HRP20000265A2 - Methods and compositions for treating rheumatoid arthritis - Google Patents
Methods and compositions for treating rheumatoid arthritis Download PDFInfo
- Publication number
- HRP20000265A2 HRP20000265A2 HR20000265A HRP20000265A HRP20000265A2 HR P20000265 A2 HRP20000265 A2 HR P20000265A2 HR 20000265 A HR20000265 A HR 20000265A HR P20000265 A HRP20000265 A HR P20000265A HR P20000265 A2 HRP20000265 A2 HR P20000265A2
- Authority
- HR
- Croatia
- Prior art keywords
- carbonyl
- tert
- prolyl
- alkyl
- isoleucyl
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 63
- 206010039073 rheumatoid arthritis Diseases 0.000 title claims description 36
- 239000000203 mixture Substances 0.000 title claims description 18
- -1 2,2-dimethylglycyl Chemical group 0.000 claims description 416
- 150000001875 compounds Chemical class 0.000 claims description 90
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- 239000001257 hydrogen Substances 0.000 claims description 38
- 229910052739 hydrogen Inorganic materials 0.000 claims description 38
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 35
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 33
- 238000011282 treatment Methods 0.000 claims description 33
- 229950003188 isovaleryl diethylamide Drugs 0.000 claims description 30
- 125000000217 alkyl group Chemical group 0.000 claims description 29
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims description 29
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 26
- 125000003277 amino group Chemical group 0.000 claims description 25
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 25
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- 229940124347 antiarthritic drug Drugs 0.000 claims description 15
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- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims description 15
- 125000001424 substituent group Chemical group 0.000 claims description 15
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 12
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- XJODGRWDFZVTKW-ZCFIWIBFSA-N n-methylleucine Chemical compound CN[C@@H](C(O)=O)CC(C)C XJODGRWDFZVTKW-ZCFIWIBFSA-N 0.000 description 1
- OFYAYGJCPXRNBL-LBPRGKRZSA-N naphthalen-2-yl-3-alanine Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CC=CC2=C1 OFYAYGJCPXRNBL-LBPRGKRZSA-N 0.000 description 1
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- 235000011007 phosphoric acid Nutrition 0.000 description 1
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 235000002906 tartaric acid Nutrition 0.000 description 1
- NPDBDJFLKKQMCM-UHFFFAOYSA-N tert-butylglycine Chemical compound CC(C)(C)C(N)C(O)=O NPDBDJFLKKQMCM-UHFFFAOYSA-N 0.000 description 1
- CBDKQYKMCICBOF-UHFFFAOYSA-N thiazoline Chemical compound C1CN=CS1 CBDKQYKMCICBOF-UHFFFAOYSA-N 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
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- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
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- ORQXBVXKBGUSBA-QMMMGPOBSA-N β-cyclohexyl-alanine Chemical compound OC(=O)[C@@H](N)CC1CCCCC1 ORQXBVXKBGUSBA-QMMMGPOBSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/944,479 US6015790A (en) | 1997-10-06 | 1997-10-06 | Methods and compositions for treating rheumatoid arthritis |
