AU2002345089A1 - Synthetic double stranded oligonucleotides for targeted inhibition of gene expression - Google Patents
Synthetic double stranded oligonucleotides for targeted inhibition of gene expressionInfo
- Publication number
- AU2002345089A1 AU2002345089A1 AU2002345089A AU2002345089A AU2002345089A1 AU 2002345089 A1 AU2002345089 A1 AU 2002345089A1 AU 2002345089 A AU2002345089 A AU 2002345089A AU 2002345089 A AU2002345089 A AU 2002345089A AU 2002345089 A1 AU2002345089 A1 AU 2002345089A1
- Authority
- AU
- Australia
- Prior art keywords
- gene expression
- double stranded
- stranded oligonucleotides
- synthetic double
- targeted inhibition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000272 Oligonucleotide Polymers 0.000 title 1
- 230000014509 gene expression Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10133858.9 | 2001-07-12 | ||
DE10133858A DE10133858A1 (en) | 2001-07-12 | 2001-07-12 | Synthetic double-stranded oligonucleotides for targeted inhibition of gene expression |
PCT/EP2002/007480 WO2003008576A2 (en) | 2001-07-12 | 2002-07-05 | Synthetic double stranded oligonucleotides for targeted inhibition of gene expression |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2002345089A1 true AU2002345089A1 (en) | 2003-05-22 |
AU2002345089B2 AU2002345089B2 (en) | 2007-04-05 |
Family
ID=7691504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002345089A Ceased AU2002345089B2 (en) | 2001-07-12 | 2002-07-05 | Synthetic double stranded oligonucleotides for targeted inhibition of gene expression |
Country Status (14)
Country | Link |
---|---|
US (1) | US8772469B2 (en) |
EP (1) | EP1409670B1 (en) |
JP (1) | JP4643906B2 (en) |
AT (1) | ATE484586T1 (en) |
AU (1) | AU2002345089B2 (en) |
CA (1) | CA2453301C (en) |
CY (1) | CY1111645T1 (en) |
DE (2) | DE10133858A1 (en) |
DK (1) | DK1409670T3 (en) |
ES (1) | ES2354062T3 (en) |
IL (2) | IL159758A0 (en) |
MX (1) | MXPA04000179A (en) |
PT (1) | PT1409670E (en) |
WO (1) | WO2003008576A2 (en) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
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US7812149B2 (en) | 1996-06-06 | 2010-10-12 | Isis Pharmaceuticals, Inc. | 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations |
US9096636B2 (en) * | 1996-06-06 | 2015-08-04 | Isis Pharmaceuticals, Inc. | Chimeric oligomeric compounds and their use in gene modulation |
US5898031A (en) * | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
US20040266706A1 (en) * | 2002-11-05 | 2004-12-30 | Muthiah Manoharan | Cross-linked oligomeric compounds and their use in gene modulation |
WO2003064625A2 (en) | 2002-02-01 | 2003-08-07 | Sequitur, Inc. | Oligonucleotide compositions with enhanced efficiency |
US20060009409A1 (en) | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
US9771578B2 (en) * | 2002-11-05 | 2017-09-26 | Ionis Pharmaceuticals, Inc. | Phosphorous-linked oligomeric compounds and their use in gene modulation |
EP1560840B1 (en) | 2002-11-05 | 2015-05-06 | Isis Pharmaceuticals, Inc. | Compositions comprising alternating 2'-modified nucleosides for use in gene modulation |
US9827263B2 (en) * | 2002-11-05 | 2017-11-28 | Ionis Pharmaceuticals, Inc. | 2′-methoxy substituted oligomeric compounds and compositions for use in gene modulations |
US8569474B2 (en) | 2004-03-09 | 2013-10-29 | Isis Pharmaceuticals, Inc. | Double stranded constructs comprising one or more short strands hybridized to a longer strand |
