HRP20040157A2 - Solvates of lercanidipine hydrochloride and new crystalline forms of lercanidipine hydrochloride - Google Patents
Solvates of lercanidipine hydrochloride and new crystalline forms of lercanidipine hydrochloride Download PDFInfo
- Publication number
- HRP20040157A2 HRP20040157A2 HR20040157A HRP20040157A HRP20040157A2 HR P20040157 A2 HRP20040157 A2 HR P20040157A2 HR 20040157 A HR20040157 A HR 20040157A HR P20040157 A HRP20040157 A HR P20040157A HR P20040157 A2 HRP20040157 A2 HR P20040157A2
- Authority
- HR
- Croatia
- Prior art keywords
- lercanidipine hydrochloride
- mol
- solvate
- lercanidipine
- methyl
- Prior art date
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- WMFYOYKPJLRMJI-UHFFFAOYSA-N Lercanidipine hydrochloride Chemical compound Cl.COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 WMFYOYKPJLRMJI-UHFFFAOYSA-N 0.000 title claims description 226
- 229960002162 lercanidipine hydrochloride Drugs 0.000 title claims description 219
- 239000012453 solvate Substances 0.000 title claims description 128
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 111
- RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 claims description 96
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 90
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 81
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 66
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 62
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 claims description 51
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 claims description 48
- 239000002904 solvent Substances 0.000 claims description 46
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 43
- 238000002441 X-ray diffraction Methods 0.000 claims description 42
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 40
- 238000000034 method Methods 0.000 claims description 38
- 229940093499 ethyl acetate Drugs 0.000 claims description 30
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- 238000002360 preparation method Methods 0.000 claims description 27
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims description 22
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 6
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- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI001727A ITMI20011727A1 (it) | 2001-08-06 | 2001-08-06 | Solvati della lercanidipina cloridrato e nuove forme cristalline della lercanidipina cloridrato ottenute da essi |
| PCT/EP2002/008700 WO2003014085A1 (en) | 2001-08-06 | 2002-08-05 | Solvates of lercanidipine hydrochloride and new crystalline forms of lercanidipine hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20040157A2 true HRP20040157A2 (en) | 2004-08-31 |
Family
ID=11448246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20040157A HRP20040157A2 (en) | 2001-08-06 | 2004-02-18 | Solvates of lercanidipine hydrochloride and new crystalline forms of lercanidipine hydrochloride |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1423367B1 (it) |
| JP (1) | JP2005502648A (it) |
| KR (1) | KR100912664B1 (it) |
| CN (1) | CN100494175C (it) |
| AR (1) | AR037230A1 (it) |
| AT (1) | ATE294162T1 (it) |
| AU (1) | AU2002331390B2 (it) |
| BR (1) | BR0211738A (it) |
| DE (1) | DE60203919D1 (it) |
| EA (1) | EA200400279A1 (it) |
| ES (1) | ES2209684T1 (it) |
| HR (1) | HRP20040157A2 (it) |
| HU (1) | HUP0401161A3 (it) |
| IL (2) | IL153916A0 (it) |
| IT (1) | ITMI20011727A1 (it) |
| MX (1) | MXPA04001073A (it) |
| NO (1) | NO20040479L (it) |
| PE (1) | PE20030350A1 (it) |
| PL (1) | PL369449A1 (it) |
| UY (1) | UY27409A1 (it) |
| WO (1) | WO2003014085A1 (it) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100651212B1 (ko) | 2004-10-27 | 2006-12-01 | 제일약품주식회사 | 무정형 레르카니디핀의 제조방법 |
| AR052918A1 (es) | 2005-02-25 | 2007-04-11 | Recordati Ireland Ltd | Clorhidrato de lercanidipina amorfo |