| PCT/US1998/019841 WO1999017792A1 (en) | 1997-10-06 | 1998-09-24 | Methods and compositions for treating rheumatoid arthritis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20000265A2 true HRP20000265A2 (en) | 2000-12-31 |
Family
ID=25481479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20000265A HRP20000265A2 (en) | 1997-10-06 | 2000-05-04 | Methods and compositions for treating rheumatoid arthritis |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6015790A (es) |
| EP (1) | EP1021200B1 (es) |
| JP (1) | JP2001518515A (es) |
| KR (1) | KR20010081900A (es) |
| CN (1) | CN1278734A (es) |
| AR (1) | AR017298A1 (es) |
| AT (1) | ATE212855T1 (es) |
| AU (2) | AU748465B2 (es) |
| BG (1) | BG104292A (es) |
| BR (1) | BR9812875A (es) |
| CA (1) | CA2305688A1 (es) |
| DE (1) | DE69803792D1 (es) |
| DK (1) | DK1021200T3 (es) |
| ES (1) | ES2173626T3 (es) |
| HR (1) | HRP20000265A2 (es) |
| HU (1) | HUP0101715A3 (es) |
| IL (1) | IL135167A0 (es) |
| NO (1) | NO20001758L (es) |
| PL (1) | PL339731A1 (es) |
| PT (1) | PT1021200E (es) |
| SK (1) | SK4272000A3 (es) |
| TR (1) | TR200000903T2 (es) |
| WO (2) | WO1999017792A1 (es) |
| ZA (1) | ZA989036B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010009901A1 (en) | 1996-12-11 | 2001-07-26 | Basf Aktiengesellschaft Germany | Antineoplastic peptides |
| KR100261114B1 (ko) * | 1998-01-24 | 2000-07-01 | 박종헌 | 히스톤을 함유하는 류마티스 관절염 치료제 조성물 |
| AU6464400A (en) * | 1999-09-14 | 2001-04-17 | Pfizer Products Inc. | Combination treatment with il-1ra and diaryl sulphonyl urea compounds |
| AU1730701A (en) * | 1999-12-07 | 2001-06-18 | Santen Pharmaceutical Co. Ltd. | Rheumatism remedy containing tetrapeptide derivative as active ingredient |
| BR0016699A (pt) * | 1999-12-24 | 2002-11-05 | Hoffmann La Roche | Compostos para o tratamento terapêutico e/ou profilático de distúrbios nos quais a catepsina "k" exerce uma função patológica significativa, processos para a manufatura dos mesmos e sua utilização |
| KR20090096716A (ko) * | 2007-01-09 | 2009-09-14 | 바이엘 쉐링 파마 악티엔게젤샤프트 | 아지리딘의 플루오르화에 의한 방사성표지 |
| EP2443136A4 (en) | 2009-06-18 | 2013-01-09 | Strongbone Ab | NOVEL PEPTIDE DERIVATIVES FOR TREATMENT, PREVENTION OR MITIGATION OF AFFECTION ASSOCIATED WITH BONE LOSS OR LOW BONE DENSITY OR INHIBITING DIFFERENTIATION AND STIMULATION OF OSTEOCLASTS |
| WO2014109414A1 (ja) * | 2013-01-11 | 2014-07-17 | 富士フイルム株式会社 | 含窒素複素環化合物またはその塩 |
| KR102372512B1 (ko) * | 2017-11-20 | 2022-03-10 | 가톨릭대학교 산학협력단 | 폴리감마글루탐산 및 메토트렉세이트를 유효성분으로 포함하는 관절염 예방 또는 치료용 조성물 |
| CN115281149A (zh) * | 2021-05-12 | 2022-11-04 | 四川大学华西医院 | 一种临床前类风湿关节炎(Pre-RA)小鼠模型 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816444A (en) * | 1987-07-10 | 1989-03-28 | Arizona Board Of Regents, Arizona State University | Cell growth inhibitory substance |
| US4879278A (en) * | 1989-05-16 | 1989-11-07 | Arizona Board Of Regents | Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15 |
| EP0934950B1 (en) * | 1991-08-09 | 2002-04-10 | Teikoku Hormone Mfg. Co., Ltd. | Tetrapeptide derivative |
| US5831002A (en) * | 1992-05-20 | 1998-11-03 | Basf Aktiengesellschaft | Antitumor peptides |
| JPH08504415A (ja) * | 1992-12-16 | 1996-05-14 | ビーエーエスエフ アクチエンゲゼルシャフト | 新規のペプチド、該ペプチドの製造及び使用 |
| US5504191A (en) * | 1994-08-01 | 1996-04-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide methyl esters |
