AR024953A1 - Oligonucleotidos para la inhibicion de la expresion de eg5 humana - Google Patents

Oligonucleotidos para la inhibicion de la expresion de eg5 humana

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Publication number
AR024953A1
AR024953A1 ARP000103872A ARP000103872A AR024953A1 AR 024953 A1 AR024953 A1 AR 024953A1 AR P000103872 A ARP000103872 A AR P000103872A AR P000103872 A ARP000103872 A AR P000103872A AR 024953 A1 AR024953 A1 AR 024953A1
Authority
AR
Argentina
Prior art keywords
human
oligonucleotidos
inhibition
expression
oligonucleotide
Prior art date
Application number
ARP000103872A
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English (en)
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Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of AR024953A1 publication Critical patent/AR024953A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invencion se refiere a un oligonucleotido o uno de sus derivados, caracterizado porque posee una secuencia que corresponde a una secuencia deácido nucleico que codifica una parte determinada de eg5 humana o una forma mutada de la misma, la invencion se refiere por otra parte a un procedimiento parala preparacion del oligonucleotido y a su empleo,
ARP000103872A 1999-07-28 2000-07-26 Oligonucleotidos para la inhibicion de la expresion de eg5 humana AR024953A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19935303A DE19935303A1 (de) 1999-07-28 1999-07-28 Oligonukleotide zur Inhibierung der Expression von humanem eg5

Publications (1)

Publication Number Publication Date
AR024953A1 true AR024953A1 (es) 2002-10-30

Family

ID=7916259

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000103872A AR024953A1 (es) 1999-07-28 2000-07-26 Oligonucleotidos para la inhibicion de la expresion de eg5 humana

Country Status (26)

Country Link
US (1) US6472521B1 (es)
EP (1) EP1204742A2 (es)
JP (1) JP2003505080A (es)
KR (1) KR20020033744A (es)
CN (1) CN1165617C (es)
AR (1) AR024953A1 (es)
AU (1) AU6568200A (es)
BR (1) BR0013180A (es)
CA (1) CA2380192A1 (es)
CZ (1) CZ2002324A3 (es)
DE (1) DE19935303A1 (es)
EE (1) EE200200044A (es)
HK (1) HK1048337B (es)
HR (1) HRP20020075A2 (es)
HU (1) HUP0202794A3 (es)
IL (1) IL147541A0 (es)
MX (1) MXPA02000817A (es)
NO (1) NO20020365L (es)
NZ (1) NZ516839A (es)
PL (1) PL353733A1 (es)
RU (1) RU2249458C2 (es)
SK (1) SK1162002A3 (es)
TR (1) TR200200201T2 (es)
WO (1) WO2001007602A2 (es)
YU (1) YU91901A (es)
ZA (1) ZA200200655B (es)

