HRP20020286A2 - Synergistic combinations of an nk<sub>1</sub> receptor antagonist and a gaba structural analog - Google Patents
Synergistic combinations of an nk<sub>1</sub> receptor antagonist and a gaba structural analog Download PDFInfo
- Publication number
- HRP20020286A2 HRP20020286A2 HR20020286A HRP20020286A HRP20020286A2 HR P20020286 A2 HRP20020286 A2 HR P20020286A2 HR 20020286 A HR20020286 A HR 20020286A HR P20020286 A HRP20020286 A HR P20020286A HR P20020286 A2 HRP20020286 A2 HR P20020286A2
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- Croatia
- Prior art keywords
- receptor antagonist
- phenyl
- methyl
- ethyl
- ethylcarbamoyl
- Prior art date
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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| US15827199P | 1999-10-07 | 1999-10-07 | |
| PCT/EP2000/009858 WO2001024792A1 (en) | 1999-10-07 | 2000-10-05 | Synergistic combinations of an nk1 receptor antagonist and a gaba structural analog |
Publications (1)
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| HRP20020286A2 true HRP20020286A2 (en) | 2003-08-31 |
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| HR20020286A HRP20020286A2 (en) | 1999-10-07 | 2002-04-04 | Synergistic combinations of an nk<sub>1</sub> receptor antagonist and a gaba structural analog |
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Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1094757C (zh) | 1996-07-24 | 2002-11-27 | 沃尼尔·朗伯公司 | 用于治疗疼痛的异丁基γ－氨基丁酸及其衍生物 |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| EP1499309A4 (en) * | 2002-04-24 | 2008-05-28 | Cypress Bioscience Inc | PREVENTION AND TREATMENT OF FUNCTIONAL SOMATIC DISEASES, INCLUDING STRESS-BASED DISEASES |
| US20060039968A1 (en) * | 2002-10-08 | 2006-02-23 | Ramalingam Manikandan | Gabapentin tablets and method for their preparation |
| EP1721607A1 (en) * | 2003-03-21 | 2006-11-15 | Dynogen Pharmaceuticals, Inc. | Methods for treating lower urinary tract disorders using smooth muscle modulators and alpha-2-delta subunit calcium channel modulators |
| WO2004084880A1 (en) * | 2003-03-21 | 2004-10-07 | Dynogen Pharmaceuticals, Inc. | METHODS FOR TREATING PAIN USING SMOOTH MUSCLE MODULATORS AND α2δ SUBUNIT CALCIUM CHANNEL MODULATORS |
| WO2004084881A1 (en) * | 2003-03-21 | 2004-10-07 | Dynogen Pharmaceuticals, Inc. | METHODS FOR TREATING FUNCTIONAL BOWEL DISORDERS USING α2δ SUBUNIT CALCIUM CHANNEL MODULATORS WITH SMOOTH MUSCLE MODULATORS |
| EP1543831A1 (en) * | 2003-12-18 | 2005-06-22 | Pfizer GmbH Arzneimittelwerk Gödecke | Pregabalin composition |
| DE102007019071A1 (de) * | 2007-04-23 | 2008-10-30 | Ratiopharm Gmbh | Stabilisierte pharmazeutische Zusammensetzung enthaltend Pregabalin |
| KR101786818B1 (ko) | 2010-07-30 | 2017-10-18 | 도레이 카부시키가이샤 | 신경장애성 동통의 치료제 또는 예방제 |
| US9089531B2 (en) * | 2010-09-28 | 2015-07-28 | The Regents Of The University Of California | GABA agonists in the treatment of disorders associated with metabolic syndrome and GABA combinations in treatment or prophylaxis of type I diabetes |
| WO2022234110A1 (en) * | 2021-05-07 | 2022-11-10 | Plus Vitech, S.L. | Gamma-aminobutyric acid derivatives for use in cancer therapy |
Family Cites Families (5)
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| US5025035A (en) * | 1990-10-12 | 1991-06-18 | Warner-Lambert Company | Method of treating depression |
