CY1105437T1 - Συνθεσεις πepιεχοντας διφωσφονικα οξεα - Google Patents

Συνθεσεις πepιεχοντας διφωσφονικα οξεα

Info

Publication number
CY1105437T1
CY1105437T1 CY20061100267T CY061100267T CY1105437T1 CY 1105437 T1 CY1105437 T1 CY 1105437T1 CY 20061100267 T CY20061100267 T CY 20061100267T CY 061100267 T CY061100267 T CY 061100267T CY 1105437 T1 CY1105437 T1 CY 1105437T1
Authority
CY
Cyprus
Prior art keywords
diphosphonic acid
acid compositions
active substance
lubricant
total weight
Prior art date
Application number
CY20061100267T
Other languages
English (en)
Inventor
Rolf-Dieter Gabel
Walter Preis
Heinrich Woog
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8232769&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1105437(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of CY1105437T1 publication Critical patent/CY1105437T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η εφεύρεση αναφέρεται σε μία στερεή φαρμακευτική μορφή χορήγησης που περιέχει ένα διφωσφονικο οξύ ή ένα φυσιολογικώς συμβατό άλας αυτού ως την δραστική ουσία, όπου η δραστική ουσία είναι παρούσα σε κοκκοποιημένη μορφή, προαιρετικά μαζί με φαρμακευτικά βοηθητικά υλικά, στην εσωτερική φάση και η εξωτερική φάση περιέχει ένα λιπαντικό στην μορφή λιγότερο των 5% στεαρικού οξέος σχετικά με το συνολικό βάρος της μορφής χορήγησης.
CY20061100267T 1998-10-09 2006-02-24 Συνθεσεις πepιεχοντας διφωσφονικα οξεα CY1105437T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98119102A EP0998932A1 (de) 1998-10-09 1998-10-09 Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung
EP99952483A EP1117412B1 (en) 1998-10-09 1999-10-01 Compositions containing diphosphonic acids
PCT/EP1999/007287 WO2000021540A1 (en) 1998-10-09 1999-10-01 Compositions containing diphosphonic acids

Publications (1)

Publication Number Publication Date
CY1105437T1 true CY1105437T1 (el) 2010-04-28

Family

ID=8232769

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061100267T CY1105437T1 (el) 1998-10-09 2006-02-24 Συνθεσεις πepιεχοντας διφωσφονικα οξεα

Country Status (35)

Country Link
US (2) US6294196B1 (el)
EP (2) EP0998932A1 (el)
JP (2) JP4471498B2 (el)
KR (1) KR100522505B1 (el)
CN (1) CN1150000C (el)
AR (3) AR014081A1 (el)
AT (1) ATE311887T1 (el)
AU (1) AU752532B2 (el)
BR (1) BR9914367A (el)
CA (1) CA2346662C (el)
CO (1) CO5050325A1 (el)
CY (1) CY1105437T1 (el)
CZ (1) CZ299008B6 (el)
DE (1) DE69928819T2 (el)
DK (1) DK1117412T3 (el)
ES (1) ES2253919T3 (el)
HK (1) HK1040914B (el)
HR (1) HRP20010243B1 (el)
HU (1) HU226457B1 (el)
ID (1) ID29876A (el)
IL (3) IL141912A0 (el)
MA (1) MA27123A1 (el)
ME (1) ME00637B (el)
MY (1) MY126625A (el)
NO (1) NO327447B1 (el)
NZ (1) NZ510433A (el)
PE (1) PE20001082A1 (el)
PL (1) PL194552B1 (el)
RS (1) RS49809B (el)
RU (1) RU2207860C2 (el)
SI (1) SI1117412T1 (el)
TR (1) TR200100889T2 (el)
TW (1) TW576742B (el)
WO (1) WO2000021540A1 (el)
ZA (1) ZA200102276B (el)

Families Citing this family (30)

