HRP20020470B1 - A PROCESS FOR THE PREPARATION OF {2-[4-(alpha-PHENYL-p-CHLORBENZYL)-PIPERAZIN-1-YL]ETHOXY} ACETIC ACID AND NOVEL INTERMEDIATES THEREFOR - Google Patents
A PROCESS FOR THE PREPARATION OF {2-[4-(alpha-PHENYL-p-CHLORBENZYL)-PIPERAZIN-1-YL]ETHOXY} ACETIC ACID AND NOVEL INTERMEDIATES THEREFORInfo
- Publication number
- HRP20020470B1 HRP20020470B1 HR20020470A HRP20020470A HRP20020470B1 HR P20020470 B1 HRP20020470 B1 HR P20020470B1 HR 20020470 A HR20020470 A HR 20020470A HR P20020470 A HRP20020470 A HR P20020470A HR P20020470 B1 HRP20020470 B1 HR P20020470B1
- Authority
- HR
- Croatia
- Prior art keywords
- phenyl
- piperazin
- ethoxy
- acid addition
- preparation
- Prior art date
Links
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 7
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 4
- 239000002184 metal Chemical class 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- DLYBHNLWSHLFON-UHFFFAOYSA-N n-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetamide Chemical compound C1CN(CCONC(=O)C)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 DLYBHNLWSHLFON-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9904439A HU226639B1 (en) | 1999-11-30 | 1999-11-30 | {2-[4-(alpha-phenyl-p-chloro-benzyl)-piperazine-1-yl]-ethoxy}-acetic acid-amides and process for producing them |
| HU9904438A HU226641B1 (en) | 1999-11-30 | 1999-11-30 | Process for producing {2-[4-(alpha-phenyl-p-chloro-benzyl)-piperazine-1-yl]-ethoxy}-acetic acid |
| PCT/HU2000/000123 WO2001040211A1 (en) | 1999-11-30 | 2000-11-29 | A PROCESS FOR THE PREPARATION OF {2-[4-(α-PHENYL-p-CHLOROBENZYL)PIPERAZIN-1-YL]ETHOXY}ACETIC ACID AND NOVEL INTERMEDIATES THEREFOR |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20020470A2 HRP20020470A2 (en) | 2004-04-30 |
| HRP20020470B1 true HRP20020470B1 (en) | 2009-04-30 |
Family
ID=90000077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20020470A HRP20020470B1 (en) | 1999-11-30 | 2002-05-28 | A PROCESS FOR THE PREPARATION OF {2-[4-(alpha-PHENYL-p-CHLORBENZYL)-PIPERAZIN-1-YL]ETHOXY} ACETIC ACID AND NOVEL INTERMEDIATES THEREFOR |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6908999B2 (de) |
| EP (1) | EP1233954B1 (de) |
| JP (1) | JP4763954B2 (de) |
| AT (1) | ATE280165T1 (de) |
| AU (1) | AU1874201A (de) |
| BG (1) | BG65455B1 (de) |
| CZ (1) | CZ304892B6 (de) |
| DE (1) | DE60015177T2 (de) |
| HR (1) | HRP20020470B1 (de) |
| PL (1) | PL200046B1 (de) |
| RU (1) | RU2248974C2 (de) |
| SI (1) | SI1233954T1 (de) |
| SK (1) | SK285641B6 (de) |
| UA (1) | UA72949C2 (de) |
| WO (1) | WO2001040211A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005503368A (ja) * | 2001-07-26 | 2005-02-03 | ユ セ ベ ソシエテ アノニム | ２−（２−（４−（ビス（４−フルオロフェニル）メチル）−ピペラジン−１−イル）エトキシ）酢酸誘導体、又は対応するその塩形態及びそのための中間体の調製方法 |
| WO2003104212A1 (en) * | 2002-06-05 | 2003-12-18 | Dr.Reddy's Laboratories Ltd. | A novel amorphous form of [2-[4-[(4-chlorophenyl)-phenyl methyl]-1- piperazinyl] ethoxy] acetic acid dihydrochloride (cetirizine dihydrochloride) |
| HU227325B1 (en) * | 2005-12-08 | 2011-03-28 | Egis Gyogyszergyar Nyrt | Process for the production of an intermediate of (dextro- and levo)- cetirizine |
| HU227319B1 (en) * | 2005-12-08 | 2011-03-28 | Egis Gyogyszergyar Nyrt | Process for the production of (2-chloro-ethoxy)-acetic acid-n,n-dimethylamide and its intermediate and the novel intermediate |
