ES2173626T3 - Metodos y composiciones para tratar la artritis reumatoide. - Google Patents
Metodos y composiciones para tratar la artritis reumatoide.Info
- Publication number
- ES2173626T3 ES2173626T3 ES98948455T ES98948455T ES2173626T3 ES 2173626 T3 ES2173626 T3 ES 2173626T3 ES 98948455 T ES98948455 T ES 98948455T ES 98948455 T ES98948455 T ES 98948455T ES 2173626 T3 ES2173626 T3 ES 2173626T3
- Authority
- ES
- Spain
- Prior art keywords
- carbonyl
- methylprolyl
- residue
- tert
- isoleucyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Uso, para la fabricación de un medicamento para el tratamiento de la artritis reumatoide en un mamífero, de un compuesto de Fórmula I: R 1 R 2 N-CHX-CO-A-B-D-(E)s-(F)t-(G)u-K (I) en la que: R 1 es alquilo, cicloalquilo, alquilsulfonilo, fluoroalquilo o aminosulfonilo; R 2 es hidrógeno, alquilo,fluoroalquilo o cicloalquilo; R 1 -N-R 2 juntos pueden ser un residuo de pirrolidino o piperidino; A es un residuo de valilo, isoleucilo, leucilo, alo-isoleucilo, 2,2-dimetilglicilo, 2-ciclopropilglicilo, 2-ciclopentilglicilo, 3-terc-butilalanilo, 2-terc-butilglicilo, 3-ciclohexilalanilo, 2-etilglicilo, 2-ciclohexilglicilo, norleucilo o norvalilo; B es un residuo de N-alquil-valilo, -norvalilo, -leucilo, -isoleucilo, -2-terc-butilglicilo, -3-terc-butilalanilo, -2-etilglicilo, -2-ciclopropilglicilo, -2-ciclopentilglicilo, -norleucilo o -2-ciclohexilglicilo; D es un residuo de prolilo, homoprolilo, hidroxiprolilo, 3,4-deshidroprolilo, 4uoroprolilo, 3-metilprolilo, 4-metilprolilo, 5-metilprolilo, azetidin-2-carbonilo, 3,3-dimetilprolilo, 4,4-di fluoroprolilo, oxazolidin4-carbonilo o tiazolidin-4-carbonilo; E es un residuo de prolilo, homoprolilo, hidroxiprolilo, 3,4-deshidroprolilo, 4uoroprolilo, 3-metilprolilo, 4-metilprolilo, 5-metilprolilo, azetidin-2-carbonilo, 3,3-dimetilprolilo, 4,4-di uoroprolilo, oxazolidin4-carbonilo o tiazolidin-4-carbonilo; F y G se seleccionan independientemente del grupo que consiste en residuos de prolilo, homoprolilo, hidroxiprolilo, tiazolidinil-4-carbonilo, 1-aminopentil-1-carbonilo, valilo, 2-terc-butilglicilo, isoleucilo, leucilo, 3-ciclohexilalanilo, fenilalanilo, N-metilfenilalanilo, tetrahidroisoquinolil-2-histidilo, 1-aminoindil-1-carbonilo, 3-piridilalanilo, 2-ciclohexilglicilo, norleucilo, norvalilo, neopentilglicilo, triptofanilo, glicilo, 2,2-dimetilglicilo, alanilo, -alanilo y 3-naftilalanilo; X eshidrógeno, alquilo, cicloalquilo, -CH2-ciclohexilo o arilalquilo; s, t y u son independientemente 0 ó 1;y K es hidroxi, alcoxi, fenoxi, benciloxi o unresto amino sustituido o no sustituido; y las sales del mismo con ácidos fisiológicamente tolerados.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/944,479 US6015790A (en) | 1997-10-06 | 1997-10-06 | Methods and compositions for treating rheumatoid arthritis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2173626T3 true ES2173626T3 (es) | 2002-10-16 |
Family
ID=25481479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98948455T Expired - Lifetime ES2173626T3 (es) | 1997-10-06 | 1998-09-24 | Metodos y composiciones para tratar la artritis reumatoide. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6015790A (es) |
