DE60226133D1 - Fragmente von retinoic acid-related orphan rezeptoren (ror) welche die ligandenbindedomaine (lbd) enthalten, kristallstruktur der lbd von ror-beta und deren verwendungen - Google Patents

Fragmente von retinoic acid-related orphan rezeptoren (ror) welche die ligandenbindedomaine (lbd) enthalten, kristallstruktur der lbd von ror-beta und deren verwendungen

Info

Publication number
DE60226133D1
DE60226133D1 DE60226133T DE60226133T DE60226133D1 DE 60226133 D1 DE60226133 D1 DE 60226133D1 DE 60226133 T DE60226133 T DE 60226133T DE 60226133 T DE60226133 T DE 60226133T DE 60226133 D1 DE60226133 D1 DE 60226133D1
Authority
DE
Germany
Prior art keywords
ror
lbd
beta
retinoic acid
orphanic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60226133T
Other languages
English (en)
Other versions
DE60226133T2 (de
Inventor
Dino Moras
Jean-Paul Renaud
Catherine Stehlin
Jean-Marie Wurtz
Roland Schuele
Erich Friedrich Greiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Publication of DE60226133D1 publication Critical patent/DE60226133D1/de
Application granted granted Critical
Publication of DE60226133T2 publication Critical patent/DE60226133T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE60226133T 2001-05-07 2002-05-07 Fragmente von retinoic acid-related orphan-rezeptoren (ror) welche die ligandenbindedomaine (lbd) enthalten, kristallstruktur der lbd von ror-beta und deren verwendungen Expired - Lifetime DE60226133T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01401175 2001-05-07
EP01401175 2001-05-07
PCT/EP2002/005024 WO2003000732A2 (en) 2001-05-07 2002-05-07 Fragments of the retinoic acid-related orphan receptor (ror) comprising the lig and binding domain (lbd), crystal structure of the lbd of ror-beta and their applications

Publications (2)

Publication Number Publication Date
DE60226133D1 true DE60226133D1 (de) 2008-05-29
DE60226133T2 DE60226133T2 (de) 2009-01-29

Family

ID=8182715

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60226133T Expired - Lifetime DE60226133T2 (de) 2001-05-07 2002-05-07 Fragmente von retinoic acid-related orphan-rezeptoren (ror) welche die ligandenbindedomaine (lbd) enthalten, kristallstruktur der lbd von ror-beta und deren verwendungen

Country Status (9)

Country Link
US (1) US20040265809A1 (de)
EP (1) EP1385885B1 (de)
JP (1) JP4409284B2 (de)
AT (1) ATE392432T1 (de)
AU (1) AU2002321018A1 (de)
CA (1) CA2446218A1 (de)
DE (1) DE60226133T2 (de)
ES (1) ES2305273T3 (de)
WO (1) WO2003000732A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006502970A (ja) * 2002-04-29 2006-01-26 ノバルティス アクチエンゲゼルシャフト レチノイン酸関連オーファンレセプターアルファ（ｒｏｒ−アルファ）のリガンド結合ドメインの結晶構造
JP2008505080A (ja) * 2004-07-01 2008-02-21 ニューヨーク ユニバーシティー ＲＯＲγｔ機能の調節のための組成物および方法
EP2042515A1 (de) * 2007-09-27 2009-04-01 sanofi-aventis Ligandenbindende Domänen von nuklearen Rezeptoren in steuerbarer Form und Verfahren damit
WO2013085890A1 (en) * 2011-12-06 2013-06-13 Glaxo Group Limited Therapeutic methods
EP2844259A4 (de) 2012-04-30 2015-11-11 Anderson Gaweco Ror-modulatoren und deren verwendungen
US9447069B2 (en) * 2012-04-30 2016-09-20 Innov17 Llc ROR modulators and their uses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2776388B1 (fr) * 1998-03-20 2006-04-28 Lipha Utilisation de recepteurs de la famille ror pour le criblage de substances utiles pour le traitement de l'atherosclerose
AU1210300A (en) * 1998-10-23 2000-05-15 Tularik Inc. Human retinoid-like orphan receptor gamma
GB9924057D0 (en) * 1999-10-11 1999-12-15 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
WO2003000732A3 (en) 2003-03-27
US20040265809A1 (en) 2004-12-30
ATE392432T1 (de) 2008-05-15
EP1385885A2 (de) 2004-02-04
AU2002321018A1 (en) 2003-01-08
JP4409284B2 (ja) 2010-02-03
DE60226133T2 (de) 2009-01-29
ES2305273T3 (es) 2008-11-01
CA2446218A1 (en) 2003-01-03
WO2003000732A2 (en) 2003-01-03
EP1385885B1 (de) 2008-04-16
JP2005505259A (ja) 2005-02-24

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