| KR102034448B1 (ko) | 2017-12-20 | 2019-10-18 | 주식회사 포스코 | 강재 및 이의 제조 방법 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0058146A1 (de) * | 1981-02-06 | 1982-08-18 | U C B, S.A. | 2-(4-(Diphenylmethyl)-1-piperazinyl)-essigsäure und ihre Amide, Verfahren zu ihrer Bereitung und pharmazeutische Zusammensetzungen |
| WO1997037982A1 (fr) * | 1996-04-10 | 1997-10-16 | Ucb S.A. | Nouveaux [2-(1-piperazinyl)ethoxy]methyle substitues |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA8337A1 (uk) * | 1981-02-06 | 1996-03-29 | Бальтес Ежен | 2-[4-(дифенілметіл)-1-піперазиніл]-оцтові кислоти або їх аміди, або їх нетоксичні фармацевтично прийняті солі, що проявляють спазмолітичну і антигістамінну активність |
| US5347060A (en) * | 1991-07-24 | 1994-09-13 | Mobil Oil Corporation | Phase-transfer catalysis with onium-containing synthetic mesoporous crystalline material |
| GB9305282D0 (en) * | 1993-03-15 | 1993-05-05 | Ucb Sa | Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine |
| CA2180993A1 (en) * | 1996-07-11 | 1998-01-12 | Yong Tao | Methods for the manufacture of cetirizine |
-
2000
- 2000-11-29 EP EP00981508A patent/EP1233954B1/de not_active Expired - Lifetime
- 2000-11-29 PL PL354677A patent/PL200046B1/pl unknown
- 2000-11-29 SK SK752-2002A patent/SK285641B6/sk not_active IP Right Cessation
- 2000-11-29 WO PCT/HU2000/000123 patent/WO2001040211A1/en active IP Right Grant
- 2000-11-29 US US10/148,704 patent/US6908999B2/en not_active Expired - Fee Related
- 2000-11-29 AT AT00981508T patent/ATE280165T1/de not_active IP Right Cessation
- 2000-11-29 RU RU2002118101/04A patent/RU2248974C2/ru not_active IP Right Cessation
- 2000-11-29 DE DE60015177T patent/DE60015177T2/de not_active Expired - Lifetime
- 2000-11-29 SI SI200030569T patent/SI1233954T1/xx unknown
- 2000-11-29 AU AU18742/01A patent/AU1874201A/en not_active Abandoned
- 2000-11-29 JP JP2001541895A patent/JP4763954B2/ja not_active Expired - Fee Related
- 2000-11-29 UA UA2002065341A patent/UA72949C2/uk unknown
- 2000-11-29 CZ CZ2002-1712A patent/CZ304892B6/cs not_active IP Right Cessation
-
2002
- 2002-05-28 HR HR20020470A patent/HRP20020470B1/xx not_active IP Right Cessation
- 2002-05-30 BG BG106760A patent/BG65455B1/bg unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0058146A1 (de) * | 1981-02-06 | 1982-08-18 | U C B, S.A. | 2-(4-(Diphenylmethyl)-1-piperazinyl)-essigsäure und ihre Amide, Verfahren zu ihrer Bereitung und pharmazeutische Zusammensetzungen |
| WO1997037982A1 (fr) * | 1996-04-10 | 1997-10-16 | Ucb S.A. | Nouveaux [2-(1-piperazinyl)ethoxy]methyle substitues |
Also Published As
| Publication number | Publication date |
|---|---|
| US20030092911A1 (en) | 2003-05-15 |
| HRP20020470A2 (en) | 2004-04-30 |
| DE60015177T2 (de) | 2005-10-27 |
| PL354677A1 (en) | 2004-02-09 |
| WO2001040211A1 (en) | 2001-06-07 |
| EP1233954B1 (de) | 2004-10-20 |
| BG65455B1 (bg) | 2008-08-29 |
| RU2002118101A (ru) | 2004-01-20 |
| SI1233954T1 (en) | 2005-02-28 |
| ATE280165T1 (de) | 2004-11-15 |
| BG106760A (en) | 2003-04-30 |
| SK7522002A3 (en) | 2002-11-06 |
| EP1233954A1 (de) | 2002-08-28 |
| CZ304892B6 (cs) | 2015-01-07 |
| SK285641B6 (sk) | 2007-05-03 |
| CZ20021712A3 (cs) | 2002-09-11 |
| DE60015177D1 (de) | 2004-11-25 |
| JP4763954B2 (ja) | 2011-08-31 |
| AU1874201A (en) | 2001-06-12 |
| RU2248974C2 (ru) | 2005-03-27 |
| PL200046B1 (pl) | 2008-11-28 |
| UA72949C2 (uk) | 2005-05-16 |
| JP2003515600A (ja) | 2003-05-07 |
| US6908999B2 (en) | 2005-06-21 |
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Payment date: 20091104 Year of fee payment: 10 |
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