WO2005121372A2 (en) * | 2004-06-03 | 2005-12-22 | Isis Pharmaceuticals, Inc. | Double strand compositions comprising differentially modified strands for use in gene modulation |
US8394947B2 (en) | 2004-06-03 | 2013-03-12 | Isis Pharmaceuticals, Inc. | Positionally modified siRNA constructs |
US7884086B2 (en) | 2004-09-08 | 2011-02-08 | Isis Pharmaceuticals, Inc. | Conjugates for use in hepatocyte free uptake assays |
US20100292301A1 (en) * | 2007-02-28 | 2010-11-18 | Elena Feinstein | Novel sirna structures |
KR20100068422A (en) * | 2007-10-09 | 2010-06-23 | 콜리 파마슈티칼 게엠베하 | Immune stimulatory oligonucleotide analogs containing modified sugar moieties |
WO2009090639A2 (en) * | 2008-01-15 | 2009-07-23 | Quark Pharmaceuticals, Inc. | Sirna compounds and methods of use thereof |
CN102016036B (en) | 2008-02-11 | 2015-04-08 | 阿克赛医药公司 | Modified RNAi polynucleotides and uses thereof |
WO2010008582A2 (en) | 2008-07-18 | 2010-01-21 | Rxi Pharmaceuticals Corporation | Phagocytic cell drug delivery system |
EP3336188B1 (en) | 2008-09-22 | 2020-05-06 | Phio Pharmaceuticals Corp. | Reduced size self-delivering rnai compounds |
WO2010059226A2 (en) | 2008-11-19 | 2010-05-27 | Rxi Pharmaceuticals Corporation | Inhibition of map4k4 through rnai |
US9493774B2 (en) | 2009-01-05 | 2016-11-15 | Rxi Pharmaceuticals Corporation | Inhibition of PCSK9 through RNAi |
US9745574B2 (en) | 2009-02-04 | 2017-08-29 | Rxi Pharmaceuticals Corporation | RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
RU2615143C2 (en) | 2010-03-24 | 2017-04-04 | Адвирна | Self-delivered rnai compounds of reduced size |
IL265674B2 (en) | 2010-03-24 | 2024-05-01 | Phio Pharm Corp | Rna interference in dermal and fibrotic indications |
CN106074591B (en) | 2010-03-24 | 2020-01-14 | 菲奥医药公司 | RNA interference in ocular symptoms |
JP6772062B2 (en) | 2013-12-02 | 2020-10-21 | フィオ ファーマシューティカルズ コーポレーションPhio Pharmaceuticals Corp. | Cancer immunotherapy |
US11279934B2 (en) | 2014-04-28 | 2022-03-22 | Phio Pharmaceuticals Corp. | Methods for treating cancer using nucleic acids targeting MDM2 or MYCN |
CN107073294A (en) | 2014-09-05 | 2017-08-18 | 阿克赛医药公司 | Use the method for targeting TYR or MMP1 exonuclease treatment aging and skin disorder |
WO2017007825A1 (en) | 2015-07-06 | 2017-01-12 | Rxi Pharmaceuticals Corporation | Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach |
EP3862005A1 (en) | 2015-07-06 | 2021-08-11 | Phio Pharmaceuticals Corp. | Nucleic acid molecules targeting superoxide dismutase 1 (sod1) |
US11021707B2 (en) | 2015-10-19 | 2021-06-01 | Phio Pharmaceuticals Corp. | Reduced size self-delivering nucleic acid compounds targeting long non-coding RNA |
MA45470A (en) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | KRAS NUCLEIC ACIDS AND THEIR USES |
MA45328A (en) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF |
MA45469A (en) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | BETA-CATENIN NUCLEIC ACIDS AND THEIR USES |
MA45349A (en) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | EGFR NUCLEIC ACIDS AND THEIR USES |
MX2020005860A (en) | 2017-12-06 | 2020-09-09 | Avidity Biosciences Inc | Compositions and methods of treating muscle atrophy and myotonic dystrophy. |
CA3157486A1 (en) * | 2019-10-11 | 2021-04-15 | Alnylam Pharmaceuticals, Inc. | Modified oligonucleotides |
