HRP20010243B1 - Compositions containing diphosphonic acids - Google Patents
Compositions containing diphosphonic acidsInfo
- Publication number
- HRP20010243B1 HRP20010243B1 HR20010243A HRP20010243A HRP20010243B1 HR P20010243 B1 HRP20010243 B1 HR P20010243B1 HR 20010243 A HR20010243 A HR 20010243A HR P20010243 A HRP20010243 A HR P20010243A HR P20010243 B1 HRP20010243 B1 HR P20010243B1
- Authority
- HR
- Croatia
- Prior art keywords
- compositions containing
- dosage form
- diphosphonic acids
- amount
- active substance
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000002552 dosage form Substances 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 235000021355 Stearic acid Nutrition 0.000 abstract 1
- XQRLCLUYWUNEEH-UHFFFAOYSA-N diphosphonic acid Chemical compound OP(=O)OP(O)=O XQRLCLUYWUNEEH-UHFFFAOYSA-N 0.000 abstract 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000008117 stearic acid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Nutrition Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98119102A EP0998932A1 (de) | 1998-10-09 | 1998-10-09 | Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung |
| PCT/EP1999/007287 WO2000021540A1 (en) | 1998-10-09 | 1999-10-01 | Compositions containing diphosphonic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20010243A2 HRP20010243A2 (en) | 2002-04-30 |
| HRP20010243B1 true HRP20010243B1 (en) | 2011-02-28 |
Family
ID=8232769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20010243A HRP20010243B1 (en) | 1998-10-09 | 2001-03-30 | Compositions containing diphosphonic acids |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US6294196B1 (es) |
| EP (2) | EP0998932A1 (es) |
| JP (2) | JP4471498B2 (es) |
| KR (1) | KR100522505B1 (es) |
| CN (1) | CN1150000C (es) |
| AR (3) | AR014081A1 (es) |
| AT (1) | ATE311887T1 (es) |
| AU (1) | AU752532B2 (es) |
| BR (1) | BR9914367A (es) |
| CA (1) | CA2346662C (es) |
| CO (1) | CO5050325A1 (es) |
| CY (1) | CY1105437T1 (es) |
| CZ (1) | CZ299008B6 (es) |
| DE (1) | DE69928819T2 (es) |
| DK (1) | DK1117412T3 (es) |
| ES (1) | ES2253919T3 (es) |
| HK (1) | HK1040914B (es) |
| HR (1) | HRP20010243B1 (es) |
| HU (1) | HU226457B1 (es) |
| ID (1) | ID29876A (es) |
| IL (3) | IL141912A0 (es) |
| MA (1) | MA27123A1 (es) |
| ME (1) | ME00637B (es) |
| MY (1) | MY126625A (es) |
| NO (1) | NO327447B1 (es) |
| NZ (1) | NZ510433A (es) |
| PE (1) | PE20001082A1 (es) |
| PL (1) | PL194552B1 (es) |
| RS (1) | RS49809B (es) |
| RU (1) | RU2207860C2 (es) |
| SI (1) | SI1117412T1 (es) |
| TR (1) | TR200100889T2 (es) |
| TW (1) | TW576742B (es) |
| WO (1) | WO2000021540A1 (es) |
| ZA (1) | ZA200102276B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6984400B2 (en) | 1998-07-14 | 2006-01-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of treating restenosis using bisphosphonate nanoparticles |
| IL125336A0 (en) | 1998-07-14 | 1999-03-12 | Yissum Res Dev Co | Compositions for inhibition and treatment of restinosis |
| US7008645B2 (en) | 1998-07-14 | 2006-03-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of inhibiting restenosis using bisphosphonates |
| EP0998932A1 (de) | 1998-10-09 | 2000-05-10 | Boehringer Mannheim Gmbh | Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung |
| KR100638122B1 (ko) * | 2001-12-21 | 2006-10-24 | 더 프록터 앤드 갬블 캄파니 | 골 장애의 치료 방법 |
| NZ534104A (en) * | 2001-12-24 | 2007-03-30 | Teva Pharma | Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material |
| US20040052843A1 (en) * | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
| PT1506041E (pt) * | 2002-05-10 | 2007-12-28 | Hoffmann La Roche | Ácido ibandrónico para o tratamento e a prevenção da osteoporose |
| SI1790347T1 (sl) * | 2002-12-20 | 2015-03-31 | F. Hoffmann-La Roche Ag | Formulacija z visokim odmerkom ibandronata |
| AU2006222690B2 (en) * | 2002-12-20 | 2009-04-23 | F. Hoffmann-La Roche Ag | High dose ibandronate formulation |
| US10517883B2 (en) | 2003-06-27 | 2019-12-31 | Zuli Holdings Ltd. | Method of treating acute myocardial infarction |
| US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
| CA2554749A1 (en) * | 2004-01-30 | 2005-08-11 | Astellas Pharma Inc. | P2x receptor inhibitor |