| US5530097A (en) * | 1994-08-01 | 1996-06-25 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory peptide amides |
| US5583153A (en) * | 1994-10-06 | 1996-12-10 | Regents Of The University Of California | Use of taxol in the treatment of rheumatoid arthritis |
-
1997
- 1997-10-06 US US08/944,479 patent/US6015790A/en not_active Expired - Fee Related
-
1998
- 1998-09-24 EP EP98948455A patent/EP1021200B1/en not_active Expired - Lifetime
- 1998-09-24 PT PT98948455T patent/PT1021200E/pt unknown
- 1998-09-24 CA CA002305688A patent/CA2305688A1/en not_active Abandoned
- 1998-09-24 AT AT98948455T patent/ATE212855T1/de not_active IP Right Cessation
- 1998-09-24 KR KR1020007003706A patent/KR20010081900A/ko not_active Application Discontinuation
- 1998-09-24 SK SK427-2000A patent/SK4272000A3/sk unknown
- 1998-09-24 DE DE69803792T patent/DE69803792D1/de not_active Expired - Fee Related
- 1998-09-24 PL PL98339731A patent/PL339731A1/xx not_active Application Discontinuation
- 1998-09-24 HU HU0101715A patent/HUP0101715A3/hu unknown
- 1998-09-24 AU AU95024/98A patent/AU748465B2/en not_active Ceased
- 1998-09-24 WO PCT/US1998/019841 patent/WO1999017792A1/en not_active Application Discontinuation
- 1998-09-24 DK DK98948455T patent/DK1021200T3/da active
- 1998-09-24 BR BR9812875-2A patent/BR9812875A/pt not_active IP Right Cessation
- 1998-09-24 ES ES98948455T patent/ES2173626T3/es not_active Expired - Lifetime
- 1998-09-24 JP JP2000514663A patent/JP2001518515A/ja not_active Withdrawn
- 1998-09-24 CN CN98811034A patent/CN1278734A/zh active Pending
- 1998-09-24 TR TR2000/00903T patent/TR200000903T2/xx unknown
- 1998-09-24 IL IL13516798A patent/IL135167A0/xx unknown
- 1998-09-30 AU AU95926/98A patent/AU9592698A/en not_active Withdrawn
- 1998-09-30 WO PCT/US1998/020465 patent/WO1999017709A2/en active Application Filing
- 1998-10-05 ZA ZA9809036A patent/ZA989036B/xx unknown
- 1998-10-06 AR ARP980104972A patent/AR017298A1/es not_active Application Discontinuation
-
2000
- 2000-04-03 BG BG104292A patent/BG104292A/xx unknown
- 2000-04-05 NO NO20001758A patent/NO20001758L/no not_active Application Discontinuation
- 2000-05-04 HR HR20000265A patent/HRP20000265A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1021200A1 (en) | 2000-07-26 |
| DK1021200T3 (da) | 2002-05-27 |
| WO1999017709A2 (en) | 1999-04-15 |
| CN1278734A (zh) | 2001-01-03 |
| US6015790A (en) | 2000-01-18 |
| ATE212855T1 (de) | 2002-02-15 |
| AU9502498A (en) | 1999-04-27 |
| PL339731A1 (en) | 2001-01-02 |
| AR017298A1 (es) | 2001-09-05 |
| CA2305688A1 (en) | 1999-04-15 |
| BR9812875A (pt) | 2000-08-08 |
| PT1021200E (pt) | 2002-07-31 |
| KR20010081900A (ko) | 2001-08-29 |
| NO20001758D0 (no) | 2000-04-05 |
| TR200000903T2 (tr) | 2001-07-23 |
| ZA989036B (en) | 2000-04-05 |
| NO20001758L (no) | 2000-06-05 |
| EP1021200B1 (en) | 2002-02-06 |
| WO1999017792A1 (en) | 1999-04-15 |
| BG104292A (en) | 2000-12-29 |
| SK4272000A3 (en) | 2001-02-12 |
| ES2173626T3 (es) | 2002-10-16 |
| AU9592698A (en) | 1999-04-27 |
| HUP0101715A3 (en) | 2001-12-28 |
| AU748465B2 (en) | 2002-06-06 |
| JP2001518515A (ja) | 2001-10-16 |
| HUP0101715A2 (hu) | 2001-11-28 |
| IL135167A0 (en) | 2001-05-20 |
| DE69803792D1 (de) | 2002-03-21 |
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