MA26228A1 - Peptides jouant a la fois de role d'agonistes du recepteur glp-1 et d'antagonistes du recepteur de glucagon et leurs methodes d'utilisation pharmacologique - Google Patents

Peptides jouant a la fois de role d'agonistes du recepteur glp-1 et d'antagonistes du recepteur de glucagon et leurs methodes d'utilisation pharmacologique

Info

Publication number
MA26228A1
MA26228A1 MA27651A MA27651A MA26228A1 MA 26228 A1 MA26228 A1 MA 26228A1 MA 27651 A MA27651 A MA 27651A MA 27651 A MA27651 A MA 27651A MA 26228 A1 MA26228 A1 MA 26228A1
Authority
MA
Morocco
Prior art keywords
glp
peptides
role
methods
pharmacological use
Prior art date
Application number
MA27651A
Other languages
English (en)
Inventor
Clark Pan
James Whelan
Kevin B Clairmont
Original Assignee
Bayer Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharmaceuticals Corp filed Critical Bayer Pharmaceuticals Corp
Publication of MA26228A1 publication Critical patent/MA26228A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA27651A 2001-10-05 2004-04-23 Peptides jouant a la fois de role d'agonistes du recepteur glp-1 et d'antagonistes du recepteur de glucagon et leurs methodes d'utilisation pharmacologique MA26228A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32773001P 2001-10-05 2001-10-05

Publications (1)

Publication Number Publication Date
MA26228A1 true MA26228A1 (fr) 2004-07-01

Family

ID=23277790

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27651A MA26228A1 (fr) 2001-10-05 2004-04-23 Peptides jouant a la fois de role d'agonistes du recepteur glp-1 et d'antagonistes du recepteur de glucagon et leurs methodes d'utilisation pharmacologique

Country Status (28)

Country Link
US (6) US7399745B2 (fr)
EP (1) EP1436330A4 (fr)
JP (1) JP2005508639A (fr)
KR (1) KR20050034580A (fr)
CN (1) CN1326876C (fr)
AR (1) AR036711A1 (fr)
BR (1) BR0213132A (fr)
CA (1) CA2462462A1 (fr)
CO (1) CO5570710A2 (fr)
DO (1) DOP2002000475A (fr)
EC (2) ECSP024346A (fr)
HK (1) HK1073117A1 (fr)
HN (1) HN2002000282A (fr)
HR (1) HRP20040327A2 (fr)
HU (1) HUP0401797A2 (fr)
IL (1) IL160706A0 (fr)
MA (1) MA26228A1 (fr)
MX (1) MXPA04002140A (fr)
MY (1) MY138267A (fr)
NO (1) NO20041792L (fr)
NZ (1) NZ532685A (fr)
PE (1) PE20030850A1 (fr)
PL (1) PL368760A1 (fr)
RU (1) RU2334761C2 (fr)
SG (2) SG158736A1 (fr)
UY (1) UY27469A1 (fr)
WO (1) WO2003040309A2 (fr)
ZA (1) ZA200403322B (fr)

