ZA200200655B - Oligonucleotides for inhibiting the expression of human eg5. - Google Patents
Oligonucleotides for inhibiting the expression of human eg5. Download PDFInfo
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- ZA200200655B ZA200200655B ZA200200655A ZA200200655A ZA200200655B ZA 200200655 B ZA200200655 B ZA 200200655B ZA 200200655 A ZA200200655 A ZA 200200655A ZA 200200655 A ZA200200655 A ZA 200200655A ZA 200200655 B ZA200200655 B ZA 200200655B
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- South Africa
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- oligonucleotide
- seq
- derivative
- antisense oligonucleotide
- modified
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19935303A DE19935303A1 (de) | 1999-07-28 | 1999-07-28 | Oligonukleotide zur Inhibierung der Expression von humanem eg5 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200200655B true ZA200200655B (en) | 2003-09-23 |
Family
ID=7916259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200200655A ZA200200655B (en) | 1999-07-28 | 2002-01-24 | Oligonucleotides for inhibiting the expression of human eg5. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6472521B1 (de) |
| EP (1) | EP1204742A2 (de) |
| JP (1) | JP2003505080A (de) |
| KR (1) | KR20020033744A (de) |
| CN (1) | CN1165617C (de) |
| AR (1) | AR024953A1 (de) |
| AU (1) | AU6568200A (de) |
| BR (1) | BR0013180A (de) |
| CA (1) | CA2380192A1 (de) |
| CZ (1) | CZ2002324A3 (de) |
| DE (1) | DE19935303A1 (de) |
| EE (1) | EE200200044A (de) |
| HK (1) | HK1048337B (de) |
| HR (1) | HRP20020075A2 (de) |
| HU (1) | HUP0202794A3 (de) |
| IL (1) | IL147541A0 (de) |
| MX (1) | MXPA02000817A (de) |
| NO (1) | NO20020365L (de) |
| NZ (1) | NZ516839A (de) |
| PL (1) | PL353733A1 (de) |
| RU (1) | RU2249458C2 (de) |
| SK (1) | SK1162002A3 (de) |
| TR (1) | TR200200201T2 (de) |
| WO (1) | WO2001007602A2 (de) |
| YU (1) | YU91901A (de) |
| ZA (1) | ZA200200655B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6617115B1 (en) | 1999-10-27 | 2003-09-09 | Cytokinetics, Inc. | Methods of screening for modulators of cell proliferation |
| US6440686B1 (en) | 2000-06-15 | 2002-08-27 | Cytokinetics, Inc. | Methods for screening and therapeutic applications of kinesin modulators |
| US6900214B2 (en) | 2001-03-29 | 2005-05-31 | Bristol-Myers Squibb Company | Cyano-substituted dihydropyrimidine compounds and their use to treat diseases |
| US6809102B2 (en) | 2001-03-29 | 2004-10-26 | Bristol-Myers Squibb Company | Cyano-substituted dihydropyrimidine compounds and their use to treat diseases |
| US20040009156A1 (en) * | 2001-10-12 | 2004-01-15 | Christoph Reinhard | Antisense therapy using oligonucleotides that target human kinesin genes for treatment of cancer |
| US7199107B2 (en) | 2002-05-23 | 2007-04-03 | Isis Pharmaceuticals, Inc. | Antisense modulation of kinesin-like 1 expression |
| US7163927B2 (en) * | 2002-05-23 | 2007-01-16 | Isis Pharmaceuticals, Inc. | Antisense modulation of kinesin-like 1 expression |
| WO2004074301A2 (en) * | 2003-02-14 | 2004-09-02 | Smithkline Beecham Corporation | Differentially expressed nucleic acids that correlate with ksp expression |
| US7662581B1 (en) | 2003-12-18 | 2010-02-16 | Novartis Vaccines And Diagnostics, Inc. | Eg5 co-crystals |
| EP1737979B9 (de) * | 2004-03-23 | 2011-09-21 | Oncotherapy Science, Inc. | Verfahren zur diagnose von nicht-kleinzelligem lungenkrebs |
