WO2001007602A3 - Oligonukleotide zur inhibierung der expression von humanem eg5 - Google Patents

Oligonukleotide zur inhibierung der expression von humanem eg5 Download PDF

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Publication number
WO2001007602A3
WO2001007602A3 PCT/EP2000/007345 EP0007345W WO0107602A3 WO 2001007602 A3 WO2001007602 A3 WO 2001007602A3 EP 0007345 W EP0007345 W EP 0007345W WO 0107602 A3 WO0107602 A3 WO 0107602A3
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WO
WIPO (PCT)
Prior art keywords
human
oligonucleotides
inhibiting
expression
oligonucleotide
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PCT/EP2000/007345
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English (en)
French (fr)
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WO2001007602A2 (de
Inventor
Eugen Uhlmann
Beate Greiner
Eberhard Unger
Gislinde Gothe
Marc Schwerdel
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Aventis Pharma Gmbh
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Priority to KR1020027001188A priority Critical patent/KR20020033744A/ko
Priority to BR0013180-6A priority patent/BR0013180A/pt
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Priority to CA002380192A priority patent/CA2380192A1/en
Priority to MXPA02000817A priority patent/MXPA02000817A/es
Priority to AU65682/00A priority patent/AU6568200A/en
Priority to PL00353733A priority patent/PL353733A1/xx
Priority to EP00953119A priority patent/EP1204742A2/de
Priority to SK116-2002A priority patent/SK1162002A3/sk
Priority to HU0202794A priority patent/HUP0202794A3/hu
Priority to JP2001512871A priority patent/JP2003505080A/ja
Priority to NZ516839A priority patent/NZ516839A/en
Priority to EEP200200044A priority patent/EE200200044A/xx
Priority to IL14754100A priority patent/IL147541A0/xx
Publication of WO2001007602A2 publication Critical patent/WO2001007602A2/de
Publication of WO2001007602A3 publication Critical patent/WO2001007602A3/de
Priority to NO20020365A priority patent/NO20020365L/no
Priority to HR20020075A priority patent/HRP20020075A2/hr
Priority to HK03100581.2A priority patent/HK1048337B/zh

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Abstract

Die vorliegende Erfindung betrifft ein Oligonukleotid oder eines seiner Derivate, dadurch gekennzeichnet, dass es eine Sequenz aufweist, die einem bestimmten Teil einer humanen eg5 oder einer davon mutierten Form kodierenden Nukleinsäuresequenz entspricht; darüberhinaus betrifft die Erfindung ein Verfahren zur Herstellung des Oligonukleotids und dessen Verwendung.
PCT/EP2000/007345 1999-07-28 2000-07-21 Oligonukleotide zur inhibierung der expression von humanem eg5 WO2001007602A2 (de)

Priority Applications (16)

Application Number Priority Date Filing Date Title
IL14754100A IL147541A0 (en) 1999-07-28 2000-07-21 Oligonucleotides for inhibiting the expression of human eg5
SK116-2002A SK1162002A3 (en) 1999-07-28 2000-07-21 Oligonucleotide for inhibiting the expression of human eg5 and pharmaceutical composition comprising this oligonucleotide
CA002380192A CA2380192A1 (en) 1999-07-28 2000-07-21 Oligonucleotides for inhibiting the expression of human eg5
MXPA02000817A MXPA02000817A (es) 1999-07-28 2000-07-21 Oligonucleotidos oara la inhibicion de la expresion de eg5 humana.
AU65682/00A AU6568200A (en) 1999-07-28 2000-07-21 Oligonucleotides for inhibiting the expression of human eg5
PL00353733A PL353733A1 (en) 1999-07-28 2000-07-21 Oligonucleotides for inhibiting the expression of human eg5
EP00953119A EP1204742A2 (de) 1999-07-28 2000-07-21 Oligonukleotide zur inhibierung der expression von humanem eg5
KR1020027001188A KR20020033744A (ko) 1999-07-28 2000-07-21 사람 eg5의 발현을 억제하는 올리고뉴클레오티드
HU0202794A HUP0202794A3 (en) 1999-07-28 2000-07-21 Oligonucleotides for inhibiting the expression of human eg5
NZ516839A NZ516839A (en) 1999-07-28 2000-07-21 Oligonucleotides for inhibiting the expression of human mitotic kinesin related motor protein eg5
JP2001512871A JP2003505080A (ja) 1999-07-28 2000-07-21 ヒトeg5の発現を阻害するためのオリゴヌクレオチド
EEP200200044A EE200200044A (et) 1999-07-28 2000-07-21 Antisenss-oligonukleotiid või selle derivaat, selle valmistamismeetod ja kasutamine, meetod eg5 ekspressiooni inhibeerimiseks ning farmatseutiline kompositsioon ja selle valmistamismeetod
BR0013180-6A BR0013180A (pt) 1999-07-28 2000-07-21 Oligonucleotìdeos para inibição da expressão de eg5 humano
NO20020365A NO20020365L (no) 1999-07-28 2002-01-23 Oligonukleotider for inhibiering av ekspresjonen av humant eg5
HR20020075A HRP20020075A2 (en) 1999-07-28 2002-01-25 Oligonucleotides for inhibiting the expression of human eg5
HK03100581.2A HK1048337B (zh) 1999-07-28 2003-01-23 用於抑制人eg5表達的寡核苷酸

