ES2134781T3 - Polipeptidos con actividad de receptor dopaminergico humano, acidos nucleicos que codifican dichos polipeptidos y uso de dichos polipeptidos para el cribado de sustancias activas para dichos polipeptidos. - Google Patents
Polipeptidos con actividad de receptor dopaminergico humano, acidos nucleicos que codifican dichos polipeptidos y uso de dichos polipeptidos para el cribado de sustancias activas para dichos polipeptidos.Info
- Publication number
- ES2134781T3 ES2134781T3 ES91918401T ES91918401T ES2134781T3 ES 2134781 T3 ES2134781 T3 ES 2134781T3 ES 91918401 T ES91918401 T ES 91918401T ES 91918401 T ES91918401 T ES 91918401T ES 2134781 T3 ES2134781 T3 ES 2134781T3
- Authority
- ES
- Spain
- Prior art keywords
- polypeptides
- dopaminergic receptor
- receptor
- screening
- code
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
POLIPEPTIDOS QUE TIENEN UNA ACTIVIDAD DE RECEPTOR DOPAMINERGICO HUMANO, ACIDOS NUCLEICOS QUE CODIFICAN ESTOS POLIPEPTIDOS Y UTILIZACION DE ESTOS POLIPEPTIDOS PARA CRIBADO DE SUSTANCIAS ACTIVAS SOBRE ESTOS POLIPEPTIDOS. LA INVENCION SE REFIERE A NUEVOS POLIPEPTIDOS QUE TIENEN UNA ACTIVIDAD DE RECEPTOR DOPAMINERGICO QUE CONTIENEN: LA SECUENCIA DE 400 AMINOACIDOS DE LA *FIG*, O UN FRAGMENTO DE ESTA SECUENCIA, SIENDO TAL ESTE FRAGMENTO QUE: O CONTIENE SIN EMBARGO LAS LOCALIZACIONES CONTENIDAS EN ESTA SECUENCIA Y CUYA PRESENCIA ES NECESARIA PARA QUE, CUANDO ESTE FRAGMENTO ES EXPUESTO A LA SUPERFICIE DE UNA CELULA, SEA CAPAZ DE ENLAZAR LA DOPAMINA, SUS AGONISTAS O ANTAGONISTAS DE MANERA ESPECIFICA Y MEDIBLE, POR EJEMPLO MEDIANTE UN LIGANDO RADIACTIVO; O ES SUSCEPTIBLE DE SER RECONOCIDO POR ANTICUERPOS QUE RECONOCEN TAMBIEN DICHA SECUENCIA DE 400 AMINOACIDOS, PERO NO RECONOCEN NI EL RECEPTOR DOPAMINERGICO D-1, NI EL RECEPTOR DOPAMINERGICO D-2, NI EL RECEPTOR D-3 DE RATA; O BIEN ES SUSCEPTIBLE DE GENERAR ANTICUERPOS QUE RECONOCEN DICHA SECUENCIA DE 446 AMINOACIDOS PERO NO RECONOCEN NI EL RECEPTOR DOPAMINERGICO D-1, NI EL RECEPTOR DOPAMINERGICO D-2, NI EL RECEPTOR D-3 DE RATA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9013731A FR2668771B1 (fr) | 1990-11-06 | 1990-11-06 | Acides nucleiques codant pour des polypeptides ayant une activite de recepteur dopaminergique humain et utilisation de ces polypeptides pour le criblage de substances actives sur ces polypeptides. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2134781T3 true ES2134781T3 (es) | 1999-10-16 |
Family
ID=9401888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91918401T Expired - Lifetime ES2134781T3 (es) | 1990-11-06 | 1991-10-16 | Polipeptidos con actividad de receptor dopaminergico humano, acidos nucleicos que codifican dichos polipeptidos y uso de dichos polipeptidos para el cribado de sustancias activas para dichos polipeptidos. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0507908B1 (es) |
| JP (1) | JPH05503219A (es) |
| AT (1) | ATE180788T1 (es) |
| AU (1) | AU8857991A (es) |
| CA (1) | CA2072874C (es) |
| DE (1) | DE69131289T2 (es) |
| ES (1) | ES2134781T3 (es) |
| FR (1) | FR2668771B1 (es) |
| WO (1) | WO1992007937A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4425143A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Substituierte Pyrimidinverbindungen und deren Verwendung |
| DE19600934A1 (de) | 1996-01-12 | 1997-07-17 | Basf Ag | Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung |
| US20010053849A1 (en) * | 1999-06-16 | 2001-12-20 | Mary Jeanne Kreek | Plural biological sample arrays, and preparation and uses thereof |
| EP1683790A1 (en) | 2005-01-24 | 2006-07-26 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | 3,4-dihydro-2-naphthamide derivatives as selective dopamine D3 ligands |
-
1990
- 1990-11-06 FR FR9013731A patent/FR2668771B1/fr not_active Expired - Lifetime
-
1991
- 1991-10-16 DE DE69131289T patent/DE69131289T2/de not_active Expired - Lifetime
- 1991-10-16 AU AU88579/91A patent/AU8857991A/en not_active Abandoned
- 1991-10-16 CA CA002072874A patent/CA2072874C/fr not_active Expired - Lifetime
- 1991-10-16 EP EP91918401A patent/EP0507908B1/fr not_active Expired - Lifetime
- 1991-10-16 JP JP3517704A patent/JPH05503219A/ja active Pending
- 1991-10-16 WO PCT/FR1991/000810 patent/WO1992007937A1/fr active IP Right Grant
- 1991-10-16 ES ES91918401T patent/ES2134781T3/es not_active Expired - Lifetime
- 1991-10-16 AT AT91918401T patent/ATE180788T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2072874C (fr) | 2004-12-28 |
| FR2668771B1 (fr) | 1995-03-17 |
| JPH05503219A (ja) | 1993-06-03 |
| ATE180788T1 (de) | 1999-06-15 |
| CA2072874A1 (fr) | 1992-05-07 |
| WO1992007937A1 (fr) | 1992-05-14 |
| DE69131289D1 (de) | 1999-07-08 |
| AU8857991A (en) | 1992-05-26 |
| DE69131289T2 (de) | 1999-12-16 |
| EP0507908A1 (fr) | 1992-10-14 |
| FR2668771A1 (fr) | 1992-05-07 |
| EP0507908B1 (fr) | 1999-06-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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