| US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
| ES2544861T3 (es) * | 2006-03-31 | 2015-09-04 | Alnylam Pharmaceuticals Inc. | Composiciones y métodos para inhibir la expresión del gen Eg5 |
| RU2464030C2 (ru) * | 2006-05-26 | 2012-10-20 | Регадо Байосайенсиз, Инк. | Введение противосвертывающей системы reg1 |
| CN101453891B (zh) * | 2006-05-26 | 2013-12-11 | 雷加多生物科学公司 | Reg1抗凝系统的给药 |
| PT2207787E (pt) * | 2007-11-06 | 2015-02-17 | Adiutide Pharmaceuticals Gmbh | Análogos de oligorribonucleótidos imunoestimulantes contendo frações de oligofosfato modificadas |
| DE102010007562A1 (de) | 2010-02-10 | 2011-08-11 | sterna biologicals GmbH & Co KG, 35043 | Dermatologische, pharmazeutische Zusammensetzung geeignet für Oligonukleotide |
| DK2750768T3 (en) | 2011-08-30 | 2019-01-21 | Astex Pharmaceuticals Inc | DECITABINE INDIVIDUAL FORMULATIONS |
| US9498540B2 (en) | 2013-03-15 | 2016-11-22 | Novartis Ag | Cell proliferation inhibitors and conjugates thereof |
| US9127276B2 (en) | 2013-05-01 | 2015-09-08 | Isis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| CA2921839A1 (en) * | 2013-08-28 | 2015-03-05 | Ionis Pharmaceuticals, Inc. | Modulation of prekallikrein (pkk) expression |
| WO2015054676A2 (en) * | 2013-10-11 | 2015-04-16 | Isis Pharmaceuticals, Inc. | Compositions for modulating c9orf72 expression |
| KR102369736B1 (ko) * | 2014-05-01 | 2022-03-02 | 아이오니스 파마수티컬즈, 인코포레이티드 | 보체 인자 b 발현을 조절하기 위한 조성물 및 방법 |
| CA2991167A1 (en) | 2015-07-02 | 2017-01-05 | Otsuka Pharmaceutical Co., Ltd. | Lyophilized pharmaceutical compositions |
| MX2020001233A (es) | 2017-08-03 | 2020-07-20 | Otsuka Pharma Co Ltd | Compuesto farmaceutico y metodos de purificacion del mismo. |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0171066A3 (de) | 1984-08-09 | 1989-02-01 | Siemens Aktiengesellschaft | Verfahren und Schaltungsanordnung zum Adressieren von Signalabgabe-/Signalaufnahmeeinrichtungen von einer zentralen Verarbeitungseinrichtung her |
| DE59108644D1 (de) | 1990-07-02 | 1997-05-07 | Hoechst Ag | Oligonucleotid-analoge mit terminalen 3'-3'-bzw. 5'-5'-Internucleotidverknüpfungen |
| NZ245720A (en) | 1992-01-22 | 1995-12-21 | Hoechst Ag | Oligonucleotide analogues; use as gene expression inhibitor or dna probe |
| US6033909A (en) | 1992-01-22 | 2000-03-07 | Hoechst Aktiengesellschaft | Oligonucleotide analogs, their preparation and use |
| DE59306170D1 (de) | 1992-09-24 | 1997-05-22 | Hoechst Ag | Oligoribonucleotid- und Ribozym-Analoga mit terminalen 3'-3'-bzw.5'-5'-Verknüpfungen |
| GB9311113D0 (en) * | 1993-05-28 | 1993-07-14 | Medical Res Council | Probes |
| DE4321946A1 (de) | 1993-07-01 | 1995-01-12 | Hoechst Ag | Methylphosphonsäureester, Verfahren zu deren Herstellung und deren Verwendung |
| US5801154A (en) * | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
| DE4338704A1 (de) | 1993-11-12 | 1995-05-18 | Hoechst Ag | Stabilisierte Oligonucleotide und deren Verwendung |
| DE4408528A1 (de) | 1994-03-14 | 1995-09-28 | Hoechst Ag | Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung |
| DE4415370A1 (de) | 1994-05-02 | 1995-11-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
| DE4438918A1 (de) | 1994-11-04 | 1996-05-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
| DE19502912A1 (de) * | 1995-01-31 | 1996-08-01 | Hoechst Ag | G-Cap Stabilisierte Oligonucleotide |
| PT739898E (pt) | 1995-03-13 | 2002-03-28 | Aventis Pharma Gmbh | Mono-esteres de acidos fosfonucleicos processo para a sua preparacao e sua utilizacao |
