HRP20020075A2 - Oligonucleotides for inhibiting the expression of human eg5 - Google Patents
Oligonucleotides for inhibiting the expression of human eg5 Download PDFInfo
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- HRP20020075A2 HRP20020075A2 HR20020075A HRP20020075A HRP20020075A2 HR P20020075 A2 HRP20020075 A2 HR P20020075A2 HR 20020075 A HR20020075 A HR 20020075A HR P20020075 A HRP20020075 A HR P20020075A HR P20020075 A2 HRP20020075 A2 HR P20020075A2
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- Prior art keywords
- oligonucleotide
- seq
- derivative according
- modified
- nucleoside
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
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- General Engineering & Computer Science (AREA)
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- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19935303A DE19935303A1 (de) | 1999-07-28 | 1999-07-28 | Oligonukleotide zur Inhibierung der Expression von humanem eg5 |
| PCT/EP2000/007345 WO2001007602A2 (de) | 1999-07-28 | 2000-07-21 | Oligonukleotide zur inhibierung der expression von humanem eg5 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20020075A2 true HRP20020075A2 (en) | 2005-10-31 |
Family
ID=7916259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20020075A HRP20020075A2 (en) | 1999-07-28 | 2002-01-25 | Oligonucleotides for inhibiting the expression of human eg5 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6472521B1 (xx) |
| EP (1) | EP1204742A2 (xx) |
| JP (1) | JP2003505080A (xx) |
| KR (1) | KR20020033744A (xx) |
| CN (1) | CN1165617C (xx) |
| AR (1) | AR024953A1 (xx) |
| AU (1) | AU6568200A (xx) |
| BR (1) | BR0013180A (xx) |
| CA (1) | CA2380192A1 (xx) |
| CZ (1) | CZ2002324A3 (xx) |
| DE (1) | DE19935303A1 (xx) |
| EE (1) | EE200200044A (xx) |
| HK (1) | HK1048337B (xx) |
| HR (1) | HRP20020075A2 (xx) |
| HU (1) | HUP0202794A3 (xx) |
| IL (1) | IL147541A0 (xx) |
| MX (1) | MXPA02000817A (xx) |
| NO (1) | NO20020365L (xx) |
| NZ (1) | NZ516839A (xx) |
| PL (1) | PL353733A1 (xx) |
| RU (1) | RU2249458C2 (xx) |
| SK (1) | SK1162002A3 (xx) |
| TR (1) | TR200200201T2 (xx) |
| WO (1) | WO2001007602A2 (xx) |
| YU (1) | YU91901A (xx) |
| ZA (1) | ZA200200655B (xx) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6617115B1 (en) * | 1999-10-27 | 2003-09-09 | Cytokinetics, Inc. | Methods of screening for modulators of cell proliferation |
| US6440686B1 (en) | 2000-06-15 | 2002-08-27 | Cytokinetics, Inc. | Methods for screening and therapeutic applications of kinesin modulators |
| US6809102B2 (en) | 2001-03-29 | 2004-10-26 | Bristol-Myers Squibb Company | Cyano-substituted dihydropyrimidine compounds and their use to treat diseases |
| US6900214B2 (en) | 2001-03-29 | 2005-05-31 | Bristol-Myers Squibb Company | Cyano-substituted dihydropyrimidine compounds and their use to treat diseases |
| US20040009156A1 (en) * | 2001-10-12 | 2004-01-15 | Christoph Reinhard | Antisense therapy using oligonucleotides that target human kinesin genes for treatment of cancer |
| US7199107B2 (en) | 2002-05-23 | 2007-04-03 | Isis Pharmaceuticals, Inc. | Antisense modulation of kinesin-like 1 expression |
| US7163927B2 (en) * | 2002-05-23 | 2007-01-16 | Isis Pharmaceuticals, Inc. | Antisense modulation of kinesin-like 1 expression |
| EP1620449A4 (en) * | 2003-02-14 | 2008-10-01 | Smithkline Beecham Corp | NUCLEIC ACIDS WITH DIFFERENTIAL EXPRESSION THAT CORRELATE WITH KSP EXPRESSION |
| US7662581B1 (en) | 2003-12-18 | 2010-02-16 | Novartis Vaccines And Diagnostics, Inc. | Eg5 co-crystals |