| EP (1) | EP1021200B1 (es) |
| JP (1) | JP2001518515A (es) |
| KR (1) | KR20010081900A (es) |
| CN (1) | CN1278734A (es) |
| AR (1) | AR017298A1 (es) |
| AT (1) | ATE212855T1 (es) |
| AU (2) | AU748465B2 (es) |
| BG (1) | BG104292A (es) |
| BR (1) | BR9812875A (es) |
| CA (1) | CA2305688A1 (es) |
| DE (1) | DE69803792D1 (es) |
| DK (1) | DK1021200T3 (es) |
| ES (1) | ES2173626T3 (es) |
| HR (1) | HRP20000265A2 (es) |
| HU (1) | HUP0101715A3 (es) |
| IL (1) | IL135167A0 (es) |
| NO (1) | NO20001758L (es) |
| PL (1) | PL339731A1 (es) |
| PT (1) | PT1021200E (es) |
| SK (1) | SK4272000A3 (es) |
| TR (1) | TR200000903T2 (es) |
| WO (2) | WO1999017792A1 (es) |
| ZA (1) | ZA989036B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010009901A1 (en) | 1996-12-11 | 2001-07-26 | Basf Aktiengesellschaft Germany | Antineoplastic peptides |
| KR100261114B1 (ko) * | 1998-01-24 | 2000-07-01 | 박종헌 | 히스톤을 함유하는 류마티스 관절염 치료제 조성물 |
| AU6464400A (en) * | 1999-09-14 | 2001-04-17 | Pfizer Products Inc. | Combination treatment with il-1ra and diaryl sulphonyl urea compounds |
| AU1730701A (en) * | 1999-12-07 | 2001-06-18 | Santen Pharmaceutical Co. Ltd. | Rheumatism remedy containing tetrapeptide derivative as active ingredient |
| BR0016699A (pt) * | 1999-12-24 | 2002-11-05 | Hoffmann La Roche | Compostos para o tratamento terapêutico e/ou profilático de distúrbios nos quais a catepsina "k" exerce uma função patológica significativa, processos para a manufatura dos mesmos e sua utilização |
| KR20090096716A (ko) * | 2007-01-09 | 2009-09-14 | 바이엘 쉐링 파마 악티엔게젤샤프트 | 아지리딘의 플루오르화에 의한 방사성표지 |
| EP2443136A4 (en) | 2009-06-18 | 2013-01-09 | Strongbone Ab | NOVEL PEPTIDE DERIVATIVES FOR TREATMENT, PREVENTION OR MITIGATION OF AFFECTION ASSOCIATED WITH BONE LOSS OR LOW BONE DENSITY OR INHIBITING DIFFERENTIATION AND STIMULATION OF OSTEOCLASTS |
| WO2014109414A1 (ja) * | 2013-01-11 | 2014-07-17 | 富士フイルム株式会社 | 含窒素複素環化合物またはその塩 |
| KR102372512B1 (ko) * | 2017-11-20 | 2022-03-10 | 가톨릭대학교 산학협력단 | 폴리감마글루탐산 및 메토트렉세이트를 유효성분으로 포함하는 관절염 예방 또는 치료용 조성물 |
| CN115281149A (zh) * | 2021-05-12 | 2022-11-04 | 四川大学华西医院 | 一种临床前类风湿关节炎(Pre-RA)小鼠模型 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816444A (en) * | 1987-07-10 | 1989-03-28 | Arizona Board Of Regents, Arizona State University | Cell growth inhibitory substance |
| US4879278A (en) * | 1989-05-16 | 1989-11-07 | Arizona Board Of Regents | Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15 |
| EP0934950B1 (en) * | 1991-08-09 | 2002-04-10 | Teikoku Hormone Mfg. Co., Ltd. | Tetrapeptide derivative |
| US5831002A (en) * | 1992-05-20 | 1998-11-03 | Basf Aktiengesellschaft | Antitumor peptides |
| JPH08504415A (ja) * | 1992-12-16 | 1996-05-14 | ビーエーエスエフ アクチエンゲゼルシャフト | 新規のペプチド、該ペプチドの製造及び使用 |
| US5504191A (en) * | 1994-08-01 | 1996-04-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide methyl esters |
| US5530097A (en) * | 1994-08-01 | 1996-06-25 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory peptide amides |