| US6309821B1 (en) * | 1996-05-16 | 2001-10-30 | Incyte Genomics, Inc. | DNA encoding a PAC10 human homolog |
| AU8656098A (en) * | 1997-07-23 | 1999-02-16 | Brigham And Women's Hospital | Lens epithelial cell derived growth factor |
| EP1053319A2 (de) * | 1998-01-28 | 2000-11-22 | Chiron Corporation | Menschliche gene und expressionsprodukte ii |
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1999
- 1999-07-28 DE DE19935303A patent/DE19935303A1/de not_active Withdrawn
-
2000
- 2000-07-21 EP EP00953119A patent/EP1204742A2/de not_active Withdrawn
- 2000-07-21 AU AU65682/00A patent/AU6568200A/en not_active Abandoned
- 2000-07-21 SK SK116-2002A patent/SK1162002A3/sk unknown
- 2000-07-21 EE EEP200200044A patent/EE200200044A/xx unknown
- 2000-07-21 NZ NZ516839A patent/NZ516839A/en unknown
- 2000-07-21 TR TR2002/00201T patent/TR200200201T2/xx unknown
- 2000-07-21 MX MXPA02000817A patent/MXPA02000817A/es unknown
- 2000-07-21 BR BR0013180-6A patent/BR0013180A/pt not_active IP Right Cessation
- 2000-07-21 CZ CZ2002324A patent/CZ2002324A3/cs unknown
- 2000-07-21 YU YU91901A patent/YU91901A/sh unknown
- 2000-07-21 JP JP2001512871A patent/JP2003505080A/ja not_active Withdrawn
- 2000-07-21 KR KR1020027001188A patent/KR20020033744A/ko not_active Application Discontinuation
- 2000-07-21 CA CA002380192A patent/CA2380192A1/en not_active Abandoned
- 2000-07-21 WO PCT/EP2000/007345 patent/WO2001007602A2/de not_active Application Discontinuation
- 2000-07-21 PL PL00353733A patent/PL353733A1/xx not_active Application Discontinuation
- 2000-07-21 CN CNB008108293A patent/CN1165617C/zh not_active Expired - Fee Related
- 2000-07-21 RU RU2002105021/15A patent/RU2249458C2/ru not_active IP Right Cessation
- 2000-07-21 HU HU0202794A patent/HUP0202794A3/hu unknown
- 2000-07-21 IL IL14754100A patent/IL147541A0/xx unknown
- 2000-07-26 AR ARP000103872A patent/AR024953A1/es unknown
- 2000-07-27 US US09/627,122 patent/US6472521B1/en not_active Expired - Fee Related
-
2002
- 2002-01-23 NO NO20020365A patent/NO20020365L/no unknown
- 2002-01-24 ZA ZA200200655A patent/ZA200200655B/en unknown
- 2002-01-25 HR HR20020075A patent/HRP20020075A2/hr not_active Application Discontinuation
-
2003
- 2003-01-23 HK HK03100581.2A patent/HK1048337B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE19935303A1 (de) | 2001-02-08 |
| US6472521B1 (en) | 2002-10-29 |
| MXPA02000817A (es) | 2002-07-30 |
| SK1162002A3 (en) | 2002-06-04 |
| HK1048337B (zh) | 2005-02-25 |
| CN1367828A (zh) | 2002-09-04 |
| RU2249458C2 (ru) | 2005-04-10 |
| HUP0202794A3 (en) | 2006-03-28 |
| KR20020033744A (ko) | 2002-05-07 |
| BR0013180A (pt) | 2002-04-09 |
| IL147541A0 (en) | 2002-08-14 |
| EP1204742A2 (de) | 2002-05-15 |
| CA2380192A1 (en) | 2001-02-01 |
| NO20020365D0 (no) | 2002-01-23 |
| NZ516839A (en) | 2004-04-30 |
| PL353733A1 (en) | 2003-12-01 |
| HUP0202794A2 (en) | 2003-03-28 |
| JP2003505080A (ja) | 2003-02-12 |
| WO2001007602A3 (de) | 2001-05-17 |
| NO20020365L (no) | 2002-03-25 |
| TR200200201T2 (tr) | 2002-05-21 |
| YU91901A (sh) | 2003-02-28 |
| HK1048337A1 (en) | 2003-03-28 |
| AR024953A1 (es) | 2002-10-30 |
| WO2001007602A2 (de) | 2001-02-01 |
| HRP20020075A2 (en) | 2005-10-31 |
| CZ2002324A3 (cs) | 2002-05-15 |
| EE200200044A (et) | 2003-06-16 |
| CN1165617C (zh) | 2004-09-08 |
| AU6568200A (en) | 2001-02-13 |
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