| ATE496142T1 (de) * | 2004-03-23 | 2011-02-15 | Oncotherapy Science Inc | Verfahren zur diagnose von nicht-kleinzelligem lungenkrebs |
| US7700567B2 (en) * | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
| KR20170061189A (ko) * | 2006-03-31 | 2017-06-02 | 알닐람 파마슈티칼스 인코포레이티드 | Ｅｇ5 유전자의 발현을 억제하는 이본쇄 리보핵산 |
| RU2464030C2 (ru) * | 2006-05-26 | 2012-10-20 | Регадо Байосайенсиз, Инк. | Введение противосвертывающей системы reg1 |
| CA2653313A1 (en) * | 2006-05-26 | 2007-12-06 | Regado Biosciences, Inc. | Administration of the reg1 anticoagulation system |
| JP5753382B2 (ja) * | 2007-11-06 | 2015-07-22 | アディウティーダ ファーマシューティカルズ ゲーエムベーハー | 修飾されたオリゴリン酸基を含有する免疫賦活オリゴリボヌクレオチドアナログ |
| DE102010007562A1 (de) * | 2010-02-10 | 2011-08-11 | sterna biologicals GmbH & Co KG, 35043 | Dermatologische, pharmazeutische Zusammensetzung geeignet für Oligonukleotide |
| DK2750768T3 (en) | 2011-08-30 | 2019-01-21 | Astex Pharmaceuticals Inc | DECITABINE INDIVIDUAL FORMULATIONS |
| US9498540B2 (en) | 2013-03-15 | 2016-11-22 | Novartis Ag | Cell proliferation inhibitors and conjugates thereof |
| EP2991661B1 (en) | 2013-05-01 | 2019-03-13 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| EP3715457A3 (en) * | 2013-08-28 | 2020-12-16 | Ionis Pharmaceuticals, Inc. | Modulation of prekallikrein (pkk) expression |
| WO2015054676A2 (en) * | 2013-10-11 | 2015-04-16 | Isis Pharmaceuticals, Inc. | Compositions for modulating c9orf72 expression |
| ES2941742T3 (es) * | 2014-05-01 | 2023-05-25 | Ionis Pharmaceuticals Inc | Composiciones y procedimientos para modular la expresión del factor B del complemento |
| CN108024535A (zh) | 2015-07-02 | 2018-05-11 | 大塚制药株式会社 | 冻干药物组合物 |
| CA3071755A1 (en) | 2017-08-03 | 2019-02-07 | Otsuka Pharmaceutical Co., Ltd. | Drug compound and purification methods thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0171066A3 (de) | 1984-08-09 | 1989-02-01 | Siemens Aktiengesellschaft | Verfahren und Schaltungsanordnung zum Adressieren von Signalabgabe-/Signalaufnahmeeinrichtungen von einer zentralen Verarbeitungseinrichtung her |
| ES2099718T3 (es) | 1990-07-02 | 1997-06-01 | Hoechst Ag | Analogos de oligonucleotidos con uniones internucleotidicas de 3'-3' o 5'-5' terminales. |
| US6033909A (en) | 1992-01-22 | 2000-03-07 | Hoechst Aktiengesellschaft | Oligonucleotide analogs, their preparation and use |
| NZ245720A (en) | 1992-01-22 | 1995-12-21 | Hoechst Ag | Oligonucleotide analogues; use as gene expression inhibitor or dna probe |
| DK0593901T3 (da) | 1992-09-24 | 1997-10-27 | Hoechst Ag | Oligoribonucleotid- og ribozym-analoge med terminale 3-3- og 5-5-bindinger. |
| GB9311113D0 (en) * | 1993-05-28 | 1993-07-14 | Medical Res Council | Probes |
| DE4321946A1 (de) | 1993-07-01 | 1995-01-12 | Hoechst Ag | Methylphosphonsäureester, Verfahren zu deren Herstellung und deren Verwendung |
| US5801154A (en) * | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
| DE4338704A1 (de) | 1993-11-12 | 1995-05-18 | Hoechst Ag | Stabilisierte Oligonucleotide und deren Verwendung |
| DE4408528A1 (de) | 1994-03-14 | 1995-09-28 | Hoechst Ag | Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung |
| DE4415370A1 (de) | 1994-05-02 | 1995-11-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
| DE4438918A1 (de) | 1994-11-04 | 1996-05-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
| DE19502912A1 (de) * | 1995-01-31 | 1996-08-01 | Hoechst Ag | G-Cap Stabilisierte Oligonucleotide |
| ATE206131T1 (de) | 1995-03-13 | 2001-10-15 | Aventis Pharma Gmbh | Phosphonomonoesternnukleinsäuren, verfahren zu ihrer herstellung und ihre verwendung |