| US5583153A (en) * | 1994-10-06 | 1996-12-10 | Regents Of The University Of California | Use of taxol in the treatment of rheumatoid arthritis |
-
1997
- 1997-10-06 US US08/944,479 patent/US6015790A/en not_active Expired - Fee Related
-
1998
- 1998-09-24 EP EP98948455A patent/EP1021200B1/en not_active Expired - Lifetime
- 1998-09-24 PT PT98948455T patent/PT1021200E/pt unknown
- 1998-09-24 CA CA002305688A patent/CA2305688A1/en not_active Abandoned
- 1998-09-24 AT AT98948455T patent/ATE212855T1/de not_active IP Right Cessation
- 1998-09-24 KR KR1020007003706A patent/KR20010081900A/ko not_active Application Discontinuation
- 1998-09-24 SK SK427-2000A patent/SK4272000A3/sk unknown
- 1998-09-24 DE DE69803792T patent/DE69803792D1/de not_active Expired - Fee Related
- 1998-09-24 PL PL98339731A patent/PL339731A1/xx not_active Application Discontinuation
- 1998-09-24 HU HU0101715A patent/HUP0101715A3/hu unknown
- 1998-09-24 AU AU95024/98A patent/AU748465B2/en not_active Ceased
- 1998-09-24 WO PCT/US1998/019841 patent/WO1999017792A1/en not_active Application Discontinuation
- 1998-09-24 DK DK98948455T patent/DK1021200T3/da active
- 1998-09-24 BR BR9812875-2A patent/BR9812875A/pt not_active IP Right Cessation
- 1998-09-24 ES ES98948455T patent/ES2173626T3/es not_active Expired - Lifetime
- 1998-09-24 JP JP2000514663A patent/JP2001518515A/ja not_active Withdrawn
- 1998-09-24 CN CN98811034A patent/CN1278734A/zh active Pending
- 1998-09-24 TR TR2000/00903T patent/TR200000903T2/xx unknown
- 1998-09-24 IL IL13516798A patent/IL135167A0/xx unknown
- 1998-09-30 AU AU95926/98A patent/AU9592698A/en not_active Withdrawn
- 1998-09-30 WO PCT/US1998/020465 patent/WO1999017709A2/en active Application Filing
- 1998-10-05 ZA ZA9809036A patent/ZA989036B/xx unknown
- 1998-10-06 AR ARP980104972A patent/AR017298A1/es not_active Application Discontinuation
-
2000
- 2000-04-03 BG BG104292A patent/BG104292A/xx unknown
- 2000-04-05 NO NO20001758A patent/NO20001758L/no not_active Application Discontinuation
- 2000-05-04 HR HR20000265A patent/HRP20000265A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1021200A1 (en) | 2000-07-26 |
| DK1021200T3 (da) | 2002-05-27 |
| WO1999017709A2 (en) | 1999-04-15 |
| CN1278734A (zh) | 2001-01-03 |
| US6015790A (en) | 2000-01-18 |
| ATE212855T1 (de) | 2002-02-15 |
| AU9502498A (en) | 1999-04-27 |
| PL339731A1 (en) | 2001-01-02 |
| AR017298A1 (es) | 2001-09-05 |
| CA2305688A1 (en) | 1999-04-15 |
| BR9812875A (pt) | 2000-08-08 |
| PT1021200E (pt) | 2002-07-31 |
| KR20010081900A (ko) | 2001-08-29 |
| NO20001758D0 (no) | 2000-04-05 |
| TR200000903T2 (tr) | 2001-07-23 |
| ZA989036B (en) | 2000-04-05 |
| NO20001758L (no) | 2000-06-05 |
| EP1021200B1 (en) | 2002-02-06 |
| WO1999017792A1 (en) | 1999-04-15 |
| BG104292A (en) | 2000-12-29 |
| SK4272000A3 (en) | 2001-02-12 |
| AU9592698A (en) | 1999-04-27 |
| HUP0101715A3 (en) | 2001-12-28 |
| AU748465B2 (en) | 2002-06-06 |
| HRP20000265A2 (en) | 2000-12-31 |
| JP2001518515A (ja) | 2001-10-16 |
| HUP0101715A2 (hu) | 2001-11-28 |
| IL135167A0 (en) | 2001-05-20 |
| DE69803792D1 (de) | 2002-03-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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