| US5792796A (en) * | 1994-07-27 | 1998-08-11 | Warner-Lambert Company | Methods for treating anxiety and panic |
| US5510381A (en) * | 1995-05-15 | 1996-04-23 | Warner-Lambert Company | Method of treatment of mania and bipolar disorder |
| JP2001502311A (ja) * | 1996-10-07 | 2001-02-20 | メルク シヤープ エンド ドーム リミテツド | 抗鬱及び／又は抗不安薬としてのｃｎｓ浸透性ｎｋ―１受容体拮抗薬 |
| AU729708B2 (en) * | 1996-12-02 | 2001-02-08 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating severe anxiety disorders |
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2000
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- 2000-10-05 PT PT00966138T patent/PT1221950E/pt unknown
- 2000-10-05 SK SK454-2002A patent/SK4542002A3/sk unknown
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- 2000-10-05 CN CN00813906A patent/CN1387434A/zh active Pending
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- 2000-10-05 IL IL14896500A patent/IL148965A0/xx unknown
- 2000-10-05 CZ CZ20021116A patent/CZ20021116A3/cs unknown
- 2000-10-05 MX MXPA02003484A patent/MXPA02003484A/es active IP Right Grant
- 2000-10-05 EP EP00966138A patent/EP1221950B1/en not_active Expired - Lifetime
- 2000-10-05 BR BR0014598-0A patent/BR0014598A/pt not_active Application Discontinuation
- 2000-10-05 TR TR2002/00913T patent/TR200200913T2/xx unknown
- 2000-10-05 NZ NZ517949A patent/NZ517949A/en unknown
- 2000-10-05 KR KR1020027004462A patent/KR20020060192A/ko not_active Application Discontinuation
- 2000-10-05 ES ES00966138T patent/ES2220542T3/es not_active Expired - Lifetime
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- 2000-10-05 EA EA200200303A patent/EA004266B1/ru not_active IP Right Cessation
- 2000-10-05 CA CA002385930A patent/CA2385930A1/en not_active Abandoned
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- 2000-10-05 AU AU76633/00A patent/AU7663300A/en not_active Abandoned
- 2000-10-05 DE DE60011650T patent/DE60011650T2/de not_active Expired - Fee Related
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- 2000-10-05 HU HU0203466A patent/HUP0203466A3/hu unknown
- 2000-10-06 CO CO00076105A patent/CO5280195A1/es not_active Application Discontinuation
- 2000-10-06 AR ARP000105296A patent/AR029646A1/es not_active Application Discontinuation
- 2000-10-06 PA PA20008504301A patent/PA8504301A1/es unknown
- 2000-10-06 PE PE2000001069A patent/PE20010708A1/es not_active Application Discontinuation
- 2000-10-06 GT GT200000166A patent/GT200000166A/es unknown
- 2000-10-06 UY UY26376A patent/UY26376A1/es not_active Application Discontinuation
- 2000-10-09 WO PCT/EP2000/010084 patent/WO2001024791A1/en not_active Application Discontinuation
- 2000-10-09 EP EP00979495A patent/EP1233766A1/en not_active Withdrawn
- 2000-10-09 JP JP2001527790A patent/JP2003510355A/ja not_active Withdrawn
- 2000-10-09 AU AU16962/01A patent/AU1696201A/en not_active Abandoned
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2002
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- 2002-03-22 BG BG106548A patent/BG106548A/xx unknown
- 2002-04-04 HR HR20020286A patent/HRP20020286A2/hr not_active Application Discontinuation
- 2002-04-05 ZA ZA200202675A patent/ZA200202675B/xx unknown
- 2002-04-05 NO NO20021625A patent/NO20021625D0/no not_active Application Discontinuation
- 2002-04-05 MA MA26587A patent/MA26826A1/fr unknown
- 2002-04-05 CR CR6614A patent/CR6614A/es not_active Application Discontinuation
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