HRP20041070A2 - Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-4h-carbazol-4-one - Google Patents

Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-4h-carbazol-4-one Download PDF

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Publication number
HRP20041070A2
HRP20041070A2 HR20041070A HRP20041070A HRP20041070A2 HR P20041070 A2 HRP20041070 A2 HR P20041070A2 HR 20041070 A HR20041070 A HR 20041070A HR P20041070 A HRP20041070 A HR P20041070A HR P20041070 A2 HRP20041070 A2 HR P20041070A2
Authority
HR
Croatia
Prior art keywords
methyl
tetrahydro
carbazol
imidazol
solvent system
Prior art date
Application number
HR20041070A
Other languages
English (en)
Croatian (hr)
Inventor
Szabo Csaba
Molnar Szandor
Meszaros-Sos Erzsebet
Salvi Szabolcs
Tamas Tivadar
Original Assignee
Biogal Gyogyszergyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar Rt. filed Critical Biogal Gyogyszergyar Rt.
Publication of HRP20041070A2 publication Critical patent/HRP20041070A2/hr

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/88Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D521/00Heterocyclic compounds containing unspecified hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
HR20041070A 2002-04-29 2004-11-16 Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-4h-carbazol-4-one HRP20041070A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37632302P 2002-04-29 2002-04-29
PCT/US2003/013221 WO2003093281A1 (fr) 2002-04-29 2003-04-29 Methode de preparation de 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-4h-carbazol-4-one

Publications (1)

Publication Number Publication Date
HRP20041070A2 true HRP20041070A2 (en) 2005-02-28

Family

ID=29401332

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20041070A HRP20041070A2 (en) 2002-04-29 2004-11-16 Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-4h-carbazol-4-one

Country Status (19)

Country Link
US (2) US7098345B2 (fr)
EP (1) EP1499623B1 (fr)
JP (1) JP2005529142A (fr)
KR (1) KR20040104654A (fr)
CN (1) CN1665823A (fr)
AT (1) ATE364611T1 (fr)
AU (1) AU2003223764A1 (fr)
CA (1) CA2483566A1 (fr)
DE (1) DE60314400T2 (fr)
DK (1) DK1499623T3 (fr)
ES (1) ES2288606T3 (fr)
HR (1) HRP20041070A2 (fr)
IL (1) IL164904A0 (fr)
MX (1) MXPA04010846A (fr)
NO (1) NO20045192L (fr)
PL (1) PL373191A1 (fr)
PT (1) PT1499623E (fr)
WO (1) WO2003093281A1 (fr)
ZA (1) ZA200408934B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE01991193T1 (de) * 2000-10-30 2004-07-08 Teva Pharmaceutical Industries Ltd. Neue kristall- und solvatformen von ondansetronhydrochlorid und verfahren zu deren herstellung
CN1665803A (zh) * 2002-04-30 2005-09-07 特瓦药厂有限公司 新晶形的昂丹司琼及其制备方法、含有该新晶形的药物组合物以及用其治疗恶心的方法
US20050131045A1 (en) * 2002-04-30 2005-06-16 Judith Aronhime Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
US7696356B2 (en) * 2004-08-17 2010-04-13 Taro Pharmaceutical Industries Limited Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
EP1828141A4 (fr) * 2004-10-26 2009-04-01 Ipca Lab Ltd Procede monotope de preparation de l'agent antiemetique 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl-1h-imidazole-1-yl)methyl]-4h-carbazol-4-one

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
HU193592B (en) 1984-01-25 1987-11-30 Glaxo Group Ltd Process for producing tetrahydro-carbazolone derivatives
EP0405617A3 (en) 1985-03-14 1992-11-25 Beecham Group P.L.C. Medicaments for the treatment of anxiety
GB8518741D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518742D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518745D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
US4859662A (en) 1986-11-28 1989-08-22 Glaxo Group Limited Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances
GB8630071D0 (en) 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
GB8816187D0 (en) * 1988-07-07 1988-08-10 Glaxo Group Ltd Medicaments
US5344658A (en) 1989-06-28 1994-09-06 Glaxo Group Limited Process and composition using ondansetron
GB8914804D0 (en) 1989-06-28 1989-08-16 Glaxo Group Ltd Process
EP0591434A4 (en) 1991-06-26 1994-09-14 Sepracor Inc Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
CA2106642C (fr) 1992-10-14 2005-08-16 Peter Bod Derives de carbazolone et procede d'obtention
GB9423588D0 (en) 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
GB9423511D0 (en) 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
CN1045437C (zh) 1994-12-29 1999-10-06 中国科学院上海有机化学研究所 恩丹西酮及其生理盐的合成
DE01991193T1 (de) 2000-10-30 2004-07-08 Teva Pharmaceutical Industries Ltd. Neue kristall- und solvatformen von ondansetronhydrochlorid und verfahren zu deren herstellung
EP1207160A1 (fr) 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Procédé de préparation de la 1,2,3,9-tétrahydro-9-méthyl-3-((2-méthyl-1H-imidazol-1-yl)-méthyl)-4H-carbazol-4-one
SK9892003A3 (en) 2001-01-11 2004-05-04 Teva Pharma An improved process for preparing pure ondansetron hydrochloride dihydrate
AU2002251329A1 (en) 2002-04-25 2003-11-10 Generics (Uk) Limited Novel crystalline forms of celecoxib and other compounds
CN1665803A (zh) 2002-04-30 2005-09-07 特瓦药厂有限公司 新晶形的昂丹司琼及其制备方法、含有该新晶形的药物组合物以及用其治疗恶心的方法

Also Published As

Publication number Publication date
US7098345B2 (en) 2006-08-29
AU2003223764A1 (en) 2003-11-17
ZA200408934B (en) 2006-07-26
PL373191A1 (en) 2005-08-22
CA2483566A1 (fr) 2003-11-13
ES2288606T3 (es) 2008-01-16
MXPA04010846A (es) 2005-01-25
US20060252942A1 (en) 2006-11-09
NO20045192L (no) 2005-01-28
US20050020655A1 (en) 2005-01-27
WO2003093281A1 (fr) 2003-11-13
DE60314400D1 (de) 2007-07-26
ATE364611T1 (de) 2007-07-15
JP2005529142A (ja) 2005-09-29
DE60314400T2 (de) 2008-02-07
CN1665823A (zh) 2005-09-07
DK1499623T3 (da) 2007-10-08
EP1499623B1 (fr) 2007-06-13
PT1499623E (pt) 2007-08-10
IL164904A0 (en) 2005-12-18
KR20040104654A (ko) 2004-12-10
EP1499623A1 (fr) 2005-01-26

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