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JO2945B1 (en) 2006-09-13 2016-03-15 سميث كلاين بيتشام كوربوريشن Methods of giving prolonged hypoglycemic agents
CN101578102B (zh) * 2007-01-05 2013-07-17 印第安纳大学研究及科技有限公司 在生理性pH缓冲液中显示增强的溶解性的胰高血糖素类似物
EP2111414B1 (fr) 2007-02-15 2014-07-02 Indiana University Research and Technology Corporation Co-agonistes des récepteurs du glucagon/glp-1
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EP2217701B9 (fr) 2007-10-30 2015-02-18 Indiana University Research and Technology Corporation Antagonistes du glucagon
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AR070844A1 (es) 2008-03-27 2010-05-05 Lilly Co Eli Fragmento fab o anticuerpo monoclonal humanizado que comprende el fragmento fab, y su uso para la manufactura de un medicamento antagonista del polipeptido del receptor de glucagon para el tratamiento o prevencion de diabetes de tipo 1 o 2
PA8830501A1 (es) * 2008-06-17 2010-07-27 Univ Indiana Res & Tech Corp Co-agonistas del receptor de glucagon/glp-1
EA020326B9 (ru) * 2008-06-17 2015-03-31 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Агонисты смешанного действия на основе глюкозозависимого инсулинотропного пептида для лечения нарушений обмена веществ и ожирения
MX2010012695A (es) * 2008-06-17 2011-03-15 Univ Indiana Res & Tech Corp Analogos de glucagon que exhiben solubilidad y estabilidad aumentadas en soluciones reguladoras de ph fisiologico.
US8865868B2 (en) 2008-08-06 2014-10-21 Novo Nordisk Healthcare Ag Conjugated proteins with prolonged in vivo efficacy
PT2373681T (pt) 2008-12-10 2017-04-11 Glaxosmithkline Llc Composições farmacêuticas de albiglutida
RU2550696C2 (ru) 2008-12-19 2015-05-10 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Основанные на амидах пролекарства пептидов глюкагонового надсемейства
RU2539797C2 (ru) 2009-01-22 2015-01-27 Ново Нордиск Хелс Кеа Аг Производное гормона роста человека с повышенной стабильностью к протеолитическому разрушению, способ получения такого производного, его применение, способ лечения и фармацевтическая композиция
WO2010148089A1 (fr) 2009-06-16 2010-12-23 Indiana University Research And Technology Corporation Composés de glucagon actifs sur le récepteur gip
EP2461831B1 (fr) 2009-08-06 2018-11-21 Novo Nordisk Health Care AG Hormones de croissance ayant une efficacité in vivo prolongée
GB0917072D0 (en) 2009-09-29 2009-11-11 Univ Ulster Peptide analogues of glucagon for diabetes therapy
WO2011075393A2 (fr) 2009-12-18 2011-06-23 Indiana University Research And Technology Corporation Co-agonistes du récepteur du glucagon/glp-i
EP2460527A1 (fr) 2010-01-21 2012-06-06 Sanofi Composition pharmaceutique pour le traitement d'un syndrome métabolique
US9695226B2 (en) 2010-01-22 2017-07-04 Novo Nordisk Healthcare Ag Growth hormones with prolonged in-vivo efficacy
US9211342B2 (en) 2010-01-22 2015-12-15 Novo Nordisk Healthcare Ag Stable growth hormone compounds resistant to proteolytic degradation
KR20120123443A (ko) 2010-01-27 2012-11-08 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 대사 장애 및 비만 치료용 글루카곤 길항제-ｇｉｐ 항진제 콘쥬게이트
JP2013525491A (ja) 2010-05-04 2013-06-20 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 心血管障害を治療または予防し心血管保護を提供する方法
WO2011143209A1 (fr) 2010-05-13 2011-11-17 Indiana University Research And Technology Corporation Peptides de la superfamille des glucagons présentant une activité de récepteur nucléaire d'hormone
EP2568993A4 (fr) 2010-05-13 2014-02-19 Univ Indiana Res & Tech Corp Peptides de la superfamille du glucagon manifestant une activité de récepteur couplé à une protéine g
CN103179979A (zh) 2010-06-24 2013-06-26 印第安纳大学研究及科技有限公司 基于酰胺的胰高血糖素超家族肽前药
MA34885B1 (fr) 2010-12-22 2014-02-01 Indiana Unversity Res And Technology Corp Analogues du glucagon presentant una ctivite de recepteur de gip
US9459187B2 (en) * 2011-03-04 2016-10-04 Becton, Dickinson And Company Blood collection device containing lysophospholipase inhibitor
RU2014101697A (ru) 2011-06-22 2015-07-27 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Коагонисты рецепторов глюкагона/glp-1
LT2723367T (lt) 2011-06-22 2017-08-25 Indiana University Research And Technology Corporation Bendri gliukagono/glp-1 receptoriaus agonistai
EP2548570A1 (fr) 2011-07-19 2013-01-23 Sanofi Composition pharmaceutique pour le traitement d'un syndrome métabolique
BR112014007124A2 (pt) 2011-11-17 2017-06-13 Univ Indiana Res & Tech Corp superfamília de peptídeos gluxagon que exibem atividade no receptor glicocorticóide
AR091477A1 (es) 2012-06-21 2015-02-04 Univ Indiana Res & Tech Corp Analogos de glucagon que presentan actividad de receptor de gip
JP6538645B2 (ja) 2013-03-14 2019-07-03 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリン‐インクレチン複合物
US11045523B2 (en) 2013-04-05 2021-06-29 Novo Nordisk Healthcare Ag Formulation of growth hormone albumin-binder conjugate
MA43289B1 (fr) 2014-01-20 2019-12-31 Hanmi Pharm Ind Co Ltd Insuline à action prolongée et utilisation associée
WO2015168135A1 (fr) * 2014-04-28 2015-11-05 The Trustees Of The University Of Pennsylvania Nouveaux peptides à modification thioamide et leurs utilisations
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US10183055B2 (en) 2014-07-21 2019-01-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications
WO2016014342A2 (fr) 2014-07-21 2016-01-28 Arizona Board Of Regents For The University Of Arizona Oligopeptides dérivés de ang-(1-7) et leurs procédés d'utilisation et de production
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Also Published As

Publication number Publication date
US20060003417A1 (en) 2006-01-05
MXPA04002140A (es) 2005-03-07
SG149693A1 (en) 2009-02-27
US20060003418A1 (en) 2006-01-05
JP2005508639A (ja) 2005-04-07
UY27469A1 (es) 2003-04-30
WO2003040309A3 (fr) 2003-12-18
CN1564828A (zh) 2005-01-12
NO20041792L (no) 2004-07-02
RU2004114243A (ru) 2005-05-10
AR036711A1 (es) 2004-09-29
ECSP024346A (es) 2003-05-26
WO2003040309A2 (fr) 2003-05-15
MY138267A (en) 2009-05-29
PE20030850A1 (es) 2003-10-31
US7488716B2 (en) 2009-02-10
US7488715B2 (en) 2009-02-10
US7494978B2 (en) 2009-02-24
SG158736A1 (en) 2010-02-26
US20060003934A1 (en) 2006-01-05
US20060003419A1 (en) 2006-01-05
ECSP045094A (es) 2004-06-28
EP1436330A2 (fr) 2004-07-14
EP1436330A4 (fr) 2006-01-18
KR20050034580A (ko) 2005-04-14
US20050288248A1 (en) 2005-12-29
HN2002000282A (es) 2002-12-12
US7399745B2 (en) 2008-07-15
PL368760A1 (en) 2005-04-04
CO5570710A2 (es) 2005-10-31
HUP0401797A2 (en) 2006-08-28
BR0213132A (pt) 2004-10-19
HRP20040327A2 (en) 2007-11-30
HK1073117A1 (en) 2005-09-23
NZ532685A (en) 2006-02-24
DOP2002000475A (es) 2003-06-30
ZA200403322B (en) 2005-05-03
IL160706A0 (en) 2004-08-31
CN1326876C (zh) 2007-07-18
US7488714B2 (en) 2009-02-10
RU2334761C2 (ru) 2008-09-27
US20050153890A1 (en) 2005-07-14
CA2462462A1 (fr) 2003-05-15

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