HK87793A - 2-aminoacetamide derivatives - Google Patents

2-aminoacetamide derivatives Download PDF

Info

Publication number
HK87793A
HK87793A HK877/93A HK87793A HK87793A HK 87793 A HK87793 A HK 87793A HK 877/93 A HK877/93 A HK 877/93A HK 87793 A HK87793 A HK 87793A HK 87793 A HK87793 A HK 87793A
Authority
HK
Hong Kong
Prior art keywords
diphenyl
amino
acetamide
compound
preparing
Prior art date
Application number
HK877/93A
Other languages
English (en)
French (fr)
Inventor
Ronald C. Griffith
James J. Napler
Original Assignee
Fisons Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Corporation filed Critical Fisons Corporation
Publication of HK87793A publication Critical patent/HK87793A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (10)

  1. Verfahren zur Herstellung einer Verbindung der Formel: worin B Wasserstoff, Niedrigalkyl-(C₁-C₄) oder Methoxycarbonyl bedeutet; R₁ Wasserstoff oder Methyl bedeutet und worin W und Q unabhängig ausgewählt werden unter Phenyl oder 4-Fluorphenyl, dadurch gekennzeichnet, daß ein Amin der Formel: mit einer geeigneten geschützten Aminosäure der Formel: worin X eine Urethan-Schutzgruppe bedeutet, umgesetzt wird und anschließend die Schutzgruppe durch katalytische Hydrierung oder Behandlung mit einer Säure entfernt wird.
  2. Verfahren zur Herstellung einer Verbindung nach Anspruch 1, dadurch gekennzeichnet, daß die Verbindung 2-Amino-N-(1,2-diphenyl-1-methylethyl)-acetamid-hydrochlorid ist.
  3. Verfahren zur Herstellung einer Verbindung nach Anspruch 1, dadurch gekennzeichnet, daß die Verbindung 2-Amino-N-[1,2-bis-(4-fluorphenyl)-1-methyl-ethyl]-acetamid ist.
  4. Verfahren zur Herstellung einer Verbindung nach Anspruch 1, dadurch gekennzeichnet, daß die Verbindung 2-Amino-N-(1-ethyl-1,2-diphenylethyl)-acetamid ist.
  5. Verfahren zur Herstellung einer Verbindung nach Anspruch 1, dadurch gekennzeichnet, daß die Verbindung 2-Amino-N-(1,2-diphenylethyl)-acetamid-hydrochlorid ist.
  6. Verfahren zur Herstellung einer Verbindung nach Anspruch 1, dadurch gekennzeichnet, daß die Verbindung 2-Amino-N-[1,2-diphenyl-1-(methoxycarbonyl)-ethyl]-acetamid-maleat ist.
  7. Verfahren zur Herstellung einer Verbindung nach Anspruch 1, dadurch gekennzeichnet, daß die Verbindung (+)-2-Amino-N-(1,2-diphenyl-1-methylethyl)-acetamid-fumarat ist.
  8. Verfahren zur Herstellung einer Verbindung nach Anspruch 1, dadurch gekennzeichnet, daß die Verbindung (-)-2-Amino-N-(1,2-diphenyl-1-methylethyl)-acetamid-fumarat ist.
  9. Verfahren zur Herstellung einer Verbindung nach Anspruch 1, dadurch gekennzeichnet, daß die Verbindung 2-Amino-N-methyl-N-(1,2-diphenylethyl)-acetamid-maleat ist.
  10. Verfahren zur Herstellung einer Verbindung nach Anspruch 1, dadurch gekennzeichnet, daß die Verbindung 2-Amino-N-methyl-N-(1,2-diphenyl-1-methylethyl)-acetamid-maleat ist.
HK877/93A 1987-02-06 1993-08-26 2-aminoacetamide derivatives HK87793A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1198287A 1987-02-06 1987-02-06

Publications (1)

Publication Number Publication Date
HK87793A true HK87793A (en) 1993-09-03

Family

ID=21752812

Family Applications (1)

Application Number Title Priority Date Filing Date
HK877/93A HK87793A (en) 1987-02-06 1993-08-26 2-aminoacetamide derivatives

Country Status (19)

Country Link
EP (1) EP0279937B1 (de)
JP (1) JPH0653715B2 (de)
KR (1) KR960004186B1 (de)
AT (1) ATE68174T1 (de)
AU (1) AU601782B2 (de)
BR (1) BR1100967A (de)
CA (1) CA1338121C (de)
DE (1) DE3773658D1 (de)
DK (1) DK175076B1 (de)
ES (1) ES2038159T3 (de)
FI (1) FI91853C (de)
HK (1) HK87793A (de)
IE (1) IE59940B1 (de)
IL (1) IL84305A (de)
MX (1) MX9202994A (de)
NO (1) NO174771C (de)
NZ (1) NZ222359A (de)
PT (1) PT86250B (de)
ZA (1) ZA878799B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG52662A1 (en) * 1988-08-12 1998-09-28 Astra Ab Arylkalkyl-amines and -amides having anticonvulsant and neuroprotective properties
AU639722B2 (en) * 1989-10-27 1993-08-05 Astra Aktiebolag Use of arylalkylamides in the treatment of neurodegenerative diseases
GB9626319D0 (en) * 1996-12-19 1997-02-05 Astra Pharma Prod Synthetic method
SE9702793D0 (sv) * 1997-07-24 1997-07-24 Astra Pharma Prod Novel formulation
AR016212A1 (es) * 1998-04-28 2001-06-20 Astra Ab Uso de compuestos farmaceuticos que tienen una actividad antagonista de nmda para preparar un medicamento para el tratamiento del sindrome de intestino irritable (ibs), y composiciones farmaceuticas
SE9901077D0 (sv) * 1999-03-23 1999-03-23 Astra Ab Novel use
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE955508C (de) * 1954-07-28 1957-01-03 Cilag Ag Verfahren zur Herstellung von antikonvulsivisch wirkenden Carbonsaeureamiden

Also Published As

Publication number Publication date
MX9202994A (es) 1992-07-01
ATE68174T1 (de) 1991-10-15
IL84305A (en) 1992-01-15
FI91853B (fi) 1994-05-13
KR880009909A (ko) 1988-10-05
EP0279937B1 (de) 1991-10-09
KR960004186B1 (ko) 1996-03-27
BR1100967A (pt) 1999-10-13
DK58588A (da) 1988-09-21
NZ222359A (en) 1989-12-21
ZA878799B (en) 1988-05-20
NO880523L (no) 1988-08-08
DK58588D0 (da) 1988-02-05
PT86250A (en) 1987-12-01
AU8143087A (en) 1988-08-04
DK175076B1 (da) 2004-05-24
EP0279937A1 (de) 1988-08-31
DE3773658D1 (de) 1991-11-14
IE59940B1 (en) 1994-05-04
FI880548A0 (fi) 1988-02-05
IL84305A0 (en) 1988-03-31
NO880523D0 (no) 1988-02-05
AU601782B2 (en) 1990-09-20
FI880548L (fi) 1988-08-07
NO174771C (no) 1994-07-06
FI91853C (fi) 1994-08-25
JPS63216853A (ja) 1988-09-09
JPH0653715B2 (ja) 1994-07-20
PT86250B (pt) 1991-02-08
IE872930L (en) 1988-08-06
ES2038159T3 (es) 1993-07-16
CA1338121C (en) 1996-03-05
NO174771B (no) 1994-03-28

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20061214