ATE392432T1 - Fragmente von retinoic acid-related orphan rezeptoren (ror) welche die ligandenbindedomaine (lbd) enthalten, kristallstruktur der lbd von ror-beta und deren verwendungen - Google Patents

Fragmente von retinoic acid-related orphan rezeptoren (ror) welche die ligandenbindedomaine (lbd) enthalten, kristallstruktur der lbd von ror-beta und deren verwendungen

Info

Publication number
ATE392432T1
ATE392432T1 AT02754563T AT02754563T ATE392432T1 AT E392432 T1 ATE392432 T1 AT E392432T1 AT 02754563 T AT02754563 T AT 02754563T AT 02754563 T AT02754563 T AT 02754563T AT E392432 T1 ATE392432 T1 AT E392432T1
Authority
AT
Austria
Prior art keywords
ror
lbd
beta
retinoic acid
fragments
Prior art date
Application number
AT02754563T
Other languages
English (en)
Inventor
Dino Moras
Jean-Paul Renaud
Catherine Stehlin
Jean-Marie Wurtz
Roland Schuele
Erich Greiner
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Application granted granted Critical
Publication of ATE392432T1 publication Critical patent/ATE392432T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT02754563T 2001-05-07 2002-05-07 Fragmente von retinoic acid-related orphan rezeptoren (ror) welche die ligandenbindedomaine (lbd) enthalten, kristallstruktur der lbd von ror-beta und deren verwendungen ATE392432T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01401175 2001-05-07

Publications (1)

Publication Number Publication Date
ATE392432T1 true ATE392432T1 (de) 2008-05-15

Family

ID=8182715

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02754563T ATE392432T1 (de) 2001-05-07 2002-05-07 Fragmente von retinoic acid-related orphan rezeptoren (ror) welche die ligandenbindedomaine (lbd) enthalten, kristallstruktur der lbd von ror-beta und deren verwendungen

Country Status (9)

Country Link
US (1) US20040265809A1 (de)
EP (1) EP1385885B1 (de)
JP (1) JP4409284B2 (de)
AT (1) ATE392432T1 (de)
AU (1) AU2002321018A1 (de)
CA (1) CA2446218A1 (de)
DE (1) DE60226133T2 (de)
ES (1) ES2305273T3 (de)
WO (1) WO2003000732A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003227689A1 (en) * 2002-04-29 2003-11-17 Novartis Ag Crystal structure of the ligand binding domain of the retinoic acid-related orphan receptor alpha (ror-alpha)
JP2008505080A (ja) * 2004-07-01 2008-02-21 ニューヨーク ユニバーシティー ＲＯＲγｔ機能の調節のための組成物および方法
EP2042515A1 (de) * 2007-09-27 2009-04-01 sanofi-aventis Ligandenbindende Domänen von nuklearen Rezeptoren in steuerbarer Form und Verfahren damit
WO2013085890A1 (en) * 2011-12-06 2013-06-13 Glaxo Group Limited Therapeutic methods
WO2013166013A1 (en) * 2012-04-30 2013-11-07 Anderson Gaweco Ror modulators and their uses
EP2844260A4 (de) * 2012-04-30 2016-06-29 Anderson Gaweco Ror-modulatoren und deren verwendungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2776388B1 (fr) * 1998-03-20 2006-04-28 Lipha Utilisation de recepteurs de la famille ror pour le criblage de substances utiles pour le traitement de l'atherosclerose
AU1210300A (en) * 1998-10-23 2000-05-15 Tularik Inc. Human retinoid-like orphan receptor gamma
GB9924057D0 (en) * 1999-10-11 1999-12-15 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
EP1385885B1 (de) 2008-04-16
EP1385885A2 (de) 2004-02-04
WO2003000732A2 (en) 2003-01-03
JP4409284B2 (ja) 2010-02-03
AU2002321018A1 (en) 2003-01-08
CA2446218A1 (en) 2003-01-03
ES2305273T3 (es) 2008-11-01
JP2005505259A (ja) 2005-02-24
DE60226133D1 (de) 2008-05-29
DE60226133T2 (de) 2009-01-29
US20040265809A1 (en) 2004-12-30
WO2003000732A3 (en) 2003-03-27

Similar Documents

Publication Publication Date Title
Yang et al. Characterization of Agouti-related protein binding to melanocortin receptors
HRP20040327A2 (en) Peptides acting as both glp-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use
Hansen et al. N‐terminally and C‐terminally truncated forms of glucose‐dependent insulinotropic polypeptide are high‐affinity competitive antagonists of the human GIP receptor
Sparre‐Ulrich et al. Species‐specific action of (Pro3) GIP–A full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors
Goding et al. Subunit structure of cell surface proteins: disulfide bonding in antigen receptors, Ly-2/3 antigens, and transferrin receptors of murine T and B lymphocytes.
ATE128359T1 (de) Behandlung von diabetes mellitus typ 2.
Grouzmann et al. Characterization of a selective antagonist of neuropeptide Y at the Y2 receptor: Synthesis and pharmacological evaluation of a Y2 antagonist
DE69417417D1 (de) Monoklonale antikörper gegen den alpha-pdgf-rezeptor und deren verwendungen
ATE335818T1 (de) Ligand polypeptide für hypophyse g-protein gekoppeltes rezeptor-protein, deren herstellung und anwendung
ATE392432T1 (de) Fragmente von retinoic acid-related orphan rezeptoren (ror) welche die ligandenbindedomaine (lbd) enthalten, kristallstruktur der lbd von ror-beta und deren verwendungen
ATE448306T1 (de) Veränderte, in gewünschter konformation stabilisierte polypeptide und verfahren zu deren herstellung
Calvo et al. Structural characterization by affinity cross‐linking of glucagon‐like peptide‐1 (7–36) amide receptor in rat brain
Jeziorski et al. Cloning and expression of a FMRFamide-gated Na+ channel from Helisoma trivolvis and comparison with the native neuronal channel
DE69906108D1 (de) Peptid-derivat
DE69633131D1 (de) Rezeptor des y-y5 neuropeptids
ATE407208T1 (de) Hemopoietin-rezeptor
CY1108643T1 (el) Κυτταρικη σειρα και χρησεις της
Yang et al. Functional properties of an agouti signaling protein variant and characteristics of its cognate radioligand
Kirby et al. Identification of high-potency neuropeptide Y analogues through systematic lactamization
Uemura et al. Effect of hormone replacement therapy on the production of bone-resorbing cytokines by peripheral blood cells in postmenopausal women
Signore et al. Labelling of interleukin-2 (IL-2) with 123-iodine with retention of its capacity to bind to activated lymphocytes
DE59105603D1 (de) Monoklonale antikörper gegen den interleukin 2-rezeptor.
Frew et al. Identification of noradrenaline in venom from the funnel-web spider Hololena curta
ES2134781T3 (es) Polipeptidos con actividad de receptor dopaminergico humano, acidos nucleicos que codifican dichos polipeptidos y uso de dichos polipeptidos para el cribado de sustancias activas para dichos polipeptidos.
ATE286734T1 (de) Verwendung von progesteronrezeptor antagonisten zur verhütung oder behinderung der fertilisation

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties