HRP20020782A2 - Carbamate caspase inhibitors and uses thereof - Google Patents
Carbamate caspase inhibitors and uses thereof Download PDFInfo
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- HRP20020782A2 HRP20020782A2 HRP20020782A HRP20020782A2 HR P20020782 A2 HRP20020782 A2 HR P20020782A2 HR P20020782 A HRP20020782 A HR P20020782A HR P20020782 A2 HRP20020782 A2 HR P20020782A2
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- compound
- ring
- indole
- triazafluorene
- oxygen
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- C07D279/30—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with acyl radicals attached to the ring nitrogen atom
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EP (1) | EP1268425B1 (ru) |
JP (2) | JP4298200B2 (ru) |
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CN (2) | CN100358869C (ru) |
AR (1) | AR027993A1 (ru) |
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AU (2) | AU4961901A (ru) |
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HR (1) | HRP20020782A2 (ru) |
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MX (1) | MXPA02009633A (ru) |
NO (1) | NO325062B1 (ru) |
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PE (1) | PE20011267A1 (ru) |
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PT (1) | PT1268425E (ru) |
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TW (1) | TWI318207B (ru) |
WO (1) | WO2001072707A2 (ru) |
YU (1) | YU73702A (ru) |
ZA (1) | ZA200207483B (ru) |
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PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
US20040192889A1 (en) * | 2001-03-30 | 2004-09-30 | Dale Bredesen | Cytotoxic peptides and peptidomimetics based thereon, and methods for use thereof |
JP4428926B2 (ja) | 2001-05-23 | 2010-03-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | カスパーゼインヒビターおよびそれらの使用 |
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AU2003225088A1 (en) * | 2002-04-19 | 2003-11-03 | Vertex Pharmaceuticals Incorporated | Regulation of tnf-alpha |
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EP1607101A4 (en) * | 2003-02-24 | 2007-10-24 | Daiichi Seiyaku Co | INHIBITOR OF DEGRADATION OF PROTEIN INTERACTING WITH HEPATITIS B VIRUS PROTEIN X |
AU2003902704A0 (en) * | 2003-05-29 | 2003-06-19 | Crc For Waste Management And Pollution Control Limited Of Unsw | Process for producing a nanoscale zero-valent metal |
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ZA200610133B (en) * | 2004-05-15 | 2008-05-28 | Vertex Pharma | Treating seizures using ice inhibitors |
KR100619440B1 (ko) | 2004-05-20 | 2006-09-08 | 한기종 | 포름아마이드 유도체 제조방법 |
EP2295054A1 (en) | 2004-05-27 | 2011-03-16 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
KR100619439B1 (ko) | 2004-05-27 | 2006-09-08 | 한기종 | 포밀기 도입된 아민유도체의 제조방법 |
US8012751B2 (en) * | 2005-03-31 | 2011-09-06 | Wisconsin Alumni Research Foundation | Differentiation of pluripotent embryonic stem cells |
CA2616337A1 (en) * | 2005-07-28 | 2007-02-08 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
CN101278598B (zh) * | 2005-10-07 | 2011-05-25 | 松下电器产业株式会社 | 音频信号处理装置以及音频信号处理方法 |
JP2009524408A (ja) | 2005-11-30 | 2009-07-02 | マサチューセッツ・インスティテュート・オブ・テクノロジー | 病原体を検出する細胞保存系 |
WO2007145704A2 (en) * | 2006-04-24 | 2007-12-21 | Gloucester Pharmaceuticals | Gemcitabine combination therapy |
EP2043672A4 (en) * | 2006-07-07 | 2009-10-21 | Univ Leland Stanford Junior | SELECTIVE CASPASE INHIBITORS |
WO2008021745A2 (en) * | 2006-08-16 | 2008-02-21 | Itherx Pharmaceuticals, Inc. | Hepatitis c virus entry inhibitors |
CA2666814A1 (en) * | 2006-08-21 | 2008-05-29 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
WO2008106167A1 (en) * | 2007-02-28 | 2008-09-04 | Conatus Pharmaceuticals, Inc. | Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases |
WO2008137567A1 (en) * | 2007-05-01 | 2008-11-13 | Cedars-Sinai Medical Center | Caspase inhibitors in the treatment of infection-associated preterm delivery |
KR101009588B1 (ko) * | 2008-06-04 | 2011-01-20 | 거진산업주식회사 | 미세여과막을 이용한 부유고형물 처리장치 |
JP2012051804A (ja) * | 2008-12-26 | 2012-03-15 | Kyoto Univ | Eg5阻害剤 |
KR101010350B1 (ko) * | 2009-03-26 | 2011-01-25 | 삼성중공업 주식회사 | 역세척 여과장치 |
WO2012061786A1 (en) | 2010-11-05 | 2012-05-10 | Brandeis University | Ice cleaved alpha-synuclein a biomarker |
TW201236239A (en) | 2010-11-16 | 2012-09-01 | Solvay | Rechargeable metal or metal-ion cell |
EP2490021A1 (en) | 2011-02-18 | 2012-08-22 | Biotempt B.V. | Modulators of PRR and GPCR signalling |
US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
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WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
KR20180101418A (ko) | 2015-12-31 | 2018-09-12 | 코나터스 파마슈티칼스, 인크. | 간 질환의 치료에서의 카스파제 억제제의 사용 방법 |
CN109789119A (zh) | 2016-10-05 | 2019-05-21 | 诺华股份有限公司 | 用于治疗或预防纤维化、硬化疾病或障碍的含fxr激动剂的复合组合物 |
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WO2000061542A1 (en) | 1999-04-09 | 2000-10-19 | Cytovia, Inc. | Caspase inhibitors and the use thereof |
WO2001016093A1 (en) | 1999-08-27 | 2001-03-08 | Cytovia, Inc. | SUBSTITUTED α-HYDROXY ACID CASPASE INHIBITORS AND THE USE THEREOF |
EA005740B1 (ru) * | 2000-03-29 | 2005-06-30 | Вертекс Фармасьютикалз Инкорпорейтед | Карбаматные ингибиторы каспазы и их использование |
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