| WO2007031865A2 (en) * | 2005-09-16 | 2007-03-22 | Glenmark Pharmaceuticals Limited | Polymorphic form of lercanidipine hydrochloride and process for the preparation thereof |
| EP2121575A2 (en) * | 2007-03-05 | 2009-11-25 | Actavis Group PTC EHF | Lercanidipine hydrochloride polymorphs and an improved process for preparation of 1,1,n-trimethyl-n-(3,3-diphenylpropyl)-2-aminoethyl acetoacetate |
| WO2008136393A1 (ja) * | 2007-04-27 | 2008-11-13 | Ajinomoto Co., Inc. | ラクタム化合物の結晶形およびその製造方法 |
| WO2011161223A2 (en) | 2010-06-23 | 2011-12-29 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts |
| SI2654729T1 (sl) | 2010-12-24 | 2016-08-31 | Krka, D.D., Novo Mesto | Homogene farmacevtske oralne dozirne oblike, ki obsegajo lerkanidipin in enalapril ali njune farmacevtsko sprejemljive soli skupaj z organsko kislino |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8403866D0 (en) * | 1984-02-14 | 1984-03-21 | Recordati Chem Pharm | Diphenylalkylaminoalkyl esters |
| US5912351A (en) | 1995-05-12 | 1999-06-15 | Recordati, S.A. Chemical And Pharmaceutical Company | Anhydrous 1,4-Dihydropyridines and salts thereof |
-
2001
- 2001-08-06 IT IT2001MI001727A patent/ITMI20011727A1/it unknown
-
2002
- 2002-08-02 AR ARP020102957A patent/AR037230A1/es not_active Application Discontinuation
- 2002-08-05 IL IL15391602A patent/IL153916A0/xx unknown
- 2002-08-05 DE DE60203919T patent/DE60203919D1/de not_active Expired - Lifetime
- 2002-08-05 MX MXPA04001073A patent/MXPA04001073A/es not_active Application Discontinuation
- 2002-08-05 EA EA200400279A patent/EA200400279A1/ru unknown
- 2002-08-05 JP JP2003519035A patent/JP2005502648A/ja active Pending
- 2002-08-05 WO PCT/EP2002/008700 patent/WO2003014085A1/en active IP Right Grant
- 2002-08-05 BR BR0211738-0A patent/BR0211738A/pt not_active IP Right Cessation
- 2002-08-05 PL PL02369449A patent/PL369449A1/xx unknown
- 2002-08-05 CN CNB028155114A patent/CN100494175C/zh not_active Expired - Fee Related
- 2002-08-05 HU HU0401161A patent/HUP0401161A3/hu unknown
- 2002-08-05 AU AU2002331390A patent/AU2002331390B2/en not_active Ceased
- 2002-08-05 EP EP02767318A patent/EP1423367B1/en not_active Expired - Lifetime
- 2002-08-05 KR KR1020047001791A patent/KR100912664B1/ko not_active IP Right Cessation
- 2002-08-05 AT AT02767318T patent/ATE294162T1/de not_active IP Right Cessation
- 2002-08-05 ES ES02767318T patent/ES2209684T1/es active Pending
- 2002-08-06 PE PE2002000716A patent/PE20030350A1/es not_active Application Discontinuation
- 2002-08-06 UY UY27409A patent/UY27409A1/es not_active Application Discontinuation
-
2003
- 2003-01-13 IL IL153916A patent/IL153916A/en unknown
-
2004
- 2004-02-03 NO NO20040479A patent/NO20040479L/no not_active Application Discontinuation
- 2004-02-18 HR HR20040157A patent/HRP20040157A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI20011727A1 (it) | 2003-02-06 |
| MXPA04001073A (es) | 2005-02-17 |
| AR037230A1 (es) | 2004-11-03 |
| PL369449A1 (en) | 2005-04-18 |
| EP1423367A1 (en) | 2004-06-02 |
| IL153916A0 (en) | 2003-07-31 |
| KR20040030932A (ko) | 2004-04-09 |
| UY27409A1 (es) | 2003-03-31 |
| KR100912664B1 (ko) | 2009-08-17 |
| JP2005502648A (ja) | 2005-01-27 |
| ITMI20011727A0 (it) | 2001-08-06 |
| EA200400279A1 (ru) | 2004-06-24 |
| IL153916A (en) | 2008-07-08 |
| NO20040479L (no) | 2004-02-03 |
| AU2002331390B2 (en) | 2008-06-05 |
| CN100494175C (zh) | 2009-06-03 |
| HUP0401161A3 (en) | 2009-04-28 |
| BR0211738A (pt) | 2004-09-28 |
| ES2209684T1 (es) | 2004-07-01 |
| ATE294162T1 (de) | 2005-05-15 |
| DE60203919D1 (de) | 2005-06-02 |
| EP1423367B1 (en) | 2005-04-27 |
| PE20030350A1 (es) | 2003-06-06 |
| WO2003014085A1 (en) | 2003-02-20 |
| CN1538958A (zh) | 2004-10-20 |
| HUP0401161A2 (hu) | 2004-09-28 |
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