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US6984400B2 (en) 1998-07-14 2006-01-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treating restenosis using bisphosphonate nanoparticles
US7008645B2 (en) 1998-07-14 2006-03-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of inhibiting restenosis using bisphosphonates
IL125336A0 (en) 1998-07-14 1999-03-12 Yissum Res Dev Co Compositions for inhibition and treatment of restinosis
EP0998932A1 (de) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung
CA2469779C (en) * 2001-12-21 2008-02-12 The Procter & Gamble Company Method for the treatment of bone disorders
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
EP1465606A4 (en) * 2001-12-24 2009-04-22 Teva Pharma DOSAGE FORM WITH PASTILLE CORE ACTIVE PRINCIPLE COATED IN COMPRESSED ANNULAR BODY OF POWDER OR GRANULAR SUBSTANCE, AND METHOD AND TOOLS FOR PRODUCTION OF SAID DOSAGE FORM
BR0308901A (pt) * 2002-05-10 2005-01-04 Hoffmann La Roche ácidos bisfosfÈnicos para tratamento e prevenção de osteoporose
AU2006222690B2 (en) * 2002-12-20 2009-04-23 F. Hoffmann-La Roche Ag High dose ibandronate formulation
SI1596870T2 (sl) * 2002-12-20 2011-07-29 Hoffmann La Roche Formulacija z visokim odmerkom ibandronata
US10517883B2 (en) 2003-06-27 2019-12-31 Zuli Holdings Ltd. Method of treating acute myocardial infarction
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
EP1709968A1 (en) * 2004-01-30 2006-10-11 Astellas Pharma Inc. P2x receptor inhibitor
PT1713489E (pt) * 2004-08-23 2011-03-03 Teva Pharma Forma cristalina de ibandronato de sódio e processos para a sua preparação
US8012949B2 (en) * 2004-10-08 2011-09-06 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS
US7358361B2 (en) * 2004-10-08 2008-04-15 The Board Of Trustees Of The University Of Illinois Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
SI1848727T1 (sl) * 2005-02-01 2015-09-30 F. Hoffmann-La Roche Ag Polimorf b ibandronata
WO2006081963A1 (en) * 2005-02-01 2006-08-10 F.Hoffmann-La Roche Ag Ibandronate polymorph a
US20070049557A1 (en) * 2005-08-24 2007-03-01 Hashim Ahmed Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers
US20070191315A1 (en) * 2006-02-16 2007-08-16 Bengt Bergstrom Method for administering ibandronate
CA2646334A1 (en) * 2006-03-17 2007-09-27 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods
GB0616794D0 (en) 2006-08-24 2006-10-04 Arrow Int Ltd Solid dosage form
US20080139514A1 (en) * 2006-11-29 2008-06-12 Subhash Pandurang Gore Diphosphonic acid pharmaceutical compositions
CA2570949A1 (en) * 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
JP5290198B2 (ja) * 2006-12-20 2013-09-18 ミラン ファーマシューティカルズ ユーエルシー ホットメルト顆粒化潤滑剤を含んでなる医薬組成物
EP2298286B8 (en) * 2009-09-18 2017-08-09 SiTec PharmaBio SL Process for dewatering of product powders
KR101244414B1 (ko) * 2010-11-05 2013-03-18 주식회사 바이오파마티스 고함량 이반드론산 함유 골다공증 예방 또는 치료용 조성물 및 이의 제조방법
WO2012093974A1 (en) 2011-01-06 2012-07-12 Mahmut Bilgic Improved bisphosphonate formulations
JP5874545B2 (ja) * 2011-06-20 2016-03-02 アステラス製薬株式会社 経口投与用医薬組成物
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture

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US4639338A (en) 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de) 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
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IL120265A0 (en) * 1996-02-28 1997-06-10 Pfizer Combination therapy to treat osteoporosis - polyphosphonates or progestins and estrogen agonists
DE19615812A1 (de) 1996-04-20 1997-10-23 Boehringer Mannheim Gmbh Pharmazeutische Zubereitung enthaltend Diphosphonsäuren zur oralen Applikation
EP0998933A1 (de) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Verfahren zur Herstellung von bisphosphonathaltigen pharmazeutischen Zusammensetzungen zur oralen Applikation
EP0998932A1 (de) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
IL141912A (en) 2006-12-10
YU20501A (sh) 2003-02-28
HUP0103931A2 (en) 2002-06-29
AR047815A2 (es) 2006-02-22
EP1117412B1 (en) 2005-12-07
AU6467599A (en) 2000-05-01
TW576742B (en) 2004-02-21
HRP20010243B1 (en) 2011-02-28
ID29876A (id) 2001-10-18
NO20011714L (no) 2001-04-05
US6627221B2 (en) 2003-09-30
CZ299008B6 (cs) 2008-04-02
DE69928819D1 (de) 2006-01-12
SI1117412T1 (sl) 2006-04-30
MY126625A (en) 2006-10-31
CN1319015A (zh) 2001-10-24
CZ20011233A3 (cs) 2001-09-12
KR20010073203A (ko) 2001-07-31
CA2346662C (en) 2006-05-09
AU752532B2 (en) 2002-09-19
HU226457B1 (en) 2008-12-29
RS49809B (sr) 2008-08-07
CN1150000C (zh) 2004-05-19
NZ510433A (en) 2003-08-29
WO2000021540A1 (en) 2000-04-20
BR9914367A (pt) 2001-06-26
NO20011714D0 (no) 2001-04-05
JP2010116408A (ja) 2010-05-27
IL141912A0 (en) 2002-03-10
RU2207860C2 (ru) 2003-07-10
ATE311887T1 (de) 2005-12-15
HRP20010243A2 (en) 2002-04-30
CA2346662A1 (en) 2000-04-20
IL177940A0 (en) 2006-12-31
AR014081A1 (es) 2001-01-31
CO5050325A1 (es) 2001-06-27
DE69928819T2 (de) 2006-07-20
KR100522505B1 (ko) 2005-10-18
HK1040914A1 (en) 2002-06-28
PL347243A1 (en) 2002-03-25
TR200100889T2 (tr) 2001-07-23
PL194552B1 (pl) 2007-06-29
JP4471498B2 (ja) 2010-06-02
IL177940A (en) 2012-05-31
AR069942A2 (es) 2010-03-03
HK1040914B (zh) 2004-12-10
US20020006441A1 (en) 2002-01-17
JP2002527398A (ja) 2002-08-27
ES2253919T3 (es) 2006-06-01
ZA200102276B (en) 2002-06-19
DK1117412T3 (da) 2006-04-03
PE20001082A1 (es) 2000-10-18
NO327447B1 (no) 2009-06-29
HUP0103931A3 (en) 2003-01-28
EP0998932A1 (de) 2000-05-10
EP1117412A1 (en) 2001-07-25
MA27123A1 (fr) 2005-01-03
US6294196B1 (en) 2001-09-25
ME00637B (me) 2008-08-07

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