HRP20050496A2 - Indolyl pyrazinone derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis - Google Patents

Info

Publication number

HRP20050496A2

HRP20050496A2 HR20050496A HRP20050496A HRP20050496A2 HR P20050496 A2 HRP20050496 A2 HR P20050496A2 HR 20050496 A HR20050496 A HR 20050496A HR P20050496 A HRP20050496 A HR P20050496A HR P20050496 A2 HRP20050496 A2 HR P20050496A2

Authority

HR

Croatia

Prior art keywords

alkyl

optionally substituted

alkoxy

phenyl

independently selected

Prior art date

2002-11-12

Links

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• Global Dossier
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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 38
• 201000010099 disease Diseases 0.000 title claims abstract description 12
• 230000003463 hyperproliferative effect Effects 0.000 title claims abstract description 12
• 230000033115 angiogenesis Effects 0.000 title claims abstract description 10
• 208000035475 disorder Diseases 0.000 title abstract description 18
• YVFNMQLTCRSZOJ-UHFFFAOYSA-N 3-(1h-indol-2-yl)-1h-pyrazin-2-one Chemical class O=C1NC=CN=C1C1=CC2=CC=CC=C2N1 YVFNMQLTCRSZOJ-UHFFFAOYSA-N 0.000 title description 2
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 343
• 125000001424 substituent group Chemical group 0.000 claims description 217
• 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims description 203
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 187
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 170
• 150000001875 compounds Chemical class 0.000 claims description 129
• 125000005843 halogen group Chemical group 0.000 claims description 94
• 125000000217 alkyl group Chemical group 0.000 claims description 91
• -1 and [image] Chemical group 0.000 claims description 87
• 125000004076 pyridyl group Chemical group 0.000 claims description 72
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 65
• 238000000034 method Methods 0.000 claims description 47
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 47
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 37
• 125000004432 carbon atom Chemical group C* 0.000 claims description 33
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 28
• 206010028980 Neoplasm Diseases 0.000 claims description 28
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 26
• 125000002541 furyl group Chemical group 0.000 claims description 25
• 229910052757 nitrogen Inorganic materials 0.000 claims description 25
• 150000003839 salts Chemical class 0.000 claims description 24
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 22
• 150000002148 esters Chemical class 0.000 claims description 20
• 125000001041 indolyl group Chemical group 0.000 claims description 19
• 125000003118 aryl group Chemical group 0.000 claims description 16
• 229910052731 fluorine Inorganic materials 0.000 claims description 16
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 15
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 15
• 125000001544 thienyl group Chemical group 0.000 claims description 15
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 13
• PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 13
• 229910052801 chlorine Inorganic materials 0.000 claims description 11
• 229910052739 hydrogen Inorganic materials 0.000 claims description 11
• 229910052760 oxygen Inorganic materials 0.000 claims description 11
• 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 11
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• 101100240516 Caenorhabditis elegans nhr-10 gene Proteins 0.000 claims description 10
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• 125000003545 alkoxy group Chemical group 0.000 claims description 9
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• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 7
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• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 6
• 125000005605 benzo group Chemical group 0.000 claims description 6
• 229910052799 carbon Inorganic materials 0.000 claims description 6
• 125000004568 thiomorpholinyl group Chemical group 0.000 claims description 6
• 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 claims description 5
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• 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 5
• 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims description 5
• 125000002883 imidazolyl group Chemical group 0.000 claims description 5
• 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims description 5
• 125000001715 oxadiazolyl group Chemical group 0.000 claims description 5
• 125000002971 oxazolyl group Chemical group 0.000 claims description 5
• 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims description 5
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 5
• 125000000168 pyrrolyl group Chemical group 0.000 claims description 5
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• 206010025323 Lymphomas Diseases 0.000 claims description 3
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