| US6309821B1 (en) * | 1996-05-16 | 2001-10-30 | Incyte Genomics, Inc. | DNA encoding a PAC10 human homolog |
| EP1066382A1 (en) * | 1997-07-23 | 2001-01-10 | Brigham & Women's Hospital, Inc. | Lens epithelial cell derived growth factor |
| EP1053319A2 (en) * | 1998-01-28 | 2000-11-22 | Chiron Corporation | Human genes and gene expression products ii |
-
1999
- 1999-07-28 DE DE19935303A patent/DE19935303A1/de not_active Withdrawn
-
2000
- 2000-07-21 YU YU91901A patent/YU91901A/sh unknown
- 2000-07-21 IL IL14754100A patent/IL147541A0/xx unknown
- 2000-07-21 JP JP2001512871A patent/JP2003505080A/ja not_active Withdrawn
- 2000-07-21 SK SK116-2002A patent/SK1162002A3/sk unknown
- 2000-07-21 CA CA002380192A patent/CA2380192A1/en not_active Abandoned
- 2000-07-21 MX MXPA02000817A patent/MXPA02000817A/es unknown
- 2000-07-21 CN CNB008108293A patent/CN1165617C/zh not_active Expired - Fee Related
- 2000-07-21 KR KR1020027001188A patent/KR20020033744A/ko not_active Application Discontinuation
- 2000-07-21 NZ NZ516839A patent/NZ516839A/en unknown
- 2000-07-21 CZ CZ2002324A patent/CZ2002324A3/cs unknown
- 2000-07-21 EE EEP200200044A patent/EE200200044A/xx unknown
- 2000-07-21 PL PL00353733A patent/PL353733A1/xx not_active Application Discontinuation
- 2000-07-21 WO PCT/EP2000/007345 patent/WO2001007602A2/de not_active Application Discontinuation
- 2000-07-21 AU AU65682/00A patent/AU6568200A/en not_active Abandoned
- 2000-07-21 RU RU2002105021/15A patent/RU2249458C2/ru not_active IP Right Cessation
- 2000-07-21 BR BR0013180-6A patent/BR0013180A/pt not_active IP Right Cessation
- 2000-07-21 TR TR2002/00201T patent/TR200200201T2/xx unknown
- 2000-07-21 HU HU0202794A patent/HUP0202794A3/hu unknown
- 2000-07-21 EP EP00953119A patent/EP1204742A2/de not_active Withdrawn
- 2000-07-26 AR ARP000103872A patent/AR024953A1/es unknown
- 2000-07-27 US US09/627,122 patent/US6472521B1/en not_active Expired - Fee Related
-
2002
- 2002-01-23 NO NO20020365A patent/NO20020365L/no unknown
- 2002-01-24 ZA ZA200200655A patent/ZA200200655B/en unknown
- 2002-01-25 HR HR20020075A patent/HRP20020075A2/hr not_active Application Discontinuation
-
2003
- 2003-01-23 HK HK03100581.2A patent/HK1048337B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR0013180A (pt) | 2002-04-09 |
| CA2380192A1 (en) | 2001-02-01 |
| CZ2002324A3 (cs) | 2002-05-15 |
| NZ516839A (en) | 2004-04-30 |
| US6472521B1 (en) | 2002-10-29 |
| AR024953A1 (es) | 2002-10-30 |
| IL147541A0 (en) | 2002-08-14 |
| WO2001007602A3 (de) | 2001-05-17 |
| ZA200200655B (en) | 2003-09-23 |
| MXPA02000817A (es) | 2002-07-30 |
| CN1165617C (zh) | 2004-09-08 |
| PL353733A1 (en) | 2003-12-01 |
| HK1048337B (zh) | 2005-02-25 |
| NO20020365D0 (no) | 2002-01-23 |
| JP2003505080A (ja) | 2003-02-12 |
| HUP0202794A2 (en) | 2003-03-28 |
| TR200200201T2 (tr) | 2002-05-21 |
| DE19935303A1 (de) | 2001-02-08 |
| HK1048337A1 (en) | 2003-03-28 |
| YU91901A (sh) | 2003-02-28 |
| NO20020365L (no) | 2002-03-25 |
| CN1367828A (zh) | 2002-09-04 |
| RU2249458C2 (ru) | 2005-04-10 |
| HUP0202794A3 (en) | 2006-03-28 |
| SK1162002A3 (en) | 2002-06-04 |
| EE200200044A (et) | 2003-06-16 |
| AU6568200A (en) | 2001-02-13 |
| KR20020033744A (ko) | 2002-05-07 |
| EP1204742A2 (de) | 2002-05-15 |
| WO2001007602A2 (de) | 2001-02-01 |
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Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, DE |
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| OBST | Application withdrawn |