01-07
DK160486B (da) 1991-03-18
ATE52249T1 (de) 1990-05-15
FI854945A0 (fi) 1985-12-13
GB8500615D0 (en) 1985-02-13
PT81808B (pt) 1987-11-30
DK5086A (da) 1986-07-11
JPS62123164A (ja) 1987-06-04
US4650900A (en) 1987-03-17
NO162154B (no) 1989-08-07
ES550744A0 (es) 1987-02-16
DK160486C (da) 1991-08-26
AU5215786A (en) 1986-07-17
EP0187700B1 (en) 1990-04-25
FI84598C (fi) 1991-12-27

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603