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US6440686B1 (en) 2000-06-15 2002-08-27 Cytokinetics, Inc. Methods for screening and therapeutic applications of kinesin modulators
US6809102B2 (en) 2001-03-29 2004-10-26 Bristol-Myers Squibb Company Cyano-substituted dihydropyrimidine compounds and their use to treat diseases
US6900214B2 (en) 2001-03-29 2005-05-31 Bristol-Myers Squibb Company Cyano-substituted dihydropyrimidine compounds and their use to treat diseases
US20040009156A1 (en) * 2001-10-12 2004-01-15 Christoph Reinhard Antisense therapy using oligonucleotides that target human kinesin genes for treatment of cancer
US7199107B2 (en) 2002-05-23 2007-04-03 Isis Pharmaceuticals, Inc. Antisense modulation of kinesin-like 1 expression
US7163927B2 (en) * 2002-05-23 2007-01-16 Isis Pharmaceuticals, Inc. Antisense modulation of kinesin-like 1 expression
WO2004074301A2 (en) * 2003-02-14 2004-09-02 Smithkline Beecham Corporation Differentially expressed nucleic acids that correlate with ksp expression
US7662581B1 (en) 2003-12-18 2010-02-16 Novartis Vaccines And Diagnostics, Inc. Eg5 co-crystals
EP1737979B9 (en) * 2004-03-23 2011-09-21 Oncotherapy Science, Inc. Method for diagnosing non-small cell lung cancer
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
KR101462874B1 (ko) * 2006-03-31 2014-11-18 알닐람 파마슈티칼스 인코포레이티드 Ｅｇ5 유전자의 발현을 억제하는 이본쇄 리보핵산
RU2464030C2 (ru) * 2006-05-26 2012-10-20 Регадо Байосайенсиз, Инк. Введение противосвертывающей системы reg1
CN101453891B (zh) * 2006-05-26 2013-12-11 雷加多生物科学公司 Reg1抗凝系统的给药
ES2530215T3 (es) * 2007-11-06 2015-02-27 Adiutide Pharmaceuticals Gmbh Análogos de oligorribonucleótidos inmunoestimulantes que contienen restos de oligofosfato modificados
DE102010007562A1 (de) 2010-02-10 2011-08-11 sterna biologicals GmbH & Co KG, 35043 Dermatologische, pharmazeutische Zusammensetzung geeignet für Oligonukleotide
PH12018501678B1 (en) 2011-08-30 2022-08-10 Astex Pharmaceuticals Inc Decitabine derivative formulations
US9498540B2 (en) 2013-03-15 2016-11-22 Novartis Ag Cell proliferation inhibitors and conjugates thereof
SG10201801507RA (en) 2013-05-01 2018-03-28 Ionis Pharmaceuticals Inc Compositions and methods for modulating hbv and ttr expression
RU2712559C9 (ru) * 2013-08-28 2020-10-08 Ионис Фармасьютикалз, Инк. Модуляция экспрессии прекалликреина (пкк)
AU2014331652B2 (en) * 2013-10-11 2020-05-21 Ionis Pharmaceuticals, Inc. Compositions for modulating C9ORF72 expression
KR102369736B1 (ko) * 2014-05-01 2022-03-02 아이오니스 파마수티컬즈, 인코포레이티드 보체 인자 b 발현을 조절하기 위한 조성물 및 방법
MX2018000016A (es) 2015-07-02 2019-01-31 Otsuka Pharma Co Ltd Composiciones farmaceuticas liofilizadas.
JP2020529409A (ja) 2017-08-03 2020-10-08 大塚製薬株式会社 薬物化合物およびその精製方法

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Also Published As

Publication number Publication date
MXPA02000817A (es) 2002-07-30
KR20020033744A (ko) 2002-05-07
YU91901A (sh) 2003-02-28
NO20020365D0 (no) 2002-01-23
CN1367828A (zh) 2002-09-04
EE200200044A (et) 2003-06-16
HRP20020075A2 (en) 2005-10-31
HUP0202794A3 (en) 2006-03-28
US6472521B1 (en) 2002-10-29
CA2380192A1 (en) 2001-02-01
TR200200201T2 (tr) 2002-05-21
NO20020365L (no) 2002-03-25
ZA200200655B (en) 2003-09-23
CZ2002324A3 (cs) 2002-05-15
JP2003505080A (ja) 2003-02-12
WO2001007602A3 (de) 2001-05-17
PL353733A1 (en) 2003-12-01
CN1165617C (zh) 2004-09-08
RU2249458C2 (ru) 2005-04-10
HK1048337B (zh) 2005-02-25
WO2001007602A2 (de) 2001-02-01
DE19935303A1 (de) 2001-02-08
HK1048337A1 (en) 2003-03-28
EP1204742A2 (de) 2002-05-15
HUP0202794A2 (en) 2003-03-28
IL147541A0 (en) 2002-08-14
BR0013180A (pt) 2002-04-09
AU6568200A (en) 2001-02-13
SK1162002A3 (en) 2002-06-04
NZ516839A (en) 2004-04-30

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