| WO2006024024A2 (en) * | 2004-08-23 | 2006-03-02 | Teva Pharmaceutical Industries Ltd. | Solid and crystalline ibandronate sodium and processes for preparation thereof |
| US7358361B2 (en) * | 2004-10-08 | 2008-04-15 | The Board Of Trustees Of The University Of Illinois | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases |
| WO2008128056A1 (en) * | 2004-10-08 | 2008-10-23 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps |
| SI1848727T1 (sl) * | 2005-02-01 | 2015-09-30 | F. Hoffmann-La Roche Ag | Polimorf b ibandronata |
| TR201902609T4 (tr) * | 2005-02-01 | 2019-03-21 | Atnahs Pharma Uk Ltd | İbandronat polimorf A nın tıbbi kullanımı. |
| US20070049557A1 (en) * | 2005-08-24 | 2007-03-01 | Hashim Ahmed | Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers |
| US20070191315A1 (en) * | 2006-02-16 | 2007-08-16 | Bengt Bergstrom | Method for administering ibandronate |
| AU2007226964B2 (en) * | 2006-03-17 | 2012-03-22 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods |
| GB0616794D0 (en) | 2006-08-24 | 2006-10-04 | Arrow Int Ltd | Solid dosage form |
| US20080139514A1 (en) * | 2006-11-29 | 2008-06-12 | Subhash Pandurang Gore | Diphosphonic acid pharmaceutical compositions |
| CA2570949A1 (en) * | 2006-12-12 | 2008-06-12 | Apotex Pharmachem Inc. | Ibandronate sodium propylene glycol solvate and processes for the preparation thereof |
| WO2008074145A1 (en) * | 2006-12-20 | 2008-06-26 | Genpharm Ulc | Pharmaceutical composition comprising a hot-melt granulated lubricant |
| EP2298286B8 (en) * | 2009-09-18 | 2017-08-09 | SiTec PharmaBio SL | Process for dewatering of product powders |
| KR101244414B1 (ko) * | 2010-11-05 | 2013-03-18 | 주식회사 바이오파마티스 | 고함량 이반드론산 함유 골다공증 예방 또는 치료용 조성물 및 이의 제조방법 |
| WO2012093974A1 (en) | 2011-01-06 | 2012-07-12 | Mahmut Bilgic | Improved bisphosphonate formulations |
| JP5874545B2 (ja) * | 2011-06-20 | 2016-03-02 | アステラス製薬株式会社 | 経口投与用医薬組成物 |
| US9993427B2 (en) | 2013-03-14 | 2018-06-12 | Biorest Ltd. | Liposome formulation and manufacture |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0275468A1 (de) * | 1986-12-20 | 1988-07-27 | Roche Diagnostics GmbH | Clodronat-haltige Arzneimittel und Verfahren zur Herstellung derselben |
| WO1993021907A1 (en) * | 1992-04-24 | 1993-11-11 | Leiras Oy | Pharmaceutical preparation and process for its manufacture |
| WO1996041618A1 (en) * | 1995-06-08 | 1996-12-27 | Sanofi | Stable pharmaceutical compositions containing tiludronate hydrates and process for producing the pharmaceutical compositions |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4639338A (en) | 1984-08-06 | 1987-01-27 | Ciba-Geigy Corporation | Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate |
| DE3434667A1 (de) | 1984-09-21 | 1986-04-03 | Henkel KGaA, 4000 Düsseldorf | 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung |
| US4798725A (en) | 1986-06-16 | 1989-01-17 | Norwich Eaton Pharmaceuticals, Inc. | Sustained release capsule |
| DE3623397A1 (de) | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE3776880D1 (de) | 1986-11-21 | 1992-04-02 | Ciba Geigy Ag | Neue substituierte alkandiphosphonsaeuren. |
| FR2629716B1 (fr) | 1988-04-07 | 1991-07-19 | Sanofi Sa | Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique |
| WO1993009785A1 (en) | 1991-11-22 | 1993-05-27 | Procter & Gamble Pharmaceuticals, Inc. | Risedronate delayed-release compositions |
| US5534262A (en) | 1992-01-10 | 1996-07-09 | Dobrotvorsky; Anatoly E. | Pharmaceutical granulated composition and method for preparing same |
| DE4228552A1 (de) | 1992-08-27 | 1994-03-03 | Boehringer Mannheim Gmbh | Diphosphonsäuren und deren Salze enthaltende Arzneimittel |
| US5358941A (en) | 1992-12-02 | 1994-10-25 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids with lactose |
| SK281193B6 (sk) | 1993-05-15 | 2001-01-18 | Roche Diagnostics Gmbh | Tableta so zlepšenou biodostupnosťou účinnej látky, kyseliny klodrónovej, spôsob jej výroby a použitie mikrokryštalickej celulózy |
| TW390813B (en) | 1994-04-29 | 2000-05-21 | Merck & Co Inc | Wet granulation formulation for bisphosphonic acids |
| IL120265A0 (en) * | 1996-02-28 | 1997-06-10 | Pfizer | Combination therapy to treat osteoporosis - polyphosphonates or progestins and estrogen agonists |
