HRP20040327A2 - Peptides acting as both glp-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use - Google Patents

Peptides acting as both glp-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use

Info

Publication number
HRP20040327A2
HRP20040327A2 HR20040327A HRP20040327A HRP20040327A2 HR P20040327 A2 HRP20040327 A2 HR P20040327A2 HR 20040327 A HR20040327 A HR 20040327A HR P20040327 A HRP20040327 A HR P20040327A HR P20040327 A2 HRP20040327 A2 HR P20040327A2
Authority
HR
Croatia
Prior art keywords
glp
pharmacological methods
receptor antagonists
peptides acting
receptor agonists
Prior art date
Application number
HR20040327A
Other languages
English (en)
Croatian (hr)
Inventor
Pan Clark
Whelan James
B. Clairmont Kevin
Original Assignee
Bayer Pharmaceuticals Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharmaceuticals Corporation filed Critical Bayer Pharmaceuticals Corporation
Publication of HRP20040327A2 publication Critical patent/HRP20040327A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20040327A 2001-10-05 2004-04-06 Peptides acting as both glp-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use HRP20040327A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32773001P 2001-10-05 2001-10-05
PCT/US2002/031693 WO2003040309A2 (en) 2001-10-05 2002-10-04 Peptides acting as both glp-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use

Publications (1)

Publication Number Publication Date
HRP20040327A2 true HRP20040327A2 (en) 2007-11-30

Family

ID=23277790

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20040327A HRP20040327A2 (en) 2001-10-05 2004-04-06 Peptides acting as both glp-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use

Country Status (28)

Country Link
US (6) US7399745B2 (zh)
EP (1) EP1436330A4 (zh)
JP (1) JP2005508639A (zh)
KR (1) KR20050034580A (zh)
CN (1) CN1326876C (zh)
AR (1) AR036711A1 (zh)
BR (1) BR0213132A (zh)
CA (1) CA2462462A1 (zh)
CO (1) CO5570710A2 (zh)
DO (1) DOP2002000475A (zh)
EC (2) ECSP024346A (zh)
HK (1) HK1073117A1 (zh)
HN (1) HN2002000282A (zh)
HR (1) HRP20040327A2 (zh)
HU (1) HUP0401797A2 (zh)
IL (1) IL160706A0 (zh)
MA (1) MA26228A1 (zh)
MX (1) MXPA04002140A (zh)
MY (1) MY138267A (zh)
NO (1) NO20041792L (zh)
NZ (1) NZ532685A (zh)
PE (1) PE20030850A1 (zh)
PL (1) PL368760A1 (zh)
RU (1) RU2334761C2 (zh)
SG (2) SG158736A1 (zh)
UY (1) UY27469A1 (zh)
WO (1) WO2003040309A2 (zh)
ZA (1) ZA200403322B (zh)