JP2023537798A (en) | 2020-03-19 | 2023-09-06 | アビディティー バイオサイエンシーズ,インク. | Compositions and methods for treating facioscapulohumeral muscular dystrophy |
WO2023220744A2 (en) * | 2022-05-13 | 2023-11-16 | Alnylam Pharmaceuticals, Inc. | Single-stranded loop oligonucleotides |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3717436A1 (en) * | 1987-05-23 | 1988-12-08 | Hoechst Ag | METHOD FOR PRODUCING DOUBLE-STRANDED DNA |
US4924624A (en) | 1987-10-22 | 1990-05-15 | Temple University-Of The Commonwealth System Of Higher Education | 2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof |
US6033909A (en) * | 1992-01-22 | 2000-03-07 | Hoechst Aktiengesellschaft | Oligonucleotide analogs, their preparation and use |
NZ255028A (en) * | 1992-07-02 | 1997-03-24 | Hybridon Inc | Antisense oligonucleotides resistant to nucleolytic degradation |
US5646042A (en) * | 1992-08-26 | 1997-07-08 | Ribozyme Pharmaceuticals, Inc. | C-myb targeted ribozymes |
US5583032A (en) * | 1992-10-21 | 1996-12-10 | The Cleveland Clinic Foundation And National Institutes Of Health | Method of cleaving specific strands of RNA |
US5532130A (en) * | 1993-07-20 | 1996-07-02 | Dyad Pharmaceutical Corporation | Methods and compositions for sequence-specific hybridization of RNA by 2'-5' oligonucleotides |
US5886165A (en) * | 1996-09-24 | 1999-03-23 | Hybridon, Inc. | Mixed backbone antisense oligonucleotides containing 2'-5'-ribonucleotide- and 3'-5'-deoxyribonucleotides segments |
US6794499B2 (en) * | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
US6010907A (en) * | 1998-05-12 | 2000-01-04 | Kimeragen, Inc. | Eukaryotic use of non-chimeric mutational vectors |
US6004804A (en) * | 1998-05-12 | 1999-12-21 | Kimeragen, Inc. | Non-chimeric mutational vectors |
AU5314999A (en) * | 1998-07-14 | 2000-02-07 | Isis Pharmaceuticals, Inc. | Modified oligonucleotides |
AU3369900A (en) | 1999-02-19 | 2000-09-04 | General Hospital Corporation, The | Gene silencing |
US6316194B1 (en) * | 1999-12-16 | 2001-11-13 | Ribotargets | Methods and kits for discovery of RNA-binding antimicrobials |
WO2002044321A2 (en) * | 2000-12-01 | 2002-06-06 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Rna interference mediating small rna molecules |
-
2001
- 2001-07-12 DE DE10133858A patent/DE10133858A1/en not_active Withdrawn
-
2002
- 2002-07-05 CA CA2453301A patent/CA2453301C/en not_active Expired - Fee Related
- 2002-07-05 PT PT02743264T patent/PT1409670E/en unknown
- 2002-07-05 DK DK02743264.0T patent/DK1409670T3/en active
- 2002-07-05 IL IL15975802A patent/IL159758A0/en unknown
- 2002-07-05 WO PCT/EP2002/007480 patent/WO2003008576A2/en active IP Right Grant
- 2002-07-05 DE DE50214715T patent/DE50214715D1/en not_active Expired - Lifetime
- 2002-07-05 AT AT02743264T patent/ATE484586T1/en active
- 2002-07-05 JP JP2003514893A patent/JP4643906B2/en not_active Expired - Fee Related
- 2002-07-05 AU AU2002345089A patent/AU2002345089B2/en not_active Ceased
- 2002-07-05 MX MXPA04000179A patent/MXPA04000179A/en active IP Right Grant
- 2002-07-05 ES ES02743264T patent/ES2354062T3/en not_active Expired - Lifetime
- 2002-07-05 EP EP02743264A patent/EP1409670B1/en not_active Expired - Lifetime
- 2002-07-11 US US10/193,747 patent/US8772469B2/en not_active Expired - Fee Related
-
2004
- 2004-01-07 IL IL159758A patent/IL159758A/en not_active IP Right Cessation
-
2011
- 2011-01-04 CY CY20111100021T patent/CY1111645T1/en unknown
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