| DE19615812A1 (de) | 1996-04-20 | 1997-10-23 | Boehringer Mannheim Gmbh | Pharmazeutische Zubereitung enthaltend Diphosphonsäuren zur oralen Applikation |
| EP0998933A1 (de) | 1998-10-09 | 2000-05-10 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung von bisphosphonathaltigen pharmazeutischen Zusammensetzungen zur oralen Applikation |
| EP0998932A1 (de) | 1998-10-09 | 2000-05-10 | Boehringer Mannheim Gmbh | Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung |
-
1998
- 1998-10-09 EP EP98119102A patent/EP0998932A1/de not_active Withdrawn
-
1999
- 1999-09-30 TW TW088116838A patent/TW576742B/zh not_active IP Right Cessation
- 1999-10-01 DE DE69928819T patent/DE69928819T2/de not_active Expired - Lifetime
- 1999-10-01 CZ CZ20011233A patent/CZ299008B6/cs not_active IP Right Cessation
- 1999-10-01 HU HU0103931A patent/HU226457B1/hu not_active IP Right Cessation
- 1999-10-01 CN CNB998112283A patent/CN1150000C/zh not_active Expired - Fee Related
- 1999-10-01 SI SI9930865T patent/SI1117412T1/sl unknown
- 1999-10-01 RU RU2001111883/14A patent/RU2207860C2/ru not_active IP Right Cessation
- 1999-10-01 JP JP2000575516A patent/JP4471498B2/ja not_active Expired - Lifetime
- 1999-10-01 IL IL14191299A patent/IL141912A0/xx active IP Right Grant
- 1999-10-01 ID IDW20010789A patent/ID29876A/id unknown
- 1999-10-01 TR TR2001/00889T patent/TR200100889T2/xx unknown
- 1999-10-01 PL PL99347243A patent/PL194552B1/pl unknown
- 1999-10-01 NZ NZ510433A patent/NZ510433A/en not_active IP Right Cessation
- 1999-10-01 DK DK99952483T patent/DK1117412T3/da active
- 1999-10-01 AT AT99952483T patent/ATE311887T1/de active
- 1999-10-01 ES ES99952483T patent/ES2253919T3/es not_active Expired - Lifetime
- 1999-10-01 CA CA002346662A patent/CA2346662C/en not_active Expired - Fee Related
- 1999-10-01 AU AU64675/99A patent/AU752532B2/en not_active Ceased
- 1999-10-01 KR KR10-2001-7004312A patent/KR100522505B1/ko not_active IP Right Cessation
- 1999-10-01 EP EP99952483A patent/EP1117412B1/en not_active Expired - Lifetime
- 1999-10-01 RS YUP-205/01A patent/RS49809B/sr unknown
- 1999-10-01 BR BR9914367-4A patent/BR9914367A/pt not_active Application Discontinuation
- 1999-10-01 WO PCT/EP1999/007287 patent/WO2000021540A1/en active IP Right Grant
- 1999-10-01 ME MEP-2001-205A patent/ME00637B/me unknown
- 1999-10-05 AR ARP990105042A patent/AR014081A1/es not_active Application Discontinuation
- 1999-10-05 CO CO99062918A patent/CO5050325A1/es unknown
- 1999-10-06 PE PE1999001011A patent/PE20001082A1/es not_active Application Discontinuation
- 1999-10-06 MA MA25808A patent/MA27123A1/fr unknown
- 1999-10-07 US US09/413,990 patent/US6294196B1/en not_active Expired - Lifetime
- 1999-10-07 MY MYPI99004336A patent/MY126625A/en unknown
-
2001
- 2001-03-08 IL IL141912A patent/IL141912A/en not_active IP Right Cessation
- 2001-03-19 ZA ZA200102276A patent/ZA200102276B/en unknown
- 2001-03-30 HR HR20010243A patent/HRP20010243B1/xx not_active IP Right Cessation
- 2001-04-05 NO NO20011714A patent/NO327447B1/no not_active IP Right Cessation
- 2001-07-20 US US09/909,727 patent/US6627221B2/en not_active Expired - Lifetime
-
2002
- 2002-03-05 HK HK02101678.5A patent/HK1040914B/zh not_active IP Right Cessation
-
2005
- 2005-02-21 AR ARP050100629A patent/AR047815A2/es not_active Application Discontinuation
-
2006
- 2006-02-24 CY CY20061100267T patent/CY1105437T1/el unknown
- 2006-09-07 IL IL177940A patent/IL177940A/en not_active IP Right Cessation
-
2008
- 2008-12-22 AR ARP080105677A patent/AR069942A2/es not_active Application Discontinuation
-
2010
- 2010-01-19 JP JP2010009189A patent/JP2010116408A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0275468A1 (de) * | 1986-12-20 | 1988-07-27 | Roche Diagnostics GmbH | Clodronat-haltige Arzneimittel und Verfahren zur Herstellung derselben |
| WO1993021907A1 (en) * | 1992-04-24 | 1993-11-11 | Leiras Oy | Pharmaceutical preparation and process for its manufacture |
| WO1996041618A1 (en) * | 1995-06-08 | 1996-12-27 | Sanofi | Stable pharmaceutical compositions containing tiludronate hydrates and process for producing the pharmaceutical compositions |
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