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AR070844A1 (es) 2008-03-27 2010-05-05 Lilly Co Eli Fragmento fab o anticuerpo monoclonal humanizado que comprende el fragmento fab, y su uso para la manufactura de un medicamento antagonista del polipeptido del receptor de glucagon para el tratamiento o prevencion de diabetes de tipo 1 o 2
PA8830501A1 (es) * 2008-06-17 2010-07-27 Univ Indiana Res & Tech Corp Co-agonistas del receptor de glucagon/glp-1
EA020326B9 (ru) * 2008-06-17 2015-03-31 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Агонисты смешанного действия на основе глюкозозависимого инсулинотропного пептида для лечения нарушений обмена веществ и ожирения
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US8865868B2 (en) 2008-08-06 2014-10-21 Novo Nordisk Healthcare Ag Conjugated proteins with prolonged in vivo efficacy
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RU2550696C2 (ru) 2008-12-19 2015-05-10 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Основанные на амидах пролекарства пептидов глюкагонового надсемейства
RU2539797C2 (ru) 2009-01-22 2015-01-27 Ново Нордиск Хелс Кеа Аг Производное гормона роста человека с повышенной стабильностью к протеолитическому разрушению, способ получения такого производного, его применение, способ лечения и фармацевтическая композиция
WO2010148089A1 (en) 2009-06-16 2010-12-23 Indiana University Research And Technology Corporation Gip receptor-active glucagon compounds
EP2461831B1 (en) 2009-08-06 2018-11-21 Novo Nordisk Health Care AG Growth hormones with prolonged in-vivo efficacy
GB0917072D0 (en) 2009-09-29 2009-11-11 Univ Ulster Peptide analogues of glucagon for diabetes therapy
WO2011075393A2 (en) 2009-12-18 2011-06-23 Indiana University Research And Technology Corporation Glucagon/glp-1 receptor co-agonists
EP2460527A1 (en) 2010-01-21 2012-06-06 Sanofi Pharmaceutical composition for treating a metabolic syndrome
US9695226B2 (en) 2010-01-22 2017-07-04 Novo Nordisk Healthcare Ag Growth hormones with prolonged in-vivo efficacy
US9211342B2 (en) 2010-01-22 2015-12-15 Novo Nordisk Healthcare Ag Stable growth hormone compounds resistant to proteolytic degradation
KR20120123443A (ko) 2010-01-27 2012-11-08 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 대사 장애 및 비만 치료용 글루카곤 길항제-ｇｉｐ 항진제 콘쥬게이트
JP2013525491A (ja) 2010-05-04 2013-06-20 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 心血管障害を治療または予防し心血管保護を提供する方法
WO2011143209A1 (en) 2010-05-13 2011-11-17 Indiana University Research And Technology Corporation Glucagon superfamily peptides exhibiting nuclear hormone receptor activity
EP2568993A4 (en) 2010-05-13 2014-02-19 Univ Indiana Res & Tech Corp GLUCAGON SUPERFAMILY PEPTIDES EXPRESSING G PROTEIN-COUPLED RECEPTOR ACTIVITY
CN103179979A (zh) 2010-06-24 2013-06-26 印第安纳大学研究及科技有限公司 基于酰胺的胰高血糖素超家族肽前药
MA34885B1 (fr) 2010-12-22 2014-02-01 Indiana Unversity Res And Technology Corp Analogues du glucagon presentant una ctivite de recepteur de gip
US9459187B2 (en) * 2011-03-04 2016-10-04 Becton, Dickinson And Company Blood collection device containing lysophospholipase inhibitor
RU2014101697A (ru) 2011-06-22 2015-07-27 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Коагонисты рецепторов глюкагона/glp-1
LT2723367T (lt) 2011-06-22 2017-08-25 Indiana University Research And Technology Corporation Bendri gliukagono/glp-1 receptoriaus agonistai
EP2548570A1 (en) 2011-07-19 2013-01-23 Sanofi Pharmaceutical composition for treating a metabolic syndrome
BR112014007124A2 (pt) 2011-11-17 2017-06-13 Univ Indiana Res & Tech Corp superfamília de peptídeos gluxagon que exibem atividade no receptor glicocorticóide
AR091477A1 (es) 2012-06-21 2015-02-04 Univ Indiana Res & Tech Corp Analogos de glucagon que presentan actividad de receptor de gip
JP6538645B2 (ja) 2013-03-14 2019-07-03 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリン‐インクレチン複合物
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Also Published As

Publication number Publication date
US20060003417A1 (en) 2006-01-05
MXPA04002140A (es) 2005-03-07
SG149693A1 (en) 2009-02-27
US20060003418A1 (en) 2006-01-05
JP2005508639A (ja) 2005-04-07
UY27469A1 (es) 2003-04-30
WO2003040309A3 (en) 2003-12-18
CN1564828A (zh) 2005-01-12
NO20041792L (no) 2004-07-02
RU2004114243A (ru) 2005-05-10
AR036711A1 (es) 2004-09-29
ECSP024346A (es) 2003-05-26
WO2003040309A2 (en) 2003-05-15
MY138267A (en) 2009-05-29
PE20030850A1 (es) 2003-10-31
US7488716B2 (en) 2009-02-10
US7488715B2 (en) 2009-02-10
US7494978B2 (en) 2009-02-24
SG158736A1 (en) 2010-02-26
US20060003934A1 (en) 2006-01-05
US20060003419A1 (en) 2006-01-05
ECSP045094A (es) 2004-06-28
EP1436330A2 (en) 2004-07-14
EP1436330A4 (en) 2006-01-18
KR20050034580A (ko) 2005-04-14
US20050288248A1 (en) 2005-12-29
MA26228A1 (fr) 2004-07-01
HN2002000282A (es) 2002-12-12
US7399745B2 (en) 2008-07-15
PL368760A1 (en) 2005-04-04
CO5570710A2 (es) 2005-10-31
HUP0401797A2 (en) 2006-08-28
BR0213132A (pt) 2004-10-19
HK1073117A1 (en) 2005-09-23
NZ532685A (en) 2006-02-24
DOP2002000475A (es) 2003-06-30
ZA200403322B (en) 2005-05-03
IL160706A0 (en) 2004-08-31
CN1326876C (zh) 2007-07-18
US7488714B2 (en) 2009-02-10
RU2334761C2 (ru) 2008-09-27
US20050153890A1 (en) 2005-07-14
CA2462462A1 (en) 2003-05-15

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