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19935303.4 1999-07-28
DE19935303A DE19935303A1 (de) 1999-07-28 1999-07-28 Oligonukleotide zur Inhibierung der Expression von humanem eg5

Publications (2)

Publication Number Publication Date
WO2001007602A2 WO2001007602A2 (de) 2001-02-01
WO2001007602A3 true WO2001007602A3 (de) 2001-05-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/007345 WO2001007602A2 (de) 1999-07-28 2000-07-21 Oligonukleotide zur inhibierung der expression von humanem eg5

Country Status (26)

Country Link
US (1) US6472521B1 (de)
EP (1) EP1204742A2 (de)
JP (1) JP2003505080A (de)
KR (1) KR20020033744A (de)
CN (1) CN1165617C (de)
AR (1) AR024953A1 (de)
AU (1) AU6568200A (de)
BR (1) BR0013180A (de)
CA (1) CA2380192A1 (de)
CZ (1) CZ2002324A3 (de)
DE (1) DE19935303A1 (de)
EE (1) EE200200044A (de)
HK (1) HK1048337B (de)
HR (1) HRP20020075A2 (de)
HU (1) HUP0202794A3 (de)
IL (1) IL147541A0 (de)
MX (1) MXPA02000817A (de)
NO (1) NO20020365L (de)
NZ (1) NZ516839A (de)
PL (1) PL353733A1 (de)
RU (1) RU2249458C2 (de)
SK (1) SK1162002A3 (de)
TR (1) TR200200201T2 (de)
WO (1) WO2001007602A2 (de)
YU (1) YU91901A (de)
ZA (1) ZA200200655B (de)

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US7662581B1 (en) 2003-12-18 2010-02-16 Novartis Vaccines And Diagnostics, Inc. Eg5 co-crystals
ATE496142T1 (de) * 2004-03-23 2011-02-15 Oncotherapy Science Inc Verfahren zur diagnose von nicht-kleinzelligem lungenkrebs
US7700567B2 (en) * 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
KR20170061189A (ko) * 2006-03-31 2017-06-02 알닐람 파마슈티칼스 인코포레이티드 Eg5 유전자의 발현을 억제하는 이본쇄 리보핵산
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CA2653313A1 (en) * 2006-05-26 2007-12-06 Regado Biosciences, Inc. Administration of the reg1 anticoagulation system
JP5753382B2 (ja) * 2007-11-06 2015-07-22 アディウティーダ ファーマシューティカルズ ゲーエムベーハー 修飾されたオリゴリン酸基を含有する免疫賦活オリゴリボヌクレオチドアナログ
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DK2750768T3 (en) 2011-08-30 2019-01-21 Astex Pharmaceuticals Inc DECITABINE INDIVIDUAL FORMULATIONS
US9498540B2 (en) 2013-03-15 2016-11-22 Novartis Ag Cell proliferation inhibitors and conjugates thereof
EP2991661B1 (de) 2013-05-01 2019-03-13 Ionis Pharmaceuticals, Inc. Konjugierte antisense-verbindungen und deren verwendung
EP3715457A3 (de) * 2013-08-28 2020-12-16 Ionis Pharmaceuticals, Inc. Modulation der prekallikrein (pkk)-expression
WO2015054676A2 (en) * 2013-10-11 2015-04-16 Isis Pharmaceuticals, Inc. Compositions for modulating c9orf72 expression
ES2941742T3 (es) * 2014-05-01 2023-05-25 Ionis Pharmaceuticals Inc Composiciones y procedimientos para modular la expresión del factor B del complemento
CN108024535A (zh) 2015-07-02 2018-05-11 大塚制药株式会社 冻干药物组合物
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BR0013180A (pt) 2002-04-09
CA2380192A1 (en) 2001-02-01
CZ2002324A3 (cs) 2002-05-15
NZ516839A (en) 2004-04-30
US6472521B1 (en) 2002-10-29
AR024953A1 (es) 2002-10-30
IL147541A0 (en) 2002-08-14
ZA200200655B (en) 2003-09-23
MXPA02000817A (es) 2002-07-30
CN1165617C (zh) 2004-09-08
PL353733A1 (en) 2003-12-01
HK1048337B (zh) 2005-02-25
NO20020365D0 (no) 2002-01-23
JP2003505080A (ja) 2003-02-12
HUP0202794A2 (en) 2003-03-28
TR200200201T2 (tr) 2002-05-21
HRP20020075A2 (en) 2005-10-31
DE19935303A1 (de) 2001-02-08
HK1048337A1 (en) 2003-03-28
YU91901A (sh) 2003-02-28
NO20020365L (no) 2002-03-25
CN1367828A (zh) 2002-09-04
RU2249458C2 (ru) 2005-04-10
HUP0202794A3 (en) 2006-03-28
SK1162002A3 (en) 2002-06-04
EE200200044A (et) 2003-06-16
AU6568200A (en) 2001-02-13
KR20020033744A (ko) 2002-05-07
EP1204742A2 (de) 2002-05-15
WO2001007602A